Interleukin-6 inhibits radiation induced apoptosis in pancreatic cancer cells

Anticancer Research

Volumn 21, Issue 4 A, 2001, Pages 2449-2456

  Miyamoto, Y ^a   Hosotani, R ^a   Doi, R ^a   Wada, M ^a   Ida, J ^a   Tsuji, S ^a   Kawaguchi, M ^a   Nakajima, S ^a   Kobayashi, H ^a   Masui, T ^a   Imamura, M ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Bcl 2 family and radiation; IL 6; Pancreatic cancer

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CORRELATION FUNCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY;

APOPTOSIS; HUMANS; INTERLEUKIN-6; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; RADIATION TOLERANCE; RECEPTORS, INTERLEUKIN-6; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED; TYROSINE;

EID: 0035153882     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV
2. Cell-replacing factor- (TRF) induced IgG secretion in a human B blastoid cell line and demonstration of acceptors for TRF
3. The myeloid blood cell differentiation-inducing protein MGI-2A is interleukin-6
4. Autoregulation of interleukin 6 and granulocyte-macrophage colony-stimulating factor in the differentiation of myeloid leukemic cells
5. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
6. Purification and characterization of human fibroblast-derived hybridoma growth factor identical to T-cellderived B-cell stimulatory factor-2 (interleukin-6)
7. Interleukin-6 family of cytokines and gp130
8. Molecular cloning and expression of an IL-6 signal transducer, gp 130
9. Growth inhibition of human breast carcinoma and leukemia/lymphoma cell lines by recombinant interferon-beta 2
10. Interleukin-1 alpha and interleukin-6 act additively to inhibit growth of MCF-7 breast cancer cells in vitro
11. Expression and function of interleukin-6 in epithelial cells
12. Observations on the growth rate of renal cell carcinoma
13. Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro
14. Interleukin-6 inhibits apoptosis of malignant plasma cells
15. Expression of Fas/Apo-1 (CD95) and apoptosis in tumor cells from patients with plasma cell disorders
16. Interleukin-6 delays neutrophil apoptosis
17. Prevention of myeloma cell apoptosis by ectopic bcl-2 expression or interleukin 6-mediated up-regulation of bcl-xl
18. Involvement of human interleukin 6 in experimental cachexia induced by a human uterine cervical carcinoma xenograft
19. Abnormal glutathione and sulfate levels after interleukin 6 treatment and in tumor-induced cachexia
20. Elevated serum interleukin-6 levels in patients with pancreatic cancer
21. Immuno-histochemical analysis of Bcl-2, Bax, Bcl-X and Mcl-1 expression in pancreatic cancers
22. Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130
23. Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components
24. Tyrosine phosphorylation of JAK-TYK kinases in malignant plasma cell lines growth-stimulated by interleukins 6 and 11
25. Activation of JAK 2 kinase mediated by the interleukin 6 signal transducer gp130
26. Interferon-beta interrupts interleukin-6-dependent signaling events in myeloma cells
27. Role of Bcl-2 family proteins (Bax, Bcl-2 and Bcl-X) on cellular susceptibility to radiation in pancreatic cancer cells
28. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
29. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
30. Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax
31. Overexpression of Bcl-XL by cytotoxic drug exposure confers resistance to ionizing radiation-induced internucleosomal DNA fragmentation
32. Bcl-xL is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis
33. Role of bcl-X(L) in the control of apoptosis in murine myeloma cells
34. The apoptosis-associated gamma-ray response of BCL-X(L) depends on normal p 53 function
35. Sensitization of human renal cell carcinoma cells to cisdiamminedichloroplatinum(II) by anti-interleukin 6 monoclonal antibody or anti-interleukin 6 receptor monoclonal antibody
36. New xenograft model of multiple myeloma and efficacy of a humanized antibody against human interleukin- 6 receptor
37. Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy
38. Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody