Biological abilities of rice bran-derived antioxidant phytochemicals for medical therapy

Current Topics in Medicinal Chemistry

Volumn 11, Issue 14, 2011, Pages 1847-1853

  Islam, Md Shafiqul ^a   Nagasaka, Reiko ^b   Ohara, Kazuyuki ^b   Hosoya, Takamitsu ^c   Ozaki, Hiroshi ^a   Ushio, Hideki ^a,b   Hori, Masatoshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO UNIVERSITY OF MARINE SCIENCE AND TECHNOLOGY   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

oryzanol; Adiponectin; Allergy; Antioxidant; Inflammation; Nuclear factor B (NF B); Rice bran; Steryl ferulates

Indexed keywords

24 METHYLENE CYCLOARTANYL FERULATE; ADIPONECTIN; ANTIINFLAMMATORY AGENT; ANTILIPEMIC AGENT; ANTINEOPLASTIC AGENT; ANTIOXIDANT; BETA SITOSTERYL FERULATE; CAFFEIC ACID; CAMPESTANYL FERULATE; CAMPESTEROL; CURCUMIN; CYCLOARTENYL FERULATE; GAMMA ORYZANOL; HERBACEOUS AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; RICE BRAN OIL; RICETRIENOL; SITOSTANOL; STIGMASTEROL; UNCLASSIFIED DRUG; VEGETABLE OIL;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; CANCER INHIBITION; DIABETES MELLITUS; DRUG CARCINOGENICITY; DRUG MECHANISM; DYSLIPIDEMIA; HUMAN; IMMUNOMODULATION; LIPID METABOLISM; NONHUMAN; OXIDATIVE STRESS; PHYTOCHEMISTRY; PROTEIN EXPRESSION; PROTEIN SECRETION; REVIEW; RICE BRAN; TRANSCRIPTION REGULATION;

ADIPONECTIN; ANIMALS; ANTI-ALLERGIC AGENTS; ANTI-INFLAMMATORY AGENTS; COUMARIC ACIDS; CYCLOOXYGENASE 2; HUMANS; HYPERSENSITIVITY; IMMUNITY; INFLAMMATION; INTERLEUKIN-6; MICE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; ORYZA SATIVA; OXIDATIVE STRESS; PHENYLPROPIONATES; PHYTOSTEROLS; PLANT EXTRACTS; PPAR GAMMA; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 79959944649     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/156802611796235099     Document Type: Review

References (62)

1. Xu, Z.; Godber, J. S. Purification and identification of components of o-oryzanol in rice bran oil. J. Agric. Food Chem., 1999, 47, 2724-2728.
2. Jariwalla, R. J. Rice-bran products: phytonutrients with potential applications in preventive and clinical medicine. Drugs Exp. Clin. Res., 2001, 27, 17-26.
3. Kim, S. J; Han, D.; Moon, K. D.; Rhee, J. S. Measurement of superoxide dismutase-like activity of natural antioxidants. Biosci. Biotechnol. Biochem., 1995, 59, 822-826.
4. Castro, L.; Freeman, B. A. Reactive oxygen species in human health and disease. Nutrition., 2001, 17, 161-165.
5. Liang, R.; Senturker, S.; Shi, X.; Bal, W.; Dizdaroglu. M.; Kasprzak, K. S. Effects of Ni(II) and Cu(II) on DNA interaction with the N-terminal sequence of human protamine P2: enhancement of binding and mediation of oxidative DNA strand scission and base damage. Carcinogenesis, 1999, 20, 893-898.
6. Raha, S.; Robinson, B. H. Mitochondria, oxygen free radicals, disease and ageing. Trends Biochem. Sci., 2000, 25, 502-508.
7. Yokozawa, T.;Kim, Y. A.; Kim, H. Y.; Lee, Y.A.; Nonaka, G. Protective effect of persimmon peel polyphenol against high glucose-induced oxidative stress in LLC-PK(1) cells. Food Chem. Toxicol., 2007, 45, 1979-1987.
8. Chun, K. S.; Cha, H. H.; Shin, J. W.; Na, H. K.; Park, K. K.; Chung, W. Y.; Surh, Y. J. Nitric oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF-2B. Carcinogenesis, 2004, 25, 445-454.
9. Surh, Y. J. NF-[B and Nrf2 as potential chemopreventive targets of some anti-inflammatory and antioxidative phytonutrients with antiinflammatory and antioxidative activities. Asia Pac. J. Clin. Nutr., 2008, 17, S269-S272.
10. Chotimarkorn, C.; Ushio, H. The effect of trans-ferulic acid and gamma-oryzanol on ethanol-induced liver injury in C57BL mouse. Phytomedicine, 2008, 15, 951-958.
11. Islam, M. S.; Yoshida, H.; Matsuki, N.; Ono, K.; Nagasaka, R.; Ushio, H.; Guo, Y., Hiramatsu, T., Hosoya, T., Murata, T., Hori, M., Ozaki, H. Antioxidant, free radical-scavenging, and NF-MBinhibitory activities of phytosteryl ferulates: structure-activity studies. J. Pharmacol. Sci., 2009, 111, 328-337.
12. Nagasaka, R.; Chotimarkorn, C.; Shafiqul, I. M.; Hori, M.; Ozaki, H.; Ushio, H. Anti-inflammatory effects of hydroxycinnamic acid derivatives. Biochem. Biophys. Res. Commun., 2007, 358, 615-619.
13. Islam, M. S.; Murata, T.; Fujisawa, M.; Nagasaka, R.; Ushio, H.; Bari, A. M.; Hori, M.; Ozaki, H. Anti-inflammatory effects of phytosteryl ferulates in colitis induced by dextran sulphate sodium in mice. Br. J. Pharmacol., 2008, 154, 812-824.
14. Oka, T.; Fujimoto, M.; Nagasaka, R.; Ushio, H.; Hori, M.; Ozaki, H. Cycloartenyl ferulate, a component of rice bran oil-derived a-oryzanol, attenuates mast cell degranulation. Phytomedicine, 2010, 17, 152-156.
15. Ohara, K.; Uchida, A.; Nagasaka, R.; Ushio, H.; Ohshima, T. The effects of hydroxycinnamic acid derivatives on adiponectin secretion. Phytomedicine, 2009, 16, 130-137.
16. Soobrattee, M. A.; Neergheen, V. S.; Luximon-Ramma, A.; Aruoma, O. I.; Bahorun, T. Phenolics as potential antioxidant therapeutic agents: mechanism and actions. Mutat. Res., 2005, 579, 200-213.
17. Fujinami, Y.; Tai, A.; Yamamoto, I. Radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl of ascorbic acid 2-glucoside (AA-2G) and 6-acyl-AA-2G. Chem. Pharm. Bull., 2001, 49, 642-644.
18. Hiramitsu, T. Armstrong, D. Preventive effect of antioxidants on lipid peroxidation in the retina. Ophthalmic Res., 1991, 23, 196-203.
19. Akiyama, Y.; Hori, K.; Hata, K.; Kawane, M.; Kawamura, Y.; Yoshiki, Y.; Okubo, K. Screening of chemiluminescence constituents of cereals and DPPH radical scavenging activity of o-oryzanol. Luminescence, 2001, 16, 237-241.
20. Xu, Z.; Hua, N.; Godber, J.S. Antioxidant activity of tocopherols, tocotrienols, and t-oryzanol components from rice bran against cholesterol oxidation accelerated by 2,2'-azobis(2-methylpropionamidine) dihydrochloride. J. Agric. Food. Chem., 2001, 49, 2077-20781.
21. Lopez-Revuelta, A.; Sanchez-Gallego, J. I.; Hernandez-Hernandez, A.; Sanchez-Yague, J.; Llanillo, M. Increase in vulnerability to oxidative damage in cholesterol-modified erythrocytes exposed to t-BuOOH. Biochim. Biophys. Acta, 2005, 1734, 74-85.
22. Nystrom, L.; Makinen, M.; Lampi, A. M.; Piironen, V. Antioxidant activity of steryl ferulate extracts from rye and wheat bran. J. Agric. Food Chem., 2005, 53, 2503-2510.
23. Abramov, A. Y.; Scorziello, A.; Duchen, M. R. Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation. J. Neurosci., 2007, 27, 1129-1138.
24. Singh, S.; Aggarwal, B. B. Activation of transcription factor NF-[B is suppressed by curcumin (diferuloylmethane). J. Biol. Chem., 1995, 270, 24995-5000.
25. Natarajan, K.; Singh, S.; Burke, T. R.; Jr. Grunberger, D.; Aggarwal, B. B. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-vB. Proc. Natl. Acad. Sci. U S A., 1996, 93, 9090-9095.
26. Akihisa, T.; Yasukawa, K.; Yamaura, M.; Ukiya, M.; Kimura, Y.; Shimizu, N.; Arai, K. Triterpene alcohol and sterol ferulates from rice bran and their anti-inflammatory effects. J. Agric. Food. Chem., 2000, 48, 2313-2319.
27. Watabe, M.; Hishikawa, K.; Takayanagi, A.; Shimizu, N.; Nakaki, T. Caffeic acid phenethyl ester induces apoptosis by inhibition of NF-NB and activation of Fas in human breast cancer MCF-7 cells. J. Biol. Chem., 2004, 279, 6017-6026.
28. Pan, M. H.; Lin-Shiau, S. Y.; Lin, J. K. Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IoB kinase and NF-BB activation in macrophages. Biochem. Pharmacol., 2000, 60, 665-676.
29. Lipkin, M.; Uehara, K.; Winawer, S.; Sanchez, A.; Bauer, C.; Phillips, R.; Lynch, H. T.; Blattner, W. A.; Fraumeni, J. F. Jr. Seventh-Day Adventist vegetarians have a quiescent proliferative activity in colonic mucosa. Cancer Lett., 1985, 26, 139-144.
30. Raicht, R. F.; Cohen, B. I.; Fazzini, E. P.; Sarwal, A. N.;Takahashi, M. Protective effect of plant sterols against chemically induced colon tumors in rats. Cancer Res., 1980, 40, 403-405.
31. Dreshner, E. E.; Cohen, B. I.; Raicht, R. F. The kinetics of the protective effect of p-sitosterol against MNU-induced colonic neoplasia. J. Cancer Res. Clin. Oncol., 1982, 103, 49-54.
32. Boateng, J. V. M.; Panala, V.; Walker, L. T. Effects of rice bran on chemically induced colon tumorigenesis may be due to synergistic/additive properties of bioactive components. Int. J. Cancer Res., 2009, 5,153-166.
33. Panala, V. V. M.; Boateng, J.; Field, R.; Shackelford, L.; Walker, L. T. A. Comparison of rice bran, corn oil and soybean oil against azoxymethane induced colon cancer in a Fisher 344 rat model. Int. J. Cancer Res., 2009, 5, 25-35.
34. Kong, C. K.; Lam, W. S.; Chiu, L. C.; Ooi, V. E.; Sun, S. S.; Wong, Y. S. A rice bran polyphenol, cycloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis. Biochem. Pharmacol., 2009, 77, 1487-1496.
35. Awad, A. B.; Chen, Y. C.; Fink, C. S.; Hennessey, T. Sitosterol inhibits HT-29 human colon cancer cell growth and alters membrane lipids. Anticancer Res., 1996, 16, 2797-2804.
36. Awad, A. B., Fink, C. S. Phytosterols as anticancer dietary components: evidence and mechanism of action. J. Nutr., 2000, 130, 2127-2130.
37. Luo, H. F.; Li, Q.; Yu, S.; Badger, T. M.; Fang, N. Cytotoxic hydroxylated triterpene alcohol ferulates from rice bran. J. Nat. Prod., 2005, 68, 94-97.
38. Parrado, J. M. E.; Jover, M.; Gutierrez, J. F.; Collantes de Terán, L.; Bautista, J. Preparation of a rice bran enzymatic extract with potential use as functional food. Food Chem. Toxicol., 2006, 98, 742-748.
39. Verschoyle, R. D.; Greaves, P.; Cai, H.; Edwards, R. E.; Steward, W. P.; Gescher, A. J. Evaluation of the cancer chemopreventive efficacy of rice bran in genetic mouse models of breast, prostate and intestinal carcinogenesis. Br. J. Cancer, 2007, 96, 248-254.
40. Hudson, E. A.; Dinh, P. A.; Kokubun, T.; Simmonds, M. S.; Gescher, A. Characterization of potentially chemopreventive phenols in extracts of brown rice that inhibit the growth of human breast and colon cancer cells. Cancer Epidemiol. Biomarkers Prev., 2000, 9, 1163-1170.
41. Yasukawa, K.; Akihisa, T.; Kimura, Y.; Tamura, T.; Takido, M. Inhibitory effect of cycloartenol ferulate, a component of rice bran, on tumor promotion in two-stage carcinogenesis in mouse skin. Biol. Pharm. Bull., 1998, 21, 1072-1076.
42. Cicero, A. F.; Gaddi, A. Rice bran oil and oryzanol in the treatment of hyperlipoproteinaemias and other conditions. Phytother. Res., 2001, 15, 277-289.
43. Wang, Y. W.; Jones, P. J.; Pischel, I.; Fairow, C. Effects of policosanols and phytosterols on lipid levels and cholesterol biosynthesis in hamsters. Lipids, 2003, 38, 165-170.
44. Wilson, T. A.; Nicolosi, R. J.; Woolfrey, B.; Kritchevsky, D. Rice bran oil and oryzanol reduce plasma lipid and lipoprotein cholesterol concentrations and aortic cholesterol ester accumulation to a greater extent than ferulic acid in hypercholesterolemic hamsters. J. Nutr. Biochem., 2007, 18, 105-112.
45. Seetharamaiah, G. S.; Chandrasekhara, N. Studies on hypocholesterolemic activity of rice bran oil. Atherosclerosis, 1989, 78, 219-223.
46. Wilson, T. A.; Ausman, L. M.; Lawton, C. W.; Hegsted. D. M.; Nicolosi, R. J. Comparative cholesterol lowering properties of vegetable oils: beyond fatty acids. J. Am. Coll. Nutr., 2000, 19, 601-607.
47. Nicolosi, R. J.; Ausman, L. M.; Hegsted, D. M. Rice bran oil lowers serum total and low density lipoprotein cholesterol and apo B levels in nonhuman primates. Atherosclerosis, 1991, 88, 133-142.
48. Sharma, R. D.; Rukmini, C. Rice bran oil and hypocholesterolemia in rats. Lipids, 1986, 21, 715-717.
49. Sasaki, J.; Takada, Y.; Handa, K.; Kusuda, M.; Tanabe, Y.; Matsunaga, A.; Arakawa, K. Effects of A-oryzanol on serum lipids and apolipoproteins in dyslipidemic schizophrenics receiving major tranquilizers. Clin. Ther., 1990, 12, 263-268.
50. Rong, N.; Ausman, L. M.; Nicolosi, R. J. Oryzanol decreases cholesterol absorption and aortic fatty streaks in hamsters. Lipids, 1997, 32, 303-309.
51. Rajnarayana, K.; Prabhakar, M. C.; Krishna, D. R. Influence of rice bran oil on serum lipid peroxides and lipids in human subjects. Indian J. Physiol. Pharmacol., 2001, 45, 442-444.
52. Accinni, R,; Rosina, M.; Bamonti, F.; Della Noce, C.; Tonini, A.; Bernacchi, F.; Campolo, J.; Caruso, R.; Novembrino, C.; Ghersi, L.; Lonati, S.; Grossi, S.; Ippoito, S.; Lorenzano, E.; Ciani, A.; Gorini, M. Effects of combined dietary supplementation on oxidative and inflammatory status in dyslipidemic subjects. Nutr. Metab. Cardiovasc. Dis., 2006, 16, 121-127.
53. Kanaya, Y.; Doi, T.; Sasaki, H.; Fujita, A.; Matsuno, S.; Okamoto, K.; Nakano, Y.; Tsujiwaki, S.; Furuta, H.; Nishi, M.; Tsuno, T.; Taniguchi, H.; Nanjo, K. Rice bran extract prevents the elevation of plasma peroxylipid in KKAy diabetic mice. Diabetes Res. Clin. Pract., 2004, 66, S157-S160.
54. Kadowaki, T., Yamauchi, T.; Kubota, N.; Hara, K.; Ueki, K.; Tobe, K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J. Clin. Invest., 2006, 116, 1784-1792.
55. Sierra, S.; Lara-Villoslada, F.; Olivares, M.; Jimenez, J.; Boza, J.; Xaus, J. Increased immune response in mice consuming rice bran oil. Eur. J. Nutr., 2005, 44, 509-516.
56. Aggarwal, B. B.; Sung, B. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol. Sci., 2009, 30, 85-94.
57. Tamagawa, M., Otaki, Y.; Takahashi, T.; Otaka, T.; Kimura, S.; Miwa, T. Carcinogenicity study of M-oryzanol in B6C3F1 mice. Food Chem. Toxicol., 1992, 30, 49-56.
58. Amended final report on the safety assessment of Oryza Sativa (rice) Bran Oil, Oryza Sativa (rice) Germ Oil, Rice Bran Acid, Oryza Sativa (rice) Bran Wax, Hydrogenated Rice Bran Wax, Oryza Sativa (rice)Bran Extract, Oryza Sativa (rice) Extract, Oryza Sativa (rice) Germ Powder, Oryza Sativa (rice) Starch, Oryza Sativa (rice) Bran, Hydrolyzed Rice Bran Extract, Hydrolyzed Rice Bran Protein, Hydrolyzed Rice Extract, and Hydrolyzed Rice Protein. Int. J. Toxicol., 2006, 25, S91-S120.
59. Mizuta, K.; Kaneta, H.; Itaya, K. Effects of [-oryzanol on gastric secretions in rats. Nippon Yakurigaku Zasshi, 1978, 74, 285-295.
60. Ichimaru, Y.; Moriyama, M.; Ichimaru, M.; Gomita, Y. Effects of [-oryzanol on gastric lesions and small intestinal propulsive activity in mice. Nippon Yakurigaku Zasshi, 1984, 84, 537-542.
61. Grunewald, K. K.; Bailey, R. S. Commercially marketed supplements for bodybuilding athletes. Sports Med., 1993, 15, 90-103.
62. Seetharamaiah, G. S.; Krishnakantha, T. P.; Chandrasekhara, N. Influence of oryzanol on platelet aggregation in rats. J. Nutr. Sci. Vitaminol., 1990, 36, 291-297.