-
1
-
-
34249676964
-
Chronic myeloid leukaemia as a model of disease evolution in human cancer
-
Melo JV, Barnes DJ. Chronic myeloid leukaemia as a model of disease evolution in human cancer. Nat Rev Cancer. 2007;7:441-53.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 441-453
-
-
Melo, J.V.1
Barnes, D.J.2
-
2
-
-
42549142280
-
Getting to the stem of chronic myeloid leukaemia
-
Savona M, Talpaz M. Getting to the stem of chronic myeloid leukaemia. Nat Rev Cancer. 2008;8:341-50.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 341-350
-
-
Savona, M.1
Talpaz, M.2
-
3
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
Druker BJ, Tamura S, Buchdunger E, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med. 1996;2:561-6.
-
(1996)
Nat Med
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
-
4
-
-
58149398623
-
Translation of the Philadelphia chromosome into therapy for CML
-
Druker BJ. Translation of the Philadelphia chromosome into therapy for CML. Blood. 2008;112:4808-17.
-
(2008)
Blood
, vol.112
, pp. 4808-4817
-
-
Druker, B.J.1
-
5
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
Gorre ME, Mohammed M, Ellwood K, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science. 2001;293:876-80.
-
(2001)
Science
, vol.293
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
-
6
-
-
3943088431
-
Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
-
Jamieson CH, Ailles LE, Dylla SJ, et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med. 2004;351:657-67.
-
(2004)
N Engl J Med
, vol.351
, pp. 657-667
-
-
Jamieson, C.H.1
Ailles, L.E.2
Dylla, S.J.3
-
7
-
-
56649114489
-
BCR-ABL-transformed GMP as myeloid leukemic stem cells
-
Minami Y, Stuart SA, Ikawa T, et al. BCR-ABL-transformed GMP as myeloid leukemic stem cells. Proc Natl Acad Sci U S A. 2008;105:17967-72.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 17967-17972
-
-
Minami, Y.1
Stuart, S.A.2
Ikawa, T.3
-
8
-
-
36649002031
-
Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo
-
Zhao C, Blum J, Chen A, et al. Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell. 2007;12:528-41.
-
(2007)
Cancer Cell
, vol.12
, pp. 528-541
-
-
Zhao, C.1
Blum, J.2
Chen, A.3
-
9
-
-
58249120738
-
Beta-catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCRABL- induced chronic myeloid leukemia
-
Hu Y, Chen Y, Douglas L, Li S. Beta-catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCRABL- induced chronic myeloid leukemia. Leukemia. 2009;23:109-16.
-
(2009)
Leukemia
, vol.23
, pp. 109-116
-
-
Hu, Y.1
Chen, Y.2
Douglas, L.3
Li, S.4
-
10
-
-
33947123268
-
Bcr-Abl stabilizes betacatenin in chronic myeloid leukemia through its tyrosine phosphorylation
-
Coluccia AM, Vacca A, Dunach M, et al. Bcr-Abl stabilizes betacatenin in chronic myeloid leukemia through its tyrosine phosphorylation. EMBO J. 2007;26:1456-66.
-
(2007)
EMBO J
, vol.26
, pp. 1456-1466
-
-
Coluccia, A.M.1
Vacca, A.2
Dunach, M.3
-
11
-
-
75649084233
-
A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib
-
McWeeney SK, Pemberton LC, Loriaux MM, et al. A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib. Blood. 2010;115:315-25.
-
(2010)
Blood
, vol.115
, pp. 315-325
-
-
McWeeney, S.K.1
Pemberton, L.C.2
Loriaux, M.M.3
-
12
-
-
37549064269
-
MUC1 oncoprotein regulates Bcr- Abl stability and pathogenesis in chronic myelogenous leukemia cells
-
Kawano T, Ito M, Raina D, et al. MUC1 oncoprotein regulates Bcr- Abl stability and pathogenesis in chronic myelogenous leukemia cells. Cancer Res. 2007;67:11576-84.
-
(2007)
Cancer Res
, vol.67
, pp. 11576-11584
-
-
Kawano, T.1
Ito, M.2
Raina, D.3
-
13
-
-
77957152778
-
Terminal differentiation of chronic myelogenous leukemia cells is induced by targeting of the MUC1-C oncoprotein
-
Yin L, Ahmad R, Kosugi M, et al. Terminal differentiation of chronic myelogenous leukemia cells is induced by targeting of the MUC1-C oncoprotein. Cancer Biol Ther. 2010;10:483-91.
-
(2010)
Cancer Biol Ther
, vol.10
, pp. 483-491
-
-
Yin, L.1
Ahmad, R.2
Kosugi, M.3
-
14
-
-
70450247207
-
Mucins in cancer: Function, prognosis and therapy
-
Kufe D. Mucins in cancer: function, prognosis and therapy. Nat Rev Cancer. 2009;9:874-85.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 874-885
-
-
Kufe, D.1
-
15
-
-
34748902247
-
The MUC1 and galectin-3 oncoproteins function in a microRNA-dependent regulatory loop
-
Ramasamy S, Duraisamy S, Barbashov S, Kawano T, Kharbanda S, Kufe D. The MUC1 and galectin-3 oncoproteins function in a microRNA-dependent regulatory loop. Mol Cell. 2007;27:992-1004.
-
(2007)
Mol Cell
, vol.27
, pp. 992-1004
-
-
Ramasamy, S.1
Duraisamy, S.2
Barbashov, S.3
Kawano, T.4
Kharbanda, S.5
Kufe, D.6
-
16
-
-
0031723707
-
Interaction of glycogen synthase kinase 3ß with the DF3/MUC1 carcinoma-associated antigen and ß-catenin
-
Li Y, Bharti A, Chen D, Gong J, Kufe D. Interaction of glycogen synthase kinase 3ß with the DF3/MUC1 carcinoma-associated antigen and ß-catenin. Mol Cell Biol. 1998;18:7216-24.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 7216-7224
-
-
Li, Y.1
Bharti, A.2
Chen, D.3
Gong, J.4
Kufe, D.5
-
17
-
-
0030958706
-
Interaction of the DF3/MUC1 breast carcinoma-associated antigen and ß-catenin in cell adhesion
-
Yamamoto M, Bharti A, Li Y, Kufe D. Interaction of the DF3/MUC1 breast carcinoma-associated antigen and ß-catenin in cell adhesion. J Biol Chem. 1997;272:12492-4.
-
(1997)
J Biol Chem
, vol.272
, pp. 12492-12494
-
-
Yamamoto, M.1
Bharti, A.2
Li, Y.3
Kufe, D.4
-
18
-
-
0030779038
-
Serine phosphorylation- regulated ubiquitination and degradation of beta-catenin
-
Orford K, Crockett C, Jensen J, Weissman A, Byers S. Serine phosphorylation- regulated ubiquitination and degradation of beta-catenin. J Biol Chem. 1997;272:24735-8.
-
(1997)
J Biol Chem
, vol.272
, pp. 24735-24738
-
-
Orford, K.1
Crockett, C.2
Jensen, J.3
Weissman, A.4
Byers, S.5
-
19
-
-
0037155691
-
Control of beta-catenin phosphorylation/ degradation by a dual-kinase mechanism
-
Liu C, Li Y, Semenov M, et al. Control of beta-catenin phosphorylation/ degradation by a dual-kinase mechanism. Cell. 2002;108:837-47.
-
(2002)
Cell
, vol.108
, pp. 837-847
-
-
Liu, C.1
Li, Y.2
Semenov, M.3
-
20
-
-
28544448610
-
MUC1 oncoprotein blocks GSK3beta-mediated phosphorylation and degradation of beta-catenin
-
Huang L, Chen D, Liu D, Yin L, Kharbanda S, Kufe D. MUC1 oncoprotein blocks GSK3beta-mediated phosphorylation and degradation of beta-catenin. Cancer Res. 2005;65:10413-22.
-
(2005)
Cancer Res
, vol.65
, pp. 10413-10422
-
-
Huang, L.1
Chen, D.2
Liu, D.3
Yin, L.4
Kharbanda, S.5
Kufe, D.6
-
21
-
-
0042818006
-
Human MUC1 carcinoma antigen regulates intracellular oxidant levels and the apoptotic response to oxidative stress
-
Yin L, Kufe D. Human MUC1 carcinoma antigen regulates intracellular oxidant levels and the apoptotic response to oxidative stress. J Biol Chem. 2003;278:35458-64.
-
(2003)
J Biol Chem
, vol.278
, pp. 35458-35464
-
-
Yin, L.1
Kufe, D.2
-
22
-
-
7944230166
-
MUC1 oncoprotein activates the FOXO3a transcription factor in a survival response to oxidative stress
-
Yin L, Huang L, Kufe D. MUC1 oncoprotein activates the FOXO3a transcription factor in a survival response to oxidative stress. J Biol Chem. 2004;279:45721-7.
-
(2004)
J Biol Chem
, vol.279
, pp. 45721-45727
-
-
Yin, L.1
Huang, L.2
Kufe, D.3
-
23
-
-
67449127094
-
Direct targeting of the MUC1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells
-
Raina D, Ahmad R, Joshi M, et al. Direct targeting of the MUC1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells. Cancer Res. 2009;69:5133-41.
-
(2009)
Cancer Res
, vol.69
, pp. 5133-5141
-
-
Raina, D.1
Ahmad, R.2
Joshi, M.3
-
24
-
-
33646858497
-
The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled
-
Funato Y, Michiue T, Asashima M, Miki H. The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled. Nat Cell Biol. 2006;8:501-8.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 501-508
-
-
Funato, Y.1
Michiue, T.2
Asashima, M.3
Miki, H.4
-
25
-
-
18844382368
-
Functional interaction between beta-catenin and FOXO in oxidative stress signaling
-
Essers MA, de Vries-Smits LM, Barker N, Polderman PE, Burgering BM, Korswagen HC. Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science. 2005;308:1181-4.
-
(2005)
Science
, vol.308
, pp. 1181-1184
-
-
Essers, M.A.1
de Vries-Smits, L.M.2
Barker, N.3
Polderman, P.E.4
Burgering, B.M.5
Korswagen, H.C.6
-
26
-
-
77954897999
-
Survival of human multiple myeloma cells is dependent on MUC1 C-terminal transmembrane subunit oncoprotein function
-
Yin L, Ahmad R, Kosugi M, et al. Survival of human multiple myeloma cells is dependent on MUC1 C-terminal transmembrane subunit oncoprotein function. Mol Pharm. 2010;78:166-74.
-
(2010)
Mol Pharm
, vol.78
, pp. 166-174
-
-
Yin, L.1
Ahmad, R.2
Kosugi, M.3
-
27
-
-
33846994065
-
Mucin 1 oncoprotein blocks hypoxiainducible factor 1 alpha activation in a survival response to hypoxia
-
Yin L, Kharbanda S, Kufe D. Mucin 1 oncoprotein blocks hypoxiainducible factor 1 alpha activation in a survival response to hypoxia. J Biol Chem. 2007;282:257-66.
-
(2007)
J Biol Chem
, vol.282
, pp. 257-266
-
-
Yin, L.1
Kharbanda, S.2
Kufe, D.3
-
28
-
-
67649419014
-
MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation
-
Yin L, Kharbanda S, Kufe D. MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation. Int J Oncol. 2009;34:1691-9.
-
(2009)
Int J Oncol
, vol.34
, pp. 1691-1699
-
-
Yin, L.1
Kharbanda, S.2
Kufe, D.3
-
29
-
-
70349172938
-
Apoptosis and glutathione: Beyond an antioxidant
-
Franco R, Cidlowski JA. Apoptosis and glutathione: beyond an antioxidant. Cell Death Differ. 2009;16:1303-14.
-
(2009)
Cell Death Differ
, vol.16
, pp. 1303-1314
-
-
Franco, R.1
Cidlowski, J.A.2
-
30
-
-
45149100643
-
Effective killing of Gleevecresistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism
-
Zhang H, Trachootham D, Lu W, et al. Effective killing of Gleevecresistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism. Leukemia. 2008;22: 1191-9.
-
(2008)
Leukemia
, vol.22
, pp. 1191-1199
-
-
Zhang, H.1
Trachootham, D.2
Lu, W.3
-
31
-
-
77951953060
-
Mammalian mitochondrial complex I: Biogenesis, regulation, and reactive oxygen species generation
-
Koopman WJ, Nijtmans LG, Dieteren CE, et al. Mammalian mitochondrial complex I: biogenesis, regulation, and reactive oxygen species generation. Antioxid Redox Signal. 2010;12:1431-70.
-
(2010)
Antioxid Redox Signal
, vol.12
, pp. 1431-1470
-
-
Koopman, W.J.1
Nijtmans, L.G.2
Dieteren, C.E.3
-
32
-
-
0037112360
-
The bioenergetic signature of cancer: A marker of tumor progression
-
Cuezva JM, Krajewska M, de Heredia ML, et al. The bioenergetic signature of cancer: a marker of tumor progression. Cancer Res. 2002;62:6674-81.
-
(2002)
Cancer Res
, vol.62
, pp. 6674-6681
-
-
Cuezva, J.M.1
Krajewska, M.2
de Heredia, M.L.3
-
33
-
-
17144430514
-
Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5- fluorouracil resistance
-
Shin YK, Yoo BC, Chang HJ, et al. Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5- fluorouracil resistance. Cancer Res. 2005;65:3162-70.
-
(2005)
Cancer Res
, vol.65
, pp. 3162-3170
-
-
Shin, Y.K.1
Yoo, B.C.2
Chang, H.J.3
-
34
-
-
0034637599
-
The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells
-
Sattler M, Verma S, Shrikhande G, et al. The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells. J Biol Chem. 2000;275:24273-8.
-
(2000)
J Biol Chem
, vol.275
, pp. 24273-24278
-
-
Sattler, M.1
Verma, S.2
Shrikhande, G.3
-
35
-
-
20844448882
-
Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species
-
Kim JH, Chu SC, Gramlich JL, et al. Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species. Blood. 2005;105:1717-23.
-
(2005)
Blood
, vol.105
, pp. 1717-1723
-
-
Kim, J.H.1
Chu, S.C.2
Gramlich, J.L.3
-
36
-
-
33745608455
-
BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance
-
Koptyra M, Falinski R, Nowicki MO, et al. BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance. Blood. 2006;108:319-27.
-
(2006)
Blood
, vol.108
, pp. 319-327
-
-
Koptyra, M.1
Falinski, R.2
Nowicki, M.O.3
-
37
-
-
33748146888
-
Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate
-
Trachootham D, Zhou Y, Zhang H, et al. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell. 2006;10:241-52.
-
(2006)
Cancer Cell
, vol.10
, pp. 241-252
-
-
Trachootham, D.1
Zhou, Y.2
Zhang, H.3
-
38
-
-
62649139996
-
Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation
-
Abrahamsson AE, Geron I, Gotlib J, et al. Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation. Proc Natl Acad Sci U S A. 2009;106:3925-9.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 3925-3929
-
-
Abrahamsson, A.E.1
Geron, I.2
Gotlib, J.3
-
39
-
-
3242883359
-
Hydrogen peroxide negatively modulates Wnt signaling through downregulation of beta-catenin
-
Shin SY, Kim CG, Jho EH, et al. Hydrogen peroxide negatively modulates Wnt signaling through downregulation of beta-catenin. Cancer Lett. 2004;212:225-31.
-
(2004)
Cancer Lett
, vol.212
, pp. 225-231
-
-
Shin, S.Y.1
Kim, C.G.2
Jho, E.H.3
-
40
-
-
44049092138
-
Interaction of FOXO with beta-catenin inhibits betacatenin/ T cell factor activity
-
Hoogeboom D, Essers MA, Polderman PE, Voets E, Smits LM, Burgering BM. Interaction of FOXO with beta-catenin inhibits betacatenin/ T cell factor activity. J Biol Chem. 2008;283:9224-30.
-
(2008)
J Biol Chem
, vol.283
, pp. 9224-9230
-
-
Hoogeboom, D.1
Essers, M.A.2
Polderman, P.E.3
Voets, E.4
Smits, L.M.5
Burgering, B.M.6
-
41
-
-
79955979073
-
MUC1-C oncoprotein suppresses reactive oxygen species-induced terminal differentiation of acute myelogenous leukemia cells
-
in press
-
Yin L, Wu Z, Avigan D, et al. MUC1-C oncoprotein suppresses reactive oxygen species-induced terminal differentiation of acute myelogenous leukemia cells. Blood. 2011;(in press).
-
(2011)
Blood
-
-
Yin, L.1
Wu, Z.2
Avigan, D.3
-
42
-
-
33846419112
-
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
-
Tothova Z, Kollipara R, Huntly BJ, et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell. 2007;128:325-39.
-
(2007)
Cell
, vol.128
, pp. 325-339
-
-
Tothova, Z.1
Kollipara, R.2
Huntly, B.J.3
-
43
-
-
0141815939
-
The novel triterpenoid CDDO induces apoptosis by disruption of intracellular redox balance
-
Ikeda T, Sporn M, Honda T, Gribble G, Kufe D. The novel triterpenoid CDDO induces apoptosis by disruption of intracellular redox balance. Cancer Res. 2003;63:5551-8.
-
(2003)
Cancer Res
, vol.63
, pp. 5551-5558
-
-
Ikeda, T.1
Sporn, M.2
Honda, T.3
Gribble, G.4
Kufe, D.5
-
44
-
-
0036095959
-
Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia
-
Konopleva M, Tsao T, Ruvolo P, et al. Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia. Blood. 2002;99:326-35.
-
(2002)
Blood
, vol.99
, pp. 326-335
-
-
Konopleva, M.1
Tsao, T.2
Ruvolo, P.3
-
45
-
-
77951046942
-
Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia
-
Callens C, Coulon S, Naudin J, et al. Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia. J Exp Med. 2010;207:731-50.
-
(2010)
J Exp Med
, vol.207
, pp. 731-750
-
-
Callens, C.1
Coulon, S.2
Naudin, J.3
-
46
-
-
7244250309
-
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
-
Ito K, Hirao A, Arai F, et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature. 2004;431:997-1002.
-
(2004)
Nature
, vol.431
, pp. 997-1002
-
-
Ito, K.1
Hirao, A.2
Arai, F.3
-
47
-
-
79952826417
-
MUC1-C oncoprotein interacts directly with ATM and promotes the DNA damage response to ionizing radiation
-
Huang L, Liao X, Beckett M, et al. MUC1-C oncoprotein interacts directly with ATM and promotes the DNA damage response to ionizing radiation. Genes Cancer. 2010;1:239-50.
-
(2010)
Genes Cancer
, vol.1
, pp. 239-250
-
-
Huang, L.1
Liao, X.2
Beckett, M.3
-
48
-
-
10744220453
-
Human MUC1 carcinoma-associated protein confers resistance to genotoxic anti-cancer agents
-
Ren J, Agata N, Chen D, et al. Human MUC1 carcinoma-associated protein confers resistance to genotoxic anti-cancer agents. Cancer Cell. 2004;5:163-75.
-
(2004)
Cancer Cell
, vol.5
, pp. 163-175
-
-
Ren, J.1
Agata, N.2
Chen, D.3
-
49
-
-
33845296622
-
MUC1 oncoprotein functions in activation of fibroblast growth factor receptor signaling
-
Ren J, Raina D, Chen W, Li G, Huang L, Kufe D. MUC1 oncoprotein functions in activation of fibroblast growth factor receptor signaling. Mol Cancer Res. 2006;4:873-83.
-
(2006)
Mol Cancer Res
, vol.4
, pp. 873-883
-
-
Ren, J.1
Raina, D.2
Chen, W.3
Li, G.4
Huang, L.5
Kufe, D.6
|