Triad of polar residues implicated in pH specificity of acidic mammalian chitinase

Protein Science

Volumn 18, Issue 3, 2009, Pages 569-578

  Olland, Andrea M ^a,c   Strand, James ^a   Presman, Eleonora ^a   Czerwinski, Robert ^a   Joseph McCarthy, Diane ^a   Krykbaev, Rustern ^a   Schlingmann, Gerhard ^b   Chopra, Rajiv ^a   Lin, Laura ^a   Fleming, Margaret ^a   Kriz, Ron ^a   Stahl, Mark ^a   Somers, William ^a   Fitz, Lori ^a   Mosyak, Lidia ^a  

^a PFIZER INC   (United States)

^b WYETH RESEARCH   (United States)

^c NONE   (United States)

Author keywords

3D structure; Asthma; Chitin degradation; Chitinase; Crystallography; Inhibitor; Structure

Indexed keywords

ACIDIC MAMMALIAN CHITINASE; CHITINASE; GLYCOSIDASE INHIBITOR; METHYLALLOSAMIDIN; UNCLASSIFIED DRUG;

ACIDITY; ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; STRUCTURE ANALYSIS;

MAMMALIA;

EID: 61449137849     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.63     Document Type: Article

References (22)

1. Boot RG, Blommaart EF, Swart E, Ghauharali-van der Vlugt K, Bijl N, Moe C, Place A, Aerts JM (2001) Identification, of a novel acidic mammalian chitinase distinct from, chitotriosidase. J Biol Chem 276:6770-6778.
2. Zhu Z, Zheng T, Homer RJ, Kim. YK, Chen NY, Colin. L, Hamid Q, Elias JA (2004) Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science 304:1678-1682.
3. Zimmermann N, Mishra A, King NE, Fulkerson PC, Doepker MP, Nikolaidis NM, Kindinger LE, Moulton EA, Aronow BJ (2004) Rothenberg ME transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways. J Immunol 172:1815-1824.
4. Follettie MT, Ellis DK, Donaldson DD, Hill AA, Diesl V, DeClercq C, Sypek JP, Dorner AJ, Wills-Karp M (2006) Gene expression analysis in a murine model of allergic asthma reveals overlapping disease and therapy dependent pathways in the lung. Pharmacogenomics J 6: 141-152.
5. Bierbaum S, Nickel R, Koch A, Lau S, Deichmann KA, Wahn U, Superti-Furga A, Heinzmann A (2005) Polymorphisms haplotypes of acid mammalian chitinase are associated with bronchial asthma. Am J Respir Crit Care Med 172:1505-1509.
6. Chatterjee R, Batra J, Das S, Sharma SK, Ghosh B (2008) Genetic association of acidic mammalian chitinase with atopic asthma and serum total IgE levels. J Allergy Clin Immunol 122:202-208, e1-e7.
7. Bussink AP, Vreede J, Aerts JM, Boot RG (2008) A single histidine residue modulates enzymatic activity in acidic mammalian chitinase. F.EBS Lett 582:931-935.
8. Fusetti F, von. Moeller H, Houston. D, Rozeboom HJ, Dijkstra BW, Boot RG, Aerts JM, van Aalten DM (2002) Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins. J Biol Chem. 277:25537-25544.
9. Rao FV, Houston DR, Boot RG, Aerts JM, Sakuda S, van Aalten DM (2003) Crystal structures of allosamidin. derivatives in complex with human macrophage chitinase. J Biol Chem 278:20110-20116.
10. Houston DR, Shiomi K, Arai N, Omura S, Peter MG, Turberg A, Synstad B, Eijsink VG, van Aalten DM (2002) High-resolution structures of a chitinase complexed with natural product cyclopentapeptide inhibitors: mimicry of carbohydrate substrate. Proc Natl Acad. Sci USA 99:9127-9132.
11. Bussink AP, Speijer D, Aerts JM, Boot RG (2007) Evolution of mammalian chitinase(-like) members of family 18 glycosyl hydrolases. Genetics 177:959-970.
12. van Aalten DM, Komander D, Synstad B, Gaseidnes S, Peter MG, Eijsink VG (2001) Structural insights into the catalytic mechanism of a family 18 exo-chitinase. Proc Natl Acad Sci USA 98:8979-8984.
13. Chou YT, Yao S, Czerwinski R, Fleming M, Krykbaev R, Xuan D, Zhou H, Brooks J, Fitz L, Strand J, Presman E, Lin L, Aulabaugh A, Huang X (2006) Kinetic characterization of recombinant human acidic mammalian chitinase. Biochemistry 45:4444-4454.
14. Miles EW (1977) Modification of histidyl residues in proteins by diethylpyrocarbonate. Methods Enzymol 47: 431-442.
15. Synstad B, Gaseidnes S, Van Aalten DM, Vriend G, Nielsen JE, Eijsink. VG (2004) Mutational and computational analysis of the role of conserved residues in the active site of a family 18 chitinase. Eur J Biochem 271: 253-262.
16. Sakuda S, Isogai A, Matsumoto S, Suzuki A (1987) Search for microbial insect growth regulators. Part II. Allosamidin, a novel insect chitinase inhibitor. J Antibiot (Tokyo) 40:296-300.
17. Otwinowski Z, Minor W (1997) Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol 276(Macromol Crystallogr Part A):307~326.
18. Brunger AT, Adams PD, Clore GM, DeLano WL, Gros P, Grosse-Kunstleve RW, Jiang JS, Kuszewski J, Nilges M, Pannu NS, Read RJ, Rice LM, Simonson T, Warren GL (1998) Crystallography & NMR system: a new software suite for macrornolecular structure determination. Acta Crystallogr D Biol. Crystallogr 54 (Part 5):905-921.
19. 4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr 50 (Part 5)760-763.
20. Emsley P, Cowtan K (2004) Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr 60 (Part 12 and Part 1): 2126-2132.
21. Jorgensen WL, Maxwell DS, Tirado-Rives J (1996) Development and testing of the OPLS all-atom force field on conformational energetics and properties of organic liquids. J Am Chem Soc 118:11225-11236.
22. Ghosh A, Rapp CS, Friesner RA (1998) Generalized born model based on a surface integral formulation. J Phys Chem B 102:10983-10990.