Ghrelin inhibits prolactin secretion in prepubertal rats

Neuroendocrinology

Volumn 79, Issue 3, 2004, Pages 133-141

  Tena Sempere, Manuel ^a   Aguilar, Enrique ^a   Fernandez Fernandez, Rafael ^a   Pinilla, Leonor ^a  

^a UNIVERSITY OF CÓRDOBA   (Spain)

Author keywords

Catecholamines; Excitatory amino acids; Ghrelin; Nitric oxide; Prolactin; Puberty; Serotonin

Indexed keywords

5 HYDROXYTRYPTOPHAN; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINO ACID; DOMPERIDONE; DOPAMINE; FLUOXETINE; GHRELIN; N METHYL DEXTRO ASPARTIC ACID; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROLACTIN; SEROTONIN;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; HYPERPROLACTINEMIA; HYPOPHYSIS; HYPOTHALAMUS; IN VITRO STUDY; MALE; NONHUMAN; ONTOGENY; PREPUBERTY; PRIORITY JOURNAL; PROLACTIN RELEASE; RAT; SEROTONINERGIC SYSTEM; SEX DIFFERENCE;

AGE FACTORS; ANIMALS; DOPAMINE; DOWN-REGULATION; EXCITATORY AMINO ACIDS; FEMALE; HYPOTHALAMUS; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENTRICULAR; MALE; NITRIC OXIDE; PEPTIDE HORMONES; PITUITARY GLAND; PROLACTIN; RATS; SEROTONIN; SEX CHARACTERISTICS; SEXUAL MATURATION;

EID: 2342511673     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000077271     Document Type: Article

References (54)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K: Ghrelin is a growth-hormone releasing acylated peptide from stomach. Nature 1999;402:656-660.
2. Kojima M, Hosoda H, Matsuo H, Kangawa K: Ghrelin: Discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends Endocrinol Metab 2001;12:118-122.
3. Hosoda H, Kojima M, Matsuo H, Kangawa K: Purification and characterization of rat des-Gln14-ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor. J Biol Chem 2000;275:1995-2000.
4. Hosoda H, Kojima M, Mizushima T, Shimizu S, Kangawa K: Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing. J Biol Chem 2003;278:64-70.
5. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, Kennedy AR, Roberts GH, Morfgan GA, Ghatei MA, Bloom SR: The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 2000;141:4325-4328.
6. Ghigo E, Arvat E, Giordano R, Broglio F, Gianotti L, Maccario M, Bisi G, Graziani A, Papotti M, Muccioli G, Deghenghi R, Camanni F: Biological activities of growth hormone secretagogues in humans. Endocrine 2001;14:87-93.
7. Arvat E, Gianotti L, Giordano R, Broglio F, Maccario M, Lanfranc F, Muccioli G, Papotti M, Graziani A, Ghigo E, Deghenghi R: Growth hormone-releasing hormone and growth hormone secretagogue-receptor ligands: Focus on reproductive system. Endocrine 2001;14:35-43.
8. Arvat E, Maccario M, Di Vito L, Broglio F, Benso A, Cottero C, Papotti M, Muccioli G, Dieguez C, Casanueva FF, Deghenghi R, Camanni F, Ghigo E: Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: Comparison and interactions with hexarelin, a non-natural peptidyl GHS and GH-releasing hormone. J Clin Endocrinol Metab 2001;86:1169-1174.
9. Tayaka K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, Mori K, Komatsu Y, Usui T, Shimatsu A, Ogawa Y, Hosoda K, Akamizu T, Kojima M, Kangawa K, Nakao K: Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 2000;85:4908-4911.
10. Ahnfelt-Ronne I, Nowak J, Olsen UB: Do growth hormone-releasing peptides act as ghrelin secretagogues? Endocrine 2001;14:133-135.
11. Hataya Y, Akamizu T, Takaya K, Kanamoto N, Ariyasu H, Saijo M: A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans. J Clin Endocrinol Metab 2001;86:4552-4555.
12. Seoane LM, Tovar S, Baldelli R, Arvat E, Ghigo E, Casanueva FF, Dieguez C: Ghrelin elicits a marked stimulatory effect on GH secretion in freely-moving rats. Eur J Endocrinol 2000;143:R7-R9.
13. Peino R, Baldelli R, Rodriguez-Garcia J, Rodriguez-Segade S, Kojima M, Kangawa K, Arvat E, Ghigo E, Dieguez C, Casanueva F: Ghrelin-induced growth hormone secretion in humans. Eur J Endocrinol 2000;143:R11-R14.
14. García A, Alvarez CV, Smith RG, Dieguez C: Regulation of pit-1 expression by ghrelin and GHRP-6 through the GH secretagogue receptor. Mol Endocrinol 2001;15:1484-1495.
15. Yamazaki M, Nakamura K, Kobayashi H, Matsubara M, Hayashi Y, Kangawa K, Sakai T: Regulational effect of ghrelin on growth hormone secretion from perifused rat anterior pituitary cells. J Neuroendocrinol 2002;14:156-162.
16. Wren AM, Small CJ, Kennedy AR, Ghatei MA, Bloom SR: Investigation of the hypothalamic mechanism mediating pituitary hormone release by ghrelin. 5th European Congress of Endocrinology, Turin 2001, O-054.
17. Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H, Wakabayashi I: Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression. Endocrinology 2000;141:4797-4800.
18. Furuta M, Funabashi T, Kimura F: Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats. Biochem Biophys Res Commun 2001;288:780-785.
19. Tolle V, Zizzari P, Tomasetto C, Rio MC, Epelnbaum J, Bluet-Pajot MT: In vivo and in vitro effects of ghrelin/motilin-related peptide on growth hormone secretion in the rat. Neuroendocrinology 2001;73:54-61.
20. Ben-Jonathan N: Dopamine: A prolactin-inhibiting hormone. Endocr Rev 1985;6:564-589.
21. Pinilla L, González D, Tena-Sempere M, Aguilar R, Aguilar E: Effects of N-methyl-D-aspartate and kainic acid on prolactin secretion in prepubertal female rats. Eur J Endocrinol 1996;135:464-468.
22. Pinilla L, González D, Tena-Sempere M, Aguilar R, Aguilar E: Mechanisms of inhibitory action of kainic acid on prolactin secretion in male rats. J Endocrinol 1996;151:159-167.
23. Aguilar E, Tena-Sempere M, Aguilar R, González D, Pinilla L: Interactions between N-methyl-D-aspartate, nitric oxide and serotonin in the control of prolactin secretion in prepubertal male rats. Eur J Endocrinol 1997;137:99-106.
24. González LC, Pinilla L, Tena-Sempere M, Aguilar E: Role of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in the control of prolactin, growth hormone and gonadotropin secretion in prepubertal rats. J Endocrinol 1999;162:417-424.
25. González LC, Pinilla L, Tena-Sempere M, Aguilar E: Regulation of prolactin secretion by α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in male rats. J Endocrinol 2000;166:669-675.
26. Pinilla L, González L, Tena-Sempere M, Aguilar E: Activation of AMPA receptors inhibits prolactin and estradiol secretion and delays the onset of puberty in female rats. J Steroid Biochem Mol Biol 2000;75:277-281.
27. Pinilla L, González LC, Tena-Sempere M, Aguilar E: Interactions between serotoninergic and aminoacidergic pathways in the control of PRL secretion in prepubertal male rats. J Physiol Biochem 2001;57:237-244.
28. Muller EE, Nistico G: Brain Messengers and Pituitary. San Diego, Academic Press, 1989.
29. Weiner RI, Findell PR, Kordon C: Role of classic and peptide neuromediators in the neuroendocrine regulation of LH and prolactin; in Knobill E, Neill JD (eds): The physiology of reproduction. New York, Raven Press, 1994, pp 1235-1281.
30. Aguilar E, Ranchal A, Tena-Sempere M, Pinilla L: Serotoninergic control of prolactin secretion in prepubertal male rats. Eur J Endocrinol 1994;131:547-554.
31. Ojeda SR, Urbanski MF: Puberty in the rat; in Knobill E, Neill JD (eds): The Physiology of Reproduction. New York, Raven Press, 1994, pp 1699-1737.
32. Pinilla L, Tena-Sempere M, Aguilar R, Aguilar E: Effects of N-methyl-D-aspartic acid and kainic acid on prolactin secretion in hyper- and hypoprolactinaemic conditions. Eur J Endocrinol 1998;138:460-466.
33. Shimon I, Yan X, Melmed S: Human fetal pituitary expresses functional growth hormone-releasing peptide receptors. J Clin Endocrinol Metab 1998;83:174-178.
34. De Keyzer Y, Lenne F, Bertagna X: Widespread transcription of the growth hormone-releasing peptide receptor gene in neuroendocrine human tumors. Eur J Endocrinol 1997;137:715-718.
35. Adams EF, Huang B, Buchfelder M, Howard A, Smith RG, Feighner SD, van der Ploeg LH, Bowers CY, Fahlbusch R: Presence of growth hormone secretagogue receptor messenger ribonucleic acid in human pituitary tumors and rat GH3 cells. J Clin Endocrinol Metab 1998;83:638-642.
36. Korbonits M, Trainer PJ, Besser GM: The effect of an opiate antagonist on the hormonal changes induced by hexarelin. Clin Endocrinol 1995;43:365-371.
37. Arvat E, Maccagno B, Ramunni J, Broglio F, Lanfranco F, Giordano R, Benso A, Deghenghi R, Ghigo E: Influence of galanin and serotonin on the endocrine response to hexarelin, a synthetic peptidyl GH-secretagogue, in normal women. J Endocrinol Invest 1998;21:673-679.
38. Döhler KD, Wuttke W: Serum LH, FSH, prolactin and progesterone from birth to puberty in female and male rats. Endocrinology 1974,94:1003-1008.
39. Döhler KD, Wuttke W: Changes with age in levels of serum gonadotropins, prolactin and gonadal steroids in prepubertal male and female rats. Endocrinology 1975;97:898-907.
40. Ramaley JA: Serum prolactin levels in the prepubertal period in male and female rats. Control by photoperiod and gonadal status and relationship to puberty onset. Int J Androl 1981;4:91-104.
41. Bredt DS, Hwang PM, Snyder SH: Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 1990;347:768-770.
42. Rettori V, Belova N, Dees WL, Nyberg CL, Gimeno M, McCann SM: Role of nitric oxide in the control of luteinizing hormone-releasing hormone secretion in vivo and in vitro. Proc Natl Acad Sci USA 1993;90:10130-10134.
43. Ceccatelli S, Hulting AL, Zhang X, Gustafsson L, Villar M, Hökfelt T: Nitric oxide synthase in the rat anterior pituitary gland and the role of nitric oxide in the regulation of luteinizing hormone secretion. Proc Natl Acad Sci USA 1993;90:11292-11296.
44. Duvilanski BH, Zambruno A, Seilicovich A, Pisera D, Lasaga M, Diaz MC, Belova N, Rettori V, McCann SM: Role of nitric oxide in the control of prolactin release by the adenohypophysis. Proc Natl Acad Sci USA 1995;92:170-174.
45. Bonavera JJ, Sahu A, Kalra PS, Kalra SP: Evidence in support of nitric oxide involvement in the cyclic release of prolactin and LH surges. Brain Res 1994;600:175-179.
46. Pinilla L, Barreiro ML, Tena-Sempere M, Aguilar E: Role of ghrelin in the control of growth hormone secretion in prepubertal rats: Interactions with excitatory amino acids. Neuroendocrinology 2003;77:83-90.
47. Demarest KT, Riegle GD, Moore KE: Characteristics of dopaminergic neurons in the aged male rat. Neuroendocrinology 1980;31:222-227.
48. Aguilar E, Lopez F, Pinilla C, Bellido C, Vaticón MD: Effects of pimozide and domperidone administration on prolactin levels in neonatally estrogenized female rats. Rev Esp Fisiol 1985;41:183-186.
49. Arita J, Reymond MJ, Porter JC: Evidence for alteration in the processing of dopamine in the anterior pituitary gland of aged rats: Receptors and intracellular compartmentalization of dopamine. Endocrinology 1984;114:974-979.
50. Demarest KT, Moore KE, Riegle GD: Dopaminergic neuronal function, anterior pituitary dopamine content, and serum concentrations of prolactin, luteinizing hormone and progesterone in the aged female rat. Brain Res 1982; 247:347-354.
51. Hill-Samli M, MacLeod RM: Interaction of thyrotropin-releasing hormone and dopamine on the release of prolactin from the anterior pituitary in vitro. Endocrinology 1974;95:1189-1192.
52. Kato Y, Iwasaki Y, Iwasaki J, Abe H, Yanaihara N, Imura H: Prolactin release by vasoactive intestinal polypeptide in rats. Endocrinology 1978;103:554-558.
53. Fagin KD, Neill JD: The effect of dopamine on thyrotropin-releasing hormone-induced prolactin secretion in vitro. Endocrinology 1981;109:1835-1840.
54. Hinuma S, Habata Y, Fujii R, Kawamata Y, Hosoya M, Fukusumi S, Kitada C, Masuo Y, Asano T, Matsumoto H, Sekiguchi M, Kurokawa T, Nishimura O, Onda H, Fujino M: A prolactin-releasing peptide in the brain. Nature 1998;393:272-276.