Engineering of a chimeric RB69 DNA polymerase sensitive to drugs targeting the cytomegalovirus enzyme

Journal of Biological Chemistry

Volumn 284, Issue 39, 2009, Pages 26439-26446

  Tchesnokov, Egor P ^a   Obikhod, Aleksandr ^b   Schinazi, Raymond F ^b   Götte, Matthias ^a  

^a MCGILL UNIVERSITY   (Canada)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL STUDIES; CHIMERIC ENZYMES; CRITICAL REGION; DNA POLYMERASE; DNA SYNTHESISS; DRUG ACTION; DRUG DEVELOPMENT; DRUG RESISTANCE; HUMAN CYTOMEGALOVIRUS; MODEL SYSTEM; NUCLEOTIDE-BINDING SITES; SURROGATE SYSTEMS;

AMINATION; AMINES; AMINO ACIDS; BINDING ENERGY; BINDING SITES; CRYSTAL STRUCTURE; DNA; DRUG PRODUCTS; GENES; NUCLEIC ACIDS; NUCLEOTIDES; ORGANIC ACIDS; POLYMERS;

ENZYMES;

ACICLOVIR; AMINO ACID; DNA POLYMERASE; FOSCARNET; NUCLEOTIDE; PROTEIN RB69; UNCLASSIFIED DRUG; VIRUS ENZYME;

ARTICLE; CHIMERA; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOMEGALOVIRUS; DNA SYNTHESIS; DRUG DESIGN; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ENGINEERING; MOLECULAR MECHANICS; NONHUMAN; NUCLEOTIDE BINDING SITE; PHENOTYPE; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ACYCLOVIR; ANTIVIRAL AGENTS; BINDING SITES; CATALYSIS; CYTOMEGALOVIRUS; DEOXYCYTOSINE NUCLEOTIDES; DNA-DIRECTED DNA POLYMERASE; DRUG RESISTANCE, VIRAL; FOSCARNET; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; VIRAL PROTEINS;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5;

EID: 70350367978     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.012500     Document Type: Article

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