Epigenetic control of differential expression of specific ERG isoforms in acute T-lymphoblastic leukemia

Leukemia Research

Volumn 33, Issue 6, 2009, Pages 817-822

  Bohne, Arend ^a   Schlee, Cornelia ^a   Mossner, Max ^a   Thibaut, Julia ^a   Heesch, Sandra ^a   Thiel, Eckhard ^a   Hofmann, Wolf Karsten ^a   Baldus, Claudia D ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Acute leukemia; ERG; Hypermethylation; Isoform expression

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CD34 ANTIGEN; TRANSCRIPTION FACTOR ERG; TRANSCRIPTION FACTOR ERG2; TRANSCRIPTION FACTOR ERG3; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EPIGENETICS; EXON; HUMAN; HUMAN CELL; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN METHYLATION; TRANSCRIPTION REGULATION;

AZACITIDINE; BASE SEQUENCE; CPG ISLANDS; DNA METHYLATION; DNA PRIMERS; EPIGENESIS, GENETIC; EXONS; ONCOGENE PROTEINS; POLYMERASE CHAIN REACTION; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTEIN ISOFORMS; TRANS-ACTIVATORS;

EID: 63349106061     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2008.11.012     Document Type: Article

References (27)

1. Seth A., and Watson D.K. ETS transcription factors and their emerging roles in human cancer. Eur J Cancer 41 (2005) 2462-2478
2. Oikawa T. ETS transcription factors: possible targets for cancer therapy. Cancer Sci 95 (2004) 626-633
3. Scott G.K., Chang C.H., Erny K.M., Xu F., Fredericks W.J., Rauscher III F.J., et al. Ets regulation of the erbB2 promoter. Oncogene 19 (2000) 6490-6502
4. Duda D.G., Sunamura M., Lefter L.P., Furukawa T., Yokoyama T., Yatsuoka T., et al. Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells. Oncogene 22 (2003) 6857-6864
5. Sorensen P.H., Lessnick S.L., Lopez-Terrada D., Liu X.F., Triche T.J., and Denny C.T. A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nat Genet 6 (1994) 146-151
6. Kong X.T., Ida K., Ichikawa H., Shimizu K., Ohki M., Maseki N., et al. Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16; 21)(p11; q22) and identification of a novel transcript. Blood 90 (1997) 1192-1199
7. Tomlins S.A., Rhodes D.R., Perner S., Dhanasekaran S.M., Mehra R., Sun X.W., et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 310 (2005) 644-648
8. Baldus C.D., Liyanarachchi S., Mrozek K., Auer H., Tanner S.M., Guimond M., et al. Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: amplification discloses overexpression of APP, ETS2, and ERG genes. Proc Natl Acad Sci USA 101 (2004) 3915-3920
9. Hart A.H., Corrick C.M., Tymms M.J., Hertzog P.J., and Kola I. Human ERG is a proto-oncogene with mitogenic and transforming activity. Oncogene 10 (1995) 1423-1430
10. McLaughlin F., Ludbrook V.J., Cox J., von C.I., Brown S., and Randi A.M. Combined genomic and antisense analysis reveals that the transcription factor Erg is implicated in endothelial cell differentiation. Blood 98 (2001) 3332-3339
11. Iwamoto M., Tamamura Y., Koyama E., Komori T., Takeshita N., Williams J.A., et al. Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis. Dev Biol 305 (2007) 40-51
12. Rainis L., Toki T., Pimanda J.E., Rosenthal E., Machol K., Strehl S., et al. The proto-oncogene ERG in megakaryoblastic leukemias. Cancer Res 65 (2005) 7596-7602
13. Lefebvre J.M., Haks M.C., Carleton M.O., Rhodes M., Sinnathamby G., Simon M.C., et al. Enforced expression of Spi-B reverses T lineage commitment and blocks {beta}-selection. J Immunol 174 (2005) 6184-6194
14. Anderson M.K., Hernandez-Hoyos G., Diamond R.A., and Rothenberg E.V. Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage. Development 126 (1999) 3131-3148
15. Baldus C.D., Burmeister T., Martus P., Schwartz S., Gokbuget N., Bloomfield C.D., et al. High expression of the ETS transcription factor ERG predicts adverse outcome in acute T-lymphoblastic leukemia in adults. J Clin Oncol 24 (2006) 4714-4720
16. Marcucci G., Baldus C.D., Ruppert A.S., Radmacher M.D., Mrozek K., Whitman S.P., et al. Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a cancer and leukemia group B study. J Clin Oncol 23 (2005) 9234-9242
17. Owczarek C.M., Portbury K.J., Hardy M.P., O'Leary D.A., Kudoh J., Shibuya K., et al. Detailed mapping of the ERG-ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16. Gene 324 (2004) 65-77
18. Hewett P.W., Nishi K., Daft E.L., and Clifford M.J. Selective expression of erg isoforms in human endothelial cells. Int J Biochem Cell Biol 33 (2001) 347-355
19. Murakami K.F., Mavrothalassitis G.F., Bhat N.K.F.A.U., Fisher R.J.F.A.U., and Papas T.S. Human ERG-2 protein is a phosphorylated DNA-binding protein-a distinct member of the ets family. Oncogene (1993) 1559-1566
20. Petrovics G., Liu A., Shaheduzzaman S., Furasato B., Sun C., Chen Y., et al. Frequent overexpression of ETS-related gene-1 (ERG1) in prostate cancer transcriptome. Oncogene 24 (2005) 3847-3852
21. Duterque-Coquillaud M., Niel C., Plaza S., and Stehelin D. New human erg isoforms generated by alternative splicing are transcriptional activators. Oncogene 8 (1993) 1865-1873
22. Rao V.N., Papas T.S., and Reddy E.S. erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation. Science 237 (1987) 635-639
23. Prasad D.D., Rao V.N., Lee L., and Reddy E.S. Differentially spliced erg-3 product functions as a transcriptional activator. Oncogene 9 (1994) 669-673
24. Loose M., and Patient R. Global genetic regulatory networks controlling hematopoietic cell fates. Curr Opin Hematol 13 (2006) 229-236
25. Carrere S., Verger A., Flourens A., Stehelin D., and Duterque-Coquillaud M. Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains. Oncogene 16 (1998) 3261-3268
26. Esteller M. Profiling aberrant DNA methylation in hematologic neoplasms: a view from the tip of the iceberg. Clin Immunol 109 (2003) 80-88
27. Melki J.R., and Clark S.J. DNA methylation changes in leukaemia. Semin Cancer Biol 12 (2002) 347-357