Clinical study of solid dispersions of itraconazole prepared by hot-stage extrusion

European Journal of Pharmaceutical Sciences

Volumn 24, Issue 2-3, 2005, Pages 179-186

  Six, Karel ^a,d   Daems, Tinne ^a   De Hoon, Jan ^b   Van Hecken, Anne ^b   Depre, Marleen ^b   Bouche, Marie Paule ^c   Prinsen, Paul ^c   Verreck, Geert ^d   Peeters, Jef ^d   Brewster, Marcus E ^d   Van Den Mooter, Guy ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^c Johnson Johnson Pharmaceutical R D ^*  (Belgium)

^d Pharmaceutical Sciences   (Belgium)

Author keywords

Hot stage extrusion; Itraconazole; Oral bioavailability; Solid dispersions; Sporanox

Indexed keywords

DRUG METABOLITE; HYDROXYITRACONAZOLE; ITRACONAZOLE;

AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; CLINICAL TRIAL; CROSSOVER PROCEDURE; DISPERSION; DISSOLUTION; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG MANUFACTURE; DRUG MARKETING; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; NORMAL HUMAN; PRIORITY JOURNAL; SOLID; VOLUNTEER;

ADMINISTRATION, ORAL; ADULT; CAPSULES; CHEMISTRY, PHARMACEUTICAL; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; ITRACONAZOLE; MALE; TECHNOLOGY, PHARMACEUTICAL;

EID: 19944432124     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2004.10.005     Document Type: Article

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