Unified compaction curve model for tensile strength of tablets made by roller compaction and direct compression

International Journal of Pharmaceutics

Volumn 346, Issue 1-2, 2008, Pages 17-24

  Farber, Leon ^a   Hapgood, Karen P ^a   Michaels, James N ^a   Fu, Xi Young ^a   Meyer, Robert ^a   Johnson, Mary Ann ^a   Li, Feng ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Compaction; Hardness; Lactose; Microcrystalline cellulose; Roller compaction; Tensile strength

Indexed keywords

LACTOSE; MICROCRYSTALLINE CELLULOSE;

ARTICLE; DRUG FORMULATION; PLASTICITY; PRIORITY JOURNAL; TABLET; TABLET COMPRESSION; TENSILE STRENGTH;

CELLULOSE; DRUG COMPOUNDING; LACTOSE; MODELS, CHEMICAL; TABLETS; TENSILE STRENGTH;

EID: 36048970122     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.06.022     Document Type: Article

References (12)

1. Bika D.G., Gentzler M., and Michaels J.N. Mechanical properties of agglomerates. Powder Technol. 117 (2001) 98-112
2. Bultmann J.M. Multiple compaction of microcrystalline cellulose in a roller compactor. Eur. J. Pharm. Biopharm. 54 (2002) 59-64
3. Dec R.T., Zavaliangos A., and Cunningham J.C. Comparison of various modeling methods for analysis of powder compaction in roller press. Powder Technol. 130 (2003) 265-271
4. Freitag F., and Kleinbudde P. How do roll compaction/dry granulation affect the tableting behaviour of inorganic materials? Comparison of four magnesium carbonates. Eur. J. Pharm. Biopharm. 19 (2003) 281-289
5. Kleinebudde P. Roll compaction/dry granulation: pharmaceutical applications. Eur. J. Pharm. Biopharm. 58 (2004) 317-326
6. Kochhar S.K., Rubinstein M.H., and Barnes D. The effects of slugging and recompression on pharmaceutical excipients. Int. J. Pharm. 115 (1995) 35-43
7. Leuenberger H. The compactability and compactability of powder systems. Int. J. Pharm. 12 (1982) 41-55
8. Malkowska S., and Khan K.A. Effect of re-compression of the properties of tablets prepared by dry granulation drug. Dev. Ind. Pharm. 9 (1983) 331-347
9. McKenna A., and McCafferty D.F. Effect of particle size on the compaction mechanism and tensile strength of tablets. J. Pharm. Pharmacol. 34 (1982) 347-351
10. Rowe R.C., and Roberts R.J. Mechanical properties. In: Alderborn G., and Nyström C. (Eds). Pharmaceutical Powder Compaction Technology (1996), Marcel Dekker Inc., New York 283-322 Chapter 11
11. Simon O., and Guigon P. Correlation between powder-packing properties and roll press compact heterogeneity. Powder Technol. 130 (2003) 257-264
12. Zinchuk A.V., Mullarney M.P., and Hancock B.C. Simulation of roller compaction using a laboratory scale compaction simulator. Int. J. Pharm. 269 (2004) 403-415