Chronic ibuprofen treatment does not affect the secondary pathology in the thalamus or improve behavioral outcome in middle cerebral artery occlusion rats

Pharmacology Biochemistry and Behavior

Volumn 99, Issue 3, 2011, Pages 468-474

  Lipsanen, Anu ^a   Hiltunen, Mikko ^a   Jolkkonen, Jukka ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

amyloid; Calcium; Ibuprofen; Inflammation; Middle cerebral artery occlusion; Thalamus

Indexed keywords

AMYLOID BETA PROTEIN; CALCIUM; IBUPROFEN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BEHAVIOR; BRAIN CORTEX; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; CONVALESCENCE; CORPUS STRIATUM; GRAY MATTER; HISTOLOGY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORIMOTOR FUNCTION; SENSORIMOTOR NEUROPATHY; TACTILE STIMULATION; THALAMUS; WALKING;

ANIMALS; IBUPROFEN; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEURAL PATHWAYS; PSYCHOMOTOR PERFORMANCE; RATS; RATS, WISTAR; THALAMUS; TREATMENT OUTCOME;

MUS; RATTUS; RATTUS NORVEGICUS;

EID: 79959817228     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2011.04.019     Document Type: Article

References (44)

1. Acarin L, Gonzalez B, Castro AJ, Castellano B. Primary cortical glial reaction versus secondary thalamic glial response in the excitotoxically injured young brain: microglial/macrophage response and major histocompatibility complex class I and II expression. Neuroscience 1999;89:549-65. (Pubitemid 29044336)
2. Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, et al. Inflammation and Alzheimer's disease. Neurobiol Aging 2000;21:383-421. (Pubitemid 30349107)
3. Antezana DF, Clatterbuck RE, Alkayed NJ, Murphy SJ, Anderson LG, Frazier J, et al. High-dose ibuprofen for reduction of striatal infarcts during middle cerebral artery occlusion in rats. J Neurosurg 2003;98:860-6. (Pubitemid 36396790)
4. Bhatia R, Lin H, Lal R. Fresh and globular amyloid beta protein (1-42) induces rapid cellular degeneration: evidence for AbetaP channel-mediated cellular toxicity. FASEB J 2000;14:1233-43.
5. Block F, Dihne M, Loos M. Inflammation in areas of remote changes following focal brain lesion. Prog Neurobiol 2005;75:342-65. (Pubitemid 40733269)
6. Browne KD, Iwata A, Putt ME, Smith DH. Chronic ibuprofen administration worsens cognitive outcome following traumatic brain injury in rats. Exp Neurol 2006;201:301-7. (Pubitemid 44344222)
7. Choi JK, Jenkins BG, Carreras I, Kaymakcalan S, Cormier K, Kowall NW, et al. Anti-inflammatory treatment in AD mice protects against neuronal pathology. Exp Neurol 2010;223:377-84.
8. Clarke J, Thornell A, Corbett D, Soininen H, Hiltunen M, Jolkkonen J. Overexpression of APP provides neuroprotection in the absence of functional benefit following middle cerebral artery occlusion in rats. Eur J Neurosci 2007;26:1845-52. (Pubitemid 47493192)
9. Cole D, Patel P, Reynolds L, Drummond J, Marcantonio S. Temporary focal cerebral ischemia in spontaneously hypertensive rats: the effect of ibuprofen on infarct volume. J Pharmacol Exp Ther 1993;266:1713-7. (Pubitemid 24175826)
10. Eriksen JL, Sagi SA, Smith TE, Weggen S, Das P, McLendon DC, et al. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J Clin Invest 2003;112:440-9. (Pubitemid 38063773)
11. Freret T, Chazalviel L, Roussel S, Bernaudin M, Schumann-Bard P, Boulouard M. Long-term functional outcome following transient middle cerebral artery occlusion in the rat: correlation between brain damage and behavioral impairment. Behav Neurosci 2006;120:1285-98. (Pubitemid 46058704)
12. Gopez JJ, Yue H, Vasudevan R, Malik AS, Fogelsanger LN, Lewis S, et al. Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury. Neurosurgery 2005;56:590-604.
13. Heneka MT, Sastre M, Dumitrescu-Ozimek L, Hanke A, Dewachter I, Kuiperi C, et al. Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain 2005;128:1442-53. (Pubitemid 40826196)
14. Hiltunen M, Mäkinen P, Peräniemi S, Sivenius J, van Groen T, Soininen H, et al. Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus. Neurobiol Dis 2009;35:103-13.
15. Hurley SD, Olschowka JA, O'Banion MK. Cyclooxygenase inhibition as a strategy to ameliorate brain injury. J Neurotrauma 2002;19:1-15. (Pubitemid 34117092)
16. Itagaki S, McGeer PL, Akiyama H, Zhu S, Selkoe D. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J Neuroimmunol 1989;24:173-82. (Pubitemid 19271472)
17. Iwata Y, Nicole O, Zurakowski D, Okamura T, Jonas RA. Ibuprofen for neuroprotection after cerebral ischemia. J Thorac Cardiovasc Surg 2010;139:489-93.
18. Jolkkonen J, Puurunen K, Rantakömi S, Härkonen A, Haapalinna A, Sivenius J. Behavioral effects of the alpha(2)-adrenoceptor antagonist, atipamezole, after focal cerebral ischemia in rats. Eur J Pharmacol 2000;400:211-9.
19. Karhunen H, Virtanen T, Schallert T, Sivenius J, Jolkkonen J. Forelimb use after focal cerebral ischemia in rats treated with an alpha(2)-adrenoceptor antagonist. Pharmacol Biochem Behav 2003;74:663-9.
20. Kawahara M, Kuroda Y. Molecular mechanism of neurodegeneration induced by Alzheimer's beta-amyloid protein: channel formation and disruption of calcium homeostasis. Brain Res Bull 2000;53:389-97. (Pubitemid 32000815)
21. Kumon Y, Sakaki S, Watanabe H, Nakano K, Ohta S, Matsuda S, et al. Ciliary neurotrophic factor attenuates spatial cognition impairment, cortical infarction and thalamic degeneration in spontaneously hypertensive rats with focal cerebral ischemia. Neurosci Lett 1996;206:141-4. (Pubitemid 26094680)
22. Lim GP, Yang F, Chu T, Chen P, Beech W, Teter B, et al. Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J Neurosci 2000;20:5709-14. (Pubitemid 30636898)
23. Lim GP, Yang F, Chu T, Gahtan E, Ubeda O, Beech W, et al. Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice. Neurobiol Aging 2001;22:983-91. (Pubitemid 34066567)
24. Lleo A, Berezovska O, Herl L, Raju S, Deng A, Bacskai BJ, et al. Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation. Nat Med 2004;10:1065-6. (Pubitemid 39424866)
25. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989;20:84-91.
26. Loos M, Dihne M, Block F. Tumor necrosis factor-alpha expression in areas of remote degeneration following middle cerebral artery occlusion of the rat. Neuroscience 2003;122:373-80. (Pubitemid 37410167)
27. Mäkinen S, van Groen T, Clarke J, Thornell A, Corbett D, Hiltunen M, et al. Coaccumulation of calcium and beta-amyloid in the thalamus after transient middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 2008;28:263-8. (Pubitemid 351161286)
28. Park E, Cho B, Volpe B, Cruz M, Joh T, Cho S. Ibuprofen protects ischemia-induced neuronal injury via up-regulating interleukin-1 receptor antagonist expression. Neuroscience 2005;132:625-31.
29. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 3 rd ed. USA: Academic Press Inc.; 1997.
30. Puurunen K, Jolkkonen J, Sirviö J, Haapalinna A, Sivenius J. An alpha(2)-adrenergic antagonist, atipamezole, facilitates behavioral recovery after focal cerebral ischemia in rats. Neuropharmacology 2001;40:597-606.
31. Richardson RL, Kim EM, Shephard RA, Gardiner T, Cleary J, O'Hare E. Behavioural and histopathological analyses of ibuprofen treatment on the effect of aggregated Abeta (1-42) injections in the rat. Brain Res 2002;954:1-10.
32. Richardson RL, Kim EM, Gardiner T, O'Hare E. Chronic intracerebroventricular infusion of lipopolysaccharide: effects of ibuprofen treatment and behavioural and histopathological correlates. Behav Pharmacol 2005;16:531-41. (Pubitemid 41416072)
33. Rupalla K, Allegrini PR, Sauer D, Wiessner C. Time course of microglia activation and apoptosis in various brain regions after permanent focal cerebral ischemia in mice. Acta Neuropathol 1998;96:172-8. (Pubitemid 28356531)
34. Sanz-Blasco S, Valero RA, Rodriguez-Crespo I, Villalobos C, Nunez L. Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs. PLoS One 2008;3:e2718.
35. Sorensen JC, Dalmau I, Zimmer J, Finsen B. Microglial reactions to retrograde degeneration of tracer-identified thalamic neurons after frontal sensorimotor cortex lesions in adult rats. Exp Brain Res 1996;112:203-12. (Pubitemid 26382057)
36. Stewart WF, Kawas C, Corrada M, Metter EJ. Risk of Alzheimer's disease and duration of NSAID use. Neurology 1997;48:626-32. (Pubitemid 27120096)
37. van Groen T, Puurunen K, Mäki HM, Sivenius J, Jolkkonen J. Transformation of diffuse beta-amyloid precursor protein and beta-amyloid deposits to plaques in the thalamus after transient occlusion of the middle cerebral artery in rats. Stroke 2005;36:1551-6. (Pubitemid 40967528)
38. Watanabe H, Kumon Y, Ohta S, Sakaki S, Matsuda S, Sakanaka M. Changes in protein synthesis and calcium homeostasis in the thalamus of spontaneously hypertensive rats with focal cerebral ischemia. J Cereb Blood Flow Metab 1998;18:686-96. (Pubitemid 28262465)
39. Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, et al. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 2001;414:212-6. (Pubitemid 33051236)
40. Willuweit A, Velden J, Godemann R, Manook A, Jetzek F, Tintrup H, et al. Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease. PLoS One 2009;4:e7931.
41. Yamada K, Kinoshita A, Kohmura E, Sakaguchi T, Taguchi J, Kataoka K, et al. Basic fibroblast growth factor prevents thalamic degeneration after cortical infarction. J Cereb Blood Flow Metab 1991;11:472-8.
42. Yan Q, Zhang J, Liu H, Babu-Khan S, Vassar R, Biere AL, et al. Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease. J Neurosci 2003;23:7504-9. (Pubitemid 37034066)
43. Zhang Y, Xing S, Zhang J, Li J, Li C, Pei Z, et al. Reduction of beta-amyloid deposits by gamma-secretase inhibitor is associated with the attenuation of secondary damage in the ipsilateral thalamus and sensory functional improvement after focal cortical infarction in hypertensive rats. J Cereb Blood Flow Metab 2011;31:572-9.
44. Zhao CS, Puurunen K, Schallert T, Sivenius J, Jolkkonen J. Effect of cholinergic medication, before and after focal photothrombotic ischemic cortical injury, on histological and functional outcome in aged and young adult rats. Behav Brain Res 2005;156:85-94. (Pubitemid 39330439)