1-Methyl-4-phenylpyridinium-induced Apoptosis in Cerebellar Granule Neurons Is Mediated by Transferrin Receptor Iron-dependent Depletion of Tetrahydrobiopterin and Neuronal Nitric-oxide Synthase-derived Superoxide

Journal of Biological Chemistry

Volumn 279, Issue 18, 2004, Pages 19099-19112

  Shang, Tiesong ^a   Kotamraju, Srigiridhar ^a   Kalivendi, Shasi V ^a   Hillard, Cecilia J ^b   Kalyanaraman, B ^a,b  

^a FREE RADICAL RESEARCH CENTER   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CELLS; DISEASES; ORGANIC COMPOUNDS; TOXIC MATERIALS; TOXICITY;

IRON SIGNALING; NEUROTOXINS;

BIOCHEMISTRY;

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ACONITATE HYDRATASE; HYDROGEN PEROXIDE; IRON; IRON REGULATORY FACTOR; NEURONAL NITRIC OXIDE SYNTHASE; NEUROTOXIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SEPIAPTERIN; SUPEROXIDE; TETRAHYDROBIOPTERIN; TRANSFERRIN RECEPTOR;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CEREBELLUM; CONTROLLED STUDY; CYTOTOXICITY; DECOMPOSITION; DEGENERATIVE DISEASE; ENZYME ACTIVITY; ENZYME INACTIVATION; FEMALE; GRANULE CELL; IRON TRANSPORT; MALE; NEWBORN; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION;

1-METHYL-4-PHENYLPYRIDINIUM; ACONITATE HYDRATASE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; BIOPTERIN; CEREBELLUM; ELECTRON TRANSPORT COMPLEX I; HUMANS; INTERNEURONS; IRON; MITOCHONDRIAL PROTEINS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; PARKINSON DISEASE; RATS; REACTIVE OXYGEN SPECIES; RECEPTORS, TRANSFERRIN; SIGNAL TRANSDUCTION; SUPEROXIDES;

ANIMALIA;

EID: 2442504779     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400101200     Document Type: Article

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