Purifying therapeutic monoclonal antibodies

Chemical Engineering Progress

Volumn 104, Issue 5, 2008, Pages

  Mehta, Amit ^a   Tse, Martha Lovato ^a   Fogle, Jace ^a   Len, Amy ^a   Shrestha, Roshan ^a   Fontes, Nuno ^a   Lebreton, Bénédicte ^a   Wolk, Bradley ^a   Van Reis, Robert ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 50949098839     PISSN: 03607275     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Article

References (9)

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2. "SBE Special Supplement: From Chinese Hamsters to Therapeutic Proteins," Chem. Eng. Progress, 103 (10), pp. 33-52 (Oct. 2007).
3. Fahrner, R. L., et al., "Industrial Purification of Pharmaceutical Antibodies: Development, Operation and Validation of Chromatography Processes," Biotech. and Genet. Eng. Rev., 18, pp. 301-327 (2001).
4. Follman, D. K., and R. L. Fahrner, "Factorial Screening of Antibody Purification Processes Using Three Chromatography Steps without Protein," J. Chromatogr. A., 1024, pp. 79-85 (2004).
5. van Reis, R., "Charged Filtration Membranes and Uses Therefor," U.S. Patent No. 7,001,550 (2006).
6. Harinarayan, C., et al., "An Exclusion Mechanism in Ion Exchange Chromatography." Biotech. Bioeng., 95, pp. 775-787 (2007).
7. Zhou, J., and T. Tressel, "Basic Concepts in Q Membrane Chromatography for Large-Scale Antibody Production," Biotechnol. Prog., 22, p. 341 (2006).
8. van Reis, R., et al., "High-Performance Tangential Flow Filtration Using Charged Membranes," Journal of Membrane Science, 159, pp. 133-142 (1999).
9. van Reis, R., and S. Saksena, "Optimization Diagram for Membrane Separations." Journal of Membrane Science, 129, pp. 19-29 (1997).