Changes in iron-regulatory gene expression occur in human cell culture models of Parkinson's disease

Neurochemistry International

Volumn 59, Issue 1, 2011, Pages 73-80

  Carroll, C B ^a   Zeissler, M L ^a   Chadborn, N ^a   Gibson, K ^a   Williams, G ^b   Zajicek, J P ^a   Morrison, K E ^b   Hanemann, C O ^a  

^a PLYMOUTH UNIVERSITY PENINSULA SCHOOLS OF MEDICINE AND DENTISTRY   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Divalent metal; Iron; Mitoferrin; MPP+; Parkinson's disease; Transferrin receptor; Transporter

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM IODIDE; CD71 ANTIGEN; FERROPORTIN; IRON; IRON BINDING PROTEIN; LACTACYSTIN; MEMBRANE PROTEIN; MESSENGER RNA; MITOFERRIN 2; PARAQUAT; PYRIDINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; TOXIN; TRANSFERRIN RECEPTOR 2; UNCLASSIFIED DRUG;

ARTICLE; CELL LEVEL; GENE EXPRESSION; HUMAN; HUMAN CELL; IRON DEFICIENCY; IRON TRANSPORT; MITOCHONDRION; OXIDATIVE STRESS; PARKINSON DISEASE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL LINE, TUMOR; CELLS, CULTURED; GENE EXPRESSION PROFILING; HUMANS; IRON; MODELS, BIOLOGICAL; PARKINSON DISEASE; POLYMERASE CHAIN REACTION;

EID: 79960164018     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2011.05.006     Document Type: Article

References (45)

1. S. Abboud, and D.J. Haile A novel mammalian iron-regulated protein involved in intracellular iron metabolism Journal of Biological Chemistry 275 2000 19906 19912 (Pubitemid 30441595)
2. P. Aguirre, N. Mena, V. Tapia, M. Arredondo, and M.T. Nunez Iron homeostasis in neuronal cells: a role for IREGI BMC Neuroscience 6 2005
3. B. Andriopoulos, S. Hegedusch, J. Mangin, H.D. Riedel, U. Hebling, J. Wang, K. Pantopoulos, and S. Mueller Sustained hydrogen peroxide induces iron uptake by transferrin receptor-1 independent of the iron regulatory protein/iron-responsive element network Journal of Biological Chemistry 282 2007 20301 20308 (Pubitemid 47100037)
4. H. Ayaki, M.J. Lee, K. Sumino, and H. Nishio Different cytoprotective effect of antioxidants and change in the iron regulatory system in rodent cells exposed to paraquat or formaldehyde Toxicology 208 2005 73 79
5. Y.M. Chen, Z.M. Qian, J.R. Du, X.L. Duan, Y.Z. Chang, Q. Wang, C.Y. Wang, Y.M. Ma, Y.J. Xu, L.Z. Li, and Y. Ke Iron loading inhibits ferroportin1 expression in PC12 cells Neurochemistry International 47 2005 507 513 (Pubitemid 41266881)
6. R.J. Dinis-Oliveira, F. Remiao, H. Carmo, J.A. Duarte, A.S. Navarro, M.L. Bastos, and F. Carvalho Paraquat exposure as an etiological factor of Parkinson's disease Neurotoxicology 27 2006 1110 1122 (Pubitemid 44838957)
7. A.F. Domingues, D.M. Arduino, A.R. Esteves, R.H. Swerdlow, C.R. Oliveira, and S.M. Cardoso Mitochondria and ubiquitin-proteasomal system interplay: relevance to Parkinson's disease Free Radical Biology and Medicine 45 2008 820 825
8. B.A. Faucheux, M.T. Herrero, J. Villares, R. Levy, F. Javoyagid, J.A. Obeso, J.J. Hauw, Y. Agid, and E.C. Hirsch Autoradiographic localization and density of [I-125] ferrotransferrin binding sites in the basal ganglia of control subjects, patients with Parkinsons disease and MPTP-lesioned monkeys Brain Research 691 1995 115 124
9. G. Fiskum, A. Starkov, B.M. Polster, and C. Chinopoulos Mitochondrial mechanisms of neural cell death and neuroprotective interventions in Parkinson's disease Parkinson's Disease: the Life Cycle of the Dopamine Neuron 991 2003 111 119 (Pubitemid 36793807)
10. R.A. Gonzalez-Polo, M. Niso-Santano, M.A. Ortiz-Ortiz, A. Gomez-Martin, J.M. Moran, L. Garcia-Rubio, J. Francisco-Morcillo, C. Zaragoza, G. Soler, and J.M. Fuentes Inhibition of paraquat-induced autophagy accelerates the apoptotic cell death in neuroblastoma SH-SY5Y cells Toxicological Sciences 97 2007 448 458 (Pubitemid 47073860)
11. R.A. Gonzalez-Polo, M. Niso-Santano, M.A. Ortiz-Ortiz, A. Gomez-Martin, J.M. Moran, L. Garcia-Rubio, J. Francisco-Morcillo, C. Zaragoza, G. Soler, and J.M. Fuentes Relationship between autophagy and apoptotic cell death in human neuroblastoma cells treated with paraquat - Could autophagy be a "brake" in paraquat-induced apoptotic death? Autophagy 3 2007 366 367 (Pubitemid 46986345)
12. Y.F. Guo, P. Xiao, S.F. Lei, F.Y. Deng, G.G. Xiao, Y.Z. Liu, X.D. Chen, L.M. Li, S. Wu, Y. Chen, H. Jiang, L.J. Tan, J.Y. Xie, X.Z. Zhu, S.P. Liang, and H.W. Deng How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes Acta Biochimica Et Biophysica Sinica 40 2008 426 436 (Pubitemid 351704046)
13. A. Hartley, J.M. Stone, C. Heron, J.M. Cooper, and A.H.V. Schapira Complex I inhibitors induce dose-dependent apoptosis in PC12 cells - relevance to Parkinsons disease Journal of Neurochemistry 63 1994 1987 1990 (Pubitemid 24326248)
14. K. Iwai, S.K. Drake, N.B. Wehr, A.M. Weissman, T. LaVaute, N. Minato, R.D. Klausner, R.L. Levine, and T.A. Rouault Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins Proceedings of the National Academy of Sciences of the United States of America 95 1998 4924 4928 (Pubitemid 28208526)
15. S.V. Kalivendi, S. Cunningham, S. Kotamraju, J. Joseph, C.J. Hillard, and B. Kalyanaraman Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells - Intermediacy of transferrin receptor iron and hydrogen peroxide Journal of Biological Chemistry 279 2004 15240 15247 (Pubitemid 38618920)
16. S.V. Kalivendi, S. Kotamraju, S. Cunningham, T. Shang, C.J. Hillard, and B. Kalyanaraman 1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide The Biochemical Journal 371 2003 151 164 (Pubitemid 36458089)
17. D. Kaur, and J. Andersen Does cellular iron dysregulation play a causative role in Parkinson's disease? Ageing Research Reviews 3 2004 327 343 (Pubitemid 38844698)
18. P.M. Keeney, J. Xie, R.A. Capaldi, and J.P. Bennett Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled Journal of Neuroscience 26 2006 5256 5264 (Pubitemid 44315308)
19. S. Kim, and P. Ponka Control of transferrin receptor expression via nitric oxide-mediated modulation of iron-regulatory protein 2 Journal of Biological Chemistry 274 1999 33035 33042 (Pubitemid 129535344)
20. P.L. Lee, T. Gelbart, C. West, C. Halloran, and E. Beutler The human nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms Blood Cells Molecules and Diseases 24 1998 199 215 (Pubitemid 28365738)
21. N. Lev, E. Melamed, and D. Offen Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage Neuroscience Letters 399 2006 27 32
22. Liu, X. B., Hill, P., Haile, D. J., 2002. Role of the ferroportin iron-responsive element in iron and nitric oxide dependent gene regulation. Chiemesee. Germany, pp. 315-326.
23. T. Maier, M. Guell, and L. Serrano Correlation of mRNA and protein in complex biological samples FEBS Letters 583 2009 3966 3973
24. P.G. Mastroberardino, E.K. Hoffman, M.P. Horowitz, R. Betarbet, G. Taylor, D.M. Cheng, H.M. Na, C.A. Gutekunst, M. Gearing, J.Q. Trojanowski, M. Anderson, C.T. Chu, J.M. Peng, and J.T. Greenamyre A novel transferrin/TfR2- mediated mitochondrial iron transport system is disrupted in Parkinson's disease Neurobiology of Disease 34 2009 417 431
25. K.S. McNaught, R. Belizaire, O. Isacson, P. Jenner, and C.W. Olanow Altered proteasomal function in sporadic Parkinson's disease Experimental Neurology 179 2003 38 46 (Pubitemid 36062617)
26. K.S.P. McNaught, D.P. Perl, A.L. Brownell, and C.W. Olanow Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease Annals of Neurology 56 2004 149 162 (Pubitemid 38857373)
27. F. Molina-Holgado, A. Gaeta, P.T. Francis, R.J. Williams, and R.C. Hider Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells Journal of Neurochemistry 105 2008 2466 2476 (Pubitemid 351782272)
28. E.W. Mullner, and L.C. Kuhn A stem-loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor messenger-RNA stability in the cytoplasm Cell 53 1988 815 825
29. E.W. Mullner, B. Neupert, and L.C. Kuhn A specific messenger-RNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor messenger-RNA Cell 58 1989 373 382 (Pubitemid 19191418)
30. P.N. Paradkar, K.B. Zumbrennen, B.H. Paw, D.M. Ward, and J. Kaplan Regulation of Mitochondrial Iron Import through Differential Turnover of Mitoferrin 1 and Mitoferrin 2 Molecular and Cellular Biology 29 2009 1007 1016
31. S. Przedborski, and M. Vila The 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine mouse model - A tool to explore the pathogenesis of Parkinson's disease Parkinson's Disease: the Life Cycle of the Dopamine Neuron 991 2003 189 198 (Pubitemid 36793814)
32. D.R. Richardson, D.J.R. Lane, E.M. Becker, M.L.H. Huang, M. Whitnall, Y.S. Rahmanto, A.D. Sheftel, and P. Ponka Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol Proceedings of the National Academy of Sciences 107 2010 10775 10782
33. J.A. Roth, C. Horbinski, L. Feng, K.G. Dolan, D. Higgins, and M.D. Garrick Differential localization of divalent metal transporter 1 with and without iron response element in rat PC12 and sympathetic neuronal cells Journal of Neuroscience 20 2000 7595 7601
34. J. Salazar, N. Mena, S. Hunot, A. Prigent, D. Alvarez-Fischer, M. Arredondo, C. Duyckaerts, V. Sazdovitch, L. Zhao, L.M. Garrick, M.T. Nunez, M.D. Garrick, R. Raisman-Vozari, and E.C. Hirsch Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease Proceedings of the National Academy of Sciences of the United States of America 105 2008 18578 18583
35. M. Santiago, E.R. Matarredona, L. Granero, J. Cano, and A. Machado Neuroprotective effect of the iron chelator desferrioxamine against MPP(+) toxicity on striatal dopaminergic terminals Journal of Neurochemistry 68 1997 732 738 (Pubitemid 27044738)
36. T. Shang, S. Kotamraju, S.V. Kalivendi, C.J. Hillard, and B. Kalyanaraman 1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide Journal of Biological Chemistry 279 2004 19099 19112 (Pubitemid 38623341)
37. N. Song, H. Jiang, J. Wang, and J.X. Xie Divalent metal transporter 1 up-regulation is involved in the 6-hydroxydopamine-induced ferrous iron influx Journal of Neuroscience Research 85 2007 3118 3126 (Pubitemid 350057367)
38. F. Sun, A. Kanthasamy, V. Anantharam, and A.G. Kanthasamy Environmental neurotoxic chemicals-induced ubiquitin proteasome system dysfunction in the pathogenesis and progression of Parkinson's disease Pharmacology & Therapeutics 114 2007 327 344 (Pubitemid 46843254)
39. K. Volz The functional duality of iron regulatory protein 1 Current Opinion in Structural Biology 18 2008 106 111
40. J. Wang, H. Jiang, and J.X. Xie Ferroportin1 and hephaestin are involved in the nigral iron accumulation of 6-OHDA-lesioned rats European Journal of Neuroscience 25 2007 2766 2772 (Pubitemid 46888831)
41. W. Wang, X.M. Di, R.B. D'Agostino, S.V. Torti, and F.M. Torti Excess capacity of the iron regulatory protein system Journal of Biological Chemistry 282 2007 24650 24659 (Pubitemid 47347505)
42. Q. Xu, A.G. Kanthasamy, and M.U.B. Reddy Neuroprotective effect of the natural iron chelator, phytic acid in a cell culture model of Parkinson's disease Toxicology 245 2008 101 108
43. S.Z. Zhang, J. Wang, N. Song, J.X. Xie, and H. Jiang Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in MES23.5 cells Cell Biology International 32 2008 S12
44. X. Zhang, W.J. Xie, S. Qu, T.H. Pan, X.T. Wang, and W.D. Le Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration Biochemical and Biophysical Research Communications 333 2005 544 549 (Pubitemid 40848325)
45. W. Zhu, W. Xie, T. Pan, P. Xu, M. Fridkin, H. Zheng, J. Jankovic, M.B.H. Youdim, and W. Le Prevention and restoration of lactacystin-induced nigrostriatal dopamine neuron degeneration by novel brain-permeable iron chelators The FASEB Journal 21 2007 3835 3844 (Pubitemid 350232341)