Potent family-18 chitinase inhibitors: X-ray structures, affinities, and binding mechanisms

Journal of Biological Chemistry

Volumn 286, Issue 27, 2011, Pages 24312-24323

  Pantoom, Supansa ^a   Vetter, Ingrid R ^b,c   Prinz, Heino ^b,c   Suginta, Wipa ^a  

^a SURANAREE UNIVERSITY OF TECHNOLOGY   (Thailand)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^c TU DORTMUND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AGLYCONES; BINDING AFFINITIES; BINDING MECHANISMS; BINDING MODES; CHITINASES; HUMAN DISEASE; HYDROPHOBIC INTERACTIONS; IN-VITRO; INHIBITOR MOLECULES; INHIBITORY EFFECT; ISOTHERMAL MICROCALORIMETRY; NANOMOLAR RANGE; PHARMACOLOGICALLY ACTIVE COMPOUNDS; SUBSTRATE-BINDING; X RAY DATA; X-RAY STRUCTURE;

AMINO ACIDS; BINDING ENERGY; HYDROPHOBICITY; LEAD COMPOUNDS; REACTION INTERMEDIATES;

COMPLEXATION;

2 (IMIDAZOLIN 2 YL) 5 ISOTHIOCYANATOBENZOFURAN; AGLYCONE; CHELERYTHRINE; CHITINASE; CHITINASE A; CHITINASE INHIBITOR; DEQUALINIUM; ENZYME INHIBITOR; GLYCINE; IDARUBICIN; PENTOXIFYLLINE; PROPENTOFYLLINE; SANGUINARINE; TRYPTOPHAN; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; IN VITRO STUDY; MICROCALORIMETRY; NONHUMAN; PRIORITY JOURNAL; VIBRIO HARVEYI;

BACTERIAL PROTEINS; CATALYTIC DOMAIN; CHITINASE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; VIBRIO;

VIBRIO HARVEYI;

EID: 79959866413     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.183376     Document Type: Article

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