Effects of inhaled corticosteroids on the consequences of asthma

Journal of Allergy and Clinical Immunology

Volumn 102, Issue 4 SUPPL., 1998, Pages

  Boushey, Homer A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Asthma; Chronic airflow obstruction; Glucocorticoids; Inflammation; Inhalation drug administration; Irreversible obstruction; Remission; Remodeling; Risk benefit assessment

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID;

AIRWAY OBSTRUCTION; ASTHMA; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; CORTICOSTEROID THERAPY; COST BENEFIT ANALYSIS; DISEASE COURSE; DISEASE SEVERITY; DRUG COST; DRUG EFFECT; DRUG EFFICACY; FIRST AID; HOSPITALIZATION; HUMAN; INHALATIONAL DRUG ADMINISTRATION; PRIORITY JOURNAL; QUALITY OF LIFE; REMISSION; REVIEW; RISK BENEFIT ANALYSIS; SYMPTOMATOLOGY; TREATMENT OUTCOME;

ADMINISTRATION, INHALATION; ADRENAL CORTEX HORMONES; ASTHMA; HUMANS;

EID: 0031792213     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0091-6749(98)70001-6     Document Type: Article

References (137)

1. Beasley R, Pearce N, Crane J. International trends in asthma mortality. Ciba Found Symp 1997;206:140-50.
2. Auerbach I, Springer C, Godfrey S. Total population survey of the frequency and severity of asthma in 17 year old boys in an urban area in Israel. Thorax 1993;48:139-41.
3. Smith DH, Malone DC, Lawson KA, Okamoto LJ, Battista C, Saunders WB. A national estimate of the economic costs of asthma. Am J Respir Crit Care Med 1997;156:787-93.
4. Robertson CF, Rubinfeld AR, Bowes G. Deaths from asthma in Victoria: a 12-month survey. Med J Aust 1990;152:511-7.
5. Robertson CF, Rubinfeld AR, Bowes G. Pediatric asthma deaths in Victoria: the mild are at risk. Pediatr Pulmonol 1992; 13:95-100.
6. Boushey HA. Relationship of asthma severity to fatalities. In: Sheffer AL, editor. Fatal asthma. Vol. 115. In Press. New York: Marcel Dekker; 1998. p. 363-85.
7. National Asthma Education and Prevention Program. Expert panel report 2: guidelines for the diagnosis and management of asthma. Bethesda (MD): NIH/National Heart, Lung, and Blood Institute; April 1997. Publication no. 97-4051.
8. National Asthma Education and Prevention Program Expert Panel. Highlights of the expert panel report 2: guidelines for the diagnosis and management of asthma. Bethesda (MD): NIH/National Heart, Lung, and Blood Institute; May 1997. Publication no. 97-405 1A.
9. Gaddie J, Reid IW, Skinner C, Petrie GR, Sinclair DJM, Palmer KNV. Aerosol beclomethasone dipropionate: a dose response study in chronic bronchial asthma. Lancet 1973;2:280-1.
10. Gaddie J, Reid IW, Skinner C, Petrie GR, Sinclair DJM, Palmer KNV. Aerosol beclomethasone dipropionate in chronic bronchial asthma. Lancet 1973;1:691-3.
11. Cameron SJ, Cooper EJ, Crompton GK, Hoare MV, Grant IWB. Substitution of beclomethasone aerosol for oral prednisolone in the treatment of chronic asthma. Br Med J 1973;4:205-7.
12. Davies G, Thomas P, Broder I, Mintz S, Silverman F, Leznoff A, et al. Steroid-dependent asthma treated with inhaled beclomethasone dipropionate - a long-term study. Ann Intern Med 1977;86:549-53.
13. National Asthma Education Program Expert Panel. Guidelines for the diagnosis and management of asthma. National Asthma Education Program/Expert Panel Report. Bethesda (MD): NIH/National Heart, Lung, and Blood Institute; 1991. Publication No. 91-3042.
14. National Asthma Education Program Expert Panel. Executive summary: guidelines for the diagnosis and management of asthma. National Asthma Education Program/Expert Panel Report. Bethesda (MD): US Department of Health and Human Services/Public Health Service/National Institutes of Health; 1991. p. 71-86. NIH Publication No. 91-3042A.
15. Boushey HA. Clinical diagnosis in adults. In: Barnes PJ, Grunstein MM, Leff AR, Woolcock AJ, editors. Asthma. Vol. 2. Philadelphia: Lippincott-Raven; 1997. p. 1391-403.
16. Blanc PD, Jones M, Besson C, Katz P, Yelin E. Work disability among adults with asthma. Chest 1993;104:1371-7.
17. Juniper EF, Guyatt GH, Ferrie PJ, Griffith LE. Measuring quality of life in asthma. Am Rev Respir Dis 1993;147:832-8.
18. Marks GB, Dunn SM, Woolcock AJ. A scale for the measurement of quality of life in adults with asthma. J Clin Epidemiol 1992;45:461-72.
19. Ellul-Micallef R. History of asthma. In: Barnes PJ, Grunstein MM, Leff AR, Woolcock AJ, editors. Asthma. Vol. 1. Philadelphia: Lippincott-Raven; 1997. p. 9-25.
20. Brown PJ, Greville HW, Finucane KE. Asthma and irreversible airflow obstruction. Thorax 1984;39:131-6.
21. Braman SS, Kaemmerlen JT, Davis SM. Asthma in the elderly: a comparison between patients with recently acquired and long-standing disease. Am Rev Respir Dis 1991;143:336-40.
22. Li D, German D, Lulla S, Thomas RG, Wilson SR. Prospective study of hospitalization for asthma: a preliminary risk factor model. Am J Respir Crit Care Med 1995;151:647-55.
23. Rea HH, Scragg R, Jackson R, Beaglehole R, Fenwick J, Sutherland DC. A case-control study of deaths from asthma. Thorax 1986;41:833-9.
24. Ulrik CS, Frederiksen J. Mortality and markers of risk of asthma death among 1075 outpatients with asthma. Chest 1995; 108:10-5.
25. Chetta A, Foresi A, del Donno M, Bertorelli G, Pesci A, Olivieri D. Airways remodeling is a distinctive feature of asthma and is related to severity of disease. Chest 1997;111:852-7.
26. Siegel D, Sheppard D, Gelb A, Weinberg PF. Aminophylline increases the toxicity but not the efficacy of an inhaled beta-adrenergic agonist in the treatment of acute exacerbation of asthma. Am Rev Respir Dis 1985;132:283-6.
27. Johnson CE. Aerosol corticosteroids for the treatment of asthma. 1987;21:784-90.
28. Kraan J, Koeter GH, van der Mark TW, Sluiter HJ, de Vries K. Changes in bronchial hyperreactivity induced by 4 weeks of treatment with antiasthmatic drugs in patients with allergic asthma: a comparison between budesonide and terbutaline. J Allergy Clin Immunol 1985;76:628-36.
29. Kerrebijn KF, van Essen-Zandvliet EEM, Neijens HJ. Effect of long-term treatment with inhaled corticesteroids and beta-agonists on the bronchial responsiveness in children with asthma. J Allergy Clin Immunol 1987;79:653-9.
30. Laitinen LA, Heino M, Laitinen A, Kava T, Haahtela T. Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis 1985;131:599-606.
31. Djukanovic R, Roche WR, Wilson JW, Beasley CRW, Twentyman OP, Howarth PH, et al. State of the art: mucosal inflammation in asthma. Am Rev Respir Dis 1990;142:434-57.
32. Dunnill MS. The pathology of asthma, with special reference to changes in the bronchial mucosa. J Clin Pathol 1960;13:27-33.
33. Bradley BL, Azzawi M, Jacobson M, Assoufi B, Collins JV, Irani AMA, et al. Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. J Allergy Clin Immunol 1991;88:661-74.
34. Bentley AM, Menz G, Storz C, Robinson DS, Bradley B, Jeffrey PK, et al. Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma: relationship to symptoms and bronchial responsiveness. Am Rev Respir Dis 1992;146:500-6.
35. Nasser SMS, Pfister R, Christie PE, Sousa AR, Barker J, Schmitz-Schumann M, et al. Inflammatory cell populations in bronchial biopsies from aspirin-sensitive asthmatic subjects. Am J Respir Crit Care Med 1996;153:90-6.
36. Saetta M, Di Stefano A, Maestrelli P, de Marzo N, Milani GF, Pivirotto F, et al. Airway mucosal inflammation in occupational asthma induced by toluene diisocyanate. Am Rev Respir Dis 1992;145:160-8.
37. Devalia JL, Rusznak C, Herdman MJ, Trigg CJ, Tarraf H, Davies RJ. Effect of nitrogen dioxide and sulphur dioxide on airway response of mild asthmatic patients to allergen inhalation. Lancet 1994;344:1668-71.
38. Jörres R, Nowak D, Magnussen H. The effect of ozone exposure on allergen responsiveness in subjects with asthma or rhinitis. Am J Respir Crit Care Med 1996;153:56-64.
39. Fraenkel DJ, Bardin PG, Sanderson G, Lampe F, Johnston SL, Holgate ST. Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects. Am J Respir Crit Care Med 1995;151:879-86.
40. Busse WW. The role of respiratory infections in airway hyperresponsiveness and asthma. Am J Respir Crit Care Med 1994;150:S77-9.
41. Godfrey S, König P. Treatment of childhood asthma for 13 months and longer with beclomethasone dipropionate aerosol. Arch Dis Child 1974;49:591-6.
42. Klein R, Waldman D, Kershnar H, Berger W, Coulson A, Katz RM, et al. Treatment of chronic childhood asthma with beclomethasone dipropionate aerosol. I. A double-blind crossover trial in nonsteroid-dependent patients. Pediatrics 1977;60:7-13.
43. Falliers CJ, Petraco AJ. Control of asthma with triamcinolone acetonide aerosol inhalations at 12-hour intervals. J Asthma 1982;19:241-7.
44. Bernstein IL, Chervinsky P, Falliers CJ. Efficacy and safety of triamcinolone acetonide aerosol in chronic asthma: results of a multicenter, short-term controlled and long-term open study. Chest 1982;81:20-6.
45. de Baets FM, Goeteyn M, Kerrebijn KF. The effect of two months of treatment with inhaled budesonide on bronchial responsiveness to histamine and house-dust mite antigen in asthmatic children. Am Rev Respir Dis 1990;142:581-6.
46. Shapiro GG, Izu AE, Furukawa CT, Pierson WE, Bierman CW Short-term double-blind evaluation of flunisolide aerosol for steroid-dependent asthmatic children and adolescents. Chest 1981;80:671-5.
47. Meltzer EO, Kemp JP, Orgel A, Izu AE. Flunisolide aerosol for treatment of severe chronic asthma in steroid-independent children. Pediatrics 1982;69:340-5.
48. Sheffer AL, LaForce C, Chervinsky P, Pearlman D, Schaberg A, the Fluticasone Propionate Asthma Study Group. Fluticasone propionate aerosol: efficacy in patients with mild to moderate asthma. J Fam Pract 1996;42:369-75.
49. Hoekstra MO, Grol MH, Bouman K, Stijnen T, Koëter GH, Kauffman HF, et al. Fluticasone propionate in children with moderate asthma. Am J Respir Crit Care Med 1996;154:1039-44.
50. Calpin C, Macarthur C, Stephens D, Feldman W, Parkin PC. Effectiveness of prophylactic inhaled steroids in childhood asthma: a systematic review of the literature. J Allergy Clin Immunol 1997;100:452-7.
51. Guyatt GH, Feeny DH, Patrick DL. Measuring health-related quality of life. Ann Intern Med 1993;118:622-9.
52. Rutten-van Mölken MPMH, van Doorslaer EKA, Jansen MCC, Kerstjens HAM, Rutten FFH. Costs and effects of inhaled corticosteroids and bronchodilators in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1995; 151:975-82.
53. Bousquet J, Knani J, Dhivert H, Richard A, Chicoye A, Ware JE Jr, et al. Quality of life in asthma. I. Internal consistency and validity of the SF-36 questionnaire. Am J Respir Crit Care Med 1994;149:371-5.
54. Mahajan P, Okamoto LJ, Schaberg A, Kellerman D, Schoenwetter WE Impact of fluticasone propionate powder on health-related quality of life in patients with moderate asthma. J Asthma 1997;34:227-34.
55. Noonan M, Chervinsky P, Busse WW, Weisberg SC, Pinnas J, de Boisblanc B, et al. Fluticasone propionate reduces oral prednisone use while it improves asthma control and quality of life. Am J Respir Crit Care Med 1995;152:1467-73.
56. Dales RE, Schweitzer I, Kerr P, Gougeon L, Rivington R, Draper J. Risk factors for recurrent emergency department visits for asthma. Thorax 1995;50:520-4.
57. Johnston SL. Bronchial hyperresponsiveness and cytokines in virus-induced asthma exacerbations. Clin Exp Allergy 1997;27:7-9.
58. Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L, et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. Br Med J 1995;310:1225-9.
59. Gustafson LM, Proud D, Hendley JO, Hayden FG, Gwaltney JM Jr. Oral prednisone therapy in experimental rhinovirus infections. J Allergy Clin Immunol 1996;97:1009-14.
60. Brunette MG, Lands L, Thibodeau L-P. Childhood asthma: prevention of attacks with short-term corticosteroid treatment of upper respiratory tract infection. Pediatrics 1988;81:624-9.
61. Wennergren G, Kristjáinsson S, Strannegård I-L. Decrease in hospitalization for treatment of childhood asthma with increased use of antiinflammatory treatment, despite an increase in the prevalence of asthma. J Allergy Clin Immunol 1996;97:742-8.
62. Donahue JG, Weiss ST, Livingston JM, Goetsch MA, Greineder DK, Platt R. Inhaled steroids and the risk of hospitalization for asthma. JAMA 1997;277:887-91.
63. Pauwels RA, Lop̈fdahl C-G, Postma DS, Tattersfield AE, O'Byrne P, Barnes PJ, et al. Effect of inhaled formoterol and budesonide on exacerbations of asthma. N Engl J Med 1997;337:1405-11.
64. Crane J, Pearce N, Burgess C, Woodman K, Robson B, Beasley R. Markers of risk of asthma death or readmission in the 12 months following a hospital admission for asthma. Int J Epidemiol 1992;21:737-44.
65. Hetzel MR, Clark TJH, Branthwaite MA. Asthma: analysis of sudden deaths and ventilatory arrests in hospital. Br Med J 1977;1:808-11.
66. Bateman JRM, Clarke SW Sudden death in asthma. Thorax 1979;34:40-4.
67. Drazen JM, Boushey HA, Holgate ST, Kaliner M, O'Byrne P, Valentine M, et al. The pathogenesis of severe asthma: a consensus from the workshop on pathogenesis. J Allergy Clin Immunol 1987;80:428-37.
68. Matsuse H, Shimoda T, Kohno S, Fujwara C, Sakai H, Takao A, et al. A clinical study of mortality due to asthma. Ann Allergy Asthma Immunol 1995;75:267-72.
69. Ruffin RE, Latimer KM, Schembri DA. Longitudinal study of near fatal asthma. Chest 1991;99:77-83.
70. Marquette CH, Saulnier F, Leroy O, Wallaert B, Chopin C, Demarco JM, et al. Long-term prognosis of near-fatal asthma: a 6-year follow-up study of 145 asthmatic patients who underwent mechanical ventilation for a near-fatal attack of asthma. Am Rev Respir Dis 1992;146:76-81.
71. Brompton Hospital/Medical Research Council Collaborative Trial. Double-blind trial comparing two dosage schedules of beclomethasone dipropionate aerosol with a placebo in chronic bronchial asthma. Br J Dis Chest 1979;73:121-32.
72. Smith MJ, Hodson ME. High-dose beclomethasone inhaler in the treatment of asthma. Lancet 1983;1:265-9.
73. Smith MJ, The place of high-dose inhaled corticosteroids in asthma therapy. Drugs 1987;33:423-9.
74. Lacronique J, Renon D, Georges D, Henry-Amar M, Marsac J. High-dose beclomethasone: oral steroid-sparing effect in severe asthmatic patients. Eur Respir J 1991;4:807-12.
75. Hummel S, Lehtonen L, Study Group. Comparison of oral-steroid sparing by high-dose and low-dose inhaled steroid in maintenance treatment of severe asthma. Lancet 1992;340:1483-7.
76. Costello JF, Clark TJH. Response of patients receiving high dose beclomethasone dipropionate. Thorax 1974;29:571-3.
77. Toogood JH, Lefcoe NM, Haines DSM, Jennings B, Errington N, Baksh L, et al. A graded dose assessment of the efficacy of beclomethasone dipropionate aerosol for severe chronic asthma. J Allergy Clin Immunol 1977;59:298-308.
78. Boe J, Rosenhall L, Alton M, Carlsson L-G, Carlsson U, Hermansson B-A, et al. Comparison of dose-response effects of inhaled beclomethasone dipropionate and budesonide in the management of asthma. Allergy 1989;44:349-55.
79. Welch MJ, Levy S, Smith JA, Feiss G, Farrar JR. Dose-ranging study of the clinical efficacy of twice-daily triamcinolone acetonide inhalation aerosol in moderately severe asthma. Chest 1997;112:597-606.
80. Pedersen S, Hansen OR. Budesonide treatment of moderate and severe asthma in children: a dose-response study. J Allergy Clin Immunol 1995;95:29-33.
81. Dahl R, Lundback B, Malo J-L, Mazza JA, Nieminen MM, Saarelainen P, et al. A dose-ranging study of fluticasone propionate in adult patients with moderate asthma. Chest 1993;104:1352-8.
82. Murray JJ, Friedman B, Chervinsky P, Fogarty C, Baker JW, Rogenes PR, et al. Asthma severity as a determinant for selecting appropriate doses of fluticasone propionate (FP) or beclomethasone dipropionate (BDP) [abstract]. J Allergy Clin Immunol 1998;101:S232.
83. Vignola AM, Chanez P, Campbell AM, Souques F, Lebel B, Enander I, et al. Airway inflammation in mild intermittent and in persistent asthma. Am J Respir Crit Care Med 1998;157:403-9.
84. Jeffery PK, Wardlaw AJ, Nelson FC, Collins JV, Kay AB. Bronchial biopsies in asthma: an ultrastructural quantitative study and correlation with hyperreactivity. Am Rev Respir Dis 1989;140:1745-53.
85. Campbell AM, Chanez P, Vignola AM, Bousquet J, Couret I, Michel FB, et al. Functional characteristics of bronchial epithelium obtained by brushing from asthmatic and normal subjects. Am Rev Respir Dis 1993;147:529-34.
86. Bousquet J, Chanez P, Lacoste JY, Barnéon G, Ghavanian N, Enander I, et al. Eosinophilic inflammation in asthma. N Engl J Med 1990;323:1033-9.
87. Roisman GL, Peiffer C, Lacronique JG, Le Cae A, Dusser DJ. Perception of bronchial obstruction in asthmatic patients: relationship with bronchial eosinophilic inflammation and epithelial damage and effect of corticosteroid treatment. J Clin Invest 1995;96:12-21.
88. Wang JH, Trigg CJ, Devalia JL, Jordan S, Davies RJ. Effect of inhaled beclomethasone dipropionate on expression of proinflammatory cytokines and activated eosinophils in the bronchial epithelium of patients with mild asthma. J Allergy Clin Immunol 1994;94:1025-34.
89. Sousa AR, Poston RN, Lane SJ, Nakhosteen JA, Lee TH. Detection of GM-CSF in asthmatic bronchial epithelium and decrease by inhaled corticosteroids. Am Rev Respir Dis 1993;147:1557-61.
90. Laitinen LA, Laitinen A, Haahtela T. A comparative study of the effects of an inhaled corticosteroid, budesonide, and a b2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: a randomized, double-blind, parallel-group controlled trial. J Allergy Clin Immunol 1992;90:32-42.
91. Wilson JW, Djukanovic R, Howarth PH, Holgate ST. Inhaled beclomethasone dipropionate downregulates airway lymphocyte activation in atopic asthma. Am J Respir Crit Care Med 1994;149:86-90.
92. Juniper EF, Kline PA, Vanzieleghem MA, Ramsdale EH, O'Byrne PM, Hargreave FE. Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyperresponsiveness and clinical asthma in nonsteroid-dependent asthmatics. Am Rev Respir Dis 1990;142:832-6.
93. 2-agonist, terbutaline, with an inhaled corticosteroid, budesonide, in newly detected asthma. N Engl J Med 1991;325:388-92.
94. Osterman K, Carlholm M, Ekelund J, Kiviloog J, Nikander K, Nilholm L, et al. Effect of 1 year daily treatment with 400 μg budesonide (Pulmicort® Turbuhaler®) in newly diagnosed asthmatics. Eur Respir J 1997;10:2210-5.
95. Hatoum HT, Schumock GT, Kendzierski DL. Meta-analysis of controlled trials of drug therapy in mild chronic asthma: the role of inhaled corticosteroids. Ann Pharmacother 1994;28:1285-9.
96. Molema J, Van Herwaarden CLA, Folgering HTM. Effects of long-term treatment with inhaled cromoglycate and budesonide on bronchial hyperre-sponsiveness in patients with allergic asthma. Eur Respir J 1989;2:308-16.
97. Dawood AG, Hendry AT, Walker SR. The combined use of betamethasone valerate and sodium cromoglycate in the treatment of asthma. Clin Allergy 1977;7:161-5.
98. Ng SH, Dash CH, Savage SJ. Betamethasone valerate compared with sodium cromoglycate in asthmatic children. Postgrad Med J 1977;53:315-20.
99. Kuzemko JA, Bedford S, Wilson L, Walker SR. A comparison of betamethasone valerate aerosol and sodium cromoglycate in children with reversible airways obstruction. Postgrad Med J 1974;50:53-8.
100. Drazen JM, Israel E. Treating mild asthma: When are inhaled steroids indicated? N Engl J Med 1994;331:737-90.
101. Wolthers OD, Pedersen S. Short term growth during treatment with inhaled fluticasone propionate and beclomethasone dipropionate. Arch Dis Child 1993;68:673-6.
102. Balfour-Lynn L. Growth and childhood asthma. Arch Dis Child 1986;61:1049-55.
103. Allen DB, Mullen M, Mullen B. A meta-analysis of the effect of oral and inhaled corticosteroids on growth. J Allergy Clin Immunol 1994;93:967-76.
104. Garbe E, LeLorier J, Boivin J-F, Suissa S. Inhaled and nasal glucocorticoids and the risks of ocular hypertension or open-angle glaucoma. JAMA 1997;277:722-7.
105. Cumming RG, Mitchell P, Leeder SR. Use of inhaled corticosteroids and the risk of cataracts. N Engl J Med 1997;337:8-14.
106. Bailey WC, Richards JM, Brooks CM, Soong S-J, Brannen AL. Features of asthma in older adults. J Asthma 1992;29:21-8.
107. Schachter EN, Doyle CA, Beck GJ. A prospective study of asthma in a rural community. Chest 1984;85:623-30.
108. Peat JK, Woolcock AJ, Cullen K. Rate of decline of lung function in subjects with asthma. Eur J Respir Dis 1987;70:171-9.
109. Ulrik CS, Backer V, Dirksen A. Mortality and decline in lung function in 213 adults with bronchial asthma: a ten-year follow up. J Asthma 1992;29:29-38.
110. Paganin F, Séneterre E, Chanez P, Daurés JP, Bruel JM, Michel FB, et al. Computed tomography of the lungs in asthma: influence of disease severity and etiology. Am J Respir Crit Care Med 1996;153:110-4.
111. Mitchell RW, Halayko AJ. Airway smooth muscle structure. In: Barnes PJ, Grunstein MM, Leff AR, Woolcock AJ, editors. Asthma. Vol. I. Philadelphia: Lippincott-Raven Publishers; 1997. p. 733-58.
112. Roberts CR, Okazawa M, Wiggs B, Pare PD. Airway wall thickening. In: Barnes PJ, Grunstein MM, Leff AR, Woolcock AJ, editors. Asthma. Vol. I. Philadelphia: Lippincott-Raven Publishers; 1997. p. 925-35.
113. Roche WR. Fibroblasts. In: Barnes PJ, Grunstein MM, Leff AR, Woolcock AJ, editors. Asthma. Vol. I. Philadelphia: Lippincott-Raven Publishers; 1977. p. 953-61.
114. Trigg CJ, Manolitsas ND, Wang J, Calderón MA, McAulay A, Jordan S, et al. Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma. Am J Respir Crit Care Med 1994;150:17-22.
115. Olivieri D, Chetta A, Del Donno M, Bertorelli G, Casalini A, Pesci A, et al. Effect of short-term treatment with low-dose inhaled fluticasone propionate on airway inflammation and remodeling in mild asthma: a placebo-controlled study. Am J Respir Crit Care Med 1997;155:1864-71.
116. Agertoft L, Pedersen S. Effects of long-term treatment with an inhaled corticosteroid on growth and pulmonary function in asthmatic children. Respir Med 1994;88:373-81.
117. Haahtela T, Järvinen M, Kava T, Kiviranta K, Koskinen S, Lehtonen K, et al. Effects of reducing or discontinuing inhaled budesonide in patients with mild asthma. N Engl J Med 1994;331:700-5.
118. Selroos O, Pietinalho A, Löfroos A-B, Riska H. Effect of early vs late intervention with inhaled corticosteroids in asthma. Chest 1995;108:1228-34.
119. Overbeek SE, Kerstjens HAM, Bogaard JM, Mulder PGH, Postma DS. Is delayed introduction of inhaled corticosteroids harmful in patients with obstructive airways disease (asthma and COPD)? Chest 1996;110:35-41.
120. Jaakkola MS, Jaakkola JJK, Ernst P, Becklake MR. Respiratory symptoms in young adults should not be overlooked. Am Rev Respir Dis 1993;147:359-66.
121. Blair H. Natural history of childhood asthma. Arch Dis Child 1977;52:613-9.
122. Martin AJ, McLennan LA, Landau LI, Phelan PD. The natural history of childhood asthma to adult life. Br Med J 1980;280:1397-400.
123. Kelly WJW, Hudson I, Phelan PD, Pain MCF, Olinsky A. Childhood asthma in adult life: a further study at 28 years of age. Br Med J 1987;294:1059-62.
124. Bronnimann S, Burrows B. A prospective study of the natural history of asthma: remission and relapse rates. Chest 1986;90:480-4.
125. Panhuysen CIM, Vonk JM, Koëter GH, Scheuten JP, van Altena R, Bleeker ER, et al. Adult patients may outgrow their asthma: a 25-year follow-up study. Am J Respir Crit Care Med 1997;155:1267-72.
126. Juniper EF, Kline PA, Vanzieleghem MA, Hargreave FE. Reduction of budesonide after a year of increased use: a randomized controlled trial to evaluate whether improvements in airway responsiveness and clinical asthma are maintained. J Allergy Clin Immunol 1991;87:483-9.
127. Pedersen S. Can steroids cause asthma to remit? Am J Respir Crit Care Med 1996;153:S31-2.
128. Bel EH, Timers MC, Zwinderman AH, Dijkman JH, Sterk PJ. The effect of inhaled corticosteroids on the maximum degree of airway narrowing to methacholine. Am Rev Respir Dis 1991;143:109-13.
129. Vathenen AS, Knox AJ, Wisniewski A, Tattersfield AE. Time course of change in bronchial reactivity with an inhaled corticosteroid in asthma. Am Rev Respir Dis 1991;143:1317-21.
130. Magnussen H, Willenbrock U, Jorres R. Airway responsiveness, lung function and symptoms after cessation of high-dose inhaled corticosteroids in patients with bronchial asthma. Am Rev Respir Dis 1992;145:A498.
131. Gibson PG, Wong BJO, Hepperte MJE, Kline PA, Girgis-Gabardo A, Guyatt G, et al. A research method to induce and examine a mild exacerbation of asthma by withdrawal of inhaled corticosteroid. Clin Exp Allergy 1992;22:525-32.
132. Chervinsky P, van As A, Bronsky EA, Dockhorn R, Noonan M, La Force C, et al. Fluticasone propionate aerosol for the treatment of adults with mild to moderate asthma. J Allergy Clin Immunol 1994;94:676-83.
133. van Essen-Zandvliet EE, Hughes MD, Waalkens HJ, Duiverman EJ, Pocock SJ, Kerrebijn KF, et al. Effects of 22 months of treatment with inhaled corticosteroids and/or beta2-agonists on lung function, airway responsiveness, and symptoms in children with asthma. Am Rev Respir Dis 1992;146:547-54.
134. van Essen-Zandvliet EE, Hughes MD, Waalkens HJ, Duiverman EJ, Kerrebijn KF, Dutch CNSLD Study Group. Remission of childhood asthma after long-term treatment with an inhaled corticosteroid (budesonide): Can it be achieved? Eur Respir J 1994;7:63-8.
135. Waalkens HJ, van Essen-Zandvliet EE, Hughes MD, Gerritsen J, Duiverman EJ, Knol K, et al. Cessation of long-term treatment with inhaled corticosteroid (budesonide) in children with asthma results in deterioration. Am Rev Respir Dis 1993;148:1252-7.
136. Djukanovic R, Wilson JW, Britten KM, Wilson SJ, Walls AF, Roche WR, et al. Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am Rev Respir Dis 1992;145:669-74.
137. Jeffery PK, Godfrey RW, Ädelroth E, Nelson F, Rogers A, Johansson SA. Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma: a quantitative light and electron microscopic study. Am Rev Respir Dis 1992;145:890-9.