메뉴 건너뛰기




Volumn 6, Issue 7, 2011, Pages

Herpes simplex virus type 1 penetrates the basement membrane in human nasal respiratory mucosa

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BASEMENT MEMBRANE; CELL ACTIVITY; DISEASE DURATION; EXPERIMENTAL MODEL; EXPLANT; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; HUMAN TISSUE; LAMINA PROPRIA; NOSE MUCOSA; PATHOGENESIS; VIRUS CELL INTERACTION; VIRUS CULTURE; VIRUS ENTRY; VIRUS INFECTION; VIRUS MORPHOLOGY; VIRUS REPLICATION; VIRUS VIABILITY; BIOLOGICAL MODEL; EPITHELIUM; FLUORESCENCE; NICK END LABELING; PHYSIOLOGY; ULTRASTRUCTURE; VIROLOGY;

EID: 79960339318     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022160     Document Type: Article
Times cited : (31)

References (59)
  • 1
    • 0035085639 scopus 로고    scopus 로고
    • Identification of herpes simplex virus genital infection: comparison of a multiplex PCR assay and traditional viral isolation techniques
    • Marshall DS, Linfert DR, Draghi A, McCarter YS, Tsongalis GJ, (2001) Identification of herpes simplex virus genital infection: comparison of a multiplex PCR assay and traditional viral isolation techniques. Mod Pathol 14: 152-156.
    • (2001) Mod Pathol , vol.14 , pp. 152-156
    • Marshall, D.S.1    Linfert, D.R.2    Draghi, A.3    McCarter, Y.S.4    Tsongalis, G.J.5
  • 2
    • 73949088324 scopus 로고    scopus 로고
    • Genital herpes simplex virus type 1 in women: detection in cervicovaginal specimens from gynecological practices in the United States
    • Peña KC, Adelson ME, Mordechai E, Blaho JA, (2010) Genital herpes simplex virus type 1 in women: detection in cervicovaginal specimens from gynecological practices in the United States. J Clin Microbiol 48: 150-153.
    • (2010) J Clin Microbiol , vol.48 , pp. 150-153
    • Peña, K.C.1    Adelson, M.E.2    Mordechai, E.3    Blaho, J.A.4
  • 3
    • 0000314691 scopus 로고    scopus 로고
    • Herpes simplex viruses
    • In: Knipe DM, Howley PM, Griffin DE, Lamb RA, Martint MA, editors, Philadelphia, Lippincott, Williams, Wilkins
    • Whitley RJ, (2001) Herpes simplex viruses. In: Knipe DM, Howley PM, Griffin DE, Lamb RA, Martint MA, editors. Fields virology Philadelphia Lippincott, Williams, Wilkins pp. 2461-2509.
    • (2001) Fields Virology , pp. 2461-2509
    • Whitley, R.J.1
  • 6
    • 2942575803 scopus 로고    scopus 로고
    • The seroepidemiology of herpes simplex virus type 1 and 2 in Europe
    • Pebody R, Andrews N, Brown D, Gopal R, de Melker H, et al. (2004) The seroepidemiology of herpes simplex virus type 1 and 2 in Europe. Sex Transm Infect 80: 185-191.
    • (2004) Sex Transm Infect , vol.80 , pp. 185-191
    • Pebody, R.1    Andrews, N.2    Brown, D.3    Gopal, R.4    de Melker, H.5
  • 8
    • 0026100403 scopus 로고
    • A controlled trial comparing vidarabine with acyclovir in neonatal herpes simplex virus infection. Infectious diseases collaborative antiviral study group
    • Whitley R, Arvin A, Prober C, Burchett S, Corey L, et al. (1991) A controlled trial comparing vidarabine with acyclovir in neonatal herpes simplex virus infection. Infectious diseases collaborative antiviral study group. N Engl J Med 324: 444-449.
    • (1991) N Engl J Med , vol.324 , pp. 444-449
    • Whitley, R.1    Arvin, A.2    Prober, C.3    Burchett, S.4    Corey, L.5
  • 11
    • 34250904076 scopus 로고    scopus 로고
    • Diverse herpes simplex virus type 1 thymidine kinase mutants in individual human neurons and ganglia
    • Wang K, Mahalingam G, Hoover SE, Mont EK, Holland SM, et al. (2007) Diverse herpes simplex virus type 1 thymidine kinase mutants in individual human neurons and ganglia. J Virol 81: 6817-6826.
    • (2007) J Virol , vol.81 , pp. 6817-6826
    • Wang, K.1    Mahalingam, G.2    Hoover, S.E.3    Mont, E.K.4    Holland, S.M.5
  • 13
    • 0037237569 scopus 로고    scopus 로고
    • Recent progress in herpes simplex virus immunobiology and vaccine research
    • Koelle DW, Corey L, (2003) Recent progress in herpes simplex virus immunobiology and vaccine research. Clin Microbiol Rev 16: 96-113.
    • (2003) Clin Microbiol Rev , vol.16 , pp. 96-113
    • Koelle, D.W.1    Corey, L.2
  • 14
    • 0037505134 scopus 로고    scopus 로고
    • Assembly, stability and integrity of basement membranes in vivo
    • Quondamatteo F, (2002) Assembly, stability and integrity of basement membranes in vivo. Histochem J 34: 369-381.
    • (2002) Histochem J , vol.34 , pp. 369-381
    • Quondamatteo, F.1
  • 17
    • 35348925371 scopus 로고    scopus 로고
    • Treatment of herpes simplex virus infection: rationale for occlusion
    • Patel AR, Romanelli P, Roberts B, Kirsner RS, (2007) Treatment of herpes simplex virus infection: rationale for occlusion. Adv Skin Wound Care 20: 408-412.
    • (2007) Adv Skin Wound Care , vol.20 , pp. 408-412
    • Patel, A.R.1    Romanelli, P.2    Roberts, B.3    Kirsner, R.S.4
  • 18
    • 58149308152 scopus 로고    scopus 로고
    • Herpes simplex virus: a histopathologic study of the depth of herpetic wounds
    • Patel AR, Romanelli P, Roberts B, Kirsner RS, (2009) Herpes simplex virus: a histopathologic study of the depth of herpetic wounds. Int J Dermatol 48: 36-40.
    • (2009) Int J Dermatol , vol.48 , pp. 36-40
    • Patel, A.R.1    Romanelli, P.2    Roberts, B.3    Kirsner, R.S.4
  • 19
    • 0023106695 scopus 로고
    • The enigma of herpes stromal disease
    • McGill J, (1987) The enigma of herpes stromal disease. Br J Ophthalmol 71: 118-125.
    • (1987) Br J Ophthalmol , vol.71 , pp. 118-125
    • McGill, J.1
  • 20
    • 0028089018 scopus 로고
    • Herpes simplex virus glycoproteins E and I facilitate cell-to-cell spread in vivo and across junctions of cultured cells
    • Dingwell KS, Brunetti CR, Hendricks RL, Tang Q, Tang M, et al. (1994) Herpes simplex virus glycoproteins E and I facilitate cell-to-cell spread in vivo and across junctions of cultured cells. J Virol 68: 834-845.
    • (1994) J Virol , vol.68 , pp. 834-845
    • Dingwell, K.S.1    Brunetti, C.R.2    Hendricks, R.L.3    Tang, Q.4    Tang, M.5
  • 21
    • 23844460518 scopus 로고    scopus 로고
    • Herpes keratitis in the absence of anterograde transport of virus from sensory ganglia to the cornea
    • Polcicova K, Biswas PS, Banerjee K, Wisner TW, Rouse BT, et al. (2005) Herpes keratitis in the absence of anterograde transport of virus from sensory ganglia to the cornea. PNAS 102: 11462-11467.
    • (2005) PNAS , vol.102 , pp. 11462-11467
    • Polcicova, K.1    Biswas, P.S.2    Banerjee, K.3    Wisner, T.W.4    Rouse, B.T.5
  • 22
    • 0034102043 scopus 로고    scopus 로고
    • Herpes simplex virus type-1 and -2 pathogenesis is restricted by the epidermal basement membrane
    • Weeks BS, Ramchandran RS, Hopkins JJ, Friedman HM, (2000) Herpes simplex virus type-1 and-2 pathogenesis is restricted by the epidermal basement membrane. Arch Virol 145: 385-396.
    • (2000) Arch Virol , vol.145 , pp. 385-396
    • Weeks, B.S.1    Ramchandran, R.S.2    Hopkins, J.J.3    Friedman, H.M.4
  • 24
    • 72849126710 scopus 로고    scopus 로고
    • Clinical correlates of herpes simplex virus viremia among hospitalized adults
    • Berrington WR, Jerome KR, Cook L, Wald A, Corey L, et al. (2009) Clinical correlates of herpes simplex virus viremia among hospitalized adults. Clin Infect Dis 49: 1295-1301.
    • (2009) Clin Infect Dis , vol.49 , pp. 1295-1301
    • Berrington, W.R.1    Jerome, K.R.2    Cook, L.3    Wald, A.4    Corey, L.5
  • 25
    • 33646129235 scopus 로고    scopus 로고
    • Anatomical mapping of human herpesvirus reservoirs of infection
    • Chen T, Hudnall SD, (2006) Anatomical mapping of human herpesvirus reservoirs of infection. Mod Pathol 19: 726-737.
    • (2006) Mod Pathol , vol.19 , pp. 726-737
    • Chen, T.1    Hudnall, S.D.2
  • 26
    • 0026042416 scopus 로고
    • The effect of cholera toxin and cholera toxin B subunit on the nasal mucosal membrane
    • Gizurarson S, Tamura S, Kurata T, Hasiguchi K, Ogawa H, (1991) The effect of cholera toxin and cholera toxin B subunit on the nasal mucosal membrane. Vaccine 9: 825-832.
    • (1991) Vaccine , vol.9 , pp. 825-832
    • Gizurarson, S.1    Tamura, S.2    Kurata, T.3    Hasiguchi, K.4    Ogawa, H.5
  • 27
    • 0038617335 scopus 로고    scopus 로고
    • Functional analysis of tight junctions
    • Matter K, Balda MS, (2003) Functional analysis of tight junctions. Methods 30: 228-234.
    • (2003) Methods , vol.30 , pp. 228-234
    • Matter, K.1    Balda, M.S.2
  • 28
    • 34247129541 scopus 로고    scopus 로고
    • In vitro culture of porcine respiratory nasal mucosa explants for studying the interaction of porcine viruses with the respiratory tract
    • Glorieux S, Van den Broeck W, van der Meulen KM, Van Reeth K, Favoreel HW, et al. (2007) In vitro culture of porcine respiratory nasal mucosa explants for studying the interaction of porcine viruses with the respiratory tract. J Virol Methods 142: 105-112.
    • (2007) J Virol Methods , vol.142 , pp. 105-112
    • Glorieux, S.1    van den Broeck, W.2    van der Meulen, K.M.3    van Reeth, K.4    Favoreel, H.W.5
  • 29
    • 0001888933 scopus 로고
    • Connective tissues and stains
    • In: Bancroft JD, Stevens A, editors, New York, Churchill Livingstone
    • Bradbury P, Gordon K, (1977) Connective tissues and stains. In: Bancroft JD, Stevens A, editors. Theory and practice of histological techniques New York Churchill Livingstone pp. 109-110.
    • (1977) Theory and Practice of Histological Techniques , pp. 109-110
    • Bradbury, P.1    Gordon, K.2
  • 31
    • 0001888933 scopus 로고
    • Connective tissues and stains
    • In: Bancroft JD, Stevens A, editors, New York, Churchill Livingstone
    • Bradbury P, Gordon K, (1977) Connective tissues and stains. In: Bancroft JD, Stevens A, editors. Theory and practice of histological techniques New York Churchill Livingstone pp. 103 p.
    • (1977) Theory and Practice of Histological Techniques , pp. 103
    • Bradbury, P.1    Gordon, K.2
  • 32
    • 0034699378 scopus 로고    scopus 로고
    • Detection of dead cells and measurement of cell killing by flow cytometry
    • King MA, (2000) Detection of dead cells and measurement of cell killing by flow cytometry. J Immunol Methods 243: 155-166.
    • (2000) J Immunol Methods , vol.243 , pp. 155-166
    • King, M.A.1
  • 33
    • 32544457702 scopus 로고    scopus 로고
    • In vitro micronucleus scoring by flow cytometry: differential staining of micronuclei versus apoptotic and necrotic chromatin enhances assay reliability
    • Avlasevich SL, Bryce SM, Cairns SE, Dertinger SD, (2006) In vitro micronucleus scoring by flow cytometry: differential staining of micronuclei versus apoptotic and necrotic chromatin enhances assay reliability. Environ Mol Mutagen 47: 56-66.
    • (2006) Environ Mol Mutagen , vol.47 , pp. 56-66
    • Avlasevich, S.L.1    Bryce, S.M.2    Cairns, S.E.3    Dertinger, S.D.4
  • 34
    • 84912736429 scopus 로고
    • Loose connective tissue and basement membrane
    • Philadelphia, J.B. Lippincott Company
    • Ham AW, Cormack DH, (1979) Loose connective tissue and basement membrane. Histology Philadelphia J.B. Lippincott Company pp. 222-224.
    • (1979) Histology , pp. 222-224
    • Ham, A.W.1    Cormack, D.H.2
  • 36
    • 0029869587 scopus 로고    scopus 로고
    • Spontaneous release of submucosal gland serous and mucous cell macromolecules from human nasal explants in vitro
    • Ali M, Maniscalco J, Baraniuk JN, (1996) Spontaneous release of submucosal gland serous and mucous cell macromolecules from human nasal explants in vitro. Am J Physiol 270: L595-L600.
    • (1996) Am J Physiol , vol.270 , pp. 595-600
    • Ali, M.1    Maniscalco, J.2    Baraniuk, J.N.3
  • 38
    • 14544281979 scopus 로고    scopus 로고
    • Development of rhinovirus study model using organ culture of turbinate mucosa
    • Jang YJ, Lee SH, Kwon H-J, Chung Y-S, Lee B-J, (2005) Development of rhinovirus study model using organ culture of turbinate mucosa. J Virol Methods 125: 41-47.
    • (2005) J Virol Methods , vol.125 , pp. 41-47
    • Jang, Y.J.1    Lee, S.H.2    Kwon, H.-J.3    Chung, Y.-S.4    Lee, B.-J.5
  • 39
    • 0036992891 scopus 로고    scopus 로고
    • Cancer as a disease of epithelial-mesenchymal interactions and extracellular matrix regulation
    • Ingber DE, (2002) Cancer as a disease of epithelial-mesenchymal interactions and extracellular matrix regulation. Differentiation 70: 547-560.
    • (2002) Differentiation , vol.70 , pp. 547-560
    • Ingber, D.E.1
  • 40
    • 0032580451 scopus 로고    scopus 로고
    • Nasal delivery of peptides: an in vitro cell culture model for the investigation of transport and metabolism in human nasal epithelium
    • Kissel T, Werner U, (1998) Nasal delivery of peptides: an in vitro cell culture model for the investigation of transport and metabolism in human nasal epithelium. J Control Release 53: 195-203.
    • (1998) J Control Release , vol.53 , pp. 195-203
    • Kissel, T.1    Werner, U.2
  • 41
    • 0031042153 scopus 로고    scopus 로고
    • Nasal polyposis: immunohistochemistry and bioelectrical findings (a hypothesis for the development of nasal polyps)
    • Bernstein JM, Gorfien J, Noble B, Yankaskas JR, (1997) Nasal polyposis: immunohistochemistry and bioelectrical findings (a hypothesis for the development of nasal polyps). J Allergy Clin Immunol 99: 165-175.
    • (1997) J Allergy Clin Immunol , vol.99 , pp. 165-175
    • Bernstein, J.M.1    Gorfien, J.2    Noble, B.3    Yankaskas, J.R.4
  • 42
    • 0023150501 scopus 로고
    • Abnormal apical cell membrane in cystic fibrosis respiratory epithelium. An in vitro electrophysiologic analysis
    • Cotton CU, Stutts MJ, Knowles MR, Gatzy JT, Boucher RC, (1987) Abnormal apical cell membrane in cystic fibrosis respiratory epithelium. An in vitro electrophysiologic analysis. J Clin Invest 79: 80-85.
    • (1987) J Clin Invest , vol.79 , pp. 80-85
    • Cotton, C.U.1    Stutts, M.J.2    Knowles, M.R.3    Gatzy, J.T.4    Boucher, R.C.5
  • 43
    • 64649104317 scopus 로고    scopus 로고
    • Different replication characteristics of historical pseudorabies virus strains in porcine respiratory nasal mucosa explants
    • Glorieux S, Favoreel HW, Meesen G, de vos W, Van den Broeck W, et al. (2009) Different replication characteristics of historical pseudorabies virus strains in porcine respiratory nasal mucosa explants. Vet Microbiol 136: 341-346.
    • (2009) Vet Microbiol , vol.136 , pp. 341-346
    • Glorieux, S.1    Favoreel, H.W.2    Meesen, G.3    de vos, W.4    van den Broeck, W.5
  • 45
    • 77955287852 scopus 로고    scopus 로고
    • Replication kinetics of neurovirulent versus non-neurovirulent equine herpesvirus type 1 strains in equine nasal mucosal explants
    • Vandekerckhove AP, Glorieux S, Gryspeerdt AC, Steukers L, Duchateau L, et al. (2010) Replication kinetics of neurovirulent versus non-neurovirulent equine herpesvirus type 1 strains in equine nasal mucosal explants. J Gen Virol 91: 2019-2028.
    • (2010) J Gen Virol , vol.91 , pp. 2019-2028
    • Vandekerckhove, A.P.1    Glorieux, S.2    Gryspeerdt, A.C.3    Steukers, L.4    Duchateau, L.5
  • 46
    • 0015043133 scopus 로고
    • The local chemical environment of nodes of Ranvier: a study of cation binding
    • Landon DN, Langley OK, (1971) The local chemical environment of nodes of Ranvier: a study of cation binding. J Anat 108: 419-432.
    • (1971) J Anat , vol.108 , pp. 419-432
    • Landon, D.N.1    Langley, O.K.2
  • 47
    • 77955174293 scopus 로고    scopus 로고
    • Apoptosis induction after herpes simplex virus infection differs according to cell type in vivo
    • Esaki S, Goshima F, Katsumi S, Watanabe D, Ozaki N, et al. (2010) Apoptosis induction after herpes simplex virus infection differs according to cell type in vivo. Arch Virol 55: 1235-1245.
    • (2010) Arch Virol , vol.55 , pp. 1235-1245
    • Esaki, S.1    Goshima, F.2    Katsumi, S.3    Watanabe, D.4    Ozaki, N.5
  • 48
    • 0032892926 scopus 로고    scopus 로고
    • US3 potein kinase of herpes simplex virus type 2 plays a role in protecting corneal epithelial cells from apoptosis in infected mice
    • Asano S, Honda T, Goshima F, Watanabe D, Miyake Y, et al. (1999) US3 potein kinase of herpes simplex virus type 2 plays a role in protecting corneal epithelial cells from apoptosis in infected mice. J Gen Virol 80: 51-56.
    • (1999) J Gen Virol , vol.80 , pp. 51-56
    • Asano, S.1    Honda, T.2    Goshima, F.3    Watanabe, D.4    Miyake, Y.5
  • 49
    • 9344221128 scopus 로고    scopus 로고
    • Ocular and neuronal cell apoptosis during HSV-1 infection: a review
    • Miles DH, Willcox MD, Athmanathan S, (2004) Ocular and neuronal cell apoptosis during HSV-1 infection: a review. Curr Eye Res 29: 79-90.
    • (2004) Curr Eye Res , vol.29 , pp. 79-90
    • Miles, D.H.1    Willcox, M.D.2    Athmanathan, S.3
  • 50
    • 0032749021 scopus 로고    scopus 로고
    • Antiapoptotic activity of herpes simplex virus type 2: the role of US3 protein kinase gene
    • Hata S, Koyama AH, Shiota H, Adachi A, Goshima F, et al. (1999) Antiapoptotic activity of herpes simplex virus type 2: the role of US3 protein kinase gene. Microbes Infect 1: 601-607.
    • (1999) Microbes Infect , vol.1 , pp. 601-607
    • Hata, S.1    Koyama, A.H.2    Shiota, H.3    Adachi, A.4    Goshima, F.5
  • 51
    • 33845985638 scopus 로고    scopus 로고
    • Apoptosis during herpes simplex virus infection
    • Nguyen ML, Blaho JA, (2007) Apoptosis during herpes simplex virus infection. Adv Virus Res 69: 67-97.
    • (2007) Adv Virus Res , vol.69 , pp. 67-97
    • Nguyen, M.L.1    Blaho, J.A.2
  • 52
    • 0032830315 scopus 로고    scopus 로고
    • Herpes simplex virus inhibits apoptosis through the action of two genes, Us5 and Us3
    • Jerome KR, Fox R, Chen Z, Sears AE, Lee H, et al. (1999) Herpes simplex virus inhibits apoptosis through the action of two genes, Us5 and Us3. J Virol 73: 8950-8957.
    • (1999) J Virol , vol.73 , pp. 8950-8957
    • Jerome, K.R.1    Fox, R.2    Chen, Z.3    Sears, A.E.4    Lee, H.5
  • 53
    • 0034712014 scopus 로고    scopus 로고
    • Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript
    • Perng GC, Jones C, Ciacci-Zanella J, Stone M, Henderson G, et al. (2000) Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript. Science 287: 1500-1503.
    • (2000) Science , vol.287 , pp. 1500-1503
    • Perng, G.C.1    Jones, C.2    Ciacci-Zanella, J.3    Stone, M.4    Henderson, G.5
  • 54
    • 0036843525 scopus 로고    scopus 로고
    • The R1 subunit of herpes simplex virus ribonucleotide reductase protects cells against apoptosis at, or upstream of, caspase-8 activation
    • Langelier Y, Bergeron S, Chabaud S, Lippens J, Guilbault C, et al. (2002) The R1 subunit of herpes simplex virus ribonucleotide reductase protects cells against apoptosis at, or upstream of, caspase-8 activation. J Gen Virol 83: 2779-2789.
    • (2002) J Gen Virol , vol.83 , pp. 2779-2789
    • Langelier, Y.1    Bergeron, S.2    Chabaud, S.3    Lippens, J.4    Guilbault, C.5
  • 55
    • 43849103204 scopus 로고    scopus 로고
    • Protection against heat and staurosporine mediated apoptosis by the HSV-1 US11 protein
    • Javouhey E, Gibert B, Arrigo AP, Diaz JJ, Diaz-Latoud C, (2008) Protection against heat and staurosporine mediated apoptosis by the HSV-1 US11 protein. Virology 376: 31-41.
    • (2008) Virology , vol.376 , pp. 31-41
    • Javouhey, E.1    Gibert, B.2    Arrigo, A.P.3    Diaz, J.J.4    Diaz-Latoud, C.5
  • 56
    • 0032978709 scopus 로고    scopus 로고
    • The herpes simplex virus type 1 regulatory protein ICP27 is required for the prevention of apoptosis in infected human cells
    • Aubert M, Blaho JA, (1999) The herpes simplex virus type 1 regulatory protein ICP27 is required for the prevention of apoptosis in infected human cells. J Virol 73: 2803-2813.
    • (1999) J Virol , vol.73 , pp. 2803-2813
    • Aubert, M.1    Blaho, J.A.2
  • 58
    • 0032493870 scopus 로고    scopus 로고
    • Differential requirement for caspase 9 in apoptotic pathways in vivo
    • Hakem R, Hakem A, Duncan GS, Henderson JT, Woo M, et al. (1998) Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94: 339-352.
    • (1998) Cell , vol.94 , pp. 339-352
    • Hakem, R.1    Hakem, A.2    Duncan, G.S.3    Henderson, J.T.4    Woo, M.5
  • 59
    • 0032584081 scopus 로고    scopus 로고
    • Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner
    • Galvan V, Roizman B, (1998) Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner. Proc Natl Acad Sci USA 95: 3931-3936.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 3931-3936
    • Galvan, V.1    Roizman, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.