GABA Receptor Activation in the Lumbosacral Spinal Cord Decreases Detrusor Overactivity in Spinal Cord Injured Rats

Journal of Urology

Volumn 179, Issue 3, 2008, Pages 1178-1183

  Miyazato, Minoru ^a,b   Sasatomi, Kurumi ^a   Hiragata, Shiro ^a   Sugaya, Kimio ^b   Chancellor, Michael B ^a   de Groat, William C ^a   Yoshimura, Naoki ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

bladder; gamma aminobutyric acid; overactive; spinal cord injuries; urethra; urinary bladder

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR; BACLOFEN; BICUCULLINE METHOBROMIDE; GLUTAMATE DECARBOXYLASE 67; MESSENGER RNA; MUSCIMOL; SACLOFEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER CONTRACTION; BLADDER FUNCTION; BLADDER SPHINCTER; CONTROLLED STUDY; CYSTOMETRY; DOSE RESPONSE; DRUG ACTIVATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG INHIBITION; ELECTROMYOGRAM; FEMALE; GABAERGIC SYSTEM; LUMBOSACRAL SPINE; MICTURITION; NONHUMAN; OVERACTIVE BLADDER; PRESSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECORDING; SPINAL CORD INJURY; SPINAL CORD TRANSSECTION; SPINAL GANGLION; SPRAGUE DAWLEY RAT; STIMULATION; THORACIC SPINAL CORD;

ANIMALS; BACLOFEN; BICUCULLINE; DISEASE MODELS, ANIMAL; FEMALE; GABA AGONISTS; GABA ANTAGONISTS; GLUTAMATE DECARBOXYLASE; INJECTIONS, SPINAL; LUMBAR VERTEBRAE; MUSCIMOL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA; SACRUM; SPINAL CORD; SPINAL CORD INJURIES; URINARY BLADDER, OVERACTIVE; URODYNAMICS;

EID: 39149085670     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2007.10.030     Document Type: Article

References (15)

1. Holstege G., Griffiths D., de Wall H., and Dalm E. Anatomical and physiological observations on supraspinal control of bladder and urethral sphincter muscles in the cat. J Comp Neurol 250 (1986) 449
2. de Groat W.C., and Yoshimura N. Mechanisms underlying the recovery of lower urinary tract function following spinal cord injury. Prog Brain Res 152 (2006) 59
3. Miyazato M., Sugaya K., Nishijima S., Ashitomi K., Hatano T., and Ogawa Y. Inhibitory effect of intrathecal glycine on the micturition reflex in normal and spinal cord injury rats. Exp Neurol 183 (2003) 232
4. Herman R.M., Wainberg M.C., delGiudice P.F., and Willscher M.K. The effect of a low dose of intrathecal morphine on impaired micturition reflexes in human subjects with spinal cord lesions. Anesthesiology 69 (1988) 313
5. Shapiro S. Neurotransmission by neurons that use serotonin, noradrenaline, glutamate, glycine, and γ-aminobutyric acid in the normal and injured spinal cord. Neurosurgery 40 (1997) 168
6. Igawa Y., Mattiasson A., and Andersson K.E. Effects of GABA-receptor stimulation and blockade on micturition in normal rats and rats with bladder outflow obstruction. J Urol 150 (1993) 537
7. Steers W.D., Meythaler J.M., Haworth C., Herrell D., and Park T.S. Effects of acute bolus and chronic continuous intrathecal baclofen on genitourinary dysfunction due to spinal cord pathology. J Urol 148 (1992) 1849
8. Hayasaki H., Sohma Y., Kanbara K., Maemura K., Kubota T., and Watanabe M. A local GABAergic system within rat trigeminal ganglion cells. Eur J Neurosci 23 (2006) 745
9. Keast J.R., and de Groat W.C. Segmental distribution and peptide content of primary afferent neurons innervating the urogenital organs and colon of male rats. J Comp Neurol 319 (1992) 615
10. Mallory B., Steers W.D., and de Groat W.C. Electrophysiological study of micturition reflexes in rats. Am J Physiol 257 (1989) R410
11. Cheng C.L., Ma C.P., and de Groat W.C. Effect of capsaicin on micturition and associated reflexes in chronic spinal rats. Brain Res 678 (1995) 40
12. Blok B.F., de Weerd H., and Holstege G. The pontine micturition center projects to sacral cord GABA immunoreactive neurons in the cat. Neurosci Lett 233 (1997) 109
13. Seki S., Sasaki K., Igawa Y., Nishizawa O., Chancellor M.B., de Groat W.C., and Yoshimura N. Suppression of detrusor-sphincter dyssynergia by immunoneutralization of nerve growth factor in lumbosacral spinal cord in spinal cord injured rats. J Urol 171 (2004) 478
14. Miyazato M., Sugaya K., Nishijima S., Ashitomi K., Morozumi M., and Ogawa Y. Dietary glycine inhibits bladder activity in normal rats and rats with spinal cord injury. J Urol 173 (2005) 314
15. Miyazato M., Sugaya K., Nishijima S., Ashitomi K., Ohyama C., and Ogawa Y. Rectal distention inhibits bladder activity via glycinergic and GABAergic mechanisms in rats. J Urol 171 (2004) 1353