Leukocytes and platelets of patients with cancer contain high levels of vascular endothelial growth factor

Clinical Cancer Research

Volumn 5, Issue 3, 1999, Pages 487-491

  Salven, Petri ^a   Orpana, Arto ^a   Joensuu, Heikki ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; VASCULOTROPIN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; DISSEMINATED CANCER; FEMALE; FOLLOW UP; HUMAN; IMMUNOASSAY; LEUKOCYTOSIS; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; THROMBOCYTE COUNT; THROMBOCYTOSIS; TUMOR GROWTH; TUMOR VASCULARIZATION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BLOOD PLATELETS; ENDOTHELIAL GROWTH FACTORS; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPHOKINES; MIDDLE AGED; NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0032995840     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med., 1: 27-31, 1995.
2. Dvorak, H. F., Brown, L. F., Detmar, M., and Dvorak, A. M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol., 146: 1029-1039, 1995.
3. Takano, S., Yoshii, Y., Kondo, S., Suzuki, H., Maruno, T., Shirai, S., and Nose, T. Concentration of vascular endothelial growth factor in the serum and tumor tissue of brain tumor patients. Cancer Res., 56: 2185-2190, 1996.
4. Yamamoto, Y., Toi, M., Kondo, S., Matsumoto, T., Suzuki, H., Kitamura, M., Tsuruta, K., Taniguchi, T., Okamoto, A., Mori. T., Yoshida, M., Ikeda, T., and Tominaga, T. Concentrations of vascular endothelial growth factor in the sera of normal controls and cancer patients. Clin. Cancer Res., 2: 821-826, 1996.
5. Dirix, L. Y., Vermeulen, P. B., Hubens, G., Benoy, I., Martin, M., De Pooter, C., and Van Oosterom, A. T. Serum basic fibroblast growth factor and vascular endothelial growth factor and tumour growth kinetics in advanced colorectal cancer. Ann. Oncol., 7: 843-848, 1996.
6. Dirix, L. Y., Vermeulen, P. B., Pawinski, A., Prove, A., Benoy, I., De Pooter, C., Martin, M., and Van Oosterom, A. T. Elevated levels of the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients. Br. J. Cancer, 76: 238-243, 1997.
7. Yamamoto, S., Konishi, I., Mandai, M., Kuroda, H., Komatsu, T., Nanbu, K., Sakahara, H., and Mori, T. Expression of vascular endothelial growth factor (VEGF) in epithelial ovarian neoplasms: correlation with clinicopathology and patient survival, and analysis of serum VEGF levels. Br. J. Cancer. 76: 1221-1227, 1997.
8. Salven, P., Mäenpää, H., Orpana, A., Alitalo, K., and Joensuu, H. Serum vascular endothelial growth factor is often elevated in disseminated cancer. Clin. Cancer Res., 3: 647-651, 1997.
9. Salven, P., Teerenhovi, L., and Joensuu, H. A high pretreatment serum vascular endothelial growth factor concentration is associated with poor outcome in non-Hodgkin's lymphoma. Blood, 90: 3167-3172, 1997.
10. Salven, P., Ruotsalainen, T., Mattson, K., and Joensuu, H. High pre-treatment serum level of vascular endothelial growth factor (VEGF) is associated with poor outcome in small-cell lung cancer. Int. J. Cancer, 79: 144-146, 1998.
11. Freeman, M. R., Schneck, F. X., Gagnon, M. L., Corless, C., Soker, S., Niknejad, K., Peoples, G. E., and Klagsbrun, M. Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: a potential role for T cells in angiogenesis. Cancer Res., 55: 4140-4145, 1995.
12. Salven, P., Heikkila, P., Anttonen, A., Kajanti, M., and Joensuu, H. Vascular endothelial growth factor in squamous cell head and neck carcinoma: expression and prognostic significance. Mod. Pathol., 10: 1128-1133, 1997.
13. Wartiovaara, U., Salven, P., Mikkola, H., Lassila, R., Kaukonen, J., Joukov. V., Orpana, A., Ristimaki, A., Heikinheimo, M., Joensuu, H., Alitalo, K., and Palotie, A. Peripheral blood platelets express VEGF-C and VEGF which are released during platelet activation. Thromb. Haemostasia, 80: 171-175, 1998.
14. Mohle, R., Green, D., Moore, M. A., Nachman, R. L., and Rafii, S. Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets. Proc. Natl. Acad. Sci. USA, 94: 663-668, 1997.
15. Muszbek, L., Polgar, J., and Boda, Z. Platelet factor XIII becomes active without the release of activation peptide during platelet activation. Thromb. Haemostasis, 69: 282-285, 1993.
16. Kitamura, M., Toi, M., Aral, K., Iwasaki, Y., Suzuki, H., and Matsuo, K. Concentrations of vascular endothelial growth factor in the sera of gastric cancer patients. Oncol. Rep., 5: 1419-1424, 1998.
17. Fujisaki, K., Mitsuyama, K., Toyonaga, A., Matsuo, K., and Tanikawa, K. Circulating vascular endothelial growth factor in patients with colorectal cancer. Am. J. Gastroenterol., 93: 249-252, 1998.
18. Kumar, H., Heer, K., Lee, P. W., Duthie, G. S., MacDonald, A. W., Greenman, J., Kerin, M. J., and Monson, J. R. Preoperative serum vascular endothelial growth factor can predict stage in colorectal cancer. Clin. Cancer Res., 4: 1279-1285, 1998.
19. Landriscina, M., Cassano, A., Ratto, C., Longo, R., Ippoliti, M., Palazzotti, B., Crucitti, F., and Barone, C. Quantitative analysis of basic fibroblast growth factor and vascular endothelial growth factor in human colorectal cancer. Br. J. Cancer, 78: 765-770, 1998.
20. Tempfer, C., Obermair, A., Hefler, L., Haeusler, G., Gitsch, G., and Kainz, C. Vascular endothelial growth factor serum concentrations in ovarian cancer. Obstet. Gynecol., 92: 360-363, 1998.
21. Evans, P., Wheeler, T., Anthony, F., and Osmond, C. Maternal serum vascular endothelial growth factor during early pregnancy. Clin. Sci., 92: 567-571, 1997.
22. Baker, P. N., Krasnow, J., Roberts, J. M., and Yeo, K. T. Elevated serum levels of vascular endothelial growth factor in patients with preeclampsia. Obstet. Gynecol., 86: 815-821, 1995.
23. Harrison, P., Wilbourn, B., Debili, N., Vainchenker, W., Breton Gorius, J., Lawrie, A. S., Masse, J. M., Savidge, G. F., and Cramer, E. M. Uptake of plasma fibrinogen into the a granules of human megakaryocytes and platelets. J. Clin. Invest., 84: 1320-1324, 1989.
24. Escolar, G., and White, J. G. The platelet open canalicular system: a final common pathway. Blood Cells, 17: 467-485, 1991.
25. Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., Declercq, C., Pawling, J., Moons, L., Collen, D., Risau, W., and Nagy, A. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature (Lond.), 380: 435-439, 1996.
26. Ferrara, N., Carver Moore, K., Chen, H., Dowd, M., Lu, L., O'Shea, K. S., Powell Braxton, L., Hillan, K. J., and Moore, M. W. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature (Lond.), 380: 439-442, 1996.
27. Gabrilovich, D. I., Chen, H. L., Girgis, K. R., Cunnigham, H. T., Meny, G. M., Nadaf, S., Kavanaugh, D., and Carbone, D. P. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat. Med., 2: 1096-1103, 1996.