Probing osmolyte participation in the unfolding transition state of a protein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 24, 2011, Pages 9759-9764

  Dougan, Lorna ^a   Genchev, Georgi Z ^b   Lu, Hui ^b,c   Fernandez, Julio M ^d  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b University of Illinois at Chicago   (United States)

^c SHANGHAI CHILDREN S HOSPITAL   (China)

^d Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Mechanical protein; Protein folding; Single molecule

Indexed keywords

CONNECTIN; ETHYLENE GLYCOL; GLYCEROL; ORGANIC COMPOUND; OSMOLYTE; POLYPROTEIN; PROPYLENE GLYCOL; PROTEIN I 27; SORBITOL; SUCROSE; UNCLASSIFIED DRUG; WATER;

ARTICLE; ATOMIC FORCE MICROSCOPY; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN UNFOLDING;

ETHYLENE GLYCOL; GLYCEROL; HUMANS; HYDROGEN BONDING; KINETICS; MICROSCOPY, ATOMIC FORCE; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUSCLE PROTEINS; MYOCARDIUM; PROPYLENE GLYCOL; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN KINASES; PROTEIN STRUCTURE, SECONDARY; PROTEIN UNFOLDING; PROTEINS; RECOMBINANT PROTEINS; SOLVENTS; SORBITOL; SUCROSE;

EID: 79959964603     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1101934108     Document Type: Article

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