Distinct functions of the Mitogen-activated Protein Kinase-activated Protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced Signal Transducers and Activators of Transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3

Journal of Biological Chemistry

Volumn 286, Issue 27, 2011, Pages 24113-24124

  Ehlting, Christian ^a   Ronkina, Natalia ^b   Böhmer, Oliver ^a   Albrecht, Ute ^a   Bode, Konrad A ^c   Lang, Karl S ^a   Kotlyarov, Alexey ^b   Radzioch, Danuta ^d   Gaestel, Matthias ^b   Häussinger, Dieter ^a   Bode, Johannes G ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INFLAMMATORY CYTOKINES; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTORS; MITOGEN-ACTIVATED PROTEINS; NUCLEAR TRANSLOCATIONS; PROTEIN EXPRESSIONS; PROTEIN KINASE; REGULATORY EFFECTS; SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTIONS; SIGNALING EVENTS; TRANSCRIPTIONAL REGULATION;

ANTIBIOTICS; DEGRADATION; ENZYMES; GENES; GLYCOPROTEINS; MACROPHAGES; SIGNALING; TRANSCRIPTION;

PROTEINS;

BETA INTERFERON; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; SMALL INTERFERING RNA; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL NUCLEUS; CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B PROTEINS; INTERFERON REGULATORY FACTOR-3; INTERFERON-BETA; INTERLEUKIN-10; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, KNOCKOUT; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RELA;

EID: 79960027929     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.235275     Document Type: Article

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