A compressibility and compactibility study of real tableting mixtures: The impact of wet and dry granulation versus a direct tableting mixture

International Journal of Pharmaceutics

Volumn 414, Issue 1-2, 2011, Pages 131-139

  Šantl, Maja ^a   Ilić, Ilija ^b   Vrečer, Franc ^a,b   Baumgartner, Saša ^b  

^a KRKA D D   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Compactibility; Compressibility; Dry granulation; Heckel; Waker; Wet granulation

Indexed keywords

ARTICLE; DRUG FORMULATION; DRUG GRANULATION; FLOW; POROSITY; POWDER; PRIORITY JOURNAL; TABLET COMPRESSION; TABLET PROPERTY;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COMPRESSIVE STRENGTH; DRUG DELIVERY SYSTEMS; EXCIPIENTS; MODELS, THEORETICAL; PARTICLE SIZE; PLACEBOS; POROSITY; POWDERS; PRESSURE; TABLETS;

EID: 79959759005     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.05.025     Document Type: Article

References (40)

1. O. Antikainen, and J. Yliruusi Determining the compression behaviour of pharmaceutical powders from the force-distance compression profile Int. J. Pharm. 252 2003 253 261 (Pubitemid 36126634)
2. N.A. Armstrong Tablet manufacture 3rd ed. J. Swarbrick, Encyclopedia of Pharmaceutical Technology vol. 4 2007 Informa Healthcare Inc New York 3653 3672
3. C. Bacher, P.M. Olsen, P. Berthelsen, J. Kristensen, and J.M. Sonnergaard Improving the compaction properties of roller compacted calcium carbonate Int. J. Pharm. 342 2007 115 123 (Pubitemid 47263498)
4. C. Bacher, P.M. Olsen, P. Berhelsen, and J.M. Sonnergaard Compressibility and compactibility of granules produced by wet and dry granulation Int. J. Pharm. 358 2008 69 74
5. S.I.F. Badawy, M.M. Menning, M.A. Gorko, and D.L. Gilbert Effect of process parameters on compressibility of granulation manufactured in a high-shear mixer Int. J. Pharm. 198 2000 51 61 (Pubitemid 30155549)
6. A.G. Dean, K.M. Sullivan, and M.M. Soe OpenEpi: Open Source Epidemiologic Statistics for Public Health. Version 2.2.1 2008 http://www.OpenEpi.com (updated 06.03.2008, accessed 16.10.2008).
7. M. Duberg, and C. Nyström Studies on direct compression of tablets XVII. Porosity-pressure curves for the characterization of volume reduction mechanisms in powder compression Powder Technol. 46 1986 67 75 (Pubitemid 16534681)
8. European Pharmacopoeia 6th Edition, 2008. Council of Europe. Strasbourg 01/2008. 2.9.36. Powder Flow (01/2008:20936).
9. L. Farber, K.P. Hapgood, J.N. Michaels, X.-Y. Fu, R. Meyer, M.-A. Johnson, and F. Li Unified compaction curve model for tensile strength of tablets made by roller compaction and direct compression Int. J. Pharm. 346 2008 17 24 (Pubitemid 350101988)
10. J.T. Fell, and J.M. Newton Determination of tablet strength by the diametral compression test J. Pharm. Sci. 59 1970 688 691
11. F. Fichtner,.C. Rasmuson, E.M. lander, and G. Alderborn Effect of preparation method on compactibility of paracetamol granules and agglomerates Int. J. Pharm. 336 2007 148 158 (Pubitemid 46551565)
12. F. Freitag, and P. Kleinebudde How do roll compaction/dry granulation affect the tableting behaviour of inorganic materials? Comparison of four magnesium carbonates Eur. J. Pharm. Sci. 19 2003 281 289 (Pubitemid 36918421)
13. F. Freitag, K. Reincke, J. Runge, W. Grellmann, and P. Kleinebudde How do roll compaction/dry granulation affect the tableting behaviours of inorganic materials? Microhardness of ribbons and mercury porosimetry measurements of tablets Eur. J. Pharm. Sci. 22 2004 325 333 (Pubitemid 38758020)
14. H. Hausner Friction conditions in a mass of metal powder Int. J. Powder Metall. 3 1967 7 13
15. M.G. Herting, and P. Kleinebudde Roll compaction/dry granulation: effect of raw material particle size on granule and tablet properties Int. J. Pharm. 338 2007 110 118 (Pubitemid 46777224)
16. E. Horisawa, K. Danjo, and H. Sunada Influence of granulating method on physical and mechanical properties, compression behavior, and compactility of lactose and microcrystalline cellulose granules Drug Dev. Ind. Pharm. 26 6 2000 583 593 (Pubitemid 30317064)
17. R.W. Heckel Density-pressure relationships in powder compaction Trans. Metall. Soc. AIME 221 1961 671 675
18. I. Ilić, P. Kása Jr.; R. Dreu, K. Pintye-Hódi, and S. Srčič The compressibility and compactibility of different types of lactose Drug Dev. Ind. Pharm. 35 10 2009 1271 1280
19. J. Ilkka, and P. Paronen Prediction of the compression behaviour of powder mixtures by the Heckel equation Int. J. Pharm. 94 1993 181 187 (Pubitemid 23204064)
20. S. Inghelbrecht, and J.P. Remon Reducing dust and improving granule and tablet quality in the roller compaction process Int. J. Pharm. 171 1998 195 206 (Pubitemid 29023112)
21. P. Kleinebudde Roll compaction/dry granulation: pharmaceutical applications Eur. J. Pharm. Biopharm. 58 2004 317 326 (Pubitemid 39037238)
22. H. Leuenberger The compressibility and compactibility of powder systems Int. J. Pharm. 12 1982 41 55 (Pubitemid 12058125)
23. S. Malkowska, and K.A. Khan Effect of re-compression on the properties of tablets prepared by dry granulation Drug Dev. Ind. Pharm. 9 3 1983 331 347 (Pubitemid 13128688)
24. P. Paronen Heckel plots as indicators of elastic properties of pharmaceuticals Drug Dev. Ind. Pharm. 12 11-13 1986 1903 1912 (Pubitemid 17178853)
25. P. Paronen, and J. Ilkka Porosity-pressure functions G. Alderborn, C. Nyström, Pharmaceutical Powder Compaction Technology 1996 Marcel Dekker Inc New York 55 75
26. S. Patel, A.M. Kaushal, and A.K. Bansal Effect of particle size and compression force on compaction behavior and derived mathematical parameters of compressibility Pharm. Res. 24 1 2007 111 124 (Pubitemid 44902576)
27. S. Patel, A.M. Kaushal, and A.K. Bansal Mechanistic investigation on pressure dependency of Heckel parameter Int. J. Pharm. 389 2010 66 73
28. G. Ragnarsson Force-displacement and network measurements G. Alderborn, C. Nyström, Pharmaceutical Powder Compaction Technology 1996 Marcel Dekker Inc New York 77 97
29. M. Riippi, O. Antikainen, T. Niskanen, and J. Yliruusi The effect of compression force on surface structure, crushing strength, friability and disintegration time of erythromycin acistrate tablets Eur. J. Pharm. Biopharm. 46 3 1998 339 345 (Pubitemid 29057682)
30. R.J. Roberts, and R.C. Rowe Brittle/ductile behaviour in pharmaceutical materials used in tableting Int. J. Pharm. 36 1987 205 209 (Pubitemid 17070789)
31. T. Sebhatu, C. Ahlneck, and G. Alderborn The effect of moisture content on the compression and bond-formation properties of amorphous lactose particles Int. J. Pharm. 146 1997 101 114 (Pubitemid 27062969)
32. J.M. Sonnergaard A critical evaluation of the Heckel equation Int. J. Pharm. 193 1999 63 71
33. J.M. Sonnergaard Impact of particle density and initial volume on mathematical compression models Eur. J. Pharm. Sci. 11 4 2000 307 315
34. J.M. Sonnergaard Quantification of the compactibility of pharmaceutical powders Eur. J. Pharm. Biopharm. 63 2006 270 277 (Pubitemid 43776224)
35. T. Sovány, P. Kása Jr.; and K. Pintye-Hódi Comparison of the halving of tablets prepared with eccentric and rotary tablet presses AAPS PharmSciTech 10 2 2009 430 436
36. C.C. Sun Mechanism of moisture induced variations in true density and compaction properties of microcrystalline cellulose Int. J. Pharm. 346 2008 93 101 (Pubitemid 350101996)
37. E.E. Walker The properties of powders VI: the compressibility of powders Trans. Faraday Soc. 19 1923 73 82
38. M. Wikberg, and G. Alderborn Compression characteristics of granulated materials. III. The relationship between air permeability and mechanical strength of tablets of some lactose granulations Int. J. Pharm. 63 1990 23 27 (Pubitemid 20305589)
39. S.F. Yap, M.J. Adams, J.P.K. Seville, and Z. Zhang Single and bulk compression of pharmaceutical excipients. Evaluation of mechanical properties Powder Technol. 185 2008 1 10 (Pubitemid 351671809)
40. B.D. Zupančič, R. Dreu, and F. Vrečer Influence of dry granulation on compactibility and capping tendency of macrolide antibiotic formulation Int. J. Pharm. 357 2008 44 54