Influence of dry granulation on compactibility and capping tendency of macrolide antibiotic formulation

International Journal of Pharmaceutics

Volumn 357, Issue 1-2, 2008, Pages 44-54

  Bozic, Damjana Zupancic ^a   Dreu, Rok ^b   Vrecer, Franc ^a,b  

^a KRKA D D   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Amorphization; Capping; Compactibility; Dry granulation; Heckel equation; Macrolide antibiotic; Particle fragmentation; Tableting

Indexed keywords

MACROLIDE; MICROCRYSTALLINE CELLULOSE;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DETERMINATION; PARTICLE SIZE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPE; TABLET COMPRESSION; TABLET FORMULATION; TABLET HARDNESS; TABLET MANUFACTURE; TABLET SURFACE; X RAY POWDER DIFFRACTION;

ANTI-BACTERIAL AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, GAS; DESICCATION; DRUG COMPOUNDING; EXCIPIENTS; HUMIDITY; LUBRICANTS; MACROLIDES; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POWDERS; TABLETS; X-RAY DIFFRACTION;

EID: 42949086131     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.01.023     Document Type: Article

References (37)

1. Adolfsson A., Olsson H., and Nyström C. Effect of particle size and compaction load on interparticulate bonding structure for some pharmaceutical materials studied by compaction and strength characterization in butanol. Eur. J. Pharm. Biophar. 44 (1997) 243-251
2. Alderborn G., and Nyström C. Studies on direct compression of tablets. III. The effect on tablet strength of changes in particle shape and texture obtained by milling. Acta Pharm. Suec. 19 (1982) 147-156
3. Alderborn G., Pasanen K., and Nyström C. Studies on direct compression of tablets. XI. Characterisation of particle fragmentation during compaction by permeametry measurements of tablets. Int. J. Pharm. 23 (1985) 79-86
4. Bultmann J.M. Multiple compaction of microcrystalline cellulose in a roller compactor. Eur. J. Pharm. Biopharm. 54 (2002) 59-64
5. Busignies V., Leclerc B., Porion P., Evesque P., Couarraze G., and Tchoreloff P. Compaction behaviour and new predictive approach to the compressibility of binary mixtures of pharmaceutical excipients. Eur. J. Pharm. Biopharm. 64 (2006) 66-74
6. De Boer A.H., Bolhuis G.K., and Lerk C.F. Bonding characteristics by scanning electron microscopy of powders mixed with magnesium stearate. Powder Technol. 20 (1978) 75-82
7. Duberg M., and Nyström C. Studies on direct compression of tablets. VI. Evaluation of methods for the estimation of particle fragmentation during compaction. Acta Pharm. Suec. 19 (1982) 421-436
8. Duberg M., and Nyström C. Studies on direct compression of tablets. XVII. Porosity-pressure curves for the characterization of volume reduction mechanisms in powder compression. Powder Technol. 46 (1986) 67-75
9. Eggelkraut-Gottanka S.G., Abu Abed S., Müller W., and Schmidt P.C. Roller compaction and tabletting of St. John's worth plant dry extract using a gap width and force controlled roller compactor. I. Granulation and tabletting of eight different extract batches. Pharm. Dev. Technol. 7 (2002) 433-443
10. El Gindy N.A., and Samaha M.W. Tensile strength of some pharmaceutical compacts and their relation to surface free energy. Int. J. Pharm. 13 (1983) 35-46
11. Freitag F., Reincke K., Runge J., Grellmann W., and Kleinebudde P. How do roll compaction/dry granulation affect the tableting behaviour of inorganic materials? Microcrushing strength of ribbons and mercury porosimetry measurement of tablets. Eur. J. Pharm. Sci. 22 (2004) 325-333
12. Heckel R.W. Density-pressure relationship in powder compaction. Trans. Metall. Soc. AIME 221 (1961) 671-675
13. Hüttenrauch R. Fundamentals of pharmaceutics. Acta Pharm. Technol. 34 (1988) 1-10
14. Ilkka J., and Paronen P. Prediction of the compression behaviour of powder mixtures by Heckel equation. Int. J. Pharm. 94 (1993) 181-187
15. Karehill P.G., Glazer M., and Nyström C. Studies on direct compression of tablets. XXIII. The importance of surface roughness for the compactibility of some directly compressible materials with different bonding and volume reduction properties. Int. J. Pharm. 64 (1990) 35-43
16. Kochhar S.K., Rubinstein M.H., and Barnes D. The effects of slugging and recompression on pharmaceutical excipients. Int. J. Pharm. 115 (1995) 35-43
17. Luangtana-Anan M., and Fell J.T. Bonding mechanisms in tabletting. Int. J. Pharm. 60 (1990) 197-202
18. McKenna A., and McCafferty D.F. Effect of particle size on the compaction mechanism and tensile strength of tablets. J. Pharm. Pharmacol. 34 (1982) 347-351
19. Monedero Perales M.C., Muñoz-Ruiz A., Velasco Antequera M.V., and Jimenez-Castellanos Ballesteros M.R. Study of the compaction mechanisms of lactose-based direct compression excipients using indentation hardness and Heckel plots. J. Pharm. Pharmacol. 46 (1994) 177-181
20. Nyström C., Mazur J., and Sjögren J. Studies on direct compression of tablets. II. The influence of the particle size of a dry binder on the mechanical strength of tablets. Int. J. Pharm. 10 (1982) 209-218
21. Nyström C., Alderborn G., Duberg M., and Karerhill P.-G. Bonding surface area and bonding mechanism-two important factors for the understanding of powder compactibility. Drug Dev. Ind. Pharm. 19 (1993) 2143-2196
22. Parrott E.L. Compression. In: Lieberman H.A., Lachmann L., and Schwartz J.B. (Eds). Pharmaceutical Dosage Forms. 2nd ed. vol. 2 (1990), Dekker, New York 201-243 Tablets
23. Pedersen S., and Kristensen H.G. Change in crystal density of acetylsalicylic acid during compaction. STP Pharm. Sci. 4 (1994) 201-206
24. Planinsek O., and Buckton G. Inverse gas chromatography: considerations about appropriate use for amorphous and crystalline powders. J. Pharm. Sci. 92 (2003) 1286-1294
25. Ragnarsson G., and Sjögren J. Force-displacement measurements in tableting. J. Pharm. Pharmacol. 37 (1985) 145-150
26. Ritter A., and Sucker H.B. Studies of variables that affect tablet capping. Pharm. Technol. 3 (1980) 56-65
27. Roberts R.J., and Rowe R.C. Brittle/ductile behaviour in pharmaceutical materials used in tableting. Int. J. Pharm. 36 (1987) 205-209
28. Rocksloh K., Rapp F.-R., Abu Abed S., Müller W., Reher M., Gauglitz G., and Schmidt P.C. Optimization of crushing strength and disintegration time of a high-dose plant extract tablet by neural networks. Drug. Dev. Ind. Pharm. 25 (1999) 1015-1025
29. Rue P.J., and Rees J.E. Limitations of the Heckel relation for predicting powder compaction mechanisms. J. Pharm. Pharmacol. 30 (1978) 642-643
30. Sebhatu T., and Alderborn G. Relationships between the effective interparticulate contact area and the tensile strength of tablets of amorphous and crystalline lactose of varying particle size. Eur. J. Pharm. Sci. 8 (1999) 235-242
31. Shotton E., and Ganderton D. The strength of compressed tablets. III. The relation of particle size, bonding and capping in tablets of sodium chloride, aspirin and hexamine. J. Pharm. Pharmacol. (1961) 144-152
32. Soares, L.A.L., Ortega, G.G., Petrovick, P.R., Schmidt, P.C., 2005. Dry granulation and compression of spray-dried plant extracts. AAPS Pharm. Sci. Technol. 6, article 45 (http://www.aapspharmscitech.org).
33. Sonnergaard J.M. A critical evaluation of the Heckel equation. Int. J. Pharm. 193 (1999) 63-71
34. Sun C., and Grant D.J.W. Influence of elastic deformation of particles on Heckel analysis. Pharm. Dev. Technol. 6 (2001) 193-200
35. Wikberg M., and Alderborn G. Compression characteristics of granulated materials. II. Evaluation of granule fragmentation during compression by tablet permeability and porosity measurements. Int. J. Pharm. 62 (1990) 214-229
36. York P. A consideration of experimental variables in the analysis of powder compaction behaviour. J. Pharm. Pharmacol. 31 (1979) 244-246
37. York P. Solid-state properties of powders in the formulation and processing of solid dosage forms. Int. J. Pharm. 14 (1983) 1-28