Urea denaturation by stronger dispersion interactions with proteins than water implies a 2-stage unfolding

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 44, 2008, Pages 16928-16933

  Hua, Lan ^a   Zhou, Ruhong ^a,b   Thirumalai C, D ^c   Berne, B J ^a,b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b IBM T J WATSON RESEARCH CENTER   (United States)

^c Bldg 142   (United States)

Author keywords

Denaturing mechanism; Dry globule; Lysozyme unfolding; Molecular dynamics; Preferential binding

Indexed keywords

AMIDE; LYSOZYME; UREA; WATER;

ARTICLE; DISPERSION; HYDRATION; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN INTERACTION; SIMULATION; SOLUBILITY;

HYDROGEN BONDING; MODELS, MOLECULAR; MURAMIDASE; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; UREA; WATER;

EID: 55949131241     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0808427105     Document Type: Article

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