The effect of centrally administered ghrelin on pituitary ACTH cells and circulating ACTH and corticosterone in rats

Life Sciences

Volumn 80, Issue 9, 2007, Pages 867-872

  Stevanovic D ^a   Milosevic V ^b   Starcevic V P ^a   Severs, W B ^c  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

ACTH cells; Ghrelin; Intracerebroventricular injection; Morphology; Pituitary; Rats

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; GHRELIN; GROWTH HORMONE; GROWTH HORMONE SECRETAGOGUE; PEPTIDE;

ADRENAL GLAND; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APPETITE; ARTICLE; CELL DENSITY; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOSTERONE RELEASE; CORTICOTROPIN BLOOD LEVEL; CORTICOTROPIN RELEASE; DRUG EFFECT; GROWTH HORMONE RELEASE; HYPERTROPHY; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MALE; MORPHOLOGY; NONHUMAN; ORGAN WEIGHT; PARACRINE SIGNALING; PROTEIN EXPRESSION; RAT; STRESS;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; BODY WEIGHT; CELL SIZE; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAVENTRICULAR; MALE; ORGAN SIZE; PEPTIDE HORMONES; PITUITARY GLAND; RATS; RATS, WISTAR;

RATTUS;

EID: 33846540210     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2006.11.018     Document Type: Article

References (41)

1. Arvat E., Maccario M., di Vito L., Broglio F., Benso A., Gottero C., Papotti M., Muccioli G., Dieguez C., Casaneuva F.F., Deghenghi R., Camanni F., and Ghigo E. Endocrine activities of ghrelin a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone. Journal of Clinical Endocrinology and Metabolism 86 (2001) 1169-1174
2. Asakawa A., Inai A., Kaga T., Juzuriha H., Nagata T., Fujiama M., Katsuura G., Makino S., Fujino M.A., and Kasuga M. A role of ghrelin in neuroendocrine and behavioral responses to stress in mice. Neuroendocrinology 74 (2001) 143-147
3. Carlini V.P., Varas M.M., Cragnolini A.B., Schioth H.B., Scimonelli T.N., and de Barioglio S.R. Differential role of the hippocampus, amygdala, and dorsal raphe nucleus in regulating feeding, memory, and anxiety-like behavioral responses to ghrelin. Biochemical and Biophysical Research Communications 313 (2004) 635-641
4. Casanueva F.F., and Dieguez C. Growth hormone secretagogues: physiological role and clinical utilities. Trends in Endocrinology and Metabolism 10 (1999) 30-38
5. Casanueva F.F., and Dieguez C. Ghrelin: the link connecting growth with metabolism and energy homeostasis. Reviews in Endocrine and Metabolic Disorders 3 4 (2002) 325-338
6. Chang C.H., Rickes E.L., Marsilio F., McGuire L., Cosgrove S., Taylor J., Chen H., Feighner S., Clark J.N., and DeVita R. Activity of novel non peptidyl GH secretagogue L-700, 653, in swine. Endocrinology 136 (1995) 1065-1071
7. Clark R.G., Thomas G.B., Mortensen D.L., Won W.B., Ma Y.H., Tomlinson E.E., Fairhall K.M., and Robinson I.C. Growth hormone secretagogues stimulate hypothalamic-pituitary-adrenal axis and are diabetogenic in the Zucker diabetic fatty rat. Endocrinology 138 (1997) 4316-4323
8. Cone R.D., Cowley M.A., Butler A.A., Fan W., Marks D.L., and Low M.J. The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis. International Journal of Obesity and Related Metabolic Disorders 25 Suppl 5 (2001) S63-S67
9. Cowely M.A., Smith R.G., Diano S., Tschop M., Pronchuk N., Grove K.L., Strasburger C.M., Bidlingmaier M., Esterman M., Heiman M.L., Garcia-Segura L.M., Nillni E.A., Mendez P., Low M.J., Sotonyi P., Friedman J.M., Liu H., Pinto S., Colmers W.F., Cone R.D., and Horvath T.L. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37 (2003) 649-661
10. Elias K.A., Ingle G.S., Burnier J.P., Hammonds R.G., McDowell R.S., Rawson T.E., Somers T.C., Stanley M.S., and Cronin M.J. In vitro characterization of novel classes of growth hormone-releasing peptide. Endocrinology 136 (1995) 5694-5699
11. Ghigo E., Arvat E., Muccioli G., and Camanni F. Growth hormone-releasing peptides. European Journal of Endocrinology 136 (1997) 445-460
12. Ghigo E., Arvat E., and Camanni F. Growth hormone secretagogues as corticotrophin releasing factors. Growth Hormone and IGF Research 8 (1998) 145-148
13. Gillies G., and Lowry P. Corticotropin releasing factor may be modulated vasopressin. Nature 278 (1979) 463-464
14. Gnanapavan S., Kola B., Bustin S.A., Morris D.G., McGee P., Fairclough P., Bhattacharya S., Carpenter R., Grossman A.B., and Korbonits M. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. Journal of Clinical Endocrinology and Metabolism 87 (2002) 2988-2995
15. Guillemin R. Starling review: hypothalamic hormones a.k.a. hypothalamic releasing factors. Journal of Endocrinology 184 (2005) 11-28
16. Hickey G., Jacks T., Judith F., Taylor J., Schoen W., Krupa D., Cunningham P., Clark J., and Smith R.G. Efficacy and specificity of L692.429. A novel non peptidyl growth hormone secretagogue, in beagles. Endocrinology 134 (1994) 695-701
17. Hickey G.I., Drisko J., Faidley T., Chang C., Anderson L.L., Nicolich S., McGuire L., Rickes E., Krupa D., Feeney W., Friscino B., Cunningham P., Frazier E., Chen H., Laroque P., and Smith R.G. Mediation by the central nervous system is critical to the in vivo activity of GH secretagogue L-692, 585. Journal of Endocrinology 148 (1996) 371-380
18. Horvath T.L., Diano S., Sotonyi P., Heiman M., and Tschop M. Minireview: ghrelin and the regulation of energy balance-a hypothalamic perspective. Endocrinology 142 (2001) 4163-4169
19. Jacks T., Hickey G., Judith F., Taylor J., Chen H., Krupa D., Feeney W., Schoen W., Ok D., and Fisher M. Effects of acute and repeated intravenous administration of L692.585. A novel non peptidyl growth hormone seretagogue, on plasma growth hormone, IGF-1, ACTH, cortisol, prolactin, insulin, and thyroxine levels in beagles. Journal of Endocrinology 143 (1994) 399-406
20. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
21. Korbonits M., and Grossman A.B. Growth hormone-releasing peptide and its analogues; novel stimuli to growth hormone release. Trends in Endocrinology and Metabolism 6 (1995) 43-49
22. Korbonits M., and Grossman A.B. Ghrelin: update on a novel hormonal system. European Journal of Endocinology 151 (2004) S67-S70
23. Korbonits M., Kaltsas G., Perry L.A., Putignanno P.P., and Grossman A.B. The growth hormone secretagogue hexarelin stimulates the hypothalamo-pituitary-adrenal axis via arginine-vasopressin. Journal of Clinical Endocrinology and Metabolism 84 (1999) 2489-2495
24. Korbonits M., Little J.A., Forsling M.L., Tringali G., Costa A., Navarra P., Trainer P.J., and Grossman A.B. The effect of growth hormone secretagogues and neuropeptide Y on hypothalamic hormone release from acute rat hypothalamic explants. Journal of Neuroendocrinology 11 (1999) 521-528
25. Malendowicz L.K. Sex differences in adrenocortical structure and function. I. The effects of postpubertal gonadectomy and gonadal hormone replacement on nuclear volume of adrenocortical cells in the rat. Cell and Tissue Research 151 (1974) 525-536
26. Mozid A.M., Tringali G., Forsling M.L., Hendricks M.S., Ajodha S., Edwards R., Navarra P., Grossman A.B., and Korbonits M. Ghrelin is released from rat hypothalamic explants and stimulates corticotrophin releasing hormone and arginine-vasopressine. Hormone and Metabolic Research 35 (2003) 455-459
27. 125I-labeled ghrelin to membranes from human hypothalamus and pituitary gland. Journal of Endocrinological Investigation 24 (2001) RC7-RC9
28. Saito E.S., Kaiya H., Tachibana T., Tomoaga S., Denbow D.M., Kangawa K., and Furose M. Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks. Regulatory Peptides 125 (2005) 201-208
29. Sato T., Rukue Y., Yoshida Y., and Kojima M. Molecular forms of hypothalamic ghrelin and its regulation by fasting and 2-deoxy-d-glucose administration. Endocrinology 146 (2005) 2510-2516
30. Smith R.G., Cheng K., Schoen W.R., Pong S.S., Hickey G., Jacks T., Butler B., Chan W.W., Chaung L.Y., and Judith F. A non-peptidyl GH secretagogue. Science 260 (1993) 1640-1643
31. Starčević V.P., Morrow B.A., Farner L.A., Keil L.C., and Severs W.B. Long-term recording of cerebrospinal fluid pressure in freely behaving rats. Brain Research 462 (1988) 112-117
32. Starcevic V.P., Milosevic V., Brkic B., and Severs W.B. Effects of centrally applied somatostatin on pituitary adrenocorticotropes in female rats. Pharmacology 60 (2000) 203-207
33. Sternberger L.A., Hardy P.H.J., Cuculius J.J., and Meyer H.G. The unlabelled antibody enzyme method of immunohistochemistry. Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. Histochemistry and Cytochemistry 18 (1970) 315-333
34. Takaya K., Ariyasu H., Kanamoto N., Iwakura I.I., Yuoshimoto A., Harada M., Mori K., Komatsu Y., Usui T., Shimatsu A., Ogawa Y., Hosoda K., Akamizu T., Kojima M., Kangawa K., and Nakao K. Ghrelin strongly stimulates growth hormone release in humans. Journal of Clinical and Endocrine Metabolism 85 (2000) 4908-4911
35. Thomas G.B., Fairhall K.M., and Robinson I.C.A.F. Activation of the hypothalamo-pituitary-adrenal axis by the growth hormone (GH) secretagogue, GH-releasing peptide-6, in rats. Endocrinology 138 (1997) 1585-1591
36. Van der Lely A.J., Tschop M., Heiman M.L., and Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocrine Reviews 25 (2004) 426-457
37. Volante M., Allia E., Gugliotta P., Funaro A., Broglio F., Deghenghi R., Mucciolo G., Ghigo R., and Papotti M. Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. Journal of Clinical and Endocrine Metabolism 87 (2002) 1300-1308
38. Weibel E.R. Stereological Methods. 1. Practical Methods for Biological Morphometry (1979), Academic Press, London
39. Weibel E.R., and Gomez D.M. A principle for counting tissue structures on random sections. Journal of Applied Physiology 17 (1962) 343-348
40. Wren A.M., Small C.J., Ward H.L., Murphy K.G., Dakin C.L., Taheri C., Kennedy A.R., Roberts G.H., Morgan D.G., Ghatei M.A., and Bloom S.R. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141 11 (2000) 4325-4328
41. Wren A.M., Small C.J., Fribbens C.V., Neary N.M., Ward H.L., Seal L.J., Ghatei M.A., and Bloom S.R. The hypothalamic mechanisms of the hypophysiotrophic action of ghrelin. Neuroendocrinology 76 (2002) 316-324