Systemic availability and lymphatic transport of human growth hormone administered by subcutaneous injection

Journal of Pharmaceutical Sciences

Volumn 89, Issue 2, 2000, Pages 168-177

  Charman, Susan A ^a   Segrave, Alicia M ^a   Edwards, Glenn A ^b   Porter, Christopher J H ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Human growth hormone; Lymphatic transport; Protein delivery; Subcutaneous administration

Indexed keywords

HUMAN GROWTH HORMONE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG LYMPH LEVEL; DRUG STABILITY; DRUG TRANSPORT; ENZYME LINKED IMMUNOSORBENT ASSAY; INJECTION SITE; LYMPH FLOW; NONHUMAN; SHEEP; VALIDATION PROCESS;

EID: 0034005256     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6017(200002)89:2<168::AID-JPS4>3.0.CO;2-Q     Document Type: Article

References (21)

1. Kompella UB, Lee VHL. 1991. In: Lee, VHL, editor. Peptide and Protein Drug Delivery. New York: Marcel Dekker. p 391-484.
2. Banerjee PS, Hosny EA, Robinson JR. 1991. In: Lee, VHL, editor. Peptide and Protein Drug Delivery. New York: Marcel Dekker. p 487-543.
3. Kastrup KW, Christiansen JS, Andersen JK, Orskov H. 1984. Increased growth rate following transfer to daily S.C. administration from three week I.M. injections of hGH in growth hormone deficient children. Acta Endocrinol (Copenh) 104: 148-152.
4. Jorgensen JOL, Flyvbjerg A, Dinesen J, Lund H, Alberti KGMM, Orskov H, Christiansen JS. 1987. Serum profiles and short-term metabolic effect of pituitary and authentic biosynthetic human growth hormone in man. A double-blind cross-over study. Acta Endocrinol (Copenh) 116:381-386.
5. Zeisel HJ, Petrykowski Wv, Wais U. 1992. Pharmacokinetics and short-term metabolic effects of mammalian cell-derived biosynthetic human grwoth hormone in man. Horm Res 37(Suppl 2): 5-13.
6. Jorgensen JO, Flyvbjerg A, Lauritzen T, Orskov H, Christiansen JS. 1988. Subcutaneous degradation of biosynthetic human growth hormone in growth hormone deficient patients. Acta Endocrinol (Copenh) 118:154-158.
7. Laursen T, Grandjean B, Jorgensen JO, Christiansen JS. 1996. Bioavailability and bioactivity of three different doses of nasal growth hormone (GH) administered to GH-deficient patients: Comparison with intravenous and subcutaneous administration. Eur J Endocrinol 135:309-315.
8. Laursen T, Moller J, Jorgensen JO, Orskov H, Christiansen JS. 1996. Bioavailability and bioactivity of intravenous vs subcutaneous infusion of growth hormone in GH-deficient patients. Clin Endocrinol 45:333-339.
9. Yoffey JM, Courtice FC. 1970. In: Lymphatics, Lymph, and the Lymphomyeloid Complex. New York: Academic Press.
10. Leak LV. 1971. Studies on the permeability of lymphatic capillaries. J Cell Biol 50:300-323.
11. Casley-Smith JR. 1980. The fine structure and functioning of tissue channels and lymphatics. Lymphology 13:177-183.
12. Porter CJH. 1997. Drug delivery to the lymphatic system. Crit Rev Ther Drug Carrier Syst 14: 333-393.
13. Hall JG, Morris B. 1962. The output of cells in lymph from the popliteal node of sheep. J Exp Physiol 47:360-369.
14. Pearlman R, Bewley TA. 1993. In: Wang YJ, Pearlman R, editors. Stability and Characterization of Protein and Peptide Drugs. Case Histories. New York: Plenum Press, p 1-58.
15. Gibaldi M, Perrier D. 1982. In: Pharmacokinetics. New York: Marcel Dekker.
16. Supersaxo A, Hein WR, Gallati H, Steffan H. 1988. Recombinant human interferon alpha-2a: Delivery to lymphoid tissue by selected modes of application. Pharm Res 5:472-476.
17. Supersaxo A, Hein WR, Steffan H. 1990. Effect of molecular weight on the lymphatic absorption of water-soluable compounds following subcutaneous administration. Pharm Res 7:167-169.
18. Mordenti J, Chen SA, Moore JA, Ferraiolo BL, Green JD. 1991. Interspecies scaling of clearance and volume of distribution data for five therapeutic proteins. Pharm Res 8:1351-1359.
19. Bocci V, Muscettola M, Grasso G, Magyar Z, Naldini A, Szabo G. 1986. The lumphatic route. 1. Albumin and hyaluronidase modify the normal distribution of interferon in lymph and plasma. Experientia 42:432-433.
20. Calnan JS, Rivero OR, Fillmore S, Mercurius-Taylor L. 1967. Permeability of normal lymphatics. Br J Surg 54:278-285.
21. Radwanski E, Chakraborty A, Van Wart S, Huhnk RD, Cutler DL, Affrime MB, Jusko WJ. 1998. Pharmacokinetics and leukocyte responses of recominant human interleukin-10. Pharm Res 15:1895-1901.