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Volumn 19, Issue 14, 2011, Pages 4366-4376

Synthesis and biological evaluation of novel 5-alkyl-2-arylthio-6-((3,4- dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

(9) Zhang, Jing a Zhan, Peng a Wu, Jingde a Li, Zhenyu a Jiang, Yan a Ge, Weiying a Pannecouque, Christophe b De Clercq, Erik b Liu, Xinyong a

a SHANDONG UNIVERSITY (China)

b REGA INSTITUTE FOR MEDICAL RESEARCH (Belgium)

Author keywords

AIDS; Anti HIV 1 activity; HIV 1; NNRTIs; S DABOs

Indexed keywords

2 [4 CHLOROBENZYLTHIO] 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 2 [4 CHLOROPHENYLCARBONYLMETHYLTHIO] 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 2 [4 CYANOBENZYLTHIO] 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 2 [4 CYANOPHENYLCARBONYLMETHYLTHIO] 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 2 [4 FLUOROBENZYLTHIO] 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 2 [4 FLUOROPHENYLCARBONYLMETHYLTHIO] 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 2 [4 METHOXYBENZYLTHIO] 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 2 [4 METHOXYLPHENYLCARBONYLMETHYLTHIO] 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 2 [4 METHYLBENZYLTHIO] 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 2 [4 METHYLPHENYLCARBONYLMETHYLTHIO] 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 2 [4 NITROBENZYLTHIO] 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 2 [4 NITROPHENYLCARBONYLMETHYLTHIO] 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 2 BENZYLTHIO 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 2 PHENYLCARBONYLMETHYLTHIO 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 5 ALKYL 2 ARYLTHIO 6 [(3,4 DIHYDROQUINOLIN 1 (2H) YL)METHYL]PYRIMIDIN 4(3H) ONE DERIVATIVE; 5 ETHYL 2 [4 FLUOROPHENYLCARBONYLMETHYLTHIO] 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 5 ETHYL 2 [4 METHOXYPHENYLCARBONYLMETHYLTHIO] 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 5 ETHYL 2 PHENYLCARBONYLMETHYLTHIO 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 5 METHYL 2 [4 CHLOROPHENYLCARBONYLMETHYLTHIO] 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 5 METHYL 2 [4 CYANOPHENYLCARBONYLMETHYLTHIO] 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 5 METHYL 2 [4 METHOXYPHENYLCARBONYLMETHYLTHIO] 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 5 METHYL 2 [4 METHYLPHENYLCARBONYLMETHYLTHIO] 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 5 METHYL 2 [4 NITROPHENYLCARBONYLMETHYLTHIO] 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; 5 METHYL 2 PHENYLCARBONYLMETHYLTHIO 6 [(3,4 DIHYDROQUINOLIN 1(2H) YL)METHYL]PYRIMIDIN 4(3H) ONE; DELAVIRDINE; EFAVIRENZ; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION;

ANTI-HIV AGENTS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; HIV REVERSE TRANSCRIPTASE; HIV-1; HIV-2; HUMANS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIMIDINONES; REVERSE TRANSCRIPTASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2;

EID: 79959946469 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2011.05.024 Document Type: Article

Times cited : (31)

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