Rodent models for urodynamic investigation

Neurourology and Urodynamics

Volumn 30, Issue 5, 2011, Pages 636-646

  Andersson, Karl Erik ^a   Soler, Roberto ^b   Füllhase, Claudius ^c  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Bladder; Guinea pig; Mouse; Pharmacology; Physiology; Rat

Indexed keywords

CYCLIC GMP DEPENDENT PROTEIN KINASE; MITOCHONDRIAL MEMBRANE PEPTIDASE 2 LIKE PROTEIN; PROSTAGLANDIN E RECEPTOR 1; PROTEIN; UNCLASSIFIED DRUG; UROPLAKIN;

ABDOMINAL PRESSURE; ANESTHESIA; ANIMAL MODEL; BLADDER; BLADDER CAPACITY; BLADDER CATHETERIZATION; BLADDER COMPLIANCE; BLADDER CONTRACTION; BLADDER PRESSURE; BLADDER SPHINCTER; CONSCIOUSNESS; CYSTOMETRY; ELECTROMYOGRAPHY; EXPERIMENTAL MODEL; GUINEA PIG; HIGH FREQUENCY OSCILLATION; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; INTERSTITIAL CYSTITIS; INTESTINE PRESSURE; LEAK POINT PRESSURE; MEDICAL INSTRUMENTATION; MICTURITION; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NOMENCLATURE; NONHUMAN; OVERACTIVE BLADDER; PARKINSON DISEASE; PERFUSION PRESSURE; PRESSURE; PROSTATE HYPERTROPHY; PROVOCATION TEST; RAT; RENAL SYSTEM PARAMETERS; RESIDUAL URINE; REVIEW; RODENT; SEX DIFFERENCE; SPINAL CORD INJURY; SPONTANEOUSLY HYPERTENSIVE RAT; SPRAGUE DAWLEY RAT; TRANSGENIC ANIMAL; URETHRA; URETHRA PERFUSION PRESSURE; URINARY FREQUENCY; URINE VOLUME; URODYNAMICS; WISTAR KYOTO RAT; WISTAR RAT;

ANESTHESIA, GENERAL; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DISEASE MODELS, ANIMAL; FEMALE; GUINEA PIGS; HUMANS; MALE; MICE; RATS; SPECIES SPECIFICITY; TERMINOLOGY AS TOPIC; TIME FACTORS; TRANSLATIONAL RESEARCH; URINARY BLADDER; URINARY CATHETERIZATION; URINATION; URINATION DISORDERS; URODYNAMICS;

EID: 79959816350     PISSN: 07332467     EISSN: 15206777     Source Type: Journal    
DOI: 10.1002/nau.21108     Document Type: Review

References (108)

1. Fry CH. Experimental models to study the physiology, pathophysiology, and pharmacology of the lower urinary tract. J Pharmacol Toxicol Methods 2004;49:201-10.
2. McMurray G, Casey JH, Naylor AM. Animal models in urological disease and sexual dysfunction. Br J Pharmacol 2006;147:S62-79.
3. Fry CH, Daneshgari F, Thor K, et al. Animal models and their use in understanding lower urinary tract dysfunction. Neurourol Urodyn 2010;29: 603-8.
4. Uvelius B, Gabella G. Intramural neurones appear in the urinary bladder wall following excision of the pelvic ganglion in the rat. Neuroreport 1995;6:2213-6.
5. Brading AF, Williams JH. Contractile responses of smooth muscle strips from rat and guinea-pig urinary bladder to transmural stimulation: Effects of atropine and alpha,beta-methylene ATP. Br J Pharmacol 1990;99:493-8. (Pubitemid 20069151)
6. Streng T, Talo A, Andersson KE. Transmitters contributing to the voiding contraction in female rats. BJU Int 2004;94:910-4. (Pubitemid 39480695)
7. Andersson KE, Arner A. Urinary bladder contraction and relaxation: Physiology and pathophysiology. Physiol Rev 2004;84:935-86. (Pubitemid 38823771)
8. Streng T, Santti R, Talo A. Similarities and differences in female and male rat voiding. Neurourol Urodyn 2002;21:136-41. (Pubitemid 34195207)
9. Cornelissen LL, Misajet B, Brooks DP, et al. Influence of genetic background and gender on bladder function in the mouse. Auton Neurosci 2008; 140:53-8.
10. Pandita RK, Fujiwara M, Alm P, et al. Cystometric evaluation of bladder function in non-anesthetized mice with and without bladder outlet obstruction. J Urol 2000;164:1385-9.
11. Smith PP, Kuchel GA. Continuous uroflow cystometry in the urethane-anesthetized mouse. Neurourol Urodyn 2010;29:1344-9.
12. Brading AF, Mostwin JL. Electrical and mechanical responses of guinea-pig bladder muscle to nerve stimulation. Br J Pharmacol 1989;98:1083-90. (Pubitemid 20011060)
13. Biers SM, Reynard JM, Doore T, et al. The functional effects of a c-kit tyrosine inhibitor on guinea-pig and human detrusor. BJU Int 2006; 97:612-6.
14. Gomez-Pinilla PJ, Gomez MF, Hedlund P, et al. Effect of melatonin on age associated changes in Guinea pig bladder function. J Urol 2007;177: 1558-61. (Pubitemid 46435996)
15. Kubota Y, Hashitani H, Shirasawa N, et al. Altered distribution of interstitial cells in the guinea pig bladder following bladder outlet obstruction. Neurourol Urodyn 2008;27:330-40. (Pubitemid 351656406)
16. Streng T, Santti R, Andersson KE, et al. The role of the rhabdosphincter in female rat voiding. BJU Int 2004;94:138-42. (Pubitemid 38986930)
17. Streng T, Santti R, Talo A. Possible action of the proximal rhabdosphincter muscle in micturition of the adult male rat. Neurourol Urodyn 2001;20:197-210; discussion 3.
18. Soler R, Fullhase C, Lu B, et al. Bladder dysfunction in a new mutant mouse model with increased superoxide - Lack of nitric oxide? J Urol 2010;183: 780-5.
19. Pehrson R, Stenman E, Andersson KE. Effects of tramadol on rat detrusor overactivity induced by experimental cerebral infarction. Eur Urol 2003; 44:495-9. (Pubitemid 37185679)
20. Persson K, Pandita RK, Spitsbergen JM, et al. Spinal and peripheral mechanisms contributing to hyperactive voiding in spontaneously hypertensive rats. Am J Physiol 1998;275:R1366-73.
21. Cannon TW, Damaser MS. Effects of anesthesia on cystometry and leak point pressure of the female rat. Life Sci 2001;69:1193-202. (Pubitemid 32722084)
22. Masuda H, Ogawa T, Kihara K, et al. Effects of anaesthesia on the nitrergic pathway during the micturition reflex in rats. BJU Int 2007;100:175-80. (Pubitemid 46878552)
23. Lee T, Andersson KE, Streng T, et al. Simultaneous registration of intraabdominal and intravesical pressures during cystometry in conscious rats - Effects of bladder outlet obstruction and intravesical PGE2. Neurourol Urodyn 2008;27:88-95.
24. Fullhase C, Soler R, Gratzke C, et al. Urodynamic evaluation of fesoterodine metabolite, doxazosin and their combination in a rat model of partial urethral obstruction. BJU Int 2009;106:287-93.
25. Yokoyama O, Yoshiyama M, Namiki M, et al. Influence of anesthesia on bladder hyperactivity induced by middle cerebral artery occlusion in the rat. Am J Physiol 1997;273:R1900-7.
26. Matsuura S, Downie JW. Effect of anesthetics on reflex micturition in the chronic cannula-implanted rat. Neurourol Urodyn 2000;19:87-99. (Pubitemid 30038856)
27. Huang YC, Shindel AW, Ning H, et al. Adipose derived stem cells ameliorate hyperlipidemia associated detrusor overactivity in a rat model. J Urol 2010;183:1232-40.
28. Yaksh TL, Durant PA, Brent CR. Micturition in rats: A chronic model for study of bladder function and effect of anesthetics. Am J Physiol 1986;251: R1177-85.
29. Nagabukuro H, Hashimoto T, Iwata M, et al. Effects of TAK-802, a novel acetylcholinesterase inhibitor, and tamsulosin, an alpha1-adrenoceptor antagonist, and their synergistic effects on the urodynamic characteristics in a guinea-pig model of functional bladder outlet obstruction. BJU Int 2005;95:1071-6. (Pubitemid 40655709)
30. Maggi CA, Giuliani S, Santicioli P, et al. Analysis of factors involved in determining urinary bladder voiding cycle in urethan-anesthetized rats. Am J Physiol 1986;251:R250-7.
31. Streng T, Hedlund P, Talo A, et al. Phasic non-micturition contractions in the bladder of the anaesthetized and awake rat. BJU Int 2006;97:1094-101.
32. Resplande J, Gholami SS, Graziottin TM, et al. Long-term effect of ovariectomy and simulated birth trauma on the lower urinary tract of female rats. J Urol 2002;168:323-30. (Pubitemid 34640851)
33. Morikawa K, Kakiuchi M, Fukuoka M, et al. Effects of various drugs on bladder function in conscious restrained-denervated rats placed in a restraining cage and produced by transection of the hypogastric nerve. Jpn J Pharmacol 1990;52:405-11. (Pubitemid 20090763)
34. Schroder A, Newgreen D, Andersson KE. Detrusor responses to prostaglandin E2 and bladder outlet obstruction in wild-type and Ep1 receptor knockout mice. J Urol 2004;172:1166-70. (Pubitemid 39096493)
35. Shieh CC, Brune ME, Buckner SA, et al. Characterization of a novel ATPsensitive K+ channel opener, A-251179, on urinary bladder relaxation and cystometric parameters. Br J Pharmacol 2007;151:467-75. (Pubitemid 46905009)
36. Persson K, Pandita RK, Aszodi A, et al. Functional characteristics of urinary tract smooth muscles in mice lacking cGMP protein kinase type I. Am J Physiol Regul Integr Comp Physiol 2000;279:R1112-20.
37. Aboushwareb T, Zhou G, Deng FM, et al. Alterations in bladder function associated with urothelial defects in uroplakin II and IIIa knockout mice. Neurourol Urodyn 2009;28:1028-33.
38. Morikawa K, Ichihashi M, Kakiuchi M, et al. Effects of various drugs on bladder function in conscious rats. Jpn J Pharmacol 1989;50:369-76. (Pubitemid 19190268)
39. Christ GJ, Day NS, Day M, et al. Bladder injection of "naked" hSlo/pcDNA3 ameliorates detrusor hyperactivity in obstructed rats in vivo. Am J Physiol Regul Integr Comp Physiol 2001;281:R1699-709.
40. Miyazato M, Sasatomi K, Hiragata S, et al. GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats. J Urol 2008;179:1178-83.
41. Fullhase C, Soler R, Gratzke C, et al. Spinal effects of the fesoterodine metabolite 5-hydroxymethyl tolterodine and/or doxazosin in rats with or without partial urethral obstruction. J Urol 2010;184:783-9.
42. Fullhase C, Santos C, et al. Development of bladder dysfunction in a rat model of dopaminergic brain lesion. Neurourol Urodyn 2011;30:188-93.
43. De Wachter S, De Laet K, Wyndaele JJ. Does the cystometric filling rate affect the afferent bladder response pattern? A study on single fibre pelvic nerve afferents in the rat urinary bladder. Neurourol Urodyn 2006;25: 162-7.
44. Juszczak K, Ziomber A, Wyczolkowski M, et al. Urodynamic effects of the bladder C-fiber afferent activity modulation in chronic model of overactive bladder in rats. J Physiol Pharmacol 2009;60:85-91.
45. Zhao W, Aboushwareb T, Turner C, et al. Impaired bladder function in aging male rats. J Urol 2010;184:378-85.
46. Chang HY, Havton LA. Differential effects of urethane and isoflurane on external urethral sphincter electromyography and cystometry in rats. Am J Physiol Renal Physiol 2008;295:F1248-53.
47. Soler R, Füllhase C, Santos C, et al. Development of bladder dysfunction in a rat model of dopaminergic brain lesion. Neurourol Urodyn 2011;30:188-93. (accepted for publication).
48. Wang CC, Nagatomi J, Toosi KK, et al. Diabetes-induced alternations in biomechanical properties of urinary bladder wall in rats. Urology 2009;73: 911-5.
49. Jung SY, Fraser MO, Ozawa H, et al. Urethral afferent nerve activity affects the micturition reflex; implication for the relationship between stress incontinence and detrusor instability. J Urol 1999;162:204-12. (Pubitemid 29420928)
50. Torimoto K, Fraser MO, Hirao Y, et al. Urethral dysfunction in diabetic rats. J Urol 2004;171:1959-64. (Pubitemid 38501053)
51. Cannon TW, Wojcik EM, Ferguson CL, et al. Effects of vaginal distension on urethral anatomy and function. BJU Int 2002;90:403-7. (Pubitemid 36124772)
52. Rodriguez LV, Chen S, Jack GS, et al. New objective measures to quantify stress urinary incontinence in a novel durable animal model of intrinsic sphincter deficiency. Am J Physiol Regul Integr Comp Physiol 2005;288: R1332-8.
53. Abrams P, Cardozo L, Fall M, et al. The standardisation of terminology of lower urinary tract function: Report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn 2002;21:167-78. (Pubitemid 34195211)
54. Yokoyama O, Yoshiyama M, Namiki M, et al. Role of the forebrain in bladder overactivity following cerebral infarction in the rat. Exp Neurol 2000;163:469-76. (Pubitemid 30399097)
55. Yoshiyama M, Kobayashi H, Araki I, et al. Sex-related differences in activity of lower urinary tract in response to intravesical acid irritation in decerebrate unanesthetized mice. Am J Physiol Regul Integr Comp Physiol 2008;295:R954-60.
56. Malmgren A, Sjogren C, Uvelius B, et al. Cystometrical evaluation of bladder instability in rats with infravesical outflow obstruction. J Urol 1987; 137:1291-4. (Pubitemid 17079086)
57. Maggi CA, Conte B. Effect of urethane anesthesia on the micturition reflex in capsaicin-treated rats. J Auton Nerv Syst 1990;30:247-51.
58. Yoshiyama M, Roppolo JR, De Groat WC. Alteration by urethane of glutamatergic control of micturition. Eur J Pharmacol 1994;264:417-25. (Pubitemid 24335485)
59. Smith PP, Hurtado E, Smith CP, et al. Comparison of cystometric methods in female rats. Neurourol Urodyn 2008;27:324-9. (Pubitemid 351656405)
60. Yoshimura N, Kuno S, Chancellor MB, et al. Dopaminergic mechanisms underlying bladder hyperactivity in rats with a unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal pathway. Br J Pharmacol 2003; 139:1425-32. (Pubitemid 37174656)
61. Matsumoto Y, Torimoto K, Matsuyoshi H, et al. Long-term effects of diabetes mellitus on voiding function in a new model of type 2 diabetes mellitus, the Spontaneously Diabetic Torii (SDT) rat. Biomed Res 2009;30: 331-5.
62. Velasco C, Guarneri L, Leonardi A, et al. Influence of pump compliance (peristaltic vs. infusion) on urodynamic measurement during cystometry in conscious rats. J Pharmacol Toxicol Methods 2001;45:215-21. (Pubitemid 34033691)
63. Angelico P, Guarneri L, Velasco C, et al. Effect of cyclooxygenase inhibitors on the micturition reflex in rats: Correlation with inhibition of cyclooxygenase isozymes. BJU Int 2006;97:837-46. (Pubitemid 43383525)
64. Grandadam F, Lluel P, Palea S, et al. Pharmacological and urodynamic changes in rat urinary bladder function after multiple pregnancies. BJU Int 1999;84:861-6. (Pubitemid 29500057)
65. Pandita RK, Andersson KE. Intravesical adenosine triphosphate stimulates the micturition reflex in awake, freely moving rats. J Urol 2002;168: 1230-4.
66. Pandita RK, Nylen A, Andersson KE. Oxytocin-induced stimulation and inhibition of bladder activity in normal, conscious rats - Influence of nitric oxide synthase inhibition. Neuroscience 1998;85:1113-9. (Pubitemid 28293417)
67. Lee KS, Na YG, Dean-McKinney T, et al. Alterations in voiding frequency and cystometry in the clomipramine induced model of endogenous depression and reversal with fluoxetine. J Urol 2003;170: 2067-71. (Pubitemid 37255010)
68. Chen Z, Ishizuka O, Imamura T, et al. Stimulation of skin menthol receptors stimulates detrusor activity in conscious rats. Neurourol Urodyn 29:506-11.
69. Jin LH, Andersson KE, Kwon YH, et al. Selection of a control rat for conscious spontaneous hypertensive rats in studies of detrusor overactivity on the basis of measurement of intra-abdominal pressures. Neurourol Urodyn 2010;29:1338-43.
70. Ishizuka O, Mattiasson A, Andersson KE. Prostaglandin E2-induced bladder hyperactivity in normal, conscious rats: Involvement of tachykinins? J Urol 1995;153:2034-8.
71. Schussler B. Comparison of the mode of action of prostaglandin E2 (PGE2) and sulprostone, a PGE2-derivative, on the lower urinary tract in healthy women. A urodynamic study. Urol Res 1990;18:349-52. (Pubitemid 20344041)
72. Ishizuka O, Mattiasson A, Andersson KE. Urodynamic effects of intravesical resiniferatoxin and capsaicin in conscious rats with and without outflow obstruction. J Urol 1995;154:611-6.
73. Streng T, Axelsson HE, Hedlund P, et al. Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. Eur Urol 2008;53:391-9.
74. Mitobe M, Inoue H, Westfall TD, et al. A new method for producing urinary bladder hyperactivity using a non-invasive transient intravesical infusion of acetic acid in conscious rats. J Pharmacol Toxicol Methods 2008;57: 188-93.
75. Chuang YC, Chancellor MB, Seki S, et al. Intravesical protamine sulfate and potassium chloride as a model for bladder hyperactivity. Urology 2003;61: 664-70. (Pubitemid 36294214)
76. Soler R, Bruschini H, Freire MP, et al. Urine is necessary to provoke bladder inflammation in protamine sulfate induced urothelial injury. J Urol 2008;180:1527-31.
77. Bjorling DE, Elkahwaji JE, Bushman W, et al. Acute acrolein-induced cystitis in mice. BJU Int 2007;99:1523-9. (Pubitemid 47164796)
78. Stein PC, Pham H, Ito T, et al. Bladder injury model induced in rats by exposure to protamine sulfate followed by bacterial endotoxin. J Urol 1996;155:1133-8. (Pubitemid 26052730)
79. Vale JA, Bowsher WG, Liu K, et al. Post-irradiation bladder dysfunction: Development of a rat model. Urol Res 1993;21:383-8. (Pubitemid 24053895)
80. LaBerge J, Malley SE, Zvarova K, et al. Expression of corticotropin-releasing factor and CRF receptors in micturition pathways after cyclophosphamide-induced cystitis. Am J Physiol Regul Integr Comp Physiol 2006;291:R692- 703.
81. Rahman NU, Phonsombat S, Bochinski D, et al. An animal model to study lower urinary tract symptoms and erectile dysfunction: The hyperlipidaemic rat. BJU Int 2007;100:658-63. (Pubitemid 47205488)
82. Son H, Lee SL, Park WH, et al. New unstable bladder model in hypercholesterolemia rats. Urology 2007;69:186-90. (Pubitemid 46161703)
83. Azadzoi KM, Tarcan T, Siroky MB, et al. Atherosclerosis-induced chronic ischemia causes bladder fibrosis and non-compliance in the rabbit. J Urol 1999;161:1626-35. (Pubitemid 29420853)
84. Azadzoi KM, Heim VK, Tarcan T, et al. Alteration of urothelial-mediated tone in the ischemic bladder: Role of eicosanoids. Neurourol Urodyn 2004;23:258-64. (Pubitemid 39549987)
85. Daneshgari F, Leiter EH, Liu G, et al. Animal models of diabetic uropathy. J Urol 2009;182:S8-13.
86. Gasbarro G, Lin DL, Vurbic D, et al. Voiding function in obese and type 2 diabetic female rats. Am J Physiol Renal Physiol 298:F72-7.
87. Janssen U, Phillips AO, Floege J. Rodent models of nephropathy associated with type II diabetes. J Nephrol 1999;12:159-72. (Pubitemid 29370823)
88. Oelke M, Baard J, Wijkstra H, et al. Age and bladder outlet obstruction are independently associated with detrusor overactivity in patients with benign prostatic hyperplasia. Eur Urol 2008;54:419-26.
89. Saito M, Miyagawa I. Bladder dysfunction after acute urinary retention in rats. J Urol 2001;165:1745-7. (Pubitemid 32410301)
90. Melman A, Tar M, Boczko J, et al. Evaluation of two techniques of partial urethral obstruction in the male rat model of bladder outlet obstruction. Urology 2005;66:1127-33. (Pubitemid 41587188)
91. Schroder A, Uvelius B, Newgreen D, et al. Bladder overactivity in mice after 1 week of outlet obstruction. Mainly afferent dysfunction? J Urol 2003; 170:1017-21. (Pubitemid 36999624)
92. de Groat WC, Yoshimura N. Changes in afferent activity after spinal cord injury. Neurourol Urodyn 29:63-76.
93. Noto H, Roppolo JR, Steers WD, et al. Electrophysiological analysis of the ascending and descending components of the micturition reflex pathway in the rat. Brain Res 1991;549:95-105.
94. Pikov V, Gillis RA, Jasmin L, et al. Assessment of lower urinary tract functional deficit in rats with contusive spinal cord injury. J Neurotrauma 1998;15:375-86. (Pubitemid 28218108)
95. Pikov V, Wrathall JR. Altered glutamate receptor function during recovery of bladder detrusor-external urethral sphincter coordination in a rat model of spinal cord injury. J Pharmacol Exp Ther 2002;300:421-7. (Pubitemid 34106232)
96. Pikov V, Wrathall JR. Coordination of the bladder detrusor and the external urethral sphincter in a rat model of spinal cord injury: Effect of injury severity. J Neurosci 2001;21:559-69. (Pubitemid 32107445)
97. Araki I, Kitahara M, Oida T, et al. Voiding dysfunction and Parkinson's disease: Urodynamic abnormalities and urinary symptoms. J Urol 2000;164: 1640-3.
98. Fowler CJ. Update on the neurology of Parkinson's disease. Neurourol Urodyn 2007;26:103-9. (Pubitemid 46175455)
99. Sammour ZM, Gomes CM, Barbosa ER, et al. Voiding dysfunction in patients with Parkinson's disease: Impact of neurological impairment and clinical parameters. Neurourol Urodyn 2009;28:510-5.
100. Seki S, Igawa Y, Kaidoh K, et al. Role of dopamine D1 and D2 receptors in the micturition reflex in conscious rats. Neurourol Urodyn 2001;20: 105-13. (Pubitemid 32096332)
101. Kitta T, Matsumoto M, Tanaka H, et al. GABAergic mechanism mediated via D receptors in the rat periaqueductal gray participates in the micturition reflex: An in vivo microdialysis study. Eur J Neurosci 2008;27: 3216-25. (Pubitemid 351847309)
102. Yokoyama O, Mizuno H, Komatsu K, et al. Role of glutamate receptors in the development and maintenance of bladder overactivity after cerebral infarction in the rat. J Urol 2004;171:1709-14. (Pubitemid 38365469)
103. Yotsuyanagi S, Yokoyama O, Komatsu K, et al. Role of cyclooxygenase-2 in the development of bladder overactivity after cerebral infarction in the rat. J Urol 2005;174:365-9. (Pubitemid 40825759)
104. Kodama K, Yokoyama O, Komatsu K, et al. Contribution of cerebral nitric oxide to bladder overactivity after cerebral infarction in rats. J Urol 2002;167:391-6. (Pubitemid 34024591)
105. Igawa Y, Zhang X, Nishizawa O, et al. Cystometric findings in mice lacking muscarinic M2 or M3 receptors. J Urol 2004;172:2460-4. (Pubitemid 39507553)
106. Lu B, Poirier C, Gaspar T, et al. A mutation in the inner mitochondrial membrane peptidase 2-like gene (Immp2l) affects mitochondrial function and impairs fertility in mice. Biol Reprod 2008;78:601-10. (Pubitemid 351469337)
107. Kim JC, Park EY, Hong SH, et al. Changes of urinary nerve growth factor and prostaglandins in male patients with overactive bladder symptom. Int J Urol 2005;12:875-80. (Pubitemid 41726958)
108. Kim JC, Park EY, Seo SI, et al. Nerve growth factor and prostaglandins in the urine of female patients with overactive bladder. J Urol 2006;175: 1773-6; discussion 6.