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Volumn 6, Issue 11, 2008, Pages 1755-1765

Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYCLIN E; JANUS KINASE; MESOTHELIN; SMALL INTERFERING RNA; STAT3 PROTEIN;

EID: 56449108335     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-08-0095     Document Type: Article
Times cited : (81)

References (47)
  • 1
    • 3042621639 scopus 로고    scopus 로고
    • Mesothelin: A new target for immunotherapy
    • Hassan R, Bera T, Pastan I. Mesothelin: a new target for immunotherapy. Clin Cancer Res 2004;10:3937-42.
    • (2004) Clin Cancer Res , vol.10 , pp. 3937-3942
    • Hassan, R.1    Bera, T.2    Pastan, I.3
  • 2
    • 0026602638 scopus 로고
    • Characterization of the antigen (CAK1) recognized by monoclonal antibody K1 present on ovarian cancers and normal mesothelium
    • Chang K, Pai LH, Batra JK, Pastan I, Willingham MC. Characterization of the antigen (CAK1) recognized by monoclonal antibody K1 present on ovarian cancers and normal mesothelium. Cancer Res 1992;52:181-6.
    • (1992) Cancer Res , vol.52 , pp. 181-186
    • Chang, K.1    Pai, L.H.2    Batra, J.K.3    Pastan, I.4    Willingham, M.C.5
  • 3
    • 0035674996 scopus 로고    scopus 로고
    • Mesothelin is overexpressed in the vast majorityof ductal adenocarcinomas of the pancreas: Identification of a new pancreatic cancer marker byserial analysis of gene expression (SAGE)
    • Argani P, Iacobuzio-Donahue C, Ryu B, et al. Mesothelin is overexpressed in the vast majorityof ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker byserial analysis of gene expression (SAGE). Clin Cancer Res 2001;7:3862-8.
    • (2001) Clin Cancer Res , vol.7 , pp. 3862-3868
    • Argani, P.1    Iacobuzio-Donahue, C.2    Ryu, B.3
  • 4
    • 33947357849 scopus 로고    scopus 로고
    • Mesothelin expression in human lung cancer
    • Ho M, Bera TK, Willingham MC, et al. Mesothelin expression in human lung cancer. Clin Cancer Res 2007;13:1571-5.
    • (2007) Clin Cancer Res , vol.13 , pp. 1571-1575
    • Ho, M.1    Bera, T.K.2    Willingham, M.C.3
  • 5
    • 0030069718 scopus 로고    scopus 로고
    • Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers
    • Chang K, Pastan I. Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. Proc Natl Acad Sci U S A 1996;93:136-40.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 136-140
    • Chang, K.1    Pastan, I.2
  • 6
    • 33750998782 scopus 로고    scopus 로고
    • Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors
    • Gubbels JA, Belisle J, Onda M, et al. Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors. Mol Cancer 2006;5:50.
    • (2006) Mol Cancer , vol.5 , pp. 50
    • Gubbels, J.A.1    Belisle, J.2    Onda, M.3
  • 7
    • 39749173738 scopus 로고    scopus 로고
    • Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer
    • Li M, Bharadwaj U, Zhang R, et al. Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer. Mol Cancer Ther 2008;7:286-96.
    • (2008) Mol Cancer Ther , vol.7 , pp. 286-296
    • Li, M.1    Bharadwaj, U.2    Zhang, R.3
  • 8
    • 33749120517 scopus 로고    scopus 로고
    • Serial analysis of gene expression (SAGE) in the rat limbal and central corneal epithelium
    • Adachi W, UlanovskyH, Li Y, et al. Serial analysis of gene expression (SAGE) in the rat limbal and central corneal epithelium. Invest Ophthalmol Vis Sci 2006;47:3801-10.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 3801-3810
    • Adachi, W.1    Ulanovsky, H.2    Li, Y.3
  • 9
    • 33746458603 scopus 로고    scopus 로고
    • Parous mammary glands exhibit distinct alterations in gene expression and proliferation responsiveness to carcinogenic stimuli in Lewis rats
    • Uehara N, Unami A, Kiyozuka Y, et al. Parous mammary glands exhibit distinct alterations in gene expression and proliferation responsiveness to carcinogenic stimuli in Lewis rats. Oncol Rep 2006;15:903-11.
    • (2006) Oncol Rep , vol.15 , pp. 903-911
    • Uehara, N.1    Unami, A.2    Kiyozuka, Y.3
  • 10
    • 34547158244 scopus 로고    scopus 로고
    • Generation and characterization of an ascitogenic mesothelin-expressing tumor model
    • Cheng WF, Hung CF, Chai CY, et al. Generation and characterization of an ascitogenic mesothelin-expressing tumor model. Cancer 2007;110:420-31.
    • (2007) Cancer , vol.110 , pp. 420-431
    • Cheng, W.F.1    Hung, C.F.2    Chai, C.Y.3
  • 11
    • 0028148191 scopus 로고
    • The cyclin-dependent protein kinases and the control of cell division
    • Doree M, Galas S. The cyclin-dependent protein kinases and the control of cell division. FASEB J 1994;8:1114-21.
    • (1994) FASEB J , vol.8 , pp. 1114-1121
    • Doree, M.1    Galas, S.2
  • 12
    • 0029286242 scopus 로고
    • Cyclins, CDKs and cancer
    • Pines J. Cyclins, CDKs and cancer. Semin Cancer Biol 1995;6:63-72.
    • (1995) Semin Cancer Biol , vol.6 , pp. 63-72
    • Pines, J.1
  • 13
    • 0027938209 scopus 로고
    • Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age
    • Hunter T, Pines J. Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. Cell 1994;79:573-82.
    • (1994) Cell , vol.79 , pp. 573-582
    • Hunter, T.1    Pines, J.2
  • 14
    • 0028918388 scopus 로고
    • Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6
    • Hirai H, Roussel MF, Kato JY, Ashmun RA, Sherr CJ. Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol Cell Biol 1995;15:2672-81.
    • (1995) Mol Cell Biol , vol.15 , pp. 2672-2681
    • Hirai, H.1    Roussel, M.F.2    Kato, J.Y.3    Ashmun, R.A.4    Sherr, C.J.5
  • 15
    • 0028875086 scopus 로고
    • Evidence for different modes of action of cyclin-dependent kinase inhibitors: P15 and p16 bind to kinases, p21 and p27 bind to cyclins
    • Hall M, Bates S, Peters G. Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins. Oncogene 1995;11:1581-8.
    • (1995) Oncogene , vol.11 , pp. 1581-1588
    • Hall, M.1    Bates, S.2    Peters, G.3
  • 17
    • 0343027284 scopus 로고    scopus 로고
    • Transcriptional control of the cell cycle
    • Sanchez I, Dynlacht BD. Transcriptional control of the cell cycle. Curr Opin Cell Biol 1996;8:318-24.
    • (1996) Curr Opin Cell Biol , vol.8 , pp. 318-324
    • Sanchez, I.1    Dynlacht, B.D.2
  • 18
    • 1642312315 scopus 로고    scopus 로고
    • Genetic alterations in pancreatic carcinoma
    • Schneider G, Schmid RM. Genetic alterations in pancreatic carcinoma. Mol Cancer 2003;2:15.
    • (2003) Mol Cancer , vol.2 , pp. 15
    • Schneider, G.1    Schmid, R.M.2
  • 20
    • 0013689209 scopus 로고    scopus 로고
    • Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro
    • Grandis JR, Drenning SD, Chakraborty A, et al. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro. J Clin Invest 1998;102:1385-92.
    • (1998) J Clin Invest , vol.102 , pp. 1385-1392
    • Grandis, J.R.1    Drenning, S.D.2    Chakraborty, A.3
  • 21
    • 0037064121 scopus 로고    scopus 로고
    • ErbB-2 activates Stat3 α in a Src- and JAK2-dependent manner
    • Ren Z, Schaefer TS. ErbB-2 activates Stat3 α in a Src- and JAK2-dependent manner. J Biol Chem 2002;277:38486-93.
    • (2002) J Biol Chem , vol.277 , pp. 38486-38493
    • Ren, Z.1    Schaefer, T.S.2
  • 22
    • 0037160057 scopus 로고    scopus 로고
    • Activation of STAT3 bythe Src family kinase Hck requires a functional SH3 domain
    • Schreiner SJ, Schiavone AP, Smithgall TE. Activation of STAT3 bythe Src family kinase Hck requires a functional SH3 domain. J Biol Chem 2002;277:45680-7.
    • (2002) J Biol Chem , vol.277 , pp. 45680-45687
    • Schreiner, S.J.1    Schiavone, A.P.2    Smithgall, T.E.3
  • 23
    • 0034722896 scopus 로고    scopus 로고
    • STAT proteins: Novel molecular targets for cancer drug discovery
    • Turkson J, Jove R. STAT proteins: novel molecular targets for cancer drug discovery. Oncogene 2000;19:6613-26.
    • (2000) Oncogene , vol.19 , pp. 6613-6626
    • Turkson, J.1    Jove, R.2
  • 24
    • 33947574564 scopus 로고    scopus 로고
    • Targeting signal-transducer-and- activator-of-transcription-3 for prevention and therapyof cancer: Modern target but ancient solution
    • Aggarwal BB, Sethi G, Ahn KS, et al. Targeting signal-transducer-and- activator-of-transcription-3 for prevention and therapyof cancer: modern target but ancient solution. Ann N Y Acad Sci 2006;1091:151-69.
    • (2006) Ann N Y Acad Sci , vol.1091 , pp. 151-169
    • Aggarwal, B.B.1    Sethi, G.2    Ahn, K.S.3
  • 25
    • 0036884187 scopus 로고    scopus 로고
    • Stat3 and NF-κB activation prevents apoptosis in pancreatic carcinogenesis
    • Greten FR, Weber CK, Greten TF, et al. Stat3 and NF-κB activation prevents apoptosis in pancreatic carcinogenesis. Gastroenterology2002;123:2052- 63.
    • Gastroenterology2002;123 , pp. 2052-2063
    • Greten, F.R.1    Weber, C.K.2    Greten, T.F.3
  • 26
    • 0042825695 scopus 로고    scopus 로고
    • Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer
    • Scholz A, Heinze S, Detjen KM, et al. Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer. Gastroenterology 2003;125:891-905.
    • (2003) Gastroenterology , vol.125 , pp. 891-905
    • Scholz, A.1    Heinze, S.2    Detjen, K.M.3
  • 27
    • 0344873744 scopus 로고    scopus 로고
    • Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines
    • DeArmond D, Brattain MG, Jessup JM, et al. Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines. Oncogene 2003;22:7781-95.
    • (2003) Oncogene , vol.22 , pp. 7781-7795
    • DeArmond, D.1    Brattain, M.G.2    Jessup, J.M.3
  • 28
    • 0142122338 scopus 로고    scopus 로고
    • Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer
    • Toyonaga T, Nakano K, Nagano M, et al. Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer. Cancer Lett 2003;201:107-16.
    • (2003) Cancer Lett , vol.201 , pp. 107-116
    • Toyonaga, T.1    Nakano, K.2    Nagano, M.3
  • 29
    • 0037461934 scopus 로고    scopus 로고
    • Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis
    • Wei D, Le X, Zheng L, et al. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene 2003;22:319-29.
    • (2003) Oncogene , vol.22 , pp. 319-329
    • Wei, D.1    Le, X.2    Zheng, L.3
  • 30
    • 0028067729 scopus 로고
    • Cell cycle regulation of the p34cdc2 inhibitorykinases
    • Atherton-Fessler S, Liu F, Gabrielli B, et al. Cell cycle regulation of the p34cdc2 inhibitorykinases. Mol Biol Cell 1994;5:989-1001.
    • (1994) Mol Biol Cell , vol.5 , pp. 989-1001
    • Atherton-Fessler, S.1    Liu, F.2    Gabrielli, B.3
  • 31
    • 1842301561 scopus 로고
    • Cyclins and cell cycle control
    • Norbury C, Nurse P. Cyclins and cell cycle control. Curr Biol 1991;1:23-4.
    • (1991) Curr Biol , vol.1 , pp. 23-24
    • Norbury, C.1    Nurse, P.2
  • 32
    • 0017785769 scopus 로고
    • Primarybioassay of human tumor stem cells
    • Hamburger AW, Salmon SE. Primarybioassay of human tumor stem cells. Science 1977;197:461-3.
    • (1977) Science , vol.197 , pp. 461-463
    • Hamburger, A.W.1    Salmon, S.E.2
  • 33
    • 0025253853 scopus 로고
    • Correlation of drug response in patients and in the clonogenic assaywith solid human tumour xenografts
    • Scholz CC, Berger DP, Winterhalter BR, Henss H, Fiebig HH. Correlation of drug response in patients and in the clonogenic assaywith solid human tumour xenografts. Eur J Cancer 1990;26:901-5.
    • (1990) Eur J Cancer , vol.26 , pp. 901-905
    • Scholz, C.C.1    Berger, D.P.2    Winterhalter, B.R.3    Henss, H.4    Fiebig, H.H.5
  • 34
    • 27944506044 scopus 로고    scopus 로고
    • Inhibition of clonogenic tumor growth: A novel function of Smac contributing to its antitumor activity
    • Vogler M, Giagkousiklidis S, Genze F, et al. Inhibition of clonogenic tumor growth: a novel function of Smac contributing to its antitumor activity. Oncogene 2005;24:7190-202.
    • (2005) Oncogene , vol.24 , pp. 7190-7202
    • Vogler, M.1    Giagkousiklidis, S.2    Genze, F.3
  • 35
    • 33750504838 scopus 로고    scopus 로고
    • Cyclin E expression and outcome in pancreatic ductal adenocarcinoma
    • Skalicky DA, Kench JG, Segara D, et al. Cyclin E expression and outcome in pancreatic ductal adenocarcinoma. Cancer Epidemiol Biomarkers Prev 2006;15:1941-7.
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 1941-1947
    • Skalicky, D.A.1    Kench, J.G.2    Segara, D.3
  • 36
    • 0141742113 scopus 로고    scopus 로고
    • Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray
    • Maitra A, AdsayNV , Argani P, et al. Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray. Mod Pathol 2003;16:902-12.
    • (2003) Mod Pathol , vol.16 , pp. 902-912
    • Maitra, A.1    AdsayNV2    Argani, P.3
  • 37
    • 0031598765 scopus 로고    scopus 로고
    • A novel strategy for inhibiting growth of human pancreatic cancer cells byblocki ng cyclin-dependent kinase activity
    • Iseki H, Ko TC, Xue XY, Seapan A, Townsend CM, Jr. A novel strategy for inhibiting growth of human pancreatic cancer cells byblocki ng cyclin-dependent kinase activity. J Gastrointest Surg 1998;2:36-43.
    • (1998) J Gastrointest Surg , vol.2 , pp. 36-43
    • Iseki, H.1    Ko, T.C.2    Xue, X.Y.3    Seapan, A.4    Townsend Jr, C.M.5
  • 38
    • 0029010606 scopus 로고
    • Concurrent amplification of cyclin E and CDK2 genes in colorectal carcinomas
    • Kitahara K, Yasui W, Kuniyasu H, et al. Concurrent amplification of cyclin E and CDK2 genes in colorectal carcinomas. Int J Cancer 1995;62:25-8.
    • (1995) Int J Cancer , vol.62 , pp. 25-28
    • Kitahara, K.1    Yasui, W.2    Kuniyasu, H.3
  • 39
    • 38149142478 scopus 로고    scopus 로고
    • Expression of nuclear Notch3 in pancreatic adenocarcinomas is associated with adverse clinical features, and correlates with the expression of STAT3 and phosphorylated Akt
    • Doucas H, Mann CD, Sutton CD, et al. Expression of nuclear Notch3 in pancreatic adenocarcinomas is associated with adverse clinical features, and correlates with the expression of STAT3 and phosphorylated Akt. J Surg Oncol 2008;97:63-8.
    • (2008) J Surg Oncol , vol.97 , pp. 63-68
    • Doucas, H.1    Mann, C.D.2    Sutton, C.D.3
  • 40
    • 13444309088 scopus 로고    scopus 로고
    • Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation
    • Yang J, Chatterjee-Kishore M, Staugaitis SM, et al. Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation. Cancer Res 2005;65:939-47.
    • (2005) Cancer Res , vol.65 , pp. 939-947
    • Yang, J.1    Chatterjee-Kishore, M.2    Staugaitis, S.M.3
  • 41
    • 0034810738 scopus 로고    scopus 로고
    • Tissue-specific autoregulation of the stat3 gene and its role in interleukin-6-induced survival signals in T cells
    • Narimatsu M, Maeda H, Itoh S, et al. Tissue-specific autoregulation of the stat3 gene and its role in interleukin-6-induced survival signals in T cells. Mol Cell Biol 2001;21:6615-25.
    • (2001) Mol Cell Biol , vol.21 , pp. 6615-6625
    • Narimatsu, M.1    Maeda, H.2    Itoh, S.3
  • 42
    • 33746238953 scopus 로고    scopus 로고
    • Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion
    • Yeh HH, Lai WW, Chen HH, Liu HSSu WC. Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion. Oncogene 2006;25:4300-9.
    • (2006) Oncogene , vol.25 , pp. 4300-4309
    • Yeh, H.H.1    Lai, W.W.2    Chen, H.H.3    Liu HSSu, W.C.4
  • 43
    • 35948977339 scopus 로고    scopus 로고
    • Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1α autocrine loop, and reduces orthotopic tumor growth
    • Lang SA, Moser C, Gaumann A, et al. Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1α autocrine loop, and reduces orthotopic tumor growth. Clin Cancer Res 2007;13:6459-68.
    • (2007) Clin Cancer Res , vol.13 , pp. 6459-6468
    • Lang, S.A.1    Moser, C.2    Gaumann, A.3
  • 44
    • 36849012237 scopus 로고    scopus 로고
    • Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
    • Gao SP, Mark KG, Leslie K, et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J Clin Invest 2007;117:3846-56.
    • (2007) J Clin Invest , vol.117 , pp. 3846-3856
    • Gao, S.P.1    Mark, K.G.2    Leslie, K.3
  • 45
    • 0034676267 scopus 로고    scopus 로고
    • Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: Role of activated STAT3 signaling
    • Sinibaldi D, Wharton W, Turkson J, et al. Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling. Oncogene 2000;19:5419-27.
    • (2000) Oncogene , vol.19 , pp. 5419-5427
    • Sinibaldi, D.1    Wharton, W.2    Turkson, J.3
  • 46
    • 34848906227 scopus 로고    scopus 로고
    • Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells
    • Fuke H, Shiraki K, Sugimoto K, et al. Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells. Biochem Biophys Res Commun 2007;363:738-44.
    • (2007) Biochem Biophys Res Commun , vol.363 , pp. 738-744
    • Fuke, H.1    Shiraki, K.2    Sugimoto, K.3
  • 47
    • 32544436240 scopus 로고    scopus 로고
    • Metastatic progression of pancreatic cancer: Changes in antioxidant enzymes and cell growth
    • Lewis A, Du J, Liu J, et al. Metastatic progression of pancreatic cancer: changes in antioxidant enzymes and cell growth. Clin Exp Metastasis 2005;22:523-32.
    • (2005) Clin Exp Metastasis , vol.22 , pp. 523-532
    • Lewis, A.1    Du, J.2    Liu, J.3


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