메뉴 건너뛰기




Volumn 51, Issue 1, 2007, Pages 89-94

Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates

Author keywords

[No Author keywords available]

Indexed keywords

CIDOFOVIR; DNA; DNA POLYMERASE; DNA POLYMERASE A834P; DNA POLYMERASE N408K; FOSCARNET; GANCICLOVIR; UNCLASSIFIED DRUG; VIRUS DNA;

EID: 33846030830     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00633-06     Document Type: Article
Times cited : (82)

References (47)
  • 1
    • 18344396751 scopus 로고    scopus 로고
    • Mutations in the UL97 ORF of ganciclovir-resistant clinical cytomegalovirus isolates differentially affect GCV phosphorylation as determined in a recombinant vaccinia virus system
    • Baldanti, F., D. Michel, L. Simoncini, M. Heuschmid, A. Zimmermann, R. Minisini, P. Schaarschmidt, T. Schmid, G. Gerna, and T. Mertens. 2002. Mutations in the UL97 ORF of ganciclovir-resistant clinical cytomegalovirus isolates differentially affect GCV phosphorylation as determined in a recombinant vaccinia virus system. Antivir. Res. 54:59-67.
    • (2002) Antivir. Res , vol.54 , pp. 59-67
    • Baldanti, F.1    Michel, D.2    Simoncini, L.3    Heuschmid, M.4    Zimmermann, A.5    Minisini, R.6    Schaarschmidt, P.7    Schmid, T.8    Gerna, G.9    Mertens, T.10
  • 2
    • 0024474078 scopus 로고
    • A conserved 3′-5′ exonuclease active site in prokaryotic and eukaryotic DNA polymerases
    • Bernad, A., L. Blanco, J. M. Lazaro, G. Martin, and M. Salas. 1989. A conserved 3′-5′ exonuclease active site in prokaryotic and eukaryotic DNA polymerases. Cell 59:219-228.
    • (1989) Cell , vol.59 , pp. 219-228
    • Bernad, A.1    Blanco, L.2    Lazaro, J.M.3    Martin, G.4    Salas, M.5
  • 3
    • 0035892802 scopus 로고    scopus 로고
    • Rate of emergence of cytomegalovirus (CMV) mutations in leukocytes of patients with acquired immunodeficiency syndrome who are receiving valganciclovir as induction and maintenance therapy for CMV retinitis
    • Boivin, G., C. Gilbert, A. Gaudreau, I. Greenfield, R. Sudlow, and N. A. Roberts. 2001. Rate of emergence of cytomegalovirus (CMV) mutations in leukocytes of patients with acquired immunodeficiency syndrome who are receiving valganciclovir as induction and maintenance therapy for CMV retinitis. J. Infect. Dis. 184:1598-1602.
    • (2001) J. Infect. Dis , vol.184 , pp. 1598-1602
    • Boivin, G.1    Gilbert, C.2    Gaudreau, A.3    Greenfield, I.4    Sudlow, R.5    Roberts, N.A.6
  • 4
    • 0033040349 scopus 로고    scopus 로고
    • Human herpesvirus 8-encoded thymidine kinase and phosphotransferase homologues confer sensitivity to ganciclovir
    • Cannon, J. S., F. Hamzeh, S. Moore, J. Nicholas, and R. F. Ambinder. 1999. Human herpesvirus 8-encoded thymidine kinase and phosphotransferase homologues confer sensitivity to ganciclovir. J. Virol. 73:4786-4793.
    • (1999) J. Virol , vol.73 , pp. 4786-4793
    • Cannon, J.S.1    Hamzeh, F.2    Moore, S.3    Nicholas, J.4    Ambinder, R.F.5
  • 5
    • 0033140391 scopus 로고    scopus 로고
    • Antiviral drug resistance in human cytomegalovirus
    • Chou, S. 1999. Antiviral drug resistance in human cytomegalovirus. Transplant. Infect. Dis. 1:105-114.
    • (1999) Transplant. Infect. Dis , vol.1 , pp. 105-114
    • Chou, S.1
  • 6
    • 0028940302 scopus 로고
    • Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance
    • Chou, S., A. Erice, M. C. Jordan, G. M. Vercellotti, K. R. Michels, C. L. Talarico, S. C. Stanat, and K. K. Biron. 1995. Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance. J. Infect. Dis. 171:576-583.
    • (1995) J. Infect. Dis , vol.171 , pp. 576-583
    • Chou, S.1    Erice, A.2    Jordan, M.C.3    Vercellotti, G.M.4    Michels, K.R.5    Talarico, C.L.6    Stanat, S.C.7    Biron, K.K.8
  • 7
    • 0038574429 scopus 로고    scopus 로고
    • Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus
    • Chou, S., N. S. Lurain, K. D. Thompson, R. C. Miner, and W. L. Drew. 2003. Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus. J. Infect. Dis. 188:32-39.
    • (2003) J. Infect. Dis , vol.188 , pp. 32-39
    • Chou, S.1    Lurain, N.S.2    Thompson, K.D.3    Miner, R.C.4    Drew, W.L.5
  • 9
    • 0031822043 scopus 로고    scopus 로고
    • Mutation in region III of the DNA polymerase gene conferring foscarnet resistance in cytomegalovirus isolates from 3 subjects receiving prolonged antiviral therapy
    • Chou, S., G. Marousek, D. M. Parenti, S. M. Gordon, A. G. LaVoy, J. G. Ross, R. C. Miner, and W. L. Drew. 1998. Mutation in region III of the DNA polymerase gene conferring foscarnet resistance in cytomegalovirus isolates from 3 subjects receiving prolonged antiviral therapy. J. Infect. Dis. 178:526-530.
    • (1998) J. Infect. Dis , vol.178 , pp. 526-530
    • Chou, S.1    Marousek, G.2    Parenti, D.M.3    Gordon, S.M.4    LaVoy, A.G.5    Ross, J.G.6    Miner, R.C.7    Drew, W.L.8
  • 10
    • 0033988505 scopus 로고    scopus 로고
    • A nine-codon deletion mutation in the cytomegalovirus UL97 phosphotransferase gene confers resistance to ganciclovir
    • Chou, S., and C. L. Meichsner. 2000. A nine-codon deletion mutation in the cytomegalovirus UL97 phosphotransferase gene confers resistance to ganciclovir. Antimicrob. Agents Chemother. 44:183-185.
    • (2000) Antimicrob. Agents Chemother , vol.44 , pp. 183-185
    • Chou, S.1    Meichsner, C.L.2
  • 11
    • 0033680466 scopus 로고    scopus 로고
    • A deletion mutation in region V of the cytomegalovirus DNA polymerase sequence confers multidrug resistance
    • Chou, S., R. C. Miner, and W. L. Drew. 2000. A deletion mutation in region V of the cytomegalovirus DNA polymerase sequence confers multidrug resistance. J. Infect. Dis. 182:1765-1768.
    • (2000) J. Infect. Dis , vol.182 , pp. 1765-1768
    • Chou, S.1    Miner, R.C.2    Drew, W.L.3
  • 12
    • 21444434735 scopus 로고    scopus 로고
    • Phenotyping of cytomegalovirus drug resistance mutations by using recombinant viruses incorporating a reporter gene
    • Chou, S., L. C. Van Wechel, H. M. Lichy, and G. I. Marousek. 2005. Phenotyping of cytomegalovirus drug resistance mutations by using recombinant viruses incorporating a reporter gene. Antimicrob. Agents Chemother. 49: 2710-2715.
    • (2005) Antimicrob. Agents Chemother , vol.49 , pp. 2710-2715
    • Chou, S.1    Van Wechel, L.C.2    Lichy, H.M.3    Marousek, G.I.4
  • 14
    • 0031775862 scopus 로고    scopus 로고
    • Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments
    • Cihlar, T., M. D. Fuller, and J. M. Cherrington. 1998. Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. J. Virol. 72:5927-5936.
    • (1998) J. Virol , vol.72 , pp. 5927-5936
    • Cihlar, T.1    Fuller, M.D.2    Cherrington, J.M.3
  • 15
    • 0032169622 scopus 로고    scopus 로고
    • A point mutation in the human cytomegalovirus DNA polymerase gene selected in vitro by cidofovir confers a slow replication phenotype in cell culture
    • Cihlar, T., M. D. Fuller, A. S. Mulato, and J. M. Cherrington. 1998. A point mutation in the human cytomegalovirus DNA polymerase gene selected in vitro by cidofovir confers a slow replication phenotype in cell culture. Virology 248:382-393.
    • (1998) Virology , vol.248 , pp. 382-393
    • Cihlar, T.1    Fuller, M.D.2    Mulato, A.S.3    Cherrington, J.M.4
  • 16
    • 0034686965 scopus 로고    scopus 로고
    • Ganciclovir resistance: A matter of time and titre
    • Drew, W. L. 2000. Ganciclovir resistance: a matter of time and titre. Lancet 356:609-610.
    • (2000) Lancet , vol.356 , pp. 609-610
    • Drew, W.L.1
  • 17
    • 15544388789 scopus 로고    scopus 로고
    • Phenotypic characterisation of cytomegalovirus DNA polymerase: A method to study cytomegalovirus isolates resistant to foscarnet
    • Ducancelle, A., J. Gravisse, S. Alain, A. M. Fillet, F. Petit, M. J. S. L. Pors, and M. C. Mazeron. 2005. Phenotypic characterisation of cytomegalovirus DNA polymerase: a method to study cytomegalovirus isolates resistant to foscarnet. J. Virol. Methods 125:145-151.
    • (2005) J. Virol. Methods , vol.125 , pp. 145-151
    • Ducancelle, A.1    Gravisse, J.2    Alain, S.3    Fillet, A.M.4    Petit, F.5    Pors, M.J.S.L.6    Mazeron, M.C.7
  • 18
    • 0036776278 scopus 로고    scopus 로고
    • Rapid development of ganciclovir-resistant cytomegalovirus infection in children after allogeneic stem cell transplantation in the early phase of immune cell recovery
    • Eckle, T., P. Lang, L. Prix, G. Jahn, T. Klingebiel, R. Handgretinger, B. Selle, D. Niethammer, and K. Hamprecht. 2002. Rapid development of ganciclovir-resistant cytomegalovirus infection in children after allogeneic stem cell transplantation in the early phase of immune cell recovery. Bone Marrow Transplant. 30:433-439.
    • (2002) Bone Marrow Transplant , vol.30 , pp. 433-439
    • Eckle, T.1    Lang, P.2    Prix, L.3    Jahn, G.4    Klingebiel, T.5    Handgretinger, R.6    Selle, B.7    Niethammer, D.8    Hamprecht, K.9
  • 19
    • 0035141424 scopus 로고    scopus 로고
    • Investigation of CMV disease in immunocompromised patients
    • Emery, V. C. 2001. Investigation of CMV disease in immunocompromised patients. J. Clin. Pathol. 54:84-88.
    • (2001) J. Clin. Pathol , vol.54 , pp. 84-88
    • Emery, V.C.1
  • 20
    • 0034608956 scopus 로고    scopus 로고
    • Prediction of cytomegalovirus load and resistance patterns after antiviral chemotherapy
    • Emery, V. C., and P. D. Griffiths. 2000. Prediction of cytomegalovirus load and resistance patterns after antiviral chemotherapy. Proc. Natl. Acad. Sci. USA 97:8039-8044.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 8039-8044
    • Emery, V.C.1    Griffiths, P.D.2
  • 21
    • 0037097799 scopus 로고    scopus 로고
    • Human cytomegalovirus (HCMV) replication dynamics in HCMV-naive and -experienced immunocompromised hosts
    • Emery, V. C., A. F. Hassan-Walker, A. K. Burroughs, and P. D. Griffiths. 2002. Human cytomegalovirus (HCMV) replication dynamics in HCMV-naive and -experienced immunocompromised hosts. J. Infect. Dis. 185:1723-1728.
    • (2002) J. Infect. Dis , vol.185 , pp. 1723-1728
    • Emery, V.C.1    Hassan-Walker, A.F.2    Burroughs, A.K.3    Griffiths, P.D.4
  • 22
    • 0030960868 scopus 로고    scopus 로고
    • Antiviral susceptibilities and analysis of UL97 and DNA polymerase sequences of clinical cytomegalovirus isolates from immunocompromised patients
    • Erice, A., C. Gil-Roda, J. L. Perez, H. H. Balfour, Jr., K. J. Sannerud, M. N. Hanson, G. Boivin, and S. Chou. 1997. Antiviral susceptibilities and analysis of UL97 and DNA polymerase sequences of clinical cytomegalovirus isolates from immunocompromised patients. J. Infect. Dis. 175:1087-1092.
    • (1997) J. Infect. Dis , vol.175 , pp. 1087-1092
    • Erice, A.1    Gil-Roda, C.2    Perez, J.L.3    Balfour Jr., H.H.4    Sannerud, K.J.5    Hanson, M.N.6    Boivin, G.7    Chou, S.8
  • 23
    • 14744270979 scopus 로고    scopus 로고
    • Human cytomegalovirus resistance to antiviral drugs
    • Gilbert, C., and G. Boivin. 2005. Human cytomegalovirus resistance to antiviral drugs. Antimicrob. Agents Chemother. 49:873-883.
    • (2005) Antimicrob. Agents Chemother , vol.49 , pp. 873-883
    • Gilbert, C.1    Boivin, G.2
  • 25
    • 0029040849 scopus 로고
    • Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir
    • Hanson, M. N., L. C. Preheim, S. Chou, C. L. Talarico, K. K. Biron, and A. Erice. 1995. Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir. Antimicrob. Agents Chemother. 39:1204-1205.
    • (1995) Antimicrob. Agents Chemother , vol.39 , pp. 1204-1205
    • Hanson, M.N.1    Preheim, L.C.2    Chou, S.3    Talarico, C.L.4    Biron, K.K.5    Erice, A.6
  • 26
    • 13044290052 scopus 로고    scopus 로고
    • The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: Relationship to the structure of alpha-like DNA polymerases
    • Huang, L., K. K. Ishii, H. Zuccola, A. M. Gehring, C. B. Hwang, J. Hogle, and D. M. Coen. 1999. The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases. Proc. Natl. Acad. Sci. USA 96:447-452.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 447-452
    • Huang, L.1    Ishii, K.K.2    Zuccola, H.3    Gehring, A.M.4    Hwang, C.B.5    Hogle, J.6    Coen, D.M.7
  • 28
    • 0034766543 scopus 로고    scopus 로고
    • Longitudinal observations on mutations conferring ganciclovir resistance in patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis: The Cytomegalovirus and Viral Resistance Study Group
    • Jabs, D. A., B. K. Martin, M. S. Forman, J. P. Dunn, J. L. Davis, D. V. Weinberg, K. K. Biron, F. Baldanti, and H. Hu. 2001. Longitudinal observations on mutations conferring ganciclovir resistance in patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis: the Cytomegalovirus and Viral Resistance Study Group report number 8. Am. J. Ophthalmol. 132:700-710.
    • (2001) Am. J. Ophthalmol , vol.132 , pp. 700-710
    • Jabs, D.A.1    Martin, B.K.2    Forman, M.S.3    Dunn, J.P.4    Davis, J.L.5    Weinberg, D.V.6    Biron, K.K.7    Baldanti, F.8    Hu, H.9
  • 30
    • 33645719843 scopus 로고    scopus 로고
    • Treatment of multi-drug resistant cytomegalovirus retinitis with systematically administered leflunomide
    • Levi, M. E., N. Mandava, L. K. Chan, A. Weinberg, and J. L. Olson. 2006. Treatment of multi-drug resistant cytomegalovirus retinitis with systematically administered leflunomide. Transplant. Infect. Dis. 8:38-43.
    • (2006) Transplant. Infect. Dis , vol.8 , pp. 38-43
    • Levi, M.E.1    Mandava, N.2    Chan, L.K.3    Weinberg, A.4    Olson, J.L.5
  • 31
    • 0034686916 scopus 로고    scopus 로고
    • Emergence of ganciclovir-resistant cytomegalovirus disease among recipients of solid-organ transplants
    • Limaye, A. P., L. Corey, D. M. Koelle, C. L. Davis, and M. Boeckh. 2000. Emergence of ganciclovir-resistant cytomegalovirus disease among recipients of solid-organ transplants. Lancet 356:645-649.
    • (2000) Lancet , vol.356 , pp. 645-649
    • Limaye, A.P.1    Corey, L.2    Koelle, D.M.3    Davis, C.L.4    Boeckh, M.5
  • 33
    • 0033796102 scopus 로고    scopus 로고
    • Prevalence of antiviral drug resistance in untreated patients with cytomegalovirus retinitis
    • Liu, W., C. Shum, D. F. Martin, B. D. Kuppermann, A. J. Hall, and T. P. Margolis. 2000. Prevalence of antiviral drug resistance in untreated patients with cytomegalovirus retinitis. J. Infect. Dis. 182:1234-1238.
    • (2000) J. Infect. Dis , vol.182 , pp. 1234-1238
    • Liu, W.1    Shum, C.2    Martin, D.F.3    Kuppermann, B.D.4    Hall, A.J.5    Margolis, T.P.6
  • 35
    • 0034812453 scopus 로고    scopus 로고
    • Lurain, N. S., A. Weinberg, C. S. Crumpacker, S. Chou, and the Adult AIDS Clinical Trials Group-CMV Laboratories. 2001. Sequencing of cytomegalovirus UL97 gene for genotypic antiviral resistance testing. Antimicrob. Agents Chemother. 45:2775-2780.
    • Lurain, N. S., A. Weinberg, C. S. Crumpacker, S. Chou, and the Adult AIDS Clinical Trials Group-CMV Laboratories. 2001. Sequencing of cytomegalovirus UL97 gene for genotypic antiviral resistance testing. Antimicrob. Agents Chemother. 45:2775-2780.
  • 36
    • 11144273948 scopus 로고    scopus 로고
    • Kinetics of cytomegalovirus load decrease in solid-organ transplant recipients after preemptive therapy with valganciclovir
    • Mattes, F. M., E. G. Hainsworth, A. F. Hassan-Walker, A. K. Burroughs, P. Sweny, P. D. Griffiths, and V. C. Emery. 2005. Kinetics of cytomegalovirus load decrease in solid-organ transplant recipients after preemptive therapy with valganciclovir. J. Infect. Dis. 191:89-92.
    • (2005) J. Infect. Dis , vol.191 , pp. 89-92
    • Mattes, F.M.1    Hainsworth, E.G.2    Hassan-Walker, A.F.3    Burroughs, A.K.4    Sweny, P.5    Griffiths, P.D.6    Emery, V.C.7
  • 37
    • 1942469969 scopus 로고    scopus 로고
    • Paya, C., A. Humar, E. Dominguez, K. Washburn, E. Blumberg, B. Alexander, R. Freeman, N. Heaton, M. D. Pescovitz, and Valganciclovir Solid Organ Transplant Study Group. 2004. Efficacy and safety of valganciclovir vs. oral ganciclovir for prevention of cytomegalovirus disease in solid organ transplant recipients. Am. J. Transplant. 4:611-620.
    • Paya, C., A. Humar, E. Dominguez, K. Washburn, E. Blumberg, B. Alexander, R. Freeman, N. Heaton, M. D. Pescovitz, and Valganciclovir Solid Organ Transplant Study Group. 2004. Efficacy and safety of valganciclovir vs. oral ganciclovir for prevention of cytomegalovirus disease in solid organ transplant recipients. Am. J. Transplant. 4:611-620.
  • 38
    • 0032567301 scopus 로고    scopus 로고
    • A herpes simplex virus DNA polymerase mutation that specifically attenuates neurovirulence in mice
    • Pelosi, E., F. Rozenberg, D. M. Coen, and K. L. Tyler. 1998. A herpes simplex virus DNA polymerase mutation that specifically attenuates neurovirulence in mice. Virology 252:364-372.
    • (1998) Virology , vol.252 , pp. 364-372
    • Pelosi, E.1    Rozenberg, F.2    Coen, D.M.3    Tyler, K.L.4
  • 39
    • 3342964201 scopus 로고    scopus 로고
    • Cytomegalovirus antiviral resistance associated with treatment induced UL97 (protein kinase) and UL54 (DNA polymerase) mutations
    • Scott, G. M., M. A. Isaacs, F. Zeng, A. M. Kesson, and W. D. Rawlinson. 2004. Cytomegalovirus antiviral resistance associated with treatment induced UL97 (protein kinase) and UL54 (DNA polymerase) mutations. J. Med. Virol. 74:85-93.
    • (2004) J. Med. Virol , vol.74 , pp. 85-93
    • Scott, G.M.1    Isaacs, M.A.2    Zeng, F.3    Kesson, A.M.4    Rawlinson, W.D.5
  • 40
    • 23044443170 scopus 로고    scopus 로고
    • Murine cytomegalovirus resistant to antivirals has genetic correlates with human cytomegalovirus
    • Scott, G. M., H. L. Ng, C. J. Morton, M. W. Parker, and W. D. Rawlinson. 2005. Murine cytomegalovirus resistant to antivirals has genetic correlates with human cytomegalovirus. J. Gen. Virol. 86:2141-2151.
    • (2005) J. Gen. Virol , vol.86 , pp. 2141-2151
    • Scott, G.M.1    Ng, H.L.2    Morton, C.J.3    Parker, M.W.4    Rawlinson, W.D.5
  • 41
    • 0035876690 scopus 로고    scopus 로고
    • Viral infections and their impact on chronic renal allograft dysfunction
    • Soderberg-Naucler, C., and V. C. Emery. 2001. Viral infections and their impact on chronic renal allograft dysfunction. Transplantation 71:SS24-SS30.
    • (2001) Transplantation , vol.71
    • Soderberg-Naucler, C.1    Emery, V.C.2
  • 42
    • 11844275363 scopus 로고    scopus 로고
    • How evolution of mutations conferring drug resistance affects viral dynamics and clinical outcomes of cytomegalovirus- infected hematopoietic cell transplant recipients
    • Springer, K. L., S. Chou, S. Li, R. H. Giller, R. Quinones, J. E. Shira, and A. Weinberg. 2005. How evolution of mutations conferring drug resistance affects viral dynamics and clinical outcomes of cytomegalovirus- infected hematopoietic cell transplant recipients. J. Clin. Microbiol. 43:208-213.
    • (2005) J. Clin. Microbiol , vol.43 , pp. 208-213
    • Springer, K.L.1    Chou, S.2    Li, S.3    Giller, R.H.4    Quinones, R.5    Shira, J.E.6    Weinberg, A.7
  • 43
    • 0026720227 scopus 로고
    • A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells
    • Sullivan, V., C. L. Talarico, S. C. Stanat, M. Davis, D. M. Coen, and K. K. Biron. 1992. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. Nature 358:162-164.
    • (1992) Nature , vol.358 , pp. 162-164
    • Sullivan, V.1    Talarico, C.L.2    Stanat, S.C.3    Davis, M.4    Coen, D.M.5    Biron, K.K.6
  • 44
    • 31144436564 scopus 로고    scopus 로고
    • Role of helix P of the human cytomegalovirus DNA polymerase in resistance and hypersusceptibility to the antiviral drug foscarnet
    • Tchesnokov, E. P., C. Gilbert, G. Boivin, and M. Gotte. 2006. Role of helix P of the human cytomegalovirus DNA polymerase in resistance and hypersusceptibility to the antiviral drug foscarnet. J. Virol. 80:1440-1450.
    • (2006) J. Virol , vol.80 , pp. 1440-1450
    • Tchesnokov, E.P.1    Gilbert, C.2    Boivin, G.3    Gotte, M.4
  • 45
    • 0031587827 scopus 로고    scopus 로고
    • Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69
    • Wang, J., A. K. Sattar, C. C. Wang, J. D. Karam, W. H. Konigsberg, and T. A. Steitz. 1997. Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69. Cell 89:1087-1099.
    • (1997) Cell , vol.89 , pp. 1087-1099
    • Wang, J.1    Sattar, A.K.2    Wang, C.C.3    Karam, J.D.4    Konigsberg, W.H.5    Steitz, T.A.6
  • 46
    • 0037332358 scopus 로고    scopus 로고
    • Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis
    • Weinberg, A., D. A. Jabs, S. Chou, B. K. Martin, N. S. Lurain, M. S. Forman, and C. Crumpacker. 2003. Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis. J. Infect. Dis. 187:777-784.
    • (2003) J. Infect. Dis , vol.187 , pp. 777-784
    • Weinberg, A.1    Jabs, D.A.2    Chou, S.3    Martin, B.K.4    Lurain, N.S.5    Forman, M.S.6    Crumpacker, C.7
  • 47
    • 0027453769 scopus 로고
    • In vitro expression of the human cytomegalovirus DNA polymerase gene: Effects of sequence alterations on enzyme activity
    • Ye, L. B., and E. S. Huang. 1993. In vitro expression of the human cytomegalovirus DNA polymerase gene: effects of sequence alterations on enzyme activity. J. Virol. 67:6339-6347.
    • (1993) J. Virol , vol.67 , pp. 6339-6347
    • Ye, L.B.1    Huang, E.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.