Diverse herpes simplex virus type 1 thymidine kinase mutants in individual human neurons and ganglia

Journal of Virology

Volumn 81, Issue 13, 2007, Pages 6817-6826

  Wang, Kening ^a   Mahalingam, Gowtham ^a   Hoover, Susan E ^a,b   Mont, Erik K ^a,c   Holland, Steven M ^a   Cohen, Jeffrey I ^a   Straus, Stephen E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c Miami Dade Medical Examiner Department   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; MUTANT PROTEIN; THYMIDINE KINASE; VIRUS ENZYME;

ARTICLE; GANGLION; GENE MUTATION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN TISSUE; LASER CAPTURE MICRODISSECTION; MOLECULAR CLOCK; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; SENSORY GANGLION; SEQUENCE ANALYSIS; SKIN INFECTION; SPINAL GANGLION; TRIGEMINUS GANGLION; VIRUS GENE; VIRUS MUTANT; VIRUS REPLICATION; WILD TYPE;

ACYCLOVIR; ANTIVIRAL AGENTS; DRUG RESISTANCE, VIRAL; GANGLIA, SPINAL; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HUMANS; NEURONS, AFFERENT; POINT MUTATION; THYMIDINE KINASE; TRIGEMINAL NUCLEI; VIRAL PROTEINS; VIRUS LATENCY;

ANIMALIA; HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 34250904076     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00166-07     Document Type: Article

References (41)

1. Balasubramaniam, N. K., V. Veerisetty, and G. A. Gentry. 1990. Herpesviral deoxythymidine kinases contain a site analogous to the phosphoryl-binding arginine-rich region of porcine adenylate kinase; comparison of secondary structure predictions and conservation. J. Gen. Virol. 71:2979-2987.
2. Boivin, G., C. K. Edelman, L. Pedneault, C. L. Talarico, K. K. Biron, and H. H. Balfour, Jr. 1994. Phenotypic and genotypic characterization of acyclovir-resistant varicella-zoster viruses isolated from persons with AIDS. J. Infect. Dis. 170:68-75.
3. Brown, D. G., R. Visse, G. Sandhu, A. Davies, P. J. Rizkallah, C. Melitz, W. C. Summers, and M. R. Sanderson. 1995. Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir. Nat. Struct. Biol. 2:876-881.
4. Chen, S. H., Y. W. Lin, A. Griffiths, W. Y. Huang, and S. H. Chen. 2006. Competition and complementation between thymidine kinase-negative and wild-type herpes simplex virus during co-infection of mouse trigeminal ganglia. J. Gen. Virol. 87:3495-3502.
5. Chen, S. H., A. Pearson, D. M. Coen, and S. H. Chen. 2004. Failure of thymidine kinase-negative herpes simplex virus to reactivate from latency following efficient establishment. J. Virol. 78:520-523.
6. Chibo, D., J. Druce, J. Sasadeusz, and C. Birch. 2004. Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus. Antivir. Res. 61:83-91.
7. Czartoski, T., C. Liu, D. M. Koelle, S. Schmechel, A. Kalus, and A. Wald. 2006. Fulminant, acyclovir-resistant, herpes simplex virus type 2 hepatitis in an immunocompetent woman. J. Clin. Microbiol. 44:1584-1586.
8. Elion, G. B. 1983. The biochemistry and mechanism of action of acyclovir. J. Antimicrob. Chemother. 12(Suppl. B):9-17.
9. Gaudreau, A., E. Hill, H. H. Balfour, Jr., A. Erice, and G. Boivin. 1998. Phenotypic and genotypic characterization of acyclovir-resistant herpes simplex viruses from immunocompromised patients. J. Infect. Dis. 178:297-303.
10. Gilbert, C., J. Bestman-Smith, and G. Boivin. 2002. Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms. Drug Resist. Updat. 5:88-114.
11. Grey, F., M. Sowa, P. Collins, R. J. Fenton, W. Harris, W. Snowden, S. Efstathiou, and G. Darby. 2003. Characterization of a neurovirulent aciclovir-resistant variant of herpes simplex virus. J. Gen. Virol. 84:1403-1410.
12. Griffiths, A., S. H. Chen, B. C. Horsburgh, and D. M. Coen. 2003. Translational compensation of a frameshift mutation affecting herpes simplex virus thymidine kinase is sufficient to permit reactivation from latency. J. Virol. 77:4703-4709.
13. Griffiths, A., and D. M. Coen. 2003. High-frequency phenotypic reversion and pathogenicity of an acyclovir-resistant herpes simplex virus mutant. J. Virol. 77:2282-2286.
14. Griffiths, A., M. A. Link, C. L. Furness, and D. M. Coen. 2006. Low-level expression and reversion both contribute to reactivation of herpes simplex virus drug-resistant mutants with mutations on homopolymeric sequences in thymidine kinase. J. Virol. 80:6568-6574.
15. Gupta, R., E. L. Hill, D. McClernon, G. Davis, S. Selke, L. Corey, and A. Wald. 2005. Acyclovir sensitivity of sequential herpes simplex virus type 2 isolates from the genital mucosa of immunocompetent women. J. Infect. Dis. 192:1102-1107.
16. Harris, W., P. Collins, R. J. Fenton, W. Snowden, M. Sowa, and G. Darby. 2003. Phenotypic and genotypic characterization of clinical isolates of herpes simplex virus resistant to aciclovir. J. Gen. Virol. 84:1393-1401.
17. Hill, E. L., G. A. Hunter, and M. N. Ellis. 1991. In vitro and in vivo characterization of herpes simplex virus clinical isolates recovered from patients infected with human immunodeficiency virus. Antimicrob. Agents Chemother. 35:2322-2328.
18. Horsburgh, B. C., S. H. Chen, A. Hu, G. B. Mulamba, W. H. Burns, and D. M. Coen. 1998. Recurrent acyclovir-resistant herpes simplex in an immunocompromised patient: can strain differences compensate for loss of thymidine kinase in pathogenesis? J. Infect. Dis. 178:618-625.
19. Hwang, C. B., and H. J. Chen. 1995. An altered spectrum of herpes simplex virus mutations mediated by an antimutator DNA polymerase. Gene 152: 191-193.
20. Hwang, C. B., B. Horsburgh, E. Pelosi, S. Roberts, P. Digard, and D. M. Coen. 1994. A net +1 frameshift permits synthesis of thymidine kinase from a drug-resistant herpes simplex virus mutant. Proc. Natl. Acad. Sci. USA 91:5461-5465.
21. Jacobson, J. G., K. L. Ruffner, M. Kosz-Vnenchak, C. B. Hwang, K. K. Wobbe, D. M. Knipe, and D. M. Coen. 1993. Herpes simplex virus thymidine kinase and specific stages of latency in murine trigeminal ganglia. J. Virol. 67:6903-6908.
22. Jamieson, A. T., G. A. Gentry, and J. H. Subak-Sharpe. 1974. Induction of both thymidine and deoxycytidine kinase activity by herpes viruses. J Gen. Virol. 24:465-480.
23. Katz, J. P., E. T. Bodin, and D. M. Coen. 1990. Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutants. J. Virol. 64:4288-4295.
24. Kost, R. G., E. L. Hill, M. Tigges, and S. E. Straus. 1993. Brief report: recurrent acyclovir-resistant genital herpes in an immunocompetent patient. N. Engl. J. Med. 329:1777-1782.
25. Kudo, E., H. Shiota, T. Naito, K. Satake, and M. Itakura. 1998. Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: analysis of clinical isolates from herpetic keratitis patients and laboratory strains. J. Med. Virol. 56:151-158.
26. Morfin, F., G. Souillet, K. Bilger, T. Ooka, M. Aymard, and D. Thouvenot. 2000. Genetic characterization of thymidine kinase from acyclovir-resistant and -susceptible herpes simplex virus type 1 isolated from bone marrow transplant recipients. J. Infect. Dis. 182:290-293.
27. Mouly, F., M. Baccard, C. Scieux, L. Schnell, S. Locq-Ebner, F. Morinet, and P. Morel. 1995. Chronic recurrent acyclovir-resistant genital herpes in an immunocompetent patient. Dermatology 190:177.
28. Palu, G., G. Gerna, F. Bevilacqua, and A. Marcello. 1992. A point mutation in the thymidine kinase gene is responsible for acyclovir-resistance in herpes simplex virus type 2 sequential isolates. Virus Res. 25:133-144.
29. Pottage, J. C., Jr., and H. A. Kessler. 1995. Herpes simplex virus resistance to acyclovir: clinical relevance. Infect. Agents Dis. 4:115-124.
30. Pramod, N. P., S. P. Thyagarajan, K. V. Mohan, and K. Anandakannan. 2000. Acyclovir resistance in herpes simplex virus isolates from keratitis cases: an analysis from a developing country. Microbiol. Immunol. 44:241-247.
31. Safrin, S., C. Crumpacker, P. Chatis, R. Davis, R. Hafner, J. Rush, H. A. Kessler, B. Landry, J. Mills, et al. 1991. A controlled trial comparing fos-carnet with vidarabine for acyclovir-resistant mucocutaneous herpes simplex in the acquired immunodeficiency syndrome. N. Engl. J. Med. 325:551-555.
32. Sago, M., T. Suzutani, K. Itoh, Y. Hirano, K. Murono, M. Nagamine, K. Mizuta, M. Niikura, and S. Morikawa. 1999. Nucleotide sequence of thymidine kinase gene of sequential acyclovir-resistant herpes simplex virus type 1 isolates recovered from a child with Wiskott-Aldrich syndrome: evidence for reactivation of acyclovir-resistant herpes simplex virus. J. Med. Virol. 58: 387-393.
33. Sasadeusz, J. J., F. Tufaro, S. Safrin, K. Schubert, M. M. Hubinette, P. K. Cheung, and S. L. Sacks. 1997. Homopolymer mutational hot spots mediate herpes simplex virus resistance to acyclovir. J. Virol. 71:3872-3878.
34. Stranska, R., R. Schuurman, E. Nienhuis, I. W. Goedegebuure, M. Polman, J. F. Weel, P. M. Wertheim-Van Dillen, R. J. Berkhout, and A. M. van Loon. 2005. Survey of acyclovir-resistant herpes simplex virus in the Netherlands: prevalence and characterization. J. Clin. Virol. 32:7-18.
35. Stranska, R., A. M. van Loon, R. G. Bredius, M. Polman, E. Nienhuis, M. F. Beersma, A. C. Lankester, and R. Schuurman. 2004. Sequential switching of DNA polymerase and thymidine kinase-mediated HSV-1 drug resistance in an immunocompromised child. Antivir. Ther. 9:97-104.
36. Stranska, R., A. M. van Loon, M. Polman, M. F. Beersma, R. G. Bredius, A. C. Lankester, E. Meijer, and R. Schuurman. 2004. Genotypic and phenotypic characterization of acyclovir-resistant herpes simplex viruses isolated from haematopoietic stem cell transplant recipients. Antivir. Ther. 9:565-575.
37. Swetter, S. M., E. L. Hill, E. R. Kern, D. M. Koelle, C. M. Posavad, W. Lawrence, and S. Safrin. 1998. Chronic vulvar ulceration in an immunocompetent woman due to acyclovir-resistant, thymidine kinase-deficient herpes simplex virus. J. Infect. Dis. 177:543-550.
38. Tenser, R. B., S. Ressel, and M. E. Dunstan. 1981. Herpes simplex virus thymidine kinase expression in trigeminal ganglion infection: correlation of enzyme activity with ganglion virus titer and evidence of in vivo complementation. Virology 112:328-341.
39. Thompson, R. L., and N. M. Sawtell. 2000. Replication of herpes simplex virus type 1 within trigeminal ganglia is required for high frequency but not high viral genome copy number latency. J. Virol. 74:965-974.
40. Wade, J. C., C. McLaren, and J. D. Meyers. 1983. Frequency and significance of acyclovir-resistant herpes simplex virus isolated from marrow transplant patients receiving multiple courses of treatment with acyclovir. J Infect. Dis. 148:1077-1082.
41. Wang, K., T. Y. Lau, M. Morales, E. K. Mont, and S. E. Straus. 2005. Laser-capture microdissection: refining estimates of the quantity and distribution of latent herpes simplex virus 1 and varicella-zoster virus DNA in human trigeminal Ganglia at the single-cell level. J. Virol. 79:14079-14087.