Curcumin induces DNA damage and caffeine-insensitive cell cycle arrest in colorectal carcinoma HCT116 cells

Molecular and Cellular Biochemistry

Volumn 354, Issue 1-2, 2011, Pages 247-252

  Lu, Jin Jian ^a,b   Cai, Yu Jun ^a   Ding, Jian ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

Author keywords

Caffeine; Curcumin; DNA damage; Mitosis arrest; S phase arrest; Tubulin

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CAFFEINE; CURCUMIN; ETOPOSIDE; MITOTIC PROTEIN MONOCLONAL ANTIBODY 2; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL STRAIN HCT116; COLORECTAL CARCINOMA; CONTROLLED STUDY; DNA DAMAGE; HUMAN; HUMAN CELL; MITOSIS INHIBITION; SURFACE PLASMON RESONANCE;

ANTINEOPLASTIC AGENTS; CAFFEINE; COLORECTAL NEOPLASMS; CURCUMIN; DNA DAMAGE; G2 PHASE; HCT116 CELLS; HUMANS; MITOSIS; PHOSPHODIESTERASE INHIBITORS; S PHASE; TUBULIN;

ATAXIA TELANGIECTASIA; CURCUMA LONGA;

EID: 79959801239     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-011-0824-3     Document Type: Article

References (28)

1. Aggarwal BB, Kumar A, Bharti AC (2003) Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 23:363-398 (Pubitemid 36361976)
2. Kunnumakkara AB, Anand P, Aggarwal BB (2008) Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett 269:199-225
3. Hatcher H, Planalp R, Cho J, Torti FM, Torti SV (2008) Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci 65:1631-1652
4. Das T, Sa G, Saha B, Das K (2010) Multifocal signal modulation therapy of cancer: ancient weapon, modern targets. Mol Cell Biochem 336:85-95
5. Lin JK (2007) Molecular targets of curcumin. Adv Exp Med Biol 595:227-243
6. Holy JM (2002) Curcumin disrupts mitotic spindle structure and induces micronucleation in MCF-7 breast cancer cells. Mutat Res 518:71-84
7. Shishodia S, Amin HM, Lai R, Aggarwal BB (2005) Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem Pharmacol 70:700-713 (Pubitemid 41058705)
8. Weir NM, Selvendiran K, Kutala VK, Tong L, Vishwanath S, Rajaram M, Tridandapani S, Anant S, Kuppusamy P (2007) Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. Cancer Biol Ther 6:178-184 (Pubitemid 46641620)
9. Sahu RP, Batra S, Srivastava SK (2009) Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells. Br J Cancer 100:1425-1433
10. Cao J, Jia L, Zhou HM, Liu Y, Zhong LF (2006) Mitochondrial and nuclear DNA damage induced by curcumin in human hepatoma G2 cells. Toxicol Sci 91:476-483 (Pubitemid 43827300)
11. Blasiak J, Trzeciak A, Kowalik J (1999) Curcumin damages DNA in human gastric mucosa cells and lymphocytes. J Environ Pathol Toxicol Oncol 18:271-276 (Pubitemid 30140319)
12. Urbina-Cano P, Bobadilla-Morales L, Ramirez-Herrera MA, Corona-Rivera JR, Mendoza-Magana ML, Troyo-Sanroman R, Corona-Rivera A (2006) DNA damage in mouse lymphocytes exposed to curcumin and copper. J Appl Genet 47:377-382 (Pubitemid 44893734)
13. Zhao H, Piwnica-Worms H (2001) ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol 21:4129-4139 (Pubitemid 32565295)
14. Yang J, Yu Y, Hamrick HE, Duerksen-Hughes PJ (2003) ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses. Carcinogenesis 24:1571-1580
15. Sarkaria JN, Busby EC, Tibbetts RS, Roos P, Taya Y, Karnitz LM, Abraham RT (1999) Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res 59:4375-4382 (Pubitemid 29418757)
16. Huang M, Gao H, Chen Y, Zhu H, Cai Y, Zhang X, Miao Z, Jiang H, Zhang J, Shen H, Lin L, Lu W, Ding J (2007) Chimmitecan, a novel 9-substituted camptothecin, with improved anticancer pharmacologic profiles in vitro and in vivo. Clin Cancer Res 13:1298-1307 (Pubitemid 46424071)
17. 2 generation and topoisomerase II inhibition. Free Radic Biol Med 45:627-635
18. Li W, Shao Y, Hu L, Zhang X, Chen Y, Tong L, Li C, Shen X, Ding J (2007) BM6, a new semi-synthetic vinca alkaloid, exhibits its potent in vivo anti-tumor activities via its high binding affinity for tubulin and improved pharmacokinetic profiles. Cancer Biol Ther 6:787-794 (Pubitemid 47328363)
19. Ren X, Dai M, Lin LP, Li PK, Ding J (2009) Anti-angiogenic and vascular disrupting effects of C9, a new microtubule-depolymerizing agent. Br J Pharmacol 156:1228-1238
20. Zhu H, Miao ZH, Huang M, Feng JM, Zhang ZX, Lu JJ, Cai YJ, Tong LJ, Xu YF, Qian XH, Ding J (2009) Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells. Neoplasia 11:1226-1234
21. Davis FM, Tsao TY, Fowler SK, Rao PN (1983) Monoclonal antibodies to mitotic cells. Proc Natl Acad Sci USA 80:2926-2930
22. Gupta KK, Bharne SS, Rathinasamy K, Naik NR, Panda D (2006) Dietary antioxidant curcumin inhibits microtubule assembly through tubulin binding. FEBS J 273:5320-5332 (Pubitemid 44772390)
23. Rojas E, Lopez MC, Valverde M (1999) Single cell gel electrophoresis assay: methodology and applications. J Chromatogr B 722:225-254 (Pubitemid 29142512)
24. Cliby WA, Lewis KA, Lilly KK, Kaufmann SH (2002) S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function. J Biol Chem 277:1599-1606 (Pubitemid 34968919)
25. Iguchi T, Miyakawa Y, Saito K, Nakabayashi C, Nakanishi M, Saya H, Ikeda Y, Kizaki M (2007) Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells. Int J Oncol 31:285-291
26. Guo N, Faller DV, Vaziri C (2002) Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive. Cell Growth Differ 13:77-86 (Pubitemid 34205515)
27. Mladenov E, Tsaneva I, Anachkova B (2007) Activation of the S phase DNA damage checkpoint by mitomycin C. J Cell Physiol 211:468-476 (Pubitemid 46580100)
28. Wolanin K, Magalska A, Mosieniak G, Klinger R, McKenna S, Vejda S, Sikora E, Piwocka K (2006) Curcumin affects components of the chromosomal passenger complex and induces mitotic catastrophe in apoptosis-resistant Bcr-Abl-expressing cells. Mol Cancer Res 4:457-469 (Pubitemid 44197041)