Feasibility of small animal cranial irradiation with the microRT system

Medical Physics

Volumn 35, Issue 10, 2008, Pages 4735-4743

  Kiehl, Erich L ^a   Stojadinovic, Strahinja ^b   Malinowski, Kathleen T ^a   Limbrick, David ^a   Jost, Sarah C ^a   Garbow, Joel R ^a   Rubin, Joshua B ^a   Deasy, Joseph O ^a   Khullar, Divya ^a   Izaguirre, Enrique W ^a   Parikh, Parag J ^a   Low, Daniel A ^a   Hope, Andrew J ^c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Brain; CNS; Conformal radiotherapy; Dose response; Small animal

Indexed keywords

ACETAL RESINS; ANIMALS; BRAIN; FLIGHT DYNAMICS; IRRADIATION; RADIOTHERAPY; TISSUE;

CONFORMAL RADIOTHERAPY; DOSE RESPONSE; FUNCTIONAL IMPROVEMENTS; IMMOBILIZATION METHOD; MULTIPLE IMAGING MODALITY; SMALL ANIMAL; TREATMENT PLANNING SYSTEMS; WHOLE-BRAIN IRRADIATION;

COMPUTERIZED TOMOGRAPHY;

IRIDIUM 192;

ANIMAL TISSUE; ARTICLE; BRAIN RADIATION; COMPUTER ASSISTED RADIOTHERAPY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; IMAGE ANALYSIS; IMAGING SYSTEM; MICRORADIATION THERAPY SYSTEM; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; REPRODUCIBILITY; SAFETY; TREATMENT PLANNING; VOLUMETRY;

ANIMALIA; MURINAE;

EID: 52949138653     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.2977762     Document Type: Article

References (10)

1. S. Stojadinovic, D. A. Low, M. Vicic, S. Mutic, J. O. Deasy, A. J. Hope, P. J. Parikh, and P. W. Grigsby, " Progress toward a microradiation therapy small animal conformal irradiator.," Med. Phys. 33, 3834-3845 (2006).
2. S. Stojadinovic, D. A. Low, A. J. Hope, M. Vicic, J. O. Deasy, J. Cui, D. Khullar, P. J. Parikh, K. T. Malinowski, E. W. Izaguirre, S. Mutic, and P. W. Grigsby, " MicroRT-small animal conformal irradiator.," Med. Phys. 34, 4706-4716 (2007).
3. C. DesRosiers, M. S. Mendonca, C. Tyree, V. Moskvin, M. Bank, L. Massaro, R. M. Bigsby, A. Caperall-Grant, S. Valluri, J. R. Dynlacht, and R. Timmerman, " Use of the Leksell Gamma Knife for localized small field lens irradiation in rodents.," Technol. Cancer Res. Treat. 2, 449-454 (2003).
4. M. L. Monje, H. Toda, and T. D. Palmer, " Inflammatory blockade restores adult hippocampal neurogenesis.," Science 302, 1760-1765 (2003).
5. H. Yuan, M. W. Gaber, K. Boyd, C. M. Wilson, M. F. Kiani, and T. E. Merchant, " Effects of fractionated radiation on the brain vasculature in a murine model: blood-brain barrier permeability, astrocyte proliferation, and ultrastructural changes.," Int. J. Radiat. Oncol., Biol., Phys. 66, 860-866 (2006).
6. S. Mizumatsu, M. L. Monje, D. R. Morhardt, R. Rola, T. D. Palmer, and J. R. Fike, " Extreme sensitivity of adult neurogenesis to low doses of X-irradiation.," Cancer Res. 63, 4021-4027 (2003).
7. A. P. Cotrim, A. L. Sowers, B. M. Lodde, J. M. Vitolo, A. Kingman, A. Russo, J. B. Mitchell, and B. J. Baum, " Kinetics of tempol for prevention of xerostomia following head and neck irradiation in a mouse model.," Clin. Cancer Res. 11, 7564-7568 (2005).
8. J. O. Deasy, A. I. Blanco, and V. H. Clark, " CERR: a computational environment for radiotherapy research.," Med. Phys. 30, 979-985 (2003).
9. Y. Sun, N. O. Schmidt, K. Schmidt, S. Doshi, J. B. Rubin, R. V. Mulkern, R. Carroll, M. Ziu, K. Erkmen, T. Y. Poussaint, P. Black, M. Albert, D. Burstein, and M. W. Kieran, " Perfusion MRI of U87 brain tumors in a mouse model.," Magn. Reson. Med. 51, 893-899 (2004).
10. A. J. Hope, S. Stojadinovic, J. O. Deasy, J. Hubenschmidt, P. W. Grigsby, and D. A. Low, " TH-C-230A-08: A prototype rotational immobilization system for a proposed static-gantry microRT device with tomographic capabilities.," Med. Phys. 33, 2272 (2006), abstract.