Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS

Journal of Virology

Volumn 70, Issue 3, 1996, Pages 1390-1395

  Baldanti, Fausto ^a   Underwood, Mark R ^b   Stanat, Sylvia C ^b   Biron, Karen K ^b   Chou, Sunwen ^c   Sarasini, Antonella ^a   Silini, Enrico ^a   Gerna, Giuseppe ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b GLAXOSMITHKLINE   (United States)

^c PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIDOFOVIR; DNA POLYMERASE; FOSCARNET; PHOSPHOTRANSFERASE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; CROSS RESISTANCE; CYTOMEGALOVIRUS INFECTION; DRUG SENSITIVITY; GENE MUTATION; HUMAN; MULTIDRUG RESISTANCE; NONHUMAN; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRUS ISOLATION; VIRUS PLAQUE; VIRUS REPLICATION;

AIDS-RELATED OPPORTUNISTIC INFECTIONS; AMINO ACID SEQUENCE; BASE SEQUENCE; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA-DIRECTED DNA POLYMERASE; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE; FOSCARNET; GANCICLOVIR; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR);

EID: 0030043162     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.3.1390-1395.1996     Document Type: Article

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