How do roll compaction/dry granulation affect the tableting behaviour of inorganic materials? Microhardness of ribbons and mercury porosimetry measurements of tablets

European Journal of Pharmaceutical Sciences

Volumn 22, Issue 4, 2004, Pages 325-333

  Freitag, Franziska ^a   Reincke, Katrin ^a   Runge, Jürgen ^a   Grellmann, Wolfgang ^a   Kleinebudde, Peter ^b  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Magnesium carbonate; Mercury porosimetry; Microhardness of ribbons; Recompression; Roll compaction dry granulation; Tablet tensile strength

Indexed keywords

MAGNESIUM CARBONATE; MERCURY;

ARTICLE; CORRELATION ANALYSIS; DRUG GRANULATION; FORCE; MEASUREMENT; PARTICLE SIZE; POROSITY; PRIORITY JOURNAL; SURFACE PROPERTY; TABLET; TABLET COMPRESSION; TABLET HARDNESS; TABLET PROPERTY; TABLET SURFACE; TENSILE STRENGTH;

CHEMISTRY, PHARMACEUTICAL; INORGANIC CHEMICALS; MERCURY; MICROSCOPY, ELECTRON, SCANNING; POROSITY; TABLETS;

EID: 2942618769     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2004.04.001     Document Type: Article

References (24)

1. Alderborn, G., Wikberg, M., 1996. Granule properties. In: Alderborn, G., Nyström, C. (Eds.), Pharmaceutical Powder Compaction Technology. Marcel Dekker, New York, pp. 77-97.
2. Aulton M.E. Indentation hardness profiles across the faces of some compressed tablets. Pharm. Acta Helv. 56(4-5):1981;133-136
3. Bierögel, C., Bethge, I., Grellmann W., Haberland, E.-J., 2001. Deformation behaviour of voice prostheses - sensitivity of mechanical test methods. In: Grellmann, W., Seidler, S. (Eds.), Deformation and Fracture Behaviour of Polymers. Springer, Berlin Heidelberg, pp. 471-476.
4. 2]. Powder Technol. 42:1985;153-157
5. Deutsches Institut für Normung, 1975. DIN 66132: Bestimmung der spezifischen Oberfläche von Feststoffen durch Stickstoffadsorption (Einpunkt-Differenzverfahren nach Haul und Dümbgen), Beuth Verlag GmbH.
6. Duberg M., Nyström C. Studies on direct compression of tablets XVII. Porosity-pressure curves for the characterisation of volume reduction mechanisms in powder compression. Powder Technol. 46:1986;67-75
7. Fell J.T., Newton J.M. Determination of tablet strength by the diametral-compression test. J. Pharm. Sci. 59:1970;688-691
8. Freitag, F., Kleinebudde, P., 2002. Effect of dry granulation on the tabletting behaviour of inorganic materials: magnesium carbonate. In: Proceedings of the Fourth World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Florence. 8-11 April 2002, pp. 235-236.
9. Freitag F., Kleinebudde P. How do roll compaction/dry granulation affect the tableting behaviour of inorganic materials? Comparison of four magnesium carbonates. Eur. J. Pharm. Sci. 19:2003;281-289
10. Hersey J.A., Rees J.E. Deformation of particles during briqueting. Nat. Phys. Sci. 230(12):1971;96
11. Hüttenrauch R. Molekulargalenik als Grundlage moderner Arzneiforschung. Acta Pharm. Technol. Suppl. 6:1978;55-127
12. Juppo A.M. Relationship between breaking force and pore structure of lactose, glucose and mannitol tablets. Int. J. Pharm. 127:1996;95-102
13. Lammens, R.F., 2002. Roll compactor instrumentation: key to rationalistic development, reproducible manufacturing, adequate trouble shooting. In: Proceedings of the Fourth World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Florence. 8-11 April 2002, pp. 29-30.
14. Leuenberger H., Rohera B.D. Fundamentals of powder compression. I. The compactibility and compressibility of pharmaceutical powders. Pharm. Res. 3(1):1986;12-22
15. Mattson S., Nyström C. Evaluation of strength-enhancing factors of a ductile binder in direct compression of sodium bicarbonate and calcium carbonate powders. Eur. J. Pharm. Sci. 10:2000;53-66
16. Riepma K.A., Vromans H., Zuurman K., Lerk C.F. The effect of dry granulation on the consolidation and compaction of crystalline lactose. Int. J. Pharm. 97:1993;29-38
17. Selkirk A.B., Ganderton D. An investigation of the pore structure of tablets of sucrose and lactose by mercury porosimetry. J. Pharm. Pharmacol. Suppl. 22:1970a;79S-85S
18. Selkirk A.B., Ganderton D. The influence of wet and dry granulation methods on the pore structure of lactose tablets. J. Pharm. Pharmacol. Suppl. 22:1970b;86S-94S
19. Vromans H., De Boer A.H., Bolhuis G.K., Lerk C.F., Kussendrager K.D., Bosch H. Studies on tableting properties of lactose. Part 2. Consolidation and compaction of different types of crystalline lactose. Pharm. Weekblad Sci. 7:1985;186-193
20. Wikberg M., Alderborn G. Compression characteristics of granulated materials. VI. Pore size distributions, assessed by mercury penetration, of compacts of two lactose granulations with different fragmentation propensities. Int. J. Pharm. 84:1992;191-195
21. Wöll, F., Shlieout, G., Kleinebudde, P., 2000. Influence of production mode and compaction force of roller compactor on the properties of ribbons and tablets. In: Proceedings of the Third World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Berlin. 3-6 April 2000, pp. 81-82.
22. York P. Crystal engineering and particle design for the powder compaction process. Drug Dev. Ind. Pharm. 18(6-7):1992;677-721
23. Zuurmann K., Riepma K.A., Bolhuis G.K., Vromans H., Lerk C.F. The relationship between bulk density and compactibility of lactose granulations. Int. J. Pharm. 102:1994;1-9
24. van der Zwan J., Siskens C.A.M. The compaction and mechanical properties of agglomerated materials. Powder Technol. 33:1982;43-54