Central effects of ghrelin, a unique peptide, on appetite and fluid/water drinking behavior

Current Protein and Peptide Science

Volumn 12, Issue 4, 2011, Pages 280-287

  Hashimoto, Hirofumi ^a   Ueta, Yoichi ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Angiotensin II; Feeding; Fluid water intake; Hypothalamus; Intracerebroventricular; Neuroendocrine; Pituitary; Polyethylene glycol

Indexed keywords

AGOUTI RELATED PROTEIN; ARGIPRESSIN; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; CORTICOTROPIN; GHRELIN; GROWTH HORMONE; HYDROCORTISONE; LUTEINIZING HORMONE; NEUROPEPTIDE Y; PROLACTIN; PROOPIOMELANOCORTIN; THYROTROPIN;

ALCOHOL CONSUMPTION; ANXIETY; APPETITE; ARTICLE; BODY FLUID; BODY TEMPERATURE; CORTICOTROPIN RELEASE; DEHYDRATION; FEEDING BEHAVIOR; FLUID INTAKE; FOOD INTAKE; GROWTH HORMONE RELEASE; HOMEOSTASIS; HUMAN; HYDROCORTISONE RELEASE; HYPOTHALAMUS HYPOPHYSIS SYSTEM; HYPOVOLEMIA; LUTEINIZING HORMONE RELEASE; MUSCLE HYPERTONIA; NEUROENDOCRINE SYSTEM; NONHUMAN; OBESITY; PROLACTIN RELEASE; PROTEIN FUNCTION; SLEEP; STOMACH ACID SECRETION; STOMACH FUNCTION; STOMACH MOTILITY; THYROTROPIN RELEASE;

ANIMALS; APPETITE; DRINKING BEHAVIOR; FEEDING BEHAVIOR; GHRELIN; HUMANS;

EID: 79959935579     PISSN: 13892037     EISSN: 18755550     Source Type: Journal    
DOI: 10.2174/138920311795906727     Document Type: Article

References (82)

1. Kojima, M.; Hosoda, H.; Date, Y.; Nakazato, M.; Matsuo, H.; Kangawa, K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature, 1999, 402, 656-660.
2. Kristenssson, E.; Sundqvist, M.; Astin, M.; Kjerling, M.; Mattsson, H.; Dornonville de la Cour, C.; Håkanson, R.; Lindström, E. Acute psychological stress raises plasma ghrelin in the rat. Regul. Pept., 2006, 134, 114-117.
3. Hashimoto, H.; Fujihara, H.; Kawasaki, M.; Saito, T.; Shibata, M.; Otsubo, H.; Takei, Y.; Ueta, Y. Centrally and peripherally administered ghrelin potently inhibits water intake in rats. Endocrinology, 2007, 148, 1638-1647.
4. Lawrence, C.B.; Snape, A.C.; Baudoin, F.M.; Luckman, S.M. Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers. Endocrinology, 2002, 143,155-162.
5. Nakazato, M.; Murakami, N.; Date, Y.; Kojima, M.; Matsuo, H.; Kangawa, K.; Matsukura, S. A role for ghrelin in the central regulation of feeding. Nature, 2001, 409, 194-198.
6. Sagar, S.M.; Sharp, F.R.; Curran, T. Expression of c-fos protein in brain: metabolic mapping at the cellular level. Science, 1988, 240, 1328-1331.
7. Hashimoto, H.; Otsubo, H.; Fujihara, H.; Suzuki, H.; Ohbuchi, T.; Yokoyama, T.; Takei, Y.; Ueta, Y. Centrally administered ghrelin potently inhibits water intake induced by angiotensin II and hypovolemia in rats. J. Physiol. Sci., 2010, 60, 19-25.
8. Mietlicki, E.G.; Nowak, E.L.; Daniels, D. The effect of ghrelin on water intake during dipsogenic conditions. Physiol. Behav., 2009, 96, 37-43.
9. Date, Y.; Murakami, N.; Kojima, M.; Kuroiwa, T.; Matsukura, S.; Kangawa, K.; Nakazato, M. Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rats. Biochem. Biophys. Res. Commun., 2000, 275, 477-480.
10. Tschop, M.; Smiley, D.L.; Heiman, M.L. Ghrelin induces adiposity in rodents. Nature, 2000, 407, 908-913.
11. Wren, A.M.; Small, C.J.; Ward, H.L.; Murphy, K.G.; Dakin, C.L.; Taheri, S.; Kennedy, A.R.; Roberts, G.H.; Morgan, D.G.; Ghatei, M.A.; Bloom, S.R. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology, 2000, 141, 4325-4328.
12. Unniappan, S.; Lin, X.; Cervini, L.; Rivier, J.; Kaiya, H.; Kangawa, K.; Peter, R.E. Goldfish ghrelin: molecular characterization of the complementary deoxyribonucleic acid, partial gene structure and evidence for its stimulatory role in food intake. Endocrinology, 2002, 143, 4143-4146.
13. Furuse, M.; Tachibana, T.; Ohgushi, A.; Ando, R.; Yoshimatsu, T.; Denbow, D.M. Intracerebroventricular injection of ghrelin and growth hormone releasing factor inhibits food intake in neonatal chicks. Neurosci. Lett., 2001, 301, 123-126.
14. Saito, E.S.; Kaiya, H.; Tachibana, T.; Tomonaga, S.; Denbow, D.M.; Kangawa, K.; Furuse, M. Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks. Regul. Pept., 2005, 125, 201-208.
15. Shousha, S.; Nakahara, K.; Kojima, M.; Miyazato, M.; Hosoda, H.; Kangawa, K.; Murakami, N. Different effects of peripheral and central ghrelin on regulation of food intake in the Japanese quail. Gen. Comp. Endocrinol., 2005, 141, 178-183.
16. Wren, A.M.; Small, C.J.; Abbott, C.R.; Dhillo, W.S.; Seal, L.J.; Cohen, M.A.; Batterham, R.L.; Taheri, S.; Stanley, S.A.; Ghatei, M.A.; Bloom, S.R. Ghrelin causes hyperphagia and obesity in rats. Diabetes, 2001, 50, 2540-2547.
17. Schwartz, M.W.; Woods, S.C.; Porte, D. Jr.; Seeley, R.J.; Baskin, D.G. Central nervous system control of food intake. Nature, 2000, 404, 661-671.
18. Schwartz, M.W.; Seeley, R.J.; Campfield, L.A.; Burn, P.; Baskin, D.G. Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest., 1996, 98, 1101-1106.
19. Mercer, J.G.; Hoggard, N.; Williams, L.M.; Lawrence, C.B.; Hannah, L.T.; Morgan, P.J.; Trayhurn, P. Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J. Neuroendocrinol., 1996, 8, 733-735.
20. Broberger, C.; Johansen, J.; Johansson, C., Schalling, M., Hökfelt, T. The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc. Natl. Acad. Sci. USA, 1998, 95, 15043-15048.
21. Schwartz, M.W.; Seeley, R.J.; Woods, S.C.; Weigle, D.S.; Campfield, L.A.; Burn, P.; Baskin, D.G. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes, 1997, 46, 2119-2123.
22. Kristensen, P.; Judge, M.E.; Thim, L.; Ribel, U.; Christjansen, K.N.; Wulff, B.S.; Clausen, J.T.; Jensen, P.B.; Madsen, O.D.; Vrang, N.; Larsen, P.J.; Hastrup, S. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature, 1998, 393, 72-76.
23. Lawrence, C.B.; Snape, A.C.; Baudoin, F.M.; Luckman, S.M. Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers. Endocrinology, 2002, 143, 155-162.
24. Tamura, H.; Kamegai, J.; Shimizu, T.; Ishii, S.; Sugihara, H.; Oikawa, S. Ghrelin stimulates GH but not food intake in arcuate nucleus ablated rats. Endocrinology, 2002, 143, 3268-3275.
25. Kamegai, J.; Tamura, H.; Shimizu, T.; Ishii, S.; Sugihara, H.; Wakabayashi, I. Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression. Endocrinology, 2000, 141, 4797-4800.
26. Shintani, M.; Ogawa, Y.; Ebihara, K.; Aizawa-Abe, M.; Miyanaga, F.; Takaya, K.; Hayashi, T.; Inoue, G.; Hosoda, K.; Kojima, M.; Kangawa, K.; Nakao, K. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes, 2001, 50, 227-232.
27. Sakurai, T.; Amemiya, A.; Ishii, M.; Matsuzaki, I.; Chemelli, R.M.; Tanaka, H.; Williams, S.C.; Richardson, J.A.; Kozlowski, G.P.; Wilson, S.; Arch, J.R.; Buckingham, R.E.; Haynes, A.C.; Carr, S.A.; Annan, R.S.; McNulty, D.E.; Liu, W.S.; Terrett, J.A.; Elshourbagy, N.A.; Bergsma, D.J.; Yanagisawa, M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell, 1998, 92, 573-585.
28. Toshinai, K.; Date, Y.; Murakami, N.; Shimada, M.; Mondal, M.S.; Shimbara, T.; Guan, J.L.; Wang, Q.P.; Funahashi, H.; Sakurai, T.; Shioda, S.; Matsukura, S.; Kangawa, K.; Nakazato, M. Ghrelin-induced food intake is mediated via the orexin pathway. Endocrinology, 2003, 144,1506-1512.
29. Qu, D.; Ludwig, D.S.; Gammeltoft, S.; Piper, M.; Pelleymounter, M.A.; Cullen, M.J.; Mathes, W.F.; Przypek, R.; Kanarek, R.; Maratos-Flier, E. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature, 1996, 380, 243-247.
30. Szentirmai, E.; Hajdu, I.; Obal, F. Jr, Krueger, J.M. Ghrelin-induced sleep responses in ad libitum fed and food-restricted rats. Brain Res., 2006, 1088, 131-140.
31. Szentirmai, E.; Kapás, L.; Krueger, J.M. Ghrelin microinjection into forebrain sites induces wakefulness and feeding in rats. Am J Physiol Regul Integr Comp Physiol., 2007, 292, R575-R585.
32. Date, Y.; Nakazato, M.; Murakami, N.; Kojima, M.; Kangawa, K.; Matsukura, S. Ghrelin acts in the central nervous system to stimulate gastric acid secretion. Biochem. Biophys. Res. Commun., 2001, 280, 904-907.
33. Mano-Otagiri, A.; Ohata, H.; Iwasaki-Sekino, A.; Nemoto, T.; Shibasaki, T. Ghrelin suppresses noradrenaline release in the brown adipose tissue of rats. J. Endocrinol., 2009, 201, 341-349.
34. Asakawa, A.; Inui, A.; Kaga, T.; Yuzuriha, H.; Nagata, T.; Ueno, N.; Makino, S.; Fujimiya, M.; Niijima, A.; Fujino, M.A.; Kasuga, M. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology, 2001, 120, 337-345.
35. Jerlhag, E.; Egecioglu, E.; Landgren, S.; Salomé, N.; Heilig, M.; Moechars, D.; Datta, R.; Perrissoud, D.; Dickson, S.L.; Engel, J.A. Requirement of central ghrelin signaling for alcohol reward. Proc. Natl. Acad. Sci. USA, 2009, 106, 11318-11323.
36. Leggio, L. Role of the ghrelin system in alcoholism: Acting on the growth hormone secretagogue receptor to treat alcohol-related diseases. Drug News Perspect., 2010, 23, 157-166.
37. Wren, A.M.; Small, C.J.; Fribbens, C.V.; Neary, N.M.; Ward, H.L.; Seal, L.J.; Ghatei, M.A.; Bloom, S.R. The hypothalamic mechanisms of the hypophysiotropic action of ghrelin. Neuroendocrinology, 2002, 76, 316-324.
38. Asakawa, A.; Inui, A.; Kaga, T.; Yuzuriha, H.; Nagata, T.; Fujimiya, M.; Katsuura, G.; Makino, S.; Fujino, M.A.; Kasuga, M. A role of ghrelin in neuroendocrine and behavioral responses to stress in mice. Neuroendocrinology, 2001, 74, 143-147.
39. Carlini, V.P.; Monzón, M.E.; Varas, M.M.; Cragnolini, A.B.; Schiöth, H.B.; Scimonelli, T.N.; de Barioglio, S.R. Ghrelin increases anxiety-like behavior and memory retention in rats. Biochem. Biophys. Res. Commun., 2002, 299, 739-743.
40. Stevanović, D.; Milosević, V.; Starcević, V.P.; Severs, W.B. The effect of centrally administered ghrelin on pituitary ACTH cells and circulating ACTH and corticosterone in rats. Life Sci., 2007, 80, 867-872.
41. Wren, A.M.; Small, C.J.; Ward, H.L.; Murphy, K.G.; Dakin, C.L.; Taheri, S.; Kennedy, A.R.; Roberts, G.H.; Morgan, D.G.; Ghatei, M.A.; Bloom, S.R. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology, 2000, 141, 4325-4328.
42. Cowley, M.A.; Smith, R.G.; Diano, S.; Tschop, M.; Pronchuk, N.; Grove, K.L.; Strasburger, C.J.; Bidlingmaier, M.; Esterman, M.; Heiman, M.L.; Garcia-Segura, L.M.; Nillni, E.A.; Mendez, P.; Low, M.J.; Sotonyi, P.; Friedman, J.M.; Liu, H.; Pinto, S.; Colmers, W.F.; Cone, R.D.; Horvath, T.L. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron, 2003, 37, 649-661.
43. Silva, J.E. Thyroid hormone control of thermogenesis and energy balance. Thyroid, 1995, 5, 481-492.
44. Kokkinos, A.; Mourouzis, I.; Kyriaki, D.; Pantos, C.; Katsilambros, N.; Cokkinos, D.V. Possible implications of leptin, adiponectin and ghrelin in the regulation of energy homeostasis by thyroid hormone. Endocrine, 2007, 32, 30-32.
45. Casanueva, F.F.; Dieguez, C. Ghrelin: the link connecting growth with metabolism and energy homeostasis. Rev. Endocr. Metab. Disord., 2002, 3, 325-338.
46. Riis, A.L.; Hansen, T.K.; Møller, N.; Weeke, J.; Jørgensen, J.O. Hyperthyroidism is associated with suppressed circulating ghrelin levels. J. Clin. Endocrinol. Metab., 2003, 88, 853-857.
47. Caminos, J.E.; Seoane, L.M.; Tovar, S.A.; Casanueva, F.F.; Dieguez, C. Influence of thyroid status and growth hormone deficiency on ghrelin. Eur. J. Endocrinol., 2002, 147, 159-163.
48. Sosić-Jurjević, B.; Stevanović, D.; Milosević, V.; Sekulić, M.; Starcević, V. Central ghrelin affects pituitary-thyroid axis: histomorphological and hormonal study in rats. Neuroendocrinology, 2009, 89, 327-336.
49. Wren, A.M.; Small, C.J.; Abbott, C.R.; Dhillo, W.S.; Seal, L.J.; Cohen, M.A.; Batterham, R.L.; Taheri, S.; Stanley, S.A.; Ghatei, M.A.; Bloom, S.R. Ghrelin causes hyperphagia and obesity in rats. Diabetes, 2001, 50, 2540-2547.
50. Broglio, F.; Benso, A.; Castiglioni, C.; Gottero, C.; Prodam, F.; Destefanis, S.; Gauna, C.; van der Lely, A.J.; Deghenghi, R.; Bo, M.; Arvat, E.; Ghigo, E. The endocrine response to ghrelin as a function of gender in humans in young and elderly subjects. J. Clin. Endocrinol. Metab., 2003, 88, 1537-1542.
51. Messini, C.I.; Dafopoulos, K.; Chalvatzas, N.; Georgoulias, P.; Messinis, I.E. Growth hormone and prolactin response to ghrelin during the normal menstrual cycle. Clin. Endocrinol. (Oxf)., 2009, 71, 383-387.
52. Tena-Sempere, M.; Aguilar, E.; Fernandez-Fernandez, R.; Pinilla, L. Ghrelin inhibits prolactin secretion in prepubertal rats. Neuroendocrinology, 2004, 79, 133-141.
53. Tena-Sempere, M.; Barreiro, M.L.; González, L.C.; Gaytán, F.; Zhang, F.P.; Caminos, J.E.; Pinilla, L.; Casanueva, F.F.; Diéguez, C.; Aguilar, E. Novel expression and functional role of ghrelin in rat testis. Endocrinology, 2002, 143, 717-725.
54. Caminos, J.E.; Tena-Sempere, M.; Gaytán, F.; Sanchez-Criado, J.E.; Barreiro, M.L.; Nogueiras, R.; Casanueva, F.F.; Aguilar, E.; Diéguez, C. Expression of ghrelin in the cyclic and pregnant rat ovary. Endocrinology, 2003, 144, 1594-1602.
55. Gaytan, F.; Barreiro, M.L.; Chopin, L.K.; Herington, A.C.; Morales, C.; Pinilla, L.; Casanueva, F.F.; Aguilar, E.; Diéguez, C.; Tena-Sempere, M. Immunolocalization of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in the cyclic human ovary. J. Clin. Endocrinol. Metab., 2003, 88, 879-887.
56. Gaytan, F.; Barreiro, M.L.; Caminos, J.E.; Chopin, L.K.; Herington, A.C.; Morales, C.; Pinilla, L.; Paniagua, R.; Nistal, M.; Casanueva, F.F.; Aguilar, E.; Diéguez, C.; Tena-Sempere, M. Expression of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in normal human testis and testicular tumors. J. Clin. Endocrinol. Metab., 2004, 89, 400-409.
57. Furuta, M.; Funabashi, T.; Kimura, F. Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats. Biochem. Biophys. Res. Commun., 2001, 288, 780-785.
58. Fernández-Fernández R, Tena-Sempere M, Aguilar E, Pinilla L. Ghrelin effects on gonadotropin secretion in male and female rats. Neurosci. Lett., 2004, 362, 103-107.
59. Ishizaki, S.; Murase, T.; Sugimura, Y.; Kakiya, S.; Yokoi, H.; Tachikawa, K.; Arima, H.; Miura, Y.; Oiso, Y. Role of ghrelin in the regulation of vasopressin release in conscious rats. Endocrinology, 2002, 143, 1589-1593.
60. Korbonits, M.; Little, J.A.; Forsling, M.L.; Tringali, G.; Costa, A.; Navarra, P.; Trainer, P.J.; Grossman, A.B. The effect of growth hormone secretagogues and neuropeptide Y on hypothalamic hormone release from acute rat hypothalamic explants. J. Neuroendocrinol., 1999, 11, 521-528.
61. Yokoyama, T.; Saito, T.; Ohbuchi, T.; Suzuki, H.; Otsubo, H.; Okamoto, T.; Fujihara, H.; Nagatomo, T.; Ueta, Y. Ghrelin Potentiates Miniature Excitatory Postsynaptic Currents in Rat Supraoptic Magnocellular Neurones. J. Neuroendocrinol., 2009, 21, 910-920
62. Wuarin, J.P.; Dudek, F.E; Patch-clamp analysis of spontaneous synaptic currents in supraoptic neuroendocrine cells of the rat hypothalamus. J. Neurosci., 1993, 13, 2323-2331.
63. Meeker, R.B.; Swanson, D.J.; Greenwood, R.S.; Hayward, J.N. Quantitative mapping of glutamate presynaptic terminals in the supraoptic nucleus and surrounding hypothalamus. Brain Res., 1993, 600, 112-122.
64. Hosoda, H.; Kojima, M.; Matsuo, H.; Kangawa, K. Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem. Biophys. Res. Commun., 2000, 279, 909-913.
65. Heijboer, A.C.; van den Hoek, A.M.; Parlevliet, E.T.; Havekes, L.M.; Romijn, J.A.; Pijl, H.; Corssmit, E.P. Ghrelin differentially affects hepatic and peripheral insulin sensitivity in mice. Diabetologia, 2006, 49, 732-738.
66. Muccioli, G.; Baragli, A.; Granata, R.; Papotti, M.; Ghigo, E. Heterogeneity of ghrelin/growth hormone secretagogue receptors. Toward the understanding of the molecular identity of novel ghrelin/GHS receptors. Neuroendocrinology, 2007, 86, 147-164.
67. Sharif Naeini, R.; Witty, M.F.; Seguela, P.; Bourque, C.W. An Nterminal variant of Trpv1 channel is required for osmosensory transduction. Nat. Neurosci., 2006, 9, 93-98.
68. Gimpl, G.; Fahrenholz, F. The oxytocin receptor system: structure, function, and regulation. Physiol. Rev., 2001, 81, 629-683.
69. Landgraf, R.; Neumann, I.D. Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication. Front Neuroendocrinol., 2004, 25, 150-176.
70. Olszewski, P.K.; Bomberg, E.M.; Martell, A.; Grace, M.K.; Levine, A.S. Intraventricular ghrelin activates oxytocin neurons: implications in feeding behavior. Neuroreport, 2007, 18, 499-503.
71. de Castro, J.M. A microregulatory analysis of spontaneous fluid intake by humans: evidence that the amount of liquid ingested and its timing is mainly governed by feeding. Physiol. Behav., 1988, 43, 705-714
72. Morgan, C.A.; Emmans, G.C.; Tolkamp, B.J.; Kyriazakis, I. Analysis of the feeding behavior of pigs using different models. Physiol. Behav., 2000, 68, 395-403.
73. Kissileff, H.R. Food-associated drinking in the rat. J. Comp. Physiol. Psychol., 1969, 67, 284-300.
74. Tsushima, H.; Mori, M. Antidipsogenic effects of a TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate, injected into the cerebroventricle. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2006, 290, R1736-R1741. 22.
75. Toshinai, K.; Yamaguchi, H.; Sun, Y.; Smith, R.G.; Yamanaka, A.; Sakurai, T.; Date, Y.; Mondal, M.S.; Shimbara, T.; Kawagoe, T.; Murakami, N.; Miyazato, M.; Kangawa, K.; Nakazato, M. Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor. Endocrinology, 2006, 147, 2306-2314.
76. Asakawa, A.; Inui, A.; Fujimiya, M.; Sakamaki, R.; Shinfuku, N.; Ueta, Y.; Meguid, M.M.; Kasuga, M. Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin. Gut, 2005, 54, 18-24.
77. Matsuda, K.; Miura, T.; Kaiya, H.; Maruyama, K.; Shimakura, S.; Uchiyama, M.; Kangawa, K.; Shioda, S. Regulation of food intake by acyl and des-acyl ghrelins in the goldfish. Peptides, 2006, 27, 2321-2325.
78. Stricker, E.M.; Verbalis, J.G. Interaction of osmotic and volume stimuli in regulation of neurohypophyseal secretion in rats. Am. J. Physiol., 1986, 250, R267-R275.
79. Johnson, A.K. The sensory psychobiology of thirst and salt appetite. Med. Sci. Sports Exerc., 2007, 39, 1388-1400.
80. McKinley, M.J.; Walker, L.L.; Alexiou, T.; Allen, A.M.; Campbell, D.J.; Di Nicolantonio, R.; Oldfield, B.J.; Denton, D.A. Osmoregulatory fluid intake but not hypovolemic thirst is intact in mice lacking angiotensin. Am J Physiol Regul Integr Comp. Physiol., 2008, 294, R1533-1543.
81. Kozaka, T.; Fujii, Y.; Ando, M. Central effects of various ligands on drinking behavior in eels acclimated to seawater. J. Exp. Biol., 2003, 206, 687-692.
82. Tachibana, T.; Kaiya, H.; Denbow, D.M.; Kangawa, K.; Furuse, M. Central ghrelin acts as an anti-dipsogenic peptide in chicks. Neurosci. Lett., 2006, 405, 241-245.