메뉴 건너뛰기




Volumn 54, Issue 4, 2011, Pages 241-246

Upregulation of Nav1.3 channel induced by rrTNF in cultured adult rat DRG neurons via the p38 MAPK and JNK pathways

Author keywords

c Jun N terminal protein kinase; Neuropathic pain; p38 mitogen activated protein kinase; Sodium channel; Tumor necrosis factor alpha

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; DIMETHYL SULFOXIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; RECOMBINANT TUMOR NECROSIS FACTOR; SODIUM CHANNEL NAV1.3; STRESS ACTIVATED PROTEIN KINASE;

EID: 79960287548     PISSN: 03044920     EISSN: 26660059     Source Type: Journal    
DOI: 10.4077/CJP.2011.AMM075     Document Type: Article
Times cited : (17)

References (43)
  • 1
    • 0035444539 scopus 로고    scopus 로고
    • Signal transduction by tumor necrosis factor and its relatives
    • Baud, V. and Karin, M. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol. 11: 372-377, 2001.
    • (2001) Trends Cell Biol , vol.11 , pp. 372-377
    • Baud, V.1    Karin, M.2
  • 2
    • 0024810594 scopus 로고
    • Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development
    • Beckh, S., Noda, M., Lubbert, H. and Numa, S. Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development. EMBO J. 8: 3611-3616, 1989.
    • (1989) EMBO J , vol.8 , pp. 3611-3616
    • Beckh, S.1    Noda, M.2    Lubbert, H.3    Numa, S.4
  • 3
    • 0032743734 scopus 로고    scopus 로고
    • Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons
    • Black, J.A., Cummins, T.R., Plumpton, C., Chen, Y.H., Hormuzdiar, W., Clare, J.J. and Waxman, S.G. Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons. J. Neurophysiol. 82: 2776-2785, 1999.
    • (1999) J. Neurophysiol , vol.82 , pp. 2776-2785
    • Black, J.A.1    Cummins, T.R.2    Plumpton, C.3    Chen, Y.H.4    Hormuzdiar, W.5    Clare, J.J.6    Waxman, S.G.7
  • 4
    • 58149232445 scopus 로고    scopus 로고
    • Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas
    • Black, J.A., Nikolajsen, L., Kroner, K., Jensen, T.S. and Waxman, S.G. Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas. Ann. Neurol. 64: 644-653, 2008.
    • (2008) Ann. Neurol , vol.64 , pp. 644-653
    • Black, J.A.1    Nikolajsen, L.2    Kroner, K.3    Jensen, T.S.4    Waxman, S.G.5
  • 5
    • 0021685206 scopus 로고
    • Discharge pattern of afferent fibers from a neuroma
    • Blumberg, H. and Janig, W. Discharge pattern of afferent fibers from a neuroma. Pain 20: 335-353, 1984.
    • (1984) Pain , vol.20 , pp. 335-353
    • Blumberg, H.1    Janig, W.2
  • 6
    • 33845653234 scopus 로고    scopus 로고
    • Uses for JNK: The many and varied substrates of the c-Jun N-terminal kinases. Microbiol
    • Bogoyevitch, M.A. and Kobe, B. Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases. Microbiol. Mol. Biol. Rev. 70: 1061-1095, 2006.
    • (2006) Mol. Biol. Rev , vol.70 , pp. 1061-1095
    • Bogoyevitch, M.A.1    Kobe, B.2
  • 7
    • 0035882277 scopus 로고    scopus 로고
    • Nav1.3 sodium channels: Rapid repriming and slow closed-state inactivation display quantitative differences after expression in a mammalian cell line and in spinal sensory neurons
    • Cummins, T.R., Aglieco, F., Renganathan, M., Herzog, R.I., Dib-Hajj, S.D. and Waxman, S.G. Nav1.3 sodium channels: rapid repriming and slow closed-state inactivation display quantitative differences after expression in a mammalian cell line and in spinal sensory neurons. J. Neurosci. 21: 5952-5961, 2001.
    • (2001) J. Neurosci , vol.21 , pp. 5952-5961
    • Cummins, T.R.1    Aglieco, F.2    Renganathan, M.3    Herzog, R.I.4    Dib-Hajj, S.D.5    Waxman, S.G.6
  • 8
    • 0034644522 scopus 로고    scopus 로고
    • Signal transduction by the JNK group of MAP kinases
    • Davis, R.J. Signal transduction by the JNK group of MAP kinases. Cell 103: 239-252, 2000.
    • (2000) Cell , vol.103 , pp. 239-252
    • Davis, R.J.1
  • 9
    • 0028935974 scopus 로고
    • Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms
    • Derijard, B., Raingeaud, J., Barrett, T., Wu, I.H., Han, J., Ulevitch, R.J. and Davis, R.J. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267: 682-685, 1995.
    • (1995) Science , vol.267 , pp. 682-685
    • Derijard, B.1    Raingeaud, J.2    Barrett, T.3    Wu, I.H.4    Han, J.5    Ulevitch, R.J.6    Davis, R.J.7
  • 10
    • 0026565417 scopus 로고
    • Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction
    • Devor, M., Wall, P.D. and Catalan, N. Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction. Pain 48: 261-268, 1992.
    • (1992) Pain , vol.48 , pp. 261-268
    • Devor, M.1    Wall, P.D.2    Catalan, N.3
  • 11
    • 0029907091 scopus 로고    scopus 로고
    • Downregulation of transcripts for Na channel alpha-SNS in spinal sensory neurons following axotomy
    • Dib-Hajj, S., Black, J.A., Felts, P. and Waxman, S.G. Downregulation of transcripts for Na channel alpha-SNS in spinal sensory neurons following axotomy. Proc. Natl. Acad. Sci. U.S.A. 93: 14950-14954, 1996.
    • (1996) Proc. Natl. Acad. Sci. U.S.A , vol.93 , pp. 14950-14954
    • Dib-Hajj, S.1    Black, J.A.2    Felts, P.3    Waxman, S.G.4
  • 12
    • 0032723079 scopus 로고    scopus 로고
    • Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain
    • Dib-Hajj, S.D., Fjell, J., Cummins, T.R., Zheng, Z., Fried, K., LaMotte, R., Black, J.A. and Waxman, S.G. Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain. Pain 83: 591-600, 1999.
    • (1999) Pain , vol.83 , pp. 591-600
    • Dib-Hajj, S.D.1    Fjell, J.2    Cummins, T.R.3    Zheng, Z.4    Fried, K.5    Lamotte, R.6    Black, J.A.7    Waxman, S.G.8
  • 13
    • 43049176430 scopus 로고    scopus 로고
    • Activation of JNK pathway in persistent pain
    • Gao, Y.J. and Ji, R.R. Activation of JNK pathway in persistent pain. Neurosci. Lett. 437: 180-183, 2008.
    • (2008) Neurosci. Lett , vol.437 , pp. 180-183
    • Gao, Y.J.1    Ji, R.R.2
  • 14
    • 65249114367 scopus 로고    scopus 로고
    • JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain
    • Gao, Y.J., Zhang, L., Samad, O.A., Suter, M.R., Yasuhiko, K., Xu, Z.Z., Park, J.Y., Lind, A.L., Ma, Q. and Ji, R.R. JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. J. Neurosci. 29: 4096-4108, 2009.
    • (2009) J. Neurosci , vol.29 , pp. 4096-4108
    • Gao, Y.J.1    Zhang, L.2    Samad, O.A.3    Suter, M.R.4    Yasuhiko, K.5    Xu, Z.Z.6    Park, J.Y.7    Lind, A.L.8    Ma, Q.9    Ji, R.R.10
  • 15
    • 0018127665 scopus 로고
    • Ongoing activity in severed nerves: Source and variation with time
    • Govrin-Lippmann, R. and Devor, M. Ongoing activity in severed nerves: source and variation with time. Brain Res. 159: 406-410, 1978.
    • (1978) Brain Res , vol.159 , pp. 406-410
    • Govrin-Lippmann, R.1    Devor, M.2
  • 16
    • 2442651551 scopus 로고    scopus 로고
    • Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury
    • Hains, B.C., Saab, C.Y., Klein, J.P., Craner, M.J. and Waxman, S.G. Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury. J. Neurosci. 24: 4832-4839, 2004.
    • (2004) J. Neurosci , vol.24 , pp. 4832-4839
    • Hains, B.C.1    Saab, C.Y.2    Klein, J.P.3    Craner, M.J.4    Waxman, S.G.5
  • 17
    • 77957893670 scopus 로고    scopus 로고
    • TNF-alpha contributes to up-regulation of Nav1.3 and Nav1.8 in DRG neurons following motor fiber injury
    • He, X.H., Zang, Y., Chen, X., Pang, R.P., Xu, J.T., Zhou, X., Wei, X.H., Li, Y.Y., Xin, W.J., Qin, Z.H. and Liu, X.G. TNF-alpha contributes to up-regulation of Nav1.3 and Nav1.8 in DRG neurons following motor fiber injury. Pain 151: 266-279, 2010.
    • (2010) Pain , vol.151 , pp. 266-279
    • He, X.H.1    Zang, Y.2    Chen, X.3    Pang, R.P.4    Xu, J.T.5    Zhou, X.6    Wei, X.H.7    Li, Y.Y.8    Xin, W.J.9    Qin, Z.H.10    Liu, X.G.11
  • 18
    • 69549122426 scopus 로고    scopus 로고
    • Spinal microglial expression and mechanical hypersensitivity in a postoperative pain model: Comparison with a neuropathic pain model
    • Ito, N., Obata, H. and Saito, S. Spinal microglial expression and mechanical hypersensitivity in a postoperative pain model: comparison with a neuropathic pain model. Anesthesiology 111: 640-648, 2009.
    • (2009) Anesthesiology , vol.111 , pp. 640-648
    • Ito, N.1    Obata, H.2    Saito, S.3
  • 19
    • 0029982565 scopus 로고    scopus 로고
    • Characterization of the structure and function of a new mitogenactivated protein kinase (p38beta)
    • Jiang, Y., Chen, C., Li, Z., Guo, W., Gegner, J.A., Lin, S. and Han, J. Characterization of the structure and function of a new mitogenactivated protein kinase (p38beta). J. Biol. Chem. 271: 17920-17926, 1996.
    • (1996) J. Biol. Chem , vol.271 , pp. 17920-17926
    • Jiang, Y.1    Chen, C.2    Li, Z.3    Guo, W.4    Gegner, J.A.5    Lin, S.6    Han, J.7
  • 20
    • 0037705314 scopus 로고    scopus 로고
    • p38 mitogenactivated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    • Jin, S.X., Zhuang, Z.Y., Woolf, C.J. and Ji, R.R. p38 mitogenactivated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J. Neurosci. 23: 4017-4022, 2003.
    • (2003) J. Neurosci , vol.23 , pp. 4017-4022
    • Jin, S.X.1    Zhuang, Z.Y.2    Woolf, C.J.3    Ji, R.R.4
  • 21
    • 0035500407 scopus 로고    scopus 로고
    • The changes in expression of three subtypes of TTX sensitive sodium channels in sensory neurons after spinal nerve ligation
    • Kim, C.H., Oh, Y., Chung, J.M. and Chung, K. The changes in expression of three subtypes of TTX sensitive sodium channels in sensory neurons after spinal nerve ligation. Brain Res. Mol. Brain Res. 95: 153-161, 2001.
    • (2001) Brain Res. Mol. Brain Res , vol.95 , pp. 153-161
    • Kim, C.H.1    Oh, Y.2    Chung, J.M.3    Chung, K.4
  • 22
    • 0037147689 scopus 로고    scopus 로고
    • Activation of p38 MAP kinase in the rat dorsal root ganglia and spinal cord following peripheral inflammation and nerve injury
    • Kim, S.Y., Bae, J.C., Kim, J.Y., Lee, H.L., Lee, K.M., Kim, D.S. and Cho, H.J. Activation of p38 MAP kinase in the rat dorsal root ganglia and spinal cord following peripheral inflammation and nerve injury. Neuroreport 13: 2483-2486, 2002.
    • (2002) Neuroreport , vol.13 , pp. 2483-2486
    • Kim, S.Y.1    Bae, J.C.2    Kim, J.Y.3    Lee, H.L.4    Lee, K.M.5    Kim, D.S.6    Cho, H.J.7
  • 23
    • 0036244959 scopus 로고    scopus 로고
    • Effect of lumbar 5 ventral root transection on pain behaviors: A novel rat model for neuropathic pain without axotomy of primary sensory neurons
    • Li, L., Xian, C.J., Zhong, J.H. and Zhou, X.F. Effect of lumbar 5 ventral root transection on pain behaviors: a novel rat model for neuropathic pain without axotomy of primary sensory neurons. Exp. Neurol. 175: 23-34, 2002.
    • (2002) Exp. Neurol , vol.175 , pp. 23-34
    • Li, L.1    Xian, C.J.2    Zhong, J.H.3    Zhou, X.F.4
  • 24
    • 28844448678 scopus 로고    scopus 로고
    • Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats
    • Lindia, J.A., Kohler, M.G., Martin, W.J. and Abbadie, C. Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats. Pain 117: 145-153, 2005.
    • (2005) Pain , vol.117 , pp. 145-153
    • Lindia, J.A.1    Kohler, M.G.2    Martin, W.J.3    Abbadie, C.4
  • 25
    • 0036711470 scopus 로고    scopus 로고
    • Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus
    • Ma, W. and Quirion, R. Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus. Pain 99: 175-184, 2002.
    • (2002) Pain , vol.99 , pp. 175-184
    • Ma, W.1    Quirion, R.2
  • 26
    • 8544239374 scopus 로고    scopus 로고
    • Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation
    • Obata, K., Yamanaka, H., Kobayashi, K., Dai, Y., Mizushima, T., Katsura, H., Fukuoka, T., Tokunaga, A. and Noguchi, K. Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation. J. Neurosci. 24: 10211-10222, 2004.
    • (2004) J. Neurosci , vol.24 , pp. 10211-10222
    • Obata, K.1    Yamanaka, H.2    Kobayashi, K.3    Dai, Y.4    Mizushima, T.5    Katsura, H.6    Fukuoka, T.7    Tokunaga, A.8    Noguchi, K.9
  • 27
    • 33644993675 scopus 로고    scopus 로고
    • Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury
    • Piao, Z.G., Cho, I.H., Park, C.K., Hong, J.P., Choi, S.Y., Lee, S.J., Lee, S., Park, K., Kim, J.S. and Oh, S.B. Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury. Pain 121: 219-231, 2006.
    • (2006) Pain , vol.121 , pp. 219-231
    • Piao, Z.G.1    Cho, I.H.2    Park, C.K.3    Hong, J.P.4    Choi, S.Y.5    Lee, S.J.6    Lee, S.7    Park, K.8    Kim, J.S.9    Oh, S.B.10
  • 29
    • 33846974357 scopus 로고    scopus 로고
    • Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons
    • Rush, A.M., Cummins, T.R. and Waxman, S.G. Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons. J. Physiol 579: 1-14, 2007.
    • (2007) J. Physiol , vol.579 , pp. 1-14
    • Rush, A.M.1    Cummins, T.R.2    Waxman, S.G.3
  • 30
    • 0345701254 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons
    • Schafers, M., Svensson, C.I., Sommer, C. and Sorkin, L.S. Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons. J. Neurosci. 23: 2517-2521, 2003.
    • (2003) J. Neurosci , vol.23 , pp. 2517-2521
    • Schafers, M.1    Svensson, C.I.2    Sommer, C.3    Sorkin, L.S.4
  • 31
    • 33847417433 scopus 로고    scopus 로고
    • Activation of transcription factor c-jun in dorsal root ganglia induces VIP and NPY upregulation and contributes to the pathogenesis of neuropathic pain
    • Son, S.J., Lee, K.M., Jeon, S.M., Park, E.S., Park, K.M. and Cho, H.J. Activation of transcription factor c-jun in dorsal root ganglia induces VIP and NPY upregulation and contributes to the pathogenesis of neuropathic pain. Exp. Neurol. 204: 467-472, 2007.
    • (2007) Exp. Neurol , vol.204 , pp. 467-472
    • Son, S.J.1    Lee, K.M.2    Jeon, S.M.3    Park, E.S.4    Park, K.M.5    Cho, H.J.6
  • 32
    • 17444408199 scopus 로고    scopus 로고
    • Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38
    • Svensson, C.I., Schafers, M., Jones, T.L., Powell, H. and Sorkin, L.S. Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38. Neurosci. Lett. 379: 209-213, 2005.
    • (2005) Neurosci. Lett , vol.379 , pp. 209-213
    • Svensson, C.I.1    Schafers, M.2    Jones, T.L.3    Powell, H.4    Sorkin, L.S.5
  • 33
    • 0346655315 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury
    • Tsuda, M., Mizokoshi, A., Shigemoto-Mogami, Y., Koizumi, S. and Inoue, K. Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury. Glia 45: 89-95, 2004.
    • (2004) Glia , vol.45 , pp. 89-95
    • Tsuda, M.1    Mizokoshi, A.2    Shigemoto-Mogami, Y.3    Koizumi, S.4    Inoue, K.5
  • 34
    • 0016319790 scopus 로고
    • Properties of afferent nerve impulses originating from a neuroma
    • Wall, P.D. and Gutnick, M. Properties of afferent nerve impulses originating from a neuroma. Nature 248: 740-743, 1974.
    • (1974) Nature , vol.248 , pp. 740-743
    • Wall, P.D.1    Gutnick, M.2
  • 35
    • 0027933696 scopus 로고
    • Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy
    • Waxman, S.G., Kocsis, J.D. and Black, J.A. Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy. J. Neurophysiol. 72: 466-470, 1994.
    • (1994) J. Neurophysiol , vol.72 , pp. 466-470
    • Waxman, S.G.1    Kocsis, J.D.2    Black, J.A.3
  • 36
    • 34248572468 scopus 로고    scopus 로고
    • Peri-sciatic administration of recombinant rat TNF-alpha induces mechanical allodynia via upregulation of TNF-alpha in dorsal root ganglia and in spinal dorsal horn: The role of NF-kappa B pathway
    • Wei, X.H., Zang, Y., Wu, C.Y., Xu, J.T., Xin, W.J. and Liu, X.G. Peri-sciatic administration of recombinant rat TNF-alpha induces mechanical allodynia via upregulation of TNF-alpha in dorsal root ganglia and in spinal dorsal horn: the role of NF-kappa B pathway. Exp. Neurol. 205: 471-484, 2007.
    • (2007) Exp. Neurol , vol.205 , pp. 471-484
    • Wei, X.H.1    Zang, Y.2    Wu, C.Y.3    Xu, J.T.4    Xin, W.J.5    Liu, X.G.6
  • 37
    • 58749098812 scopus 로고    scopus 로고
    • Activation of p38 mitogenactivated protein kinase in spinal microglia contributes to incisioninduced mechanical allodynia
    • Wen, Y.R., Suter, M.R., Ji, R.R., Yeh, G.C., Wu, Y.S., Wang, K.C., Kohno, T., Sun, W.Z. and Wang, C.C. Activation of p38 mitogenactivated protein kinase in spinal microglia contributes to incisioninduced mechanical allodynia. Anesthesiology 110: 155-165, 2009.
    • (2009) Anesthesiology , vol.110 , pp. 155-165
    • Wen, Y.R.1    Suter, M.R.2    Ji, R.R.3    Yeh, G.C.4    Wu, Y.S.5    Wang, K.C.6    Kohno, T.7    Sun, W.Z.8    Wang, C.C.9
  • 38
    • 33847754623 scopus 로고    scopus 로고
    • The JNK signal transduction pathway
    • Weston, C.R. and Davis, R.J. The JNK signal transduction pathway. Curr. Opin. Cell Biol. 19: 142-149, 2007.
    • (2007) Curr. Opin. Cell Biol , vol.19 , pp. 142-149
    • Weston, C.R.1    Davis, R.J.2
  • 39
    • 33847325194 scopus 로고    scopus 로고
    • p38 Activation in uninjured primary afferent neurons and in spinal microglia contributes to the development of neuropathic pain induced by selective motor fiber injury
    • Xu, J.T., Xin, W.J., Wei, X.H., Wu, C.Y., Ge, Y.X., Liu, Y.L., Zang, Y., Zhang, T., Li, Y.Y. and Liu, X.G. p38 Activation in uninjured primary afferent neurons and in spinal microglia contributes to the development of neuropathic pain induced by selective motor fiber injury. Exp. Neurol. 204: 355-365, 2007.
    • (2007) Exp. Neurol , vol.204 , pp. 355-365
    • Xu, J.T.1    Xin, W.J.2    Wei, X.H.3    Wu, C.Y.4    Ge, Y.X.5    Liu, Y.L.6    Zang, Y.7    Zhang, T.8    Li, Y.Y.9    Liu, X.G.10
  • 40
    • 33745700149 scopus 로고    scopus 로고
    • The role of tumor necrosis factor-alpha in the neuropathic pain induced by Lumbar 5 ventral root transection in rat
    • Xu, J.T., Xin, W.J., Zang, Y., Wu, C.Y. and Liu, X.G. The role of tumor necrosis factor-alpha in the neuropathic pain induced by Lumbar 5 ventral root transection in rat. Pain 123: 306-321, 2006.
    • (2006) Pain , vol.123 , pp. 306-321
    • Xu, J.T.1    Xin, W.J.2    Zang, Y.3    Wu, C.Y.4    Liu, X.G.5
  • 41
    • 78149466023 scopus 로고    scopus 로고
    • Inhibition of NF-κB prevents mechanical allodynia induced by spinal ventral root transection and suppresses the re-expression of Nav1.3 in DRG neurons in vivo and in vitro
    • doi:10.1016/j.brainres.2010.09.048
    • Zang, Y., He, X.H., Xin, W.J., Pang, R.P., Wei, X.H., Zhou, L.J., Li, Y.Y. and Liu, X.G. Inhibition of NF-κB prevents mechanical allodynia induced by spinal ventral root transection and suppresses the re-expression of Nav1.3 in DRG neurons in vivo and in vitro. Brain Res. (2010), doi:10.1016/j.brainres.2010.09.048.
    • (2010) Brain Res
    • Zang, Y.1    He, X.H.2    Xin, W.J.3    Pang, R.P.4    Wei, X.H.5    Zhou, L.J.6    Li, Y.Y.7    Liu, X.G.8
  • 42
    • 33645460235 scopus 로고    scopus 로고
    • A peptide c-Jun Nterminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: Respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance
    • Zhuang, Z.Y., Wen, Y.R., Zhang, D.R., Borsello, T., Bonny, C., Strichartz, G.R., Decosterd, I. and Ji, R.R. A peptide c-Jun Nterminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. J. Neurosci. 26: 3551-3560, 2006.
    • (2006) J. Neurosci , vol.26 , pp. 3551-3560
    • Zhuang, Z.Y.1    Wen, Y.R.2    Zhang, D.R.3    Borsello, T.4    Bonny, C.5    Strichartz, G.R.6    Decosterd, I.7    Ji, R.R.8
  • 43
    • 0020525719 scopus 로고
    • Ethical guidelines for investigations of experimental pain in conscious animals
    • Zimmermann, M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16: 109-110, 1983.
    • (1983) Pain , vol.16 , pp. 109-110
    • Zimmermann, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.