Constrained optimization of a preparative ion-exchange step for antibody purification

Journal of Chromatography A

Volumn 1113, Issue 1-2, 2006, Pages 92-100

  Degerman, Marcus ^a   Jakobsson, Niklas ^a   Nilsson, Bernt ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Chromatography; Downstream processing; Gradient elution; Modeling; Nonlinear constraint; Nonlinear constraints; Optimization; Simulation

Indexed keywords

ANTIBODIES; CHROMATOGRAPHIC ANALYSIS; COMPUTER SIMULATION; MATHEMATICAL MODELS; OPTIMIZATION; REACTION KINETICS;

DOWNSTREAM PROCESSING; GRADIENT ELUTION; NONLINEAR CONSTRAINT; NONLINEAR CONSTRAINTS;

ION EXCHANGE;

ANTIBODY; IMMUNOGLOBULIN G; PROTEIN;

ARTICLE; COST BENEFIT ANALYSIS; DECISION MAKING; FLOW RATE; ION EXCHANGE CHROMATOGRAPHY; KINETICS; MOLECULAR MODEL; PRIORITY JOURNAL; PURIFICATION; SEPARATION TECHNIQUE;

ANTIBODIES; CHROMATOGRAPHY, ION EXCHANGE;

EID: 33646013329     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2006.01.121     Document Type: Article

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