Artemisinin pharmacokinetics in healthy adults after 250, 500 and 1000 mg single oral doses

Biopharmaceutics and Drug Disposition

Volumn 19, Issue 4, 1998, Pages 245-250

  Ashton, Michael ^a,d   Gordi, Toufigh ^a   Hai, Trinh Ngoc ^b   Van Huong, Nguyen ^b   Sy, Nguyen Duy ^b   Nieu, Nguyen Thi ^b   Huong, Dinh Xuan ^b   Johansson, Monika ^c,e   Công, Le Dinh ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b Inst Malariology   (Viet Nam)

^c MEDICAL PRODUCTS AGENCY   (Sweden)

^d UPPSALA UNIVERSITY   (Sweden)

^e IQVIA   (United States)

Author keywords

Artemisinin; Auto induction; Dose dependency; Intra subject variability; Malaria; Pharmacokinetics; Time dependency

Indexed keywords

ARTEMISININ;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD PRESSURE; BODY TEMPERATURE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DRUG CLEARANCE; DRUG ELIMINATION; DRUG EXPOSURE; DRUG HALF LIFE; DRUG TOLERANCE; HEART RATE; HUMAN; MALARIA; MALE; ORAL DRUG ADMINISTRATION; PREDICTION; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, ORAL; ADULT; ANALYSIS OF VARIANCE; ANTIMALARIALS; AREA UNDER CURVE; ARTEMISININS; BLOOD PRESSURE; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INDIVIDUALITY; MALE; SESQUITERPENES;

EID: 0031959993     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-081X(199805)19:4<245::AID-BDD99>3.0.CO;2-Z     Document Type: Article

References (19)

1. D.L. Klayman, Qinghaosu (artemisinin): An antimalarial drug from China. Science, 228, 1049-1055 (1985).
2. Qinghaosu Antimalarial Coordinating Research Group, Antimalarial studies on qinghaosu. Chin. Med. J., 92, 811-816 (1979).
3. T.T. Hien and N.J. White, Qinghaosu. Lancet, 341, 603-608 (1993).
4. N.D. Sy, D.B. Hoan, N.P. Dung, N.V. Huong, L.N. Binh, M.V. Son and S.R. Meshnick, Treatment of malaria in Vietnam with oral artemisinin. Am. J. Trop. Med. Hyg., 48, 398-402 (1993).
5. P.O. Edlund, D. Westerlund, J. Carlqvist, W. Bo-Liang and J. Yunhua, Determination of artesunate and dihydroartemisinine in plasma by liquid chromatography with post-column derivatization and UV-detection. Acta Pharm. Suec., 21, 223-234 (1984).
6. M. Ashton, N.D. Sy, T. Gordi, T.N. Hai, D.C. Thach, N.V. Huong, M.H. Farah, M. Johansson and L.D. Công, Evidence for time-dependent artemisinin kinetics in adults with uncomplicated malaria. Pharm. Pharmacol. Lett., 6, 127-130 (1996).
7. V.P. Shah, K.K. Midha, S. Dighe, I.J. McGilveray, J.P. Skelly, A. Yacobi, T. Layloff, C.T. Viswanathan, C.E. Cook, R.D. McDowall, K.A. Pittman and S. Spector, Analytical methods validation: bioavailability, bioequivalence and pharmacokinetic studies. Pharm. Res., 9, 588-592 (1992).
8. K. Yamaoka, T. Nakagawa and T. Uno, Statistical moments in pharmacokinetics. J. Pharmacokinet. Biopharm., 6, 547-558 (1978).
9. D. Perrier D and M. Meyersohn, Noncompartmental determination of the steady-state volume of distribution for any mode of administration. J. Pharm. Sci., 71, 372-373 (1982).
10. H.A.C. Titulaer, J. Zuidema, P.A. Kager, J.C.F.M. Wetsteyn, Ch.B. Lugt and F.W.H.M. Merkus, The pharmacokinetics of artemisinin after oral, intramuscular and rectal administration to volunteers. J. Pharm. Pharmacol., 42, 810-813 (1990).
11. D.D. Duc, P.J. de Vries, N.X. Khanh, L.N. Binh, P.A. Kager and C.J. van Boxtel, The pharmacokinetics of a single dose of artemisinin in healthy Vietnamese subjects. Am. J. Trop. Med. Hyg., 51, 785-790 (1994).
12. U.S.H. Svensson, M. Ashton, T.N. Hai, D.X. Huong, N.V. Huong, L. Bertilsson, N.T. Nieu, N.D. Sy, J. Lykkesfeldt and L.D. Cong, Artemisinin and omeprazole pharmacokinetics in healthy male subjects after repeated coadministration; omeprazole as in vivo marker for CYP3A4 and CYP2C19 activity. Exp. Toxic. Pathol., 48, 393 (abstract) (1996).
13. J.S. Sidhu and M. Ashton, Single-dose comparative study of venous, capillary and salivary artemisinin concentrations in healthy male, adults. Am. J. Trop. Med. Hyg., 56, 13-16 (1997).
14. M. Hassan Alin, M. Ashton, C.M. Kihamia, G.J.B. Mtey and A. Björkman, Multiple dose pharmacokinetics of oral artemisinin and comparison of its efficacy with that of oral artesunate in falciparum malaria patients. Trans. Roy. Soc. Trop. Med. Hyg., 90, 61-65 (1996).
15. M. Hassan Alin, M. Ashton, C.M. Kihamia, G.J.B. Mtey and A. Björkman, Clinical efficacy and pharmacokinetics of artemisinin monotherapy and in combination with mefloquine in patients with falciparum malaria. Br. J. Clin. Pharmacol., 41, 587-592 (1996).
16. P. Augustijns, A. D'Hulst, J. Van Daele and R. Kinget, Transport of artemisinin and sodium artesunate in Caco-2 intestinal epithelial cells. J. Pharm. Sci., 85, 577-579 (1996).
17. S.R. Meshnick, T.E. Taylor and S. Kamchonwongpaisan, Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy. Microbiol. Rev., 60, 301-315 (1996).
18. H. Bakhshi, T. Gordi and M. Ashton, In-vitro interaction of artemisinin with intact human erythrocytes, erythrocyte ghosts, haemoglobin and carbonic anhydrase. J. Pharm. Pharmacol., 49, 223-226 (1997).
19. V.W. Steinijans, R. Sauter, D. Hauschke, E. Diletti, R. Schall, H.G. Luus, M. Elze, H. Blume, C. Hoffmann, G. Franke and W. Siegmund, Reference tables for the intrasubject coefficient of variation in bioequivalence studies. Int. J. Clin. Pharmacol. Ther., 33, 427-430 (1995).