Early alveolar bone regeneration in rats after topical administration of simvastatin

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology

Volumn 112, Issue 2, 2011, Pages 170-179

  MacIel Oliveira, Newton ^a   Bradaschia Correa, Vivian ^a   Arana Chavez, Victor E ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; OSTEOPONTIN; SIMVASTATIN; SPP1 PROTEIN, RAT;

ALVEOLAR BONE LOSS; ANIMAL; ARTICLE; BONE DEVELOPMENT; BONE MARROW; BONE MATRIX; BONE REGENERATION; DRUG EFFECT; GEL; IMMUNOHISTOCHEMISTRY; JAW; JAW DISEASE; MALE; MANDIBLE; OSTEOBLAST; OSTEOLYSIS; RAT; SCANNING ELECTRON MICROSCOPY; TIME; TOPICAL DRUG ADMINISTRATION; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; WISTAR RAT;

ADMINISTRATION, TOPICAL; ALVEOLAR BONE LOSS; ALVEOLAR PROCESS; ANIMALS; BONE MARROW; BONE MATRIX; BONE REGENERATION; BONE RESORPTION; COLLAGEN; GELS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNOHISTOCHEMISTRY; MALE; MANDIBLE; MANDIBULAR DISEASES; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; OSTEOBLASTS; OSTEOGENESIS; OSTEOPONTIN; RATS; RATS, WISTAR; SIMVASTATIN; TIME FACTORS;

EID: 79960201965     PISSN: 10792104     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tripleo.2010.08.027     Document Type: Article

References (35)

1. M. Zeichner-David Regeneration of periodontal tissues: cementogenesis revisited Periodontol 41 2006 196 217 2000 (Pubitemid 43937572)
2. A. Corsini, S. Bellosta, R. Baetta, R. Fumagalli, R. Paoletti, and F. Bernini New insights into the pharmacodynamic and pharmacokinetic properties of statins Pharmacol Ther 84 1999 413 428
3. G. Mundy, R. Garret, S. Harris, J. Chan, D. Chen, and G. Rossini Stimulation of bone formation in vitro and in rodents by statins Science 286 1999 1946 1949 (Pubitemid 129515901)
4. B.W. Phillips, N. Belmonte, C. Vernochet, G. Ailhaud, and C. Dani Compactin enhances osteogenesis in murine embryonic stem cells Biochem Biophys Res Commun 284 2001 478 484 (Pubitemid 32918002)
5. H. Hatano, A. Maruo, M.E. Bolander, and G. Sakar Statin stimulates bone morphogenetic protein-2, aggrecan, and type 2 collagen gene expression and proteoglycan synthesis in rat chondrocytes J Orthop Sci 8 2003 842 848 (Pubitemid 38017674)
6. Y. Ayukawa, E. Yasukawa, Y. Moriyama, Y. Ogino, H. Wada, and I. Atsuta Local application of statin promotes bone repair through the suppression of osteoclasts and the enhancement of osteoblasts at bone-healing sites in rats Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107 2009 336 342
7. T. Maeda, T. Kawane, and N. Horiuchi Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation Endocrinologist 144 2003 681 692 (Pubitemid 36205242)
8. W.A. Grasser, A.P. Baumann, S.F. Petras, H.J. Harwood, R. Devalajara, and R. Renkiewicz Regulation of osteoclast differentiation by statins J Musculoskelet Neuronal Interact 3 2003 53 62 (Pubitemid 36443183)
9. I. Oze, E. Kili, C. Gm, and F. Göze Effect of local simvastatin application on mandibular defects J Craniofac Surg 18 2007 546 550 (Pubitemid 46849954)
10. Z. Wu, C. Liu, G. Zang, and H. Sun The effect of simvastatin on remodeling of the alveolar bone following tooth extraction Int J Oral Maxillofac Surg 37 2008 170 176 (Pubitemid 351220967)
11. M. Nyan, D. Sato, M. Oda, T. Machida, H. Kobayashi, and T. Nakamura Bone formation with the combination of simvastatin and calcium sulfate in critical-sized rat calvarial defect J Pharmacol Sci 104 2007 384 386 (Pubitemid 47378426)
12. J.B. Park The use of simvastatin in bone regeneration Med Oral Patol Oral Cir Bucal 14 2009 485 488
13. A.H. Melcher Repair of wounds in the periodontium of the rat Influence of periodontal ligament on osteogenesis Arch Oral Biol 15 1970 1183 1204
14. T.R. Gould, A.H. Melcher, and D.M. Brunette Migration and division of progenitor cell populations in periodontal ligament after wounding J Periodontal Res 15 1980 20 42 (Pubitemid 10133076)
15. A. Nanci Content and distribution of noncollagenous matrix proteins in bone and cementum: relationship to speed of formation and collagen packing density J Struct Biol 126 1999 256 269 (Pubitemid 29402572)
16. V.E. Arana-Chavez, and A. Nanci High resolution immunocytochemistry of noncollagenous matrix proteins in rat mandibles processed with microwave irradiation J Histochem Cytochem 49 2001 1099 1109 (Pubitemid 32800531)
17. H. Xie, F. Yang, L. Deng, J. Luo, T. Qin, and X. Li The performance of a bone-derived scaffold material in the repair of critical bone defects in a rhesus monkey model Biomaterials 28 2007 3314 3324 (Pubitemid 46693971)
18. M.R. Messora, M.J. Nagata, R.C. Mariano, R.C. Dornelles, S.R. Bomfim, and S.E. Fucini Bone healing in critical-size defects treated with platelet-rich plasma: a histologic and histometric study in rat calvaria J Periodontal Res 43 2008 217 223
19. T. Fujii, T. Ueno, T. Kagawa, Y. Sakata, and T. Sugahara Comparison of bone formation ingrafted periosteum harvested from tibia and calvaria Microsc Res Tech 69 2006 580 584 (Pubitemid 44087207)
20. T.R. Gould, A.H. Melcher, and D.M. Brunette Location of progenitor cells in periodontal ligament stimulated by wounding Anat Rec 188 1977 133 141 (Pubitemid 8132238)
21. P. Lekic, J. Sodek, and C.A. McCulloch Osteopontin and bone sialoprotein expression in regeneration of rat periodontal ligament and alveolar bone Anat Rec 244 1996 50 58 (Pubitemid 26005797)
22. P. Lekic, J. Sodek, and C.A. McCulloch Relationship of cellular proliferation to expression of osteopontin and bone sialoprotein in regeneration rat periodontium Cell Tissue Res 285 1996 491 500 (Pubitemid 26294660)
23. L. Nguyen, P. Lekic, and C.A. McCulloch Collagen implants do not preserve periodontal ligament homeostasis in periodontal wounds J Periodontal Res 32 1997 419 429 (Pubitemid 127520484)
24. D. Rajshankar, C.A. McCulloch, H.C. Tenenbaum, and P.C. Lekic Osteogenic inhibition by rat periodontal ligament cells: modulation of bone morphogenetic protein-7 activity in vivo Cell Tissue Res 294 1998 475 483 (Pubitemid 28510860)
25. L. Chano, H.C. Tenenbaum, P.C. Lekic, J. Sodek, and C.A. McCulloch Emdogain regulation of cellular differentiation in wounded rat periodontium J Periodontal Res 38 2003 164 174 (Pubitemid 37485615)
26. S.B. Jadhav, and G.K. Jain Statins and osteoporosis: new role for old drugs J Pharm Pharmacol 58 2006 3 18 (Pubitemid 43041991)
27. D. Stein, Y. Lee, M.J. Schmid, B. Killpack, M.A. Genrich, and N. Narayana Local simvastatin effects on mandibular bone growth and inflammation J Periodontol 11 2005 1861 1870 (Pubitemid 41748975)
28. A.M. Parfitt The cellular basis of bone remodeling: the quantum concept reexamined in light of recent advances in the cell biology of bone Calcif Tissue Int 36 1984 S37 S45
29. V.E. Arana-Chavez, and V. Bradaschia-Correa Clastic cells: mineralized tissue resorption in health and disease Int J Biochem Cell Biol 40 2009 446 450
30. J.T. Woo, S. Kasai, P.H. Stern, and K. Nagai Compaction suppresses bone resorption by inhibiting the fusion of perfusion osteoclasts and disrupting the actin ring in osteoclasts J Bone Miner Res 15 2000 650 662 (Pubitemid 30174019)
31. M.C. Groeneveld, V. Everts, and W. Beertsen A quantitative enzyme histochemical analysis of the distribution of alkaline phosphatase activity in the periodontal ligament of the rat incisor J Dent Res 72 1993 1344 1350
32. A.H. Yazawa, B. Zimmermann, Y. Asami, and J.P. Bernimoulin Simvastatin promotes cell metabolism, proliferation, and osteoblastic differentiation in human periodontal ligament cells J Periodontol 76 2005 295 302 (Pubitemid 40542260)
33. D.H. Walter, A.M. Zeiher, and S. Dimmeler Effects of statin on endothelium and their contribution to neovascularization by mobilization of endothelial progenitor cells Coron Artery Dis 14 2004 235 242 (Pubitemid 39061605)
34. S. Garip, and F. Severcam Determination of simvastatin-induced changes in bone composition and structure by Fourier transform infrared spectroscopy in rat animal model J Pharma Biomed Anal 52 2010 580 588
35. C.A. McCulloch, P. Lekic, and M.D. McKee Role of physical forces in regulating the form and function of the periodontal ligament Periodontol 24 2000 56 72 2000