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Volumn 79, Issue 2, 2011, Pages 103-111

Is VEGF a predictive biomarker to anti-angiogenic therapy?

Author keywords

Angiogenesis; Anti angiogenic therapy; Biomarker; Response; Review; VEGF

Indexed keywords

ANGIOGENESIS INHIBITOR; BEVACIZUMAB; CARBOPLATIN; EVEROLIMUS; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; IMATINIB; IRINOTECAN; OXALIPLATIN; PACLITAXEL; PLACEBO; SORAFENIB; STI 157; SUNITINIB; UNCLASSIFIED DRUG; VANDETANIB; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VATALANIB;

EID: 79960160320     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2010.07.008     Document Type: Review
Times cited : (34)

References (85)
  • 1
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W. Mechanisms of angiogenesis. Nature 1997, 386:671-674.
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 2
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • Folkman J. What is the evidence that tumors are angiogenesis dependent?. J Natl Cancer Inst 1990, 82:4-6.
    • (1990) J Natl Cancer Inst , vol.82 , pp. 4-6
    • Folkman, J.1
  • 3
    • 0036088478 scopus 로고    scopus 로고
    • Mechanisms of normal and tumor-derived angiogenesis
    • Papetti M., Herman I.M. Mechanisms of normal and tumor-derived angiogenesis. Am J Physiol Cell Physiol 2002, 282:C947-C970.
    • (2002) Am J Physiol Cell Physiol , vol.282
    • Papetti, M.1    Herman, I.M.2
  • 5
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971, 285:1182-1186.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 6
    • 74949105013 scopus 로고    scopus 로고
    • Biomarkers of antiangiogenic therapy: how do we move from candidate biomarkers to valid biomarkers?
    • Duda D.G., Ancukiewicz M., Jain R.K. Biomarkers of antiangiogenic therapy: how do we move from candidate biomarkers to valid biomarkers?. J Clin Oncol 2010, 28:183-185.
    • (2010) J Clin Oncol , vol.28 , pp. 183-185
    • Duda, D.G.1    Ancukiewicz, M.2    Jain, R.K.3
  • 7
    • 26944496117 scopus 로고    scopus 로고
    • REporting recommendations for tumor MARKer prognostic studies (REMARK)
    • McShane L.M., Altman D.G., Sauerbrei W., et al. REporting recommendations for tumor MARKer prognostic studies (REMARK). Nat Clin Pract Urol 2005, 2:416-422.
    • (2005) Nat Clin Pract Urol , vol.2 , pp. 416-422
    • McShane, L.M.1    Altman, D.G.2    Sauerbrei, W.3
  • 8
    • 67650380136 scopus 로고    scopus 로고
    • Biomarkers of response and resistance to antiangiogenic therapy
    • Jain R.K., Duda D.G., Willett C.G., et al. Biomarkers of response and resistance to antiangiogenic therapy. Nat Rev Clin Oncol 2009, 6:327-338.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 327-338
    • Jain, R.K.1    Duda, D.G.2    Willett, C.G.3
  • 9
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G., Benjamin L.E. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003, 3:401-410.
    • (2003) Nat Rev Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 10
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • Dvorak H.F. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002, 20:4368-4380.
    • (2002) J Clin Oncol , vol.20 , pp. 4368-4380
    • Dvorak, H.F.1
  • 11
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: basic science and clinical progress
    • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004, 25:581-611.
    • (2004) Endocr Rev , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 12
    • 0035003384 scopus 로고    scopus 로고
    • Structure and function of VEGF/VEGF-receptor system involved in angiogenesis
    • Shibuya M. Structure and function of VEGF/VEGF-receptor system involved in angiogenesis. Cell Struct Funct 2001, 26:25-35.
    • (2001) Cell Struct Funct , vol.26 , pp. 25-35
    • Shibuya, M.1
  • 13
    • 34047141776 scopus 로고    scopus 로고
    • Vascular endothelial growth factor family of ligands and receptors: review
    • Otrock Z.K., Makarem J.A., Shamseddine A.I. Vascular endothelial growth factor family of ligands and receptors: review. Blood Cells Mol Dis 2007, 38:258-268.
    • (2007) Blood Cells Mol Dis , vol.38 , pp. 258-268
    • Otrock, Z.K.1    Makarem, J.A.2    Shamseddine, A.I.3
  • 14
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N., Gerber H.P., LeCouter J. The biology of VEGF and its receptors. Nat Med 2003, 9:669-676.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 15
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin D.J., Ellis L.M. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005, 23:1011-1027.
    • (2005) J Clin Oncol , vol.23 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 16
    • 0030641090 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: a multifunctional angiogenic cytokine
    • Brown L.F., Detmar M., Claffey K., et al. Vascular permeability factor/vascular endothelial growth factor: a multifunctional angiogenic cytokine. EXS 1997, 79:233-269.
    • (1997) EXS , vol.79 , pp. 233-269
    • Brown, L.F.1    Detmar, M.2    Claffey, K.3
  • 17
    • 0029004025 scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
    • Dvorak H.F., Brown L.F., Detmar M., Dvorak A.M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 1995, 146:1029-1039.
    • (1995) Am J Pathol , vol.146 , pp. 1029-1039
    • Dvorak, H.F.1    Brown, L.F.2    Detmar, M.3    Dvorak, A.M.4
  • 18
    • 0035045564 scopus 로고    scopus 로고
    • Multiple myeloma. Advances in disease biology: therapeutic implications
    • Anderson K.C. Multiple myeloma. Advances in disease biology: therapeutic implications. Semin Hematol 2001, 38(2 (Suppl. 3)):6-10.
    • (2001) Semin Hematol , vol.38 , Issue.2 SUPPL. 3 , pp. 6-10
    • Anderson, K.C.1
  • 19
    • 0033083962 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies
    • Bellamy W.T., Richter L., Frutiger Y., Grogan T.M. Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies. Cancer Res 1999, 59:728-733.
    • (1999) Cancer Res , vol.59 , pp. 728-733
    • Bellamy, W.T.1    Richter, L.2    Frutiger, Y.3    Grogan, T.M.4
  • 20
    • 0034329298 scopus 로고    scopus 로고
    • In vitro and in vivo production of vascular endothelial growth factor by chronic lymphocytic leukemia cells
    • Chen H., Treweeke A.T., West D.C., et al. In vitro and in vivo production of vascular endothelial growth factor by chronic lymphocytic leukemia cells. Blood 2000, 96:3181-3187.
    • (2000) Blood , vol.96 , pp. 3181-3187
    • Chen, H.1    Treweeke, A.T.2    West, D.C.3
  • 21
    • 0030764802 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor in lymphomas and Castleman's disease
    • Foss H.D., Araujo I., Demel G., Klotzbach H., Hummel M., Stein H. Expression of vascular endothelial growth factor in lymphomas and Castleman's disease. J Pathol 1997, 183:44-50.
    • (1997) J Pathol , vol.183 , pp. 44-50
    • Foss, H.D.1    Araujo, I.2    Demel, G.3    Klotzbach, H.4    Hummel, M.5    Stein, H.6
  • 22
    • 0035877993 scopus 로고    scopus 로고
    • Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid
    • Kini A.R., Peterson L.A., Tallman M.S., Lingen M.W. Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid. Blood 2001, 97:3919-3924.
    • (2001) Blood , vol.97 , pp. 3919-3924
    • Kini, A.R.1    Peterson, L.A.2    Tallman, M.S.3    Lingen, M.W.4
  • 23
    • 0028861231 scopus 로고
    • Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer
    • Brown L.F., Berse B., Jackman R.W., et al. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer. Hum Pathol 1995, 26:86-91.
    • (1995) Hum Pathol , vol.26 , pp. 86-91
    • Brown, L.F.1    Berse, B.2    Jackman, R.W.3
  • 24
    • 0029155712 scopus 로고
    • Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia
    • Guidi A.J., Abu-Jawdeh G., Berse B., et al. Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia. J Natl Cancer Inst 1995, 87:1237-1245.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 1237-1245
    • Guidi, A.J.1    Abu-Jawdeh, G.2    Berse, B.3
  • 25
    • 0033010512 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is up-regulated in the early pre-malignant stage of colorectal tumour progression
    • Wong M.P., Cheung N., Yuen S.T., Leung S.Y., Chung L.P. Vascular endothelial growth factor is up-regulated in the early pre-malignant stage of colorectal tumour progression. Int J Cancer 1999, 81:845-850.
    • (1999) Int J Cancer , vol.81 , pp. 845-850
    • Wong, M.P.1    Cheung, N.2    Yuen, S.T.3    Leung, S.Y.4    Chung, L.P.5
  • 26
    • 0036395643 scopus 로고    scopus 로고
    • Determination of vascular endothelial growth factor (VEGF) in circulating blood: significance of VEGF in various leucocytes and platelets
    • Werther K., Christensen I.J., Nielsen H.J. Determination of vascular endothelial growth factor (VEGF) in circulating blood: significance of VEGF in various leucocytes and platelets. Scand J Clin Lab Invest 2002, 62:343-350.
    • (2002) Scand J Clin Lab Invest , vol.62 , pp. 343-350
    • Werther, K.1    Christensen, I.J.2    Nielsen, H.J.3
  • 27
    • 3343016654 scopus 로고    scopus 로고
    • Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor
    • Kusumanto Y.H., Dam W.A., Hospers G.A., Meijer C., Mulder N.H. Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor. Angiogenesis 2003, 6:283-287.
    • (2003) Angiogenesis , vol.6 , pp. 283-287
    • Kusumanto, Y.H.1    Dam, W.A.2    Hospers, G.A.3    Meijer, C.4    Mulder, N.H.5
  • 28
    • 0033875585 scopus 로고    scopus 로고
    • Correlation of plasma and serum vascular endothelial growth factor levels with platelet count in colorectal cancer: clinical evidence of platelet scavenging?
    • George M.L., Eccles S.A., Tutton M.G., Abulafi A.M., Swift R.I. Correlation of plasma and serum vascular endothelial growth factor levels with platelet count in colorectal cancer: clinical evidence of platelet scavenging?. Clin Cancer Res 2000, 6:3147-3152.
    • (2000) Clin Cancer Res , vol.6 , pp. 3147-3152
    • George, M.L.1    Eccles, S.A.2    Tutton, M.G.3    Abulafi, A.M.4    Swift, R.I.5
  • 29
    • 0032995840 scopus 로고    scopus 로고
    • Leukocytes and platelets of patients with cancer contain high levels of vascular endothelial growth factor
    • Salven P., Orpana A., Joensuu H. Leukocytes and platelets of patients with cancer contain high levels of vascular endothelial growth factor. Clin Cancer Res 1999, 5:487-491.
    • (1999) Clin Cancer Res , vol.5 , pp. 487-491
    • Salven, P.1    Orpana, A.2    Joensuu, H.3
  • 30
    • 0037731710 scopus 로고    scopus 로고
    • Quantitative correlation of serum levels and tumor expression of vascular endothelial growth factor in patients with hepatocellular carcinoma
    • Poon R.T., Lau C.P., Cheung S.T., Yu W.C., Fan S.T. Quantitative correlation of serum levels and tumor expression of vascular endothelial growth factor in patients with hepatocellular carcinoma. Cancer Res 2003, 63:3121-3126.
    • (2003) Cancer Res , vol.63 , pp. 3121-3126
    • Poon, R.T.1    Lau, C.P.2    Cheung, S.T.3    Yu, W.C.4    Fan, S.T.5
  • 31
    • 0034489115 scopus 로고    scopus 로고
    • The prognostic value of angiogenesis factor expression for predicting recurrence and metastasis of bladder cancer after neoadjuvant chemotherapy and radical cystectomy
    • Inoue K., Slaton J.W., Karashima T., et al. The prognostic value of angiogenesis factor expression for predicting recurrence and metastasis of bladder cancer after neoadjuvant chemotherapy and radical cystectomy. Clin Cancer Res 2000, 6:4866-4873.
    • (2000) Clin Cancer Res , vol.6 , pp. 4866-4873
    • Inoue, K.1    Slaton, J.W.2    Karashima, T.3
  • 32
    • 0029935566 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer
    • Yoshiji H., Gomez D.E., Shibuya M., Thorgeirsson U.P. Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer. Cancer Res 1996, 56:2013-2016.
    • (1996) Cancer Res , vol.56 , pp. 2013-2016
    • Yoshiji, H.1    Gomez, D.E.2    Shibuya, M.3    Thorgeirsson, U.P.4
  • 33
    • 0030700901 scopus 로고    scopus 로고
    • Association of vascular endothelial growth factor expression with tumor angiogenesis, survival and thymidine phosphorylase/platelet-derived endothelial cell growth factor expression in human colorectal cancer
    • Amaya H., Tanigawa N., Lu C., et al. Association of vascular endothelial growth factor expression with tumor angiogenesis, survival and thymidine phosphorylase/platelet-derived endothelial cell growth factor expression in human colorectal cancer. Cancer Lett 1997, 119:227-235.
    • (1997) Cancer Lett , vol.119 , pp. 227-235
    • Amaya, H.1    Tanigawa, N.2    Lu, C.3
  • 34
    • 0030680070 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in head and neck squamous cell carcinoma
    • Eisma R.J., Spiro J.D., Kreutzer D.L. Vascular endothelial growth factor expression in head and neck squamous cell carcinoma. Am J Surg 1997, 174:513-517.
    • (1997) Am J Surg , vol.174 , pp. 513-517
    • Eisma, R.J.1    Spiro, J.D.2    Kreutzer, D.L.3
  • 35
    • 0034024352 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, platelet-derived endothelial cell growth factor and angiogenesis in non-small-cell lung cancer
    • O'Byrne K.J., Koukourakis M.I., Giatromanolaki A., et al. Vascular endothelial growth factor, platelet-derived endothelial cell growth factor and angiogenesis in non-small-cell lung cancer. Br J Cancer 2000, 82:1427-1432.
    • (2000) Br J Cancer , vol.82 , pp. 1427-1432
    • O'Byrne, K.J.1    Koukourakis, M.I.2    Giatromanolaki, A.3
  • 36
    • 0028904030 scopus 로고
    • Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma
    • Boocock C.A., Charnock-Jones D.S., Sharkey A.M., et al. Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma. J Natl Cancer Inst 1995, 87:506-516.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 506-516
    • Boocock, C.A.1    Charnock-Jones, D.S.2    Sharkey, A.M.3
  • 37
    • 0033992036 scopus 로고    scopus 로고
    • Vascular endothelial growth factor as prognostic factor in renal cell carcinoma
    • Jacobsen J., Rasmuson T., Grankvist K., Ljungberg B. Vascular endothelial growth factor as prognostic factor in renal cell carcinoma. J Urol 2000, 163:343-347.
    • (2000) J Urol , vol.163 , pp. 343-347
    • Jacobsen, J.1    Rasmuson, T.2    Grankvist, K.3    Ljungberg, B.4
  • 38
    • 22844445338 scopus 로고    scopus 로고
    • Comparison of the prognosis indication of VEGFR-1 and VEGFR-2 and Tie2 receptor expression in breast carcinoma
    • Meunier-Carpentier S., Dales J.P., Djemli A., et al. Comparison of the prognosis indication of VEGFR-1 and VEGFR-2 and Tie2 receptor expression in breast carcinoma. Int J Oncol 2005, 26:977-984.
    • (2005) Int J Oncol , vol.26 , pp. 977-984
    • Meunier-Carpentier, S.1    Dales, J.P.2    Djemli, A.3
  • 39
    • 33744812156 scopus 로고    scopus 로고
    • Prognostic value of expression of vascular endothelial growth factor and its flt-1 and KDR receptors in stage I non-small-cell lung cancer
    • Seto T., Higashiyama M., Funai H., et al. Prognostic value of expression of vascular endothelial growth factor and its flt-1 and KDR receptors in stage I non-small-cell lung cancer. Lung Cancer 2006, 53:91-96.
    • (2006) Lung Cancer , vol.53 , pp. 91-96
    • Seto, T.1    Higashiyama, M.2    Funai, H.3
  • 40
    • 33646021965 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, FLT-1, and FLK-1 analysis in a pancreatic cancer tissue microarray
    • Chung G.G., Yoon H.H., Zerkowski M.P., et al. Vascular endothelial growth factor, FLT-1, and FLK-1 analysis in a pancreatic cancer tissue microarray. Cancer 2006, 106:1677-1684.
    • (2006) Cancer , vol.106 , pp. 1677-1684
    • Chung, G.G.1    Yoon, H.H.2    Zerkowski, M.P.3
  • 41
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • Presta L.G., Chen H., O'Connor S.J., et al. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 1997, 57:4593-4599.
    • (1997) Cancer Res , vol.57 , pp. 4593-4599
    • Presta, L.G.1    Chen, H.2    O'Connor, S.J.3
  • 42
    • 0035253586 scopus 로고    scopus 로고
    • Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: pharmacologic and long-term safety data
    • Margolin K., Gordon M.S., Holmgren E., et al. Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: pharmacologic and long-term safety data. J Clin Oncol 2001, 19:851-856.
    • (2001) J Clin Oncol , vol.19 , pp. 851-856
    • Margolin, K.1    Gordon, M.S.2    Holmgren, E.3
  • 43
    • 0035253739 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
    • Gordon M.S., Margolin K., Talpaz M., et al. Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J Clin Oncol 2001, 19:843-850.
    • (2001) J Clin Oncol , vol.19 , pp. 843-850
    • Gordon, M.S.1    Margolin, K.2    Talpaz, M.3
  • 44
    • 11144354392 scopus 로고    scopus 로고
    • Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
    • Willett C.G., Boucher Y., di Tomaso E., et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 2004, 10:145-147.
    • (2004) Nat Med , vol.10 , pp. 145-147
    • Willett, C.G.1    Boucher, Y.2    di Tomaso, E.3
  • 45
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H., Fehrenbacher L., Novotny W., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004, 350:2335-2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 46
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Kabbinavar F., Hurwitz H.I., Fehrenbacher L., et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 2003, 21:60-65.
    • (2003) J Clin Oncol , vol.21 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3
  • 47
    • 20544478429 scopus 로고    scopus 로고
    • Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized phase II trial
    • Kabbinavar F.F., Schulz J., McCleod M., et al. Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized phase II trial. J Clin Oncol 2005, 23:3697-3705.
    • (2005) J Clin Oncol , vol.23 , pp. 3697-3705
    • Kabbinavar, F.F.1    Schulz, J.2    McCleod, M.3
  • 48
    • 33750631921 scopus 로고    scopus 로고
    • Spotlight on bevacizumab in advanced colorectal cancer, breast cancer, and non-small cell lung cancer
    • Lyseng-Williamson K.A., Robinson D.M. Spotlight on bevacizumab in advanced colorectal cancer, breast cancer, and non-small cell lung cancer. BioDrugs 2006, 20:193-195.
    • (2006) BioDrugs , vol.20 , pp. 193-195
    • Lyseng-Williamson, K.A.1    Robinson, D.M.2
  • 49
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Yang J.C., Haworth L., Sherry R.M., et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003, 349:427-434.
    • (2003) N Engl J Med , vol.349 , pp. 427-434
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3
  • 50
    • 20044364346 scopus 로고    scopus 로고
    • Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
    • Miller K.D., Chap L.I., Holmes F.A., et al. Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J Clin Oncol 2005, 23:792-799.
    • (2005) J Clin Oncol , vol.23 , pp. 792-799
    • Miller, K.D.1    Chap, L.I.2    Holmes, F.A.3
  • 51
    • 33644823334 scopus 로고    scopus 로고
    • Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizumab in metastatic colorectal cancer
    • Jubb A.M., Hurwitz H.I., Bai W., et al. Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizumab in metastatic colorectal cancer. J Clin Oncol 2006, 24:217-227.
    • (2006) J Clin Oncol , vol.24 , pp. 217-227
    • Jubb, A.M.1    Hurwitz, H.I.2    Bai, W.3
  • 52
    • 30944452436 scopus 로고    scopus 로고
    • Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients
    • Willett C.G., Boucher Y., Duda D.G., et al. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. J Clin Oncol 2005, 23:8136-8139.
    • (2005) J Clin Oncol , vol.23 , pp. 8136-8139
    • Willett, C.G.1    Boucher, Y.2    Duda, D.G.3
  • 53
    • 15244362063 scopus 로고    scopus 로고
    • Association between intratumoral free and total VEGF, soluble VEGFR-1, VEGFR-2 and prognosis in breast cancer
    • Bando H., Weich H.A., Brokelmann M., et al. Association between intratumoral free and total VEGF, soluble VEGFR-1, VEGFR-2 and prognosis in breast cancer. Br J Cancer 2005, 92:553-561.
    • (2005) Br J Cancer , vol.92 , pp. 553-561
    • Bando, H.1    Weich, H.A.2    Brokelmann, M.3
  • 54
    • 79960199647 scopus 로고    scopus 로고
    • First-line bevacizumab and paclitaxel in patients with locally recurrent or metastatic breast cancer: a randomized, phase III trial coordinated by the Eastern Cooperative Oncology Group (E2100)
    • [abstr. 3]
    • Miller K. First-line bevacizumab and paclitaxel in patients with locally recurrent or metastatic breast cancer: a randomized, phase III trial coordinated by the Eastern Cooperative Oncology Group (E2100). Breast Cancer Res Treat 2005, 94(Suppl. 6). [abstr. 3].
    • (2005) Breast Cancer Res Treat , vol.94 , Issue.SUPPL. 6
    • Miller, K.1
  • 55
    • 0037303885 scopus 로고    scopus 로고
    • E2100: a phase III trial of paclitaxel versus paclitaxel/bevacizumab for metastatic breast cancer
    • Miller K.D. E2100: a phase III trial of paclitaxel versus paclitaxel/bevacizumab for metastatic breast cancer. Clin Breast Cancer 2003, 3:421-422.
    • (2003) Clin Breast Cancer , vol.3 , pp. 421-422
    • Miller, K.D.1
  • 56
    • 58149232648 scopus 로고    scopus 로고
    • Evolution of bevacizumab-based therapy in the management of breast cancer
    • Sachdev J.C., Jahanzeb M. Evolution of bevacizumab-based therapy in the management of breast cancer. Clin Breast Cancer 2008, 8:402-410.
    • (2008) Clin Breast Cancer , vol.8 , pp. 402-410
    • Sachdev, J.C.1    Jahanzeb, M.2
  • 57
    • 0346694519 scopus 로고    scopus 로고
    • The role of VEGF expression in response to bevacizumab plus capecitabine in metastatic breast cancer (MBC)
    • [abstr. 766]
    • Hillan K.J., Koeppen H.K.W., Tobin P., et al. The role of VEGF expression in response to bevacizumab plus capecitabine in metastatic breast cancer (MBC). Proc Am Soc Clin Oncol 2003, 22:191. [abstr. 766].
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 191
    • Hillan, K.J.1    Koeppen, H.K.W.2    Tobin, P.3
  • 58
    • 27644517412 scopus 로고    scopus 로고
    • Benefit from bevacizumab (BV) is independent of pretreatment plasma vascular endothelial growth factor-A (pl-VEGF) in patients (pts) with metastatic colorectal cancer (mCRC)
    • [abstr. 3555]
    • Holden S.N., Ryan E., Kearns A., Holmgren E., Hurwitz H. Benefit from bevacizumab (BV) is independent of pretreatment plasma vascular endothelial growth factor-A (pl-VEGF) in patients (pts) with metastatic colorectal cancer (mCRC). Proc Am Soc Clin Oncol 2005, 23:259. [abstr. 3555].
    • (2005) Proc Am Soc Clin Oncol , vol.23 , pp. 259
    • Holden, S.N.1    Ryan, E.2    Kearns, A.3    Holmgren, E.4    Hurwitz, H.5
  • 59
    • 32944478346 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer
    • Kindler H.L., Friberg G., Singh D.A., et al. Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer. J Clin Oncol 2005, 23:8033-8040.
    • (2005) J Clin Oncol , vol.23 , pp. 8033-8040
    • Kindler, H.L.1    Friberg, G.2    Singh, D.A.3
  • 60
    • 0038204144 scopus 로고    scopus 로고
    • SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
    • O'Farrell A.M., Abrams T.J., Yuen H.A., et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood 2003, 101:3597-3605.
    • (2003) Blood , vol.101 , pp. 3597-3605
    • O'Farrell, A.M.1    Abrams, T.J.2    Yuen, H.A.3
  • 61
    • 0037468875 scopus 로고    scopus 로고
    • Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase
    • Sun L., Liang C., Shirazian S., et al. Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase. J Med Chem 2003, 46:1116-1119.
    • (2003) J Med Chem , vol.46 , pp. 1116-1119
    • Sun, L.1    Liang, C.2    Shirazian, S.3
  • 62
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm S.M., Carter C., Tang L., et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004, 64:7099-7109.
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 63
    • 0034655182 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
    • Wood J.M., Bold G., Buchdunger E., et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res 2000, 60:2178-2189.
    • (2000) Cancer Res , vol.60 , pp. 2178-2189
    • Wood, J.M.1    Bold, G.2    Buchdunger, E.3
  • 64
    • 0037075812 scopus 로고    scopus 로고
    • Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors
    • Hennequin L.F., Stokes E.S., Thomas A.P., et al. Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors. J Med Chem 2002, 45:1300-1312.
    • (2002) J Med Chem , vol.45 , pp. 1300-1312
    • Hennequin, L.F.1    Stokes, E.S.2    Thomas, A.P.3
  • 65
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    • Wedge S.R., Ogilvie D.J., Dukes M., et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res 2002, 62:4645-4655.
    • (2002) Cancer Res , vol.62 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 66
    • 0141430503 scopus 로고    scopus 로고
    • Analysis of biomarkers of SU11248 action in an exploratory study in patients with advanced malignancies
    • [Abstr 939]
    • O'Farrell A.M., Deprimo S.E., Manning W.C., et al. Analysis of biomarkers of SU11248 action in an exploratory study in patients with advanced malignancies. Proc Am Soc Clin Oncol 2003, 22:234. [Abstr 939].
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 234
    • O'Farrell, A.M.1    Deprimo, S.E.2    Manning, W.C.3
  • 67
    • 1842328560 scopus 로고    scopus 로고
    • Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer
    • Volm M., Koomägi R., Mattern J. Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer. Int J Cancer 1997, 74:64-68.
    • (1997) Int J Cancer , vol.74 , pp. 64-68
    • Volm, M.1    Koomägi, R.2    Mattern, J.3
  • 68
    • 0141653352 scopus 로고    scopus 로고
    • Final results of a phase I and pharmacokinetic study of SU11248, a novel multi-target tyrosine kinase inhibitor, in patients with advanced cancers
    • [abstr. 769]
    • Raymond E., Faivre S., Vera K., et al. Final results of a phase I and pharmacokinetic study of SU11248, a novel multi-target tyrosine kinase inhibitor, in patients with advanced cancers. Proc Am Soc Clin Oncol 2003, 22:192. [abstr. 769].
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 192
    • Raymond, E.1    Faivre, S.2    Vera, K.3
  • 69
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
    • Motzer R.J., Michaelson M.D., Redman B.G., et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 2006, 24:16-24.
    • (2006) J Clin Oncol , vol.24 , pp. 16-24
    • Motzer, R.J.1    Michaelson, M.D.2    Redman, B.G.3
  • 70
    • 33644847440 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
    • Faivre S., Delbaldo C., Vera K., et al. Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J Clin Oncol 2006, 24:25-35.
    • (2006) J Clin Oncol , vol.24 , pp. 25-35
    • Faivre, S.1    Delbaldo, C.2    Vera, K.3
  • 71
    • 36749040908 scopus 로고    scopus 로고
    • Inaugural article: VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade
    • Rudge J.S., Holash J., Hylton D., et al. Inaugural article: VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade. Proc Natl Acad Sci USA 2007, 104:18363-18370.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 18363-18370
    • Rudge, J.S.1    Holash, J.2    Hylton, D.3
  • 72
    • 36749052895 scopus 로고    scopus 로고
    • Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy
    • Ebos J.M., Lee C.R., Christensen J.G., Mutsaers A.J., Kerbel R.S. Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy. Proc Natl Acad Sci USA 2007, 104:17069-17074.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 17069-17074
    • Ebos, J.M.1    Lee, C.R.2    Christensen, J.G.3    Mutsaers, A.J.4    Kerbel, R.S.5
  • 73
    • 20944441692 scopus 로고    scopus 로고
    • Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials
    • Drevs J., Zirrgiebel U., Schmidt-Gersbach C.I., et al. Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials. Ann Oncol 2005, 16:558-565.
    • (2005) Ann Oncol , vol.16 , pp. 558-565
    • Drevs, J.1    Zirrgiebel, U.2    Schmidt-Gersbach, C.I.3
  • 74
    • 16844382092 scopus 로고    scopus 로고
    • A phase I/II trial of single-agent PTK 787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in patients with recurrent glioblastoma multiforme (GBM)
    • [abstr. 1512]
    • Conrad C., Friedman H., Reardon D., et al. A phase I/II trial of single-agent PTK 787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in patients with recurrent glioblastoma multiforme (GBM). Proc Am Soc Clin Oncol 2004, 22(Suppl. 14). [abstr. 1512].
    • (2004) Proc Am Soc Clin Oncol , vol.22 , Issue.SUPPL. 14
    • Conrad, C.1    Friedman, H.2    Reardon, D.3
  • 75
    • 23044432756 scopus 로고    scopus 로고
    • Phase I study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of PTK787/ZK 222584 administered twice daily in patients with advanced cancer
    • Thomas A.L., Morgan B., Horsfield M.A., et al. Phase I study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of PTK787/ZK 222584 administered twice daily in patients with advanced cancer. J Clin Oncol 2005, 23:4162-4171.
    • (2005) J Clin Oncol , vol.23 , pp. 4162-4171
    • Thomas, A.L.1    Morgan, B.2    Horsfield, M.A.3
  • 76
    • 20444473802 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of PTK/ZK, a multiple VEGF receptor inhibitor, in patients with liver metastases from solid tumours
    • Mross K., Drevs J., Müller M., et al. Phase I clinical and pharmacokinetic study of PTK/ZK, a multiple VEGF receptor inhibitor, in patients with liver metastases from solid tumours. Eur J Cancer 2005, 41:1291-1299.
    • (2005) Eur J Cancer , vol.41 , pp. 1291-1299
    • Mross, K.1    Drevs, J.2    Müller, M.3
  • 77
    • 23844548194 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled, phase III study in patients (Pts) with metastatic adenocarcinoma of the colon or rectum receiving first-line chemotherapy with oxaliplatin/5-fluorouracil/leucovorin and PTK787/ZK 222584 or placebo (CONFIRM-1)
    • [abstr. LBA3]
    • Hecht J.R., Trarbach T., Jaeger E., et al. Randomized, double-blind, placebo-controlled, phase III study in patients (Pts) with metastatic adenocarcinoma of the colon or rectum receiving first-line chemotherapy with oxaliplatin/5-fluorouracil/leucovorin and PTK787/ZK 222584 or placebo (CONFIRM-1). Proc Am Soc Clin Oncol 2005, 23(Suppl. 16). [abstr. LBA3].
    • (2005) Proc Am Soc Clin Oncol , vol.23 , Issue.SUPPL. 16
    • Hecht, J.R.1    Trarbach, T.2    Jaeger, E.3
  • 78
    • 70249097380 scopus 로고    scopus 로고
    • Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial
    • Escudier B., Eisen T., Stadler W.M., et al. Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J Clin Oncol 2009, 27:3312-3318.
    • (2009) J Clin Oncol , vol.27 , pp. 3312-3318
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 79
    • 4644359863 scopus 로고    scopus 로고
    • ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor with additional activity against epidermal growth factor receptor tyrosine kinase, inhibits orthotopic growth and angiogenesis of gastric cancer
    • McCarty M.F., Wey J., Stoeltzing O., et al. ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor with additional activity against epidermal growth factor receptor tyrosine kinase, inhibits orthotopic growth and angiogenesis of gastric cancer. Mol Cancer Ther 2004, 3:1041-1048.
    • (2004) Mol Cancer Ther , vol.3 , pp. 1041-1048
    • McCarty, M.F.1    Wey, J.2    Stoeltzing, O.3
  • 80
    • 20044375036 scopus 로고    scopus 로고
    • The VEGF receptor tyrosine kinase inhibitor, ZD6474, inhibits angiogenesis and affects microvascular architecture within an orthotopically implanted renal cell carcinoma
    • Drevs J., Konerding M.A., Wolloscheck T., et al. The VEGF receptor tyrosine kinase inhibitor, ZD6474, inhibits angiogenesis and affects microvascular architecture within an orthotopically implanted renal cell carcinoma. Angiogenesis 2004, 7:347-354.
    • (2004) Angiogenesis , vol.7 , pp. 347-354
    • Drevs, J.1    Konerding, M.A.2    Wolloscheck, T.3
  • 81
    • 33645873707 scopus 로고    scopus 로고
    • ZD6474, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, inhibits growth of experimental lung metastasis and production of malignant pleural effusions in a non-small cell lung cancer model
    • Matsumori Y., Yano S., Goto H., et al. ZD6474, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, inhibits growth of experimental lung metastasis and production of malignant pleural effusions in a non-small cell lung cancer model. Oncol Res 2006, 16:15-26.
    • (2006) Oncol Res , vol.16 , pp. 15-26
    • Matsumori, Y.1    Yano, S.2    Goto, H.3
  • 82
    • 67650872993 scopus 로고    scopus 로고
    • Impact of tumor cell VEGF expression on the in vivo efficacy of vandetanib (ZACTIMA; ZD6474)
    • Siemann D.W., Norris C.M., Ryan A., Shi W. Impact of tumor cell VEGF expression on the in vivo efficacy of vandetanib (ZACTIMA; ZD6474). Anticancer Res 2009, 29:1987-1992.
    • (2009) Anticancer Res , vol.29 , pp. 1987-1992
    • Siemann, D.W.1    Norris, C.M.2    Ryan, A.3    Shi, W.4
  • 83
    • 66149188254 scopus 로고    scopus 로고
    • Baseline vascular endothelial growth factor concentration as a potential predictive marker of benefit from vandetanib in non-small cell lung cancer
    • Hanrahan E.O., Ryan A.J., Mann H., et al. Baseline vascular endothelial growth factor concentration as a potential predictive marker of benefit from vandetanib in non-small cell lung cancer. Clin Cancer Res 2009, 15:3600-3609.
    • (2009) Clin Cancer Res , vol.15 , pp. 3600-3609
    • Hanrahan, E.O.1    Ryan, A.J.2    Mann, H.3
  • 84
    • 6944235080 scopus 로고    scopus 로고
    • Antitumour efficacy of VEGFR2 tyrosine kinase inhibitor correlates with expression of VEGF and its receptor VEGFR2 in tumour models
    • Dev I.K., Dornsife R.E., Hopper T.M., et al. Antitumour efficacy of VEGFR2 tyrosine kinase inhibitor correlates with expression of VEGF and its receptor VEGFR2 in tumour models. Br J Cancer 2004, 91:1391-1398.
    • (2004) Br J Cancer , vol.91 , pp. 1391-1398
    • Dev, I.K.1    Dornsife, R.E.2    Hopper, T.M.3
  • 85
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • Jain R.K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005, 307:58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1


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