Mathematical modeling of elution curves for a protein mixture in ion exchange chromatography applied to high protein concentration

Biotechnology and Bioengineering

Volumn 104, Issue 3, 2009, Pages 572-581

  Orellana, C A ^a   Shene, C ^b   Asenjo, J A ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSIDAD DE LA FRONTERA   (Chile)

Author keywords

Chromatography; High protein concentration; Mathematical model; Optimization; Simulation

Indexed keywords

ADSORPTION KINETICS; AXIAL DISPERSIONS; ELUTION CURVES; EXPERIMENTAL DATA; HIGH PROTEIN CONCENTRATION; INTRA-PARTICLE DIFFUSION; ION-EXCHANGE CHROMATOGRAPHY; LANGMUIR ISOTHERM; MASS TRANSFER PARAMETERS; MATHEMATICAL MODELING; MATRIX Q; MINIMUM COST; OPERATIONAL CONDITIONS; PEAK FRACTION; PROCESS TIME; PRODUCTION PROCESS; PROTEIN CONCENTRATIONS; PROTEIN MIXTURES; PROTEIN-PROTEIN INTERACTIONS; RATE MODELS; RELATIVE ERRORS; RETENTION TIME; SALT CONCENTRATION; SAMPLE SIZES; SIMULATION; TOTAL PROTEIN;

ADSORPTION; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; CONCENTRATION (PROCESS); EQUILIBRIUM CONSTANTS; FLOW RATE; GEL PERMEATION CHROMATOGRAPHY; ION CHROMATOGRAPHY; ION EXCHANGE; ION EXCHANGERS; IONIC STRENGTH; KINETIC PARAMETERS; MASS TRANSFER; MIXTURES; PARAMETER ESTIMATION; PROTEINS; SIMULATORS;

MATHEMATICAL MODELS;

ALPHA LACTALBUMIN; BOVINE SERUM ALBUMIN; OVOTRANSFERRIN; SEPHAROSE;

ADSORPTION; ARTICLE; CALCULATION; CONCENTRATION RESPONSE; CORRELATION ANALYSIS; DIFFUSION; ELUTION; EQUILIBRIUM CONSTANT; FLOW RATE; ION EXCHANGE CHROMATOGRAPHY; IONIC STRENGTH; ISOTHERM; KINETICS; MATHEMATICAL MODEL; PARAMETER; PREDICTION; PROTEIN INTERACTION; SAMPLE SIZE; SIMULATION;

ADSORPTION; CHROMATOGRAPHY, ION EXCHANGE; KINETICS; MODELS, THEORETICAL; OSMOLAR CONCENTRATION; PROTEINS; SEPHAROSE;

EID: 70349314563     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22422     Document Type: Article

References (19)

1. Asenjo JA, Andrews BA. 2008. Mini-review: Challenges and trends in bioseparations. J Chem Technol Biotechnol 83:117-120.
2. Chang C, Lenhoff AM. 1998. Comparison of protein adsorption isotherms and uptake rates in preparative cation-exchange materials. J Chromatogr A 827(2):281-293. (Pubitemid 28552569)
3. Geankoplis CJ. 1998. Transport processes and unit operations. 3rd edition. Mexico: Prentice Hall International, p. 1007.
4. Giddings JC, Eyring H. 1955. A molecular dynamic theory of chromatography. J Phys Chem 59(5):416-421.
5. Gu T. 1995. Mathematical modeling and scale-up of liquid chromatography. Berlin: Springer. p. 123.
6. Gu T, Zheng Y. 1999. A study of the scale-up of reversed-phase liquid chromatography. Sep Purif Technol 15:41-58. (Pubitemid 29347638)
7. Hunter AK, Carta G. 2002. Protein adsorption on novel acrylamido-based polymeric ion-exchangers: IV. Effects of protein size on adsorption capacity and rate. J Chromatogr A 971(1-2):105-116. (Pubitemid 35247673)
8. Kataoka T, Yoshida H, Yamada T. 1973. Liquid phase mass transfer in ion exchange based on the hydraulic radius model. J Chem Eng Jpn 6(2):172-177.
9. LeVan MD, Carta G. 2007. Adsorption and ion exchange, section 16. In: Green DW, editor. Perry's Chemical Engineers' Handbook. 8th edition. McGraw-Hill: New York.
10. Lienqueo ME, Shene C, Asenjo JA. 2009. Optimization of hydrophobic interaction chromatography using a mathematical model of elution curves of a protein mixture. J Mol Recognit 22:110-120.
11. Matlab 7.4. 2007. The language of technical computing. The MathWorks: Natick, MA.
12. Melander WR, Rassi ZE, Horvath Cs. 1989. Interplay of hydrophobic and electrostatic interactions in biopolymer chromatography. J Chromatogr A 469:3.
13. Ruthven DM. 1984. Principles of adsorption and adsorption processes. New York: Wiley. p. 433.
14. Satterfield CN. 1970. Mass transfer in heterogeneous catalysis. Cambridge MA: MIT Press. p. 64.
15. Shene C, Lucero A, Andrews BA, Asenjo JA. 2006. Mathematical modeling of elution curves for a protein mixture in ion exchange chromatography and for the optimal selection of operational conditions. Biotechnol Bioeng 95:704-713. (Pubitemid 44671472)
16. Shukla AA, Etzel MR, Gadam S. 2007. Process scale bioseparations for the biopharmaceutical industry. CRC Press: Boca Raton, Florida.
17. Stokes R. 1950. The diffusion coefficients of eight univalent electrolytes in aqueous solution at 258. J Am Chem Soc 72:2243-2247.
18. Yamamoto S. 2005. Electrostatic interaction chromatography process for protein separations: Impact of engineering analysis of biorecognition mechanism on process optimization. Chem Eng Technol 28(11):1387-1393. (Pubitemid 41694151)
19. Yao Y, Lenhoff AM. 2006. Pore size distributions of ion exchangers and relation to protein binding capacity. J Chromatogr A 1126:107-119. (Pubitemid 44278811)