Artemether Bioavailability after Oral or Intramuscular Administration in Uncomplicated Falciparum Malaria

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 12, 2003, Pages 3795-3798

  Silamut, Kamolrat ^a   Newton, Paul N ^a,d   Teja Isavadharm, Paktiya ^b   Suputtamongkol, Yupin ^c   Siriyanonda, Duangsuda ^b   Rasameesoraj, Maneerat ^b   Pukrittayakamee, Sasithon ^a   White, Nicholas J ^a,d  

^a MAHIDOL UNIVERSITY   (Thailand)

^b ARMED FORCES RESEARCH INSTITUTE OF MEDICAL SCIENCES   (Thailand)

^c MAHIDOL UNIVERSITY   (Thailand)

^d JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMETHER; DIHYDROARTEMISININ;

ACUTE DISEASE; ADOLESCENT; ADULT; ANTIMALARIAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CONVALESCENCE; DISEASE SEVERITY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; FEMALE; HUMAN; MALARIA FALCIPARUM; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ANTIMALARIALS; AREA UNDER CURVE; ARTEMISININS; BIOLOGICAL ASSAY; BIOLOGICAL AVAILABILITY; BIOTRANSFORMATION; CHLOROQUINE; DRUG RESISTANCE; FEMALE; HUMANS; INJECTIONS, INTRAMUSCULAR; INTESTINAL ABSORPTION; MALARIA, FALCIPARUM; MALE; MIDDLE AGED; QUININE; SESQUITERPENES;

EID: 0344012029     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.12.3795-3798.2003     Document Type: Article

References (21)

1. Anonymous. 1998. WinNonlin user's guide, version 3.0. Pharsight Corp., Mountain View, Calif.
2. The Artemether-Quinine Meta-Analysis Study Group. 2001. A meta-analysis using individual patient data of trials comparing artemether with quinine in the treatment of severe falciparum malaria. Trans. R. Soc. Trop. Med. Hyg. 95:637-650.
3. Brockman, A., R. N. Price, M. van Vugt, D. G. Heppner, D. Walsh, P. Sookto, T. Wimonwattrawatee, S. Looareesuwan, N. J. White, and F. Nosten. 2000. Plasmodium falciparum antimalarial drug susceptibility on the northwestern border of Thailand during five years of extensive artesunate-mefloquine use. Trans. R. Soc. Trop. Med. Hyg. 94:537-544.
4. Hien, T. T., N. P. J. Day, N. H. Phu, N. T. H. Mai, T. T. H. Chau, P. P. Loc, D. X. Sinh, L. V. Chuong, H. Vinh, D. Waller, T. E. A. Peto, and N. J. White. 1996. A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria. N. Engl. J. Med. 335:76-83.
5. Hien, T. T., T. M. E. Davis, L. V. Chuong, K. F. Ilett, N. T. H. Mai, T. T. H. Chau, C. Agus, G. M. Chiswell, N. J. White, and J. Farrar. Comparative pharmacokinetics of intramuscular artesunate and artemether in severe falciparum malaria. Antimicrob. Agents Chemother., in press.
6. Karbwang, J., K. Na-Bangchang, K. Congpuong, P. Molunto, and A. Thanavibul. 1997. Pharmacokinetics and bioavailability of oral and intramuscular artemether. Eur. J. Clin. Pharmacol. 52:307-310.
7. Karbwang, J., K. Na-Bangchang, T. Tin, K. Sukontason, W. Rimchala, and T. Harinasuta. 1998. Pharmacokinetics of intramuscular artemether in patients with severe falciparum malaria with or without acute renal failure. Br. J. Clin. Pharmacol. 45:597-600.
8. Looareesuwan, S., B. Oosterhuis, B. M. Schilizzi, F. A. Sollie, P. Wilairatana, S. Krudsood, C. B. Lugt, P. A. Peeters, and J. O. Peggins. 2002. Dose-finding and efficacy study for i.m. artemotil (beta-arteether) and comparison with i.m. artemether in acute uncomplicated P. falciparum malaria. Br. J. Clin. Pharmacol. 53:492-500.
9. Murphy, S., E. Mberu, D. Muhia, M. English, J. Crawley, C. Waruiru, B. Lowe, C. Newton, P. Winstanley, K. Marsh, and W. Watkins. 1997. The disposition of artemether in children with cerebral malaria: a preliminary study. Trans. R. Soc. Trop. Med. Hyg. 91:331-334.
10. Newton, P. N., M. Van Vugt, P. Teja-Isavadharm, D. Keeratithakul, M. Rasameesoroj, P. Teerapong, R. Ruangveerayuth, T. Slight, F. Nosten, Y. Suputtamongkol, S. Looareesuwan, and N. J. White. 2002. A comparison of oral artesunate and dihydroartemisinin antimalarial bioavailability in acute falciparum malaria. Antimicrob. Agents Chemother. 46:125-127.
11. Newton, P. N., B. J. Angus, W. Chierakul, A. Dondorp, R. Ruangveerayuth, K. Silamut, P. Teerapong, Y. Suputtamongkol, S. Looareesuwan, and N. J. White. 2003. A randomised comparison of artesunate or quinine in the treatment of severe falciparum malaria. Clin. Infect. Dis. 37:7-16.
12. Pukrittayakamee, S., S. Looareesuwan, D. Keeratithakul, T. M. E. Davis, P. Teja Isavadharm, B. Nagachinta, A. Weber, A. Smith, D. Kyle, and N. J. White. 1997. A study of the factors affecting the metabolic clearance of quinine in malaria. Eur. J. Clin. Pharmacol. 52:487-493.
13. Silamut, K., R. Hough, T. Eggelte, S. Pukrittayakamee, B. Angus, and N. J. White. 1995. A simple method for assessing quinine pre-treatment in acute malaria. Trans. R. Soc. Trop. Med. Hyg. 89:665-667.
14. Suputtamongkol, Y., P. N. Newton, B. Angus, P. Teja-Isavadharm, D. Keeratithakul, M. Rasameesoraj, S. Pukrittayakamee, and N. J. White. 2001. A comparison of oral artesunate and artemether antimalarial bioactivities in acute falciparum malaria. Br. J. Clin. Pharmacol. 52:655-661.
15. Teja-Isavadharm, P., F. Nosten, D. E. Kyle, C. Luxemburger, F. ter Kuile, J. O. Peggins, T. G. Brewer, and N. J. White. 1996. Comparative bioavailability of oral, rectal, and intramuscular artemether in healthy subjects-use of simultaneous measurement by high performance liquid chromatography with electrochemical detection and bioassay. Br. J. Clin. Pharmacol. 42:599-604.
16. van Agtmael, M. A., S. C. Qi, J. X. Qing, R. Mull, and C. J. van Boxtel. 1999. Multiple dose pharmacokinetics of artemether in Chinese patients with uncomplicated falciparum malaria. Int. J. Antimicrob. Agents 12:151-158.
17. van Agtmael, M. A., V. Gupta, T. H. vander Wosten, J. P. Rutten, and C. J. van Boxtel. 1999. Grapefruit juice increases the bioavailability of artemether. Eur. J. Clin. Pharmacol. 55:405-410.
18. White, N. J. 1994. Clinical pharmacokinetics and pharmacodynamics of artemisinin and its derivatives. Trans. R. Soc. Trop. Med. Hyg. 88(Suppl. 1):41-43.
19. White, N. J. 2003. Malaria, p. 1205-1296. In G. Cook and A. Zumla (ed.), Manson's tropical diseases. W. B. Saunders, London, United Kingdom.
20. White, N. J., M. van Vugt, and F. Ezzet. 1999. Clinical pharmacokinetics and pharmacodynamics of artemether-lumefantrine. Clin. Pharmacokinet. 37:105-125.
21. World Health Organization, Division of Control of Tropical Diseases. 1990. Severe and complicated malaria. Trans. R. Soc. Trop. Med. Hyg. 84(Suppl. 2):1-65.