Facile Synthesis [5- 13C-4- 2H 2]-L-Glutamine for Hyperpolarized MRS Imaging of Cancer Cell Metabolism

Academic Radiology

Volumn 18, Issue 8, 2011, Pages 932-939

  Qu, Wenchao ^a   Zha, Zhihao ^a   Lieberman, Brian P ^a   Mancuso, Anthony ^a,b   Stetz, Mathew ^a   Rizzi, Rahim ^a   Ploessl, Karl ^a   Wise, David ^b   Thompson, Craig ^b   Kung, Hank F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Glioma; Glutaminolysis; MRI; Myc gene; Tumor metabolism

Indexed keywords

2 AMINO (4 2 H 2) (5 13 C) 5 OXOPENTANOIC ACID[ (5 13 C 4 2 H 2) LEVO GLUTAMINE, 8]; 4 BENZYL 1 TERT BUTYL 2 (TERT BUTOXYCARBONYLAMINO)SUCCINATE; 4 TERT BUTOXY 3 (TERT BUTOXYCARBONYLAMINO) 4 OXOBUTANOIC ACID; CARBON 13; FLUORODEOXYGLUCOSE F 18; GLUTAMIC ACID; GLUTAMINE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TERT BUTYL 2 (TERT BUTOXYCARBONYLAMINO) 4 (13 C)CYANO (4 2 H 2)BUTANOATE; TERT BUTYL 2 (TERT BUTOXYCARBONYLAMINO) 4 (TOSYLOXY) (4 2 H 2)BUTANOATE; TERT BUTYL 2 (TERT BUTOXYCARBONYLAMINO) 4 HYDROXY (4 2 H 2)BUTANOATE; UNCLASSIFIED DRUG;

AMINO ACID METABOLISM; AMINO ACID SYNTHESIS; ARTICLE; BIOSYNTHESIS; CANCER CELL; CARBON NUCLEAR MAGNETIC RESONANCE; CELL METABOLISM; ESTERIFICATION; GLIOMA CELL; GLUTAMINOLYSIS; HUMAN; HYDROLYSIS; HYPERPOLARIZATION; ONCOGENE MYC; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REDUCTION; SUBSTITUTION REACTION;

CARBON ISOTOPES; CELL LINE, TUMOR; ENERGY METABOLISM; GLIOMA; GLUTAMINE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PROTO-ONCOGENE PROTEINS C-MYC;

EID: 79959755614     PISSN: 10766332     EISSN: 18784046     Source Type: Journal    
DOI: 10.1016/j.acra.2011.05.002     Document Type: Article

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