-
1
-
-
2642550862
-
Challenges in the development of high protein concentration formulations
-
DOI 10.1002/jps.20079
-
Shire SJ, Shahrokh Z, Liu J. Challenges in the development of high protein concentration formulations. J. Pharm. Sci. 93(6) 1390-1402 (2004) (Pubitemid 38725014)
-
(2004)
Journal of Pharmaceutical Sciences
, vol.93
, Issue.6
, pp. 1390-1402
-
-
Shire, S.J.1
Shahrokh, Z.2
Liu, J.3
-
3
-
-
0025218116
-
Solubility as a function of protein structure and solvent components
-
Schein C. Solubility as a function of protein structure and solvent components. Biotechnol. Bioeng. 8, 308-317 (1990)
-
(1990)
Biotechnol. Bioeng.
, vol.8
, pp. 308-317
-
-
Schein, C.1
-
4
-
-
14844334231
-
Induction and analysis of aggregates in a liquid IgG1-antibody formulation
-
DOI 10.1016/j.ejpb.2004.12.004
-
Mahler H-C, Mueller R, Friess W, Delille A, Matheus S. Induction and analysis of aggregates in a liquid IgG1-antibody formulation. Eur. J. Pharm. Biopharm. 59(3), 407-417 (2005) (Pubitemid 40342515)
-
(2005)
European Journal of Pharmaceutics and Biopharmaceutics
, vol.59
, Issue.3
, pp. 407-417
-
-
Mahler, H.-C.1
Muller, R.2
Friess, W.3
Delille, A.4
Matheus, S.5
-
5
-
-
33745413982
-
Protein structural conformation and not second virial coefficient relates to long-term irreversible aggregation of a monoclonal antibody and ovalbumin in solution
-
DOI 10.1007/s11095-006-0018-y
-
Bajaj H, Sharma VK, Badkar A, Zeng D, Nema S, Kalonia DS. Protein structural conformation and not second virial coefficient relates to long-term irreversible aggregation of a monoclonal antibody and ovalbumin in solution. Pharm. Res. 23(6), 1382-1394 (2006) (Pubitemid 43946160)
-
(2006)
Pharmaceutical Research
, vol.23
, Issue.6
, pp. 1382-1394
-
-
Bajaj, H.1
Sharma, V.K.2
Badkar, A.3
Zeng, D.4
Nema, S.5
Kalonia, D.S.6
-
6
-
-
3242670796
-
Opalescent appearance of an IgG1 antibody at high concentrations and its relationship to noncovalent association
-
DOI 10.1023/B:PHAM.0000032993.98705.73
-
Sukumar M, Doyle BL, Combs JL, Pekar AH. Opalescent appearance of an IgG1 antibody at high concentrations and its relationship to noncovalent association. Pharm. Res. 21(7), 1087-1093 (2004) (Pubitemid 38954191)
-
(2004)
Pharmaceutical Research
, vol.21
, Issue.7
, pp. 1087-1093
-
-
Sukumar, M.1
Doyle, B.L.2
Combs, J.L.3
Pekar, A.H.4
-
7
-
-
77953171768
-
Stability of protein pharmaceuticals: An update
-
Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. Stability of protein pharmaceuticals: an update. Pharm. Res. 27(4), 544-575 (2010)
-
(2010)
Pharm. Res.
, vol.27
, Issue.4
, pp. 544-575
-
-
Manning, M.C.1
Chou, D.K.2
Murphy, B.M.3
Payne, R.W.4
Katayama, D.S.5
-
8
-
-
0027729733
-
The development of stable protein formulations: A close look at protein aggregation, deamidation, and oxidation
-
Cleland JL, Powell MF, Shire SJ. The development of stable protein formulations: a close look at protein aggregation, deamidation, and oxidation. Crit. Rev. Ther. Drug Carrier Syst. 10(4), 307-377 (1993) (Pubitemid 24021947)
-
(1993)
Critical Reviews in Therapeutic Drug Carrier Systems
, vol.10
, Issue.4
, pp. 307-377
-
-
Cleland, J.L.1
Powell, M.F.2
Shire, S.J.3
-
10
-
-
0025287316
-
Effect of molecular weight on the lymphatic absorption of water-soluble compounds following subcutaneous administration
-
DOI 10.1023/A:1015880819328
-
Supersaxo A, Hein WR, Steffen H. Effect of molecular weight on the lymphatic absorption of water-soluble compounds following subcutaneous administration. Pharm. Res. 7(2), 167-169 (1990) (Pubitemid 20208069)
-
(1990)
Pharmaceutical Research
, vol.7
, Issue.2
, pp. 167-169
-
-
Supersaxo, A.1
Hein, W.R.2
Steffen, H.3
-
11
-
-
0034005256
-
Systemic availability and lymphatic transport of human growth hormone administered by subcutaneous injection
-
DOI 10.1002/(SICI)1520-6017(200002)89:2<168::AID-JPS4>3.0.CO;2-Q
-
Charman SA, Segrave AM, Edwards GA, Porter CJ. Systemic availability and lymphatic transport of human growth hormone administered by subcutaneous injection. J. Pharm. Sci. 89(2), 168-177 (2005) (Pubitemid 30120797)
-
(2000)
Journal of Pharmaceutical Sciences
, vol.89
, Issue.2
, pp. 168-177
-
-
Charman, S.A.1
Segrave, A.M.2
Edwards, G.A.3
Porter, C.J.H.4
-
12
-
-
0034020054
-
Lymphatic transport of proteins after subcutaneous administration
-
DOI 10.1002/(SICI)1520-6017(200003)89:3<297::AID-JPS2>3.0.CO;2-P
-
Porter CJ, Charman SA. Lymphatic transport of proteins after subcutaneous administration. J. Pharm. Sci. 89(3), 297-310 (2000) (Pubitemid 30152431)
-
(2000)
Journal of Pharmaceutical Sciences
, vol.89
, Issue.3
, pp. 297-310
-
-
Porter, C.J.H.1
Charman, S.A.2
-
13
-
-
0025078913
-
Monomeric insulins and their experimental and clinical implications
-
Brange J, Owens DR, Kang S, Volund A. Monomeric insulins and their experimental and clinical implications. Diabetes Care 13(9), 923-954 (1990) (Pubitemid 20260734)
-
(1990)
Diabetes Care
, vol.13
, Issue.9
, pp. 923-954
-
-
Brange, J.1
Owens, D.R.2
Kang, S.3
Volund, A.4
-
14
-
-
0023005901
-
Effects of physical exercise on insulin absorption in insulin-dependent diabetics. A comparison between human and porcine insulin
-
Fernqvist E, Linde B, Ostman J, Gunnarsson R. Effects of physical exercise on insulin absorption in insulin-dependent diabetics. A comparison between human and porcine insulin. Clin. Physiol. 6(6), 489-497 (1986)
-
(1986)
Clin. Physiol.
, vol.6
, Issue.6
, pp. 489-497
-
-
Fernqvist, E.1
Linde, B.2
Ostman, J.3
Gunnarsson, R.4
-
15
-
-
0023019314
-
Dissociation of insulin absorption and blood flow during massage of a subcutaneous injection site
-
Linde B. Dissociation of insulin absorption and blood flow during massage of a subcutaneous injection site. Diabetes Care 9(6), 570-574 (1986) (Pubitemid 17208934)
-
(1986)
Diabetes Care
, vol.9
, Issue.6
, pp. 570-574
-
-
Linde, B.1
-
16
-
-
0020512215
-
The absorption of subcutaneously injected short-acting soluble insulin: Influence of injection technique and concentration
-
Hildebrandt P, Sestoft L, Nielsen SL. The absorption of subcutaneously injected short-acting soluble insulin: influence of injection technique and concentration. Diabetes Care 6(5), 459-462 (1983) (Pubitemid 13005552)
-
(1983)
Diabetes Care
, vol.6
, Issue.5
, pp. 459-462
-
-
Hildebrandt, P.1
Sestoft, L.2
Nielsen, S.L.3
-
17
-
-
77649211091
-
Subcutaneous bioavailability of golimumab at 3 different injection sites in healthy subjects
-
Xu Z, Wang Q, Zhuang Y et al. Subcutaneous bioavailability of golimumab at 3 different injection sites in healthy subjects. J. Clin. Pharmacol. 50(3), 276-284 (2010)
-
(2010)
J. Clin. Pharmacol.
, vol.50
, Issue.3
, pp. 276-284
-
-
Xu, Z.1
Wang, Q.2
Zhuang, Y.3
-
18
-
-
85157081798
-
Development of high protein concentration pharmaceuticals for SC delivery: Fitting all the pieces together
-
Abstracts of Papers San Francisco, CA, USA, 25 January
-
Shire SJ, Liu JJ. Development of high protein concentration pharmaceuticals for SC delivery: fitting all the pieces together. Abstracts of Papers: 239th ACS National Meeting. San Francisco, CA, USA, 25 January 2010
-
(2010)
239th ACS National Meeting
-
-
Shire, S.J.1
Liu, J.J.2
-
19
-
-
3042604253
-
Applications of ultraviolet absorption spectroscopy to the analysis of biopharmaceuticals
-
Shahrokh Z, Sluzky V, Cleland JL, Shire SJ, Randolph TW (Eds). American Chemical Society Symposium Series, DC, USA
-
Mach H, Sanyal G, Volkin DB, Middaugh CR. Applications of ultraviolet absorption spectroscopy to the analysis of biopharmaceuticals. In:Therapeutic Protein and Peptide Formulation and Delivery (Volume 675). Shahrokh Z, Sluzky V, Cleland JL, Shire SJ, Randolph TW (Eds). American Chemical Society Symposium Series, DC, USA (1997)
-
(1997)
Therapeutic Protein and Peptide Formulation and Delivery (Volume 675)
-
-
MacH, H.1
Sanyal, G.2
Volkin, D.B.3
Middaugh, C.R.4
-
20
-
-
79951862242
-
Ultraviolet Spectroscopy as a tool in therapeutic protein development
-
Mach H, Middaugh CR. Ultraviolet Spectroscopy as a tool in therapeutic protein development. J. Pharm. Sci. 100(4) 1214-1227 (2011)
-
(2011)
J. Pharm. Sci.
, vol.100
, Issue.4
, pp. 1214-1227
-
-
MacH, H.1
Middaugh, C.R.2
-
21
-
-
0028350433
-
Effect of protein adsorption on the surface charge characteristics of aluminium-containing adjuvants
-
DOI 10.1016/0264-410X(94)90127-9
-
Al-Shakhshir R, Regnier F, White JL, Hem SL. Effect of protein adsorption on the surface charge characteristics of aluminum-containing adjuvants. Vaccine 12(5), 472-474 (1994) (Pubitemid 24107587)
-
(1994)
Vaccine
, vol.12
, Issue.5
, pp. 472-474
-
-
Al-Shakhshir, R.1
Regnier, F.2
White, J.L.3
Hem, S.L.4
-
23
-
-
0032978516
-
Evaluation of commonly used electrophoretic methods for the analysis of proteins and peptides and their application to biotechnology
-
DOI 10.1016/S0003-2670(98)00487-5, PII S0003267098004875
-
Chiou S-H, Wu S-H. Evaluation of commonly used electrophoretic methods for the analysis of proteins and peptides and their application to biotechnology. Anal. Chim. Acta 383(1-2), 47-60 (1999) (Pubitemid 29097660)
-
(1999)
Analytica Chimica Acta
, vol.383
, Issue.1-2
, pp. 47-60
-
-
Chiou, S.-H.1
Wu, S.-H.2
-
24
-
-
0033083494
-
Prediction of electrophoretic mobilities. 3. Effect of ionic strength in capillary zone electrophoresis
-
Li D, Fu S, Lucy CA. Prediction of electrophoretic mobilities. 3. Effect of ionic strength in capillary zone electrophoresis. Anal. Chem. 71(3), 687-699 (1999)
-
(1999)
Anal. Chem.
, vol.71
, Issue.3
, pp. 687-699
-
-
Li, D.1
Fu, S.2
Lucy, C.A.3
-
25
-
-
63449086888
-
Investigation of the interaction mechanism of the recombinant human antibody MDJ8 and its fragments with chromatographic apatite phases
-
Schubert S, Freitag R. Investigation of the interaction mechanism of the recombinant human antibody MDJ8 and its fragments with chromatographic apatite phases. J. Chromatogr. A 1216(18), 3831-3840 (2009)
-
(2009)
J. Chromatogr. A
, vol.1216
, Issue.18
, pp. 3831-3840
-
-
Schubert, S.1
Freitag, R.2
-
26
-
-
34250343442
-
Changes in the rat subcutaneous connective tissue after saline and histamine injection in relation to fluid storage and excretion
-
DOI 10.1679/aohc.70.29
-
Daitoku D, Kurose T, Mori E, Hashimoto M, Kawamata S. Changes in the rat subcutaneous connective tissue after saline and histamine injection in relation to fluid storage and excretion. Arch. Histol. Cytol. 70(1), 29-41 (2007) (Pubitemid 46917491)
-
(2007)
Archives of Histology and Cytology
, vol.70
, Issue.1
, pp. 29-41
-
-
Daitoku, D.1
Kurose, T.2
Mori, E.3
Hashimoto, M.4
Kawamata, S.5
-
27
-
-
34548014804
-
PH-gradient ion-exchange chromatography: An analytical tool for design and optimization of protein separations
-
DOI 10.1016/j.chroma.2007.07.010, PII S0021967307011806
-
Ahamed T, Nfor BK, Verhaert PDEM et al. pH-gradient ion-exchange chromatography: an analytical tool for design and optimization of protein separations. J. Chromatogr. A 1164(1-2), 181-188 (2007) (Pubitemid 47284107)
-
(2007)
Journal of Chromatography A
, vol.1164
, Issue.1-2
, pp. 181-188
-
-
Ahamed, T.1
Nfor, B.K.2
Verhaert, P.D.E.M.3
Van Dedem, G.W.K.4
Van Der Wielen, L.A.M.5
Eppink, M.H.M.6
Van De Sandt, E.J.A.X.7
Ottens, M.8
-
28
-
-
0027632026
-
Adsorption and immunoreactivity of proteins on polystyrene and on silica. Competition with surfactants
-
Lichtenbelt JWT, Heuvelsland WJM, Oldenzeel ME, Zsom RLJ. Adsorption and immunoreactivity of proteins on polystyrene and on silica. Competition with surfactants. Colloids Surf. B 1(2), 75-82 (1993)
-
(1993)
Colloids Surf. B
, vol.1
, Issue.2
, pp. 75-82
-
-
Jwt, L.1
Wjm, H.2
Oldenzeel, M.E.3
Rlj, Z.4
-
29
-
-
0002445915
-
Structure of adsorbed and desorbed proteins
-
Norde W, Favier JP. Structure of adsorbed and desorbed proteins. Colloids Surf. 64(1), 87-93 (1992)
-
(1992)
Colloids Surf.
, vol.64
, Issue.1
, pp. 87-93
-
-
Norde, W.1
Favier, J.P.2
-
30
-
-
33747878559
-
A recombinant human enzyme for enhanced interstitial transport of therapeutics
-
DOI 10.1016/j.jconrel.2006.05.027, PII S0168365906002392, Third International Nanomedicine and Drug Delivery Symposium
-
Bookbinder LH, Hofer A, Haller MF et al. A recombinant human enzyme for enhanced interstitial transport of therapeutics. J. Control. Release 114(2), 230-241 (2006) (Pubitemid 44291844)
-
(2006)
Journal of Controlled Release
, vol.114
, Issue.2
, pp. 230-241
-
-
Bookbinder, L.H.1
Hofer, A.2
Haller, M.F.3
Zepeda, M.L.4
Keller, G.-A.5
Lim, J.E.6
Edgington, T.S.7
Shepard, H.M.8
Patton, J.S.9
Frost, G.I.10
-
31
-
-
0014283667
-
Experimental and clinical study on the lymph circulation
-
Seki K, Yamane Y, Shinoura A et al. Experimental and clinical study on the lymph circulation. Am. Heart J. 75(5), 620-629 (1968)
-
(1968)
Am. Heart J.
, vol.75
, Issue.5
, pp. 620-629
-
-
Seki, K.1
Yamane, Y.2
Shinoura, A.3
-
32
-
-
0016719545
-
Surface charge properties of the luminal front of blood vessel walls: An electron microscopical analysis
-
Skutelsky E, Rudich Z, Danon D. Surface charge properties of the luminal front of blood vessel walls: an electron microscopical analysis. Thromb. Res. 7(4), 623-634 (1975)
-
(1975)
Thromb. Res.
, vol.7
, Issue.4
, pp. 623-634
-
-
Skutelsky, E.1
Rudich, Z.2
Danon, D.3
-
33
-
-
67650079740
-
Quantitative analysis of monclonal antibody by cation-exchange chromatofocusing
-
Rozhkova A. Quantitative analysis of monclonal antibody by cation-exchange chromatofocusing. J. Chromatogr. A 1216, 5989-5994 (2009)
-
(2009)
J. Chromatogr. A
, vol.1216
, pp. 5989-5994
-
-
Rozhkova, A.1
-
34
-
-
0037143764
-
VEGF-Trap: A VEGF blocker with potent antitumor effects
-
DOI 10.1073/pnas.172398299
-
Holash J, Davis S, Papadopoulos N et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc. Natl Acad. Sci. USA 99(17), 11393-11398 (2002) (Pubitemid 34920936)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.17
, pp. 11393-11398
-
-
Holash, J.1
Davis, S.2
Papadopoulos, N.3
Croll, S.D.4
Ho, L.5
Russell, M.6
Boland, P.7
Leidich, R.8
Hylton, D.9
Burova, E.10
Ioffe, E.11
Huang, T.12
Radziejewski, C.13
Bailey, K.14
Fandl, J.P.15
Daly, T.16
Wiegand, S.J.17
Yancopoulos, G.D.18
Rudge, J.S.19
-
35
-
-
54249138516
-
Monoclonal antibody pharmacokinetics and pharmacodynamics
-
Wang W, Balthasar JP. Monoclonal antibody pharmacokinetics and pharmacodynamics. Clin. Pharm. Therapeutics 84, 548-558 (2008)
-
(2008)
Clin. Pharm. Therapeutics
, vol.84
, pp. 548-558
-
-
Wang, W.1
Balthasar, J.P.2
-
37
-
-
0030993535
-
Finally! the Brambell receptor (FcRB). Mediator of transmission of immunity and protection from catabolism for IgG
-
Junghans RP. Finally! The Brambell receptor (FcRB). Mediator of transmission of immunity and protection from catabolism for IgG. Immunol. Res. 16(1), 29-57 (1997)
-
(1997)
Immunol. Res.
, vol.16
, Issue.1
, pp. 29-57
-
-
Junghans, R.P.1
-
38
-
-
60349128880
-
-
Humira®
-
Humira®. Prescribing information www.rxabbott.com/u4-prescribing- info.cfm
-
Prescribing Information
-
-
-
39
-
-
60349128880
-
-
Raptiva®
-
Raptiva®. Prescribing information www.gene.com/gene/products/ information/pdf/raptiva-prescribing.pdf
-
Prescribing Information
-
-
-
41
-
-
60349128880
-
-
Humalog®
-
Humalog®. Prescribing information http://pi.lilly.com/us/humalog7525- pi.pdf
-
Prescribing Information
-
-
-
42
-
-
60349128880
-
-
Lantus®
-
Lantus®. Prescribing information www.products.sanofi-aventis.us/ lantus/lantus.html
-
Prescribing Information
-
-
|