-
1
-
-
0030968939
-
Targeting gene expression to hypoxic tumor cells
-
Dachs GU, Patterson AV, Firth JD, Ratcliffe PJ, Townsend KM, Stratford IJ, Harris AL. 1997. Targeting gene expression to hypoxic tumor cells. Nat Med 3:515-520.
-
(1997)
Nat Med
, vol.3
, pp. 515-520
-
-
Dachs, G.U.1
Patterson, A.V.2
Firth, J.D.3
Ratcliffe, P.J.4
Townsend, K.M.5
Stratford, I.J.6
Harris, A.L.7
-
2
-
-
0031039243
-
The biology of vascular endothelial growth factor
-
Ferrara N, Davis-Smyth T. 1997. The biology of vascular endothelial growth factor. Endocr Rev 18:4-25.
-
(1997)
Endocr Rev
, vol.18
, pp. 4-25
-
-
Ferrara, N.1
Davis-Smyth, T.2
-
3
-
-
0036984640
-
Role of angiogenesis in tumor growth and metastasis
-
Folkman J. 2002. Role of angiogenesis in tumor growth and metastasis. Semin Oncol 29:15-18.
-
(2002)
Semin Oncol
, vol.29
, pp. 15-18
-
-
Folkman, J.1
-
4
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, Semenza GL. 1996. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16:4604-4613.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
Agani, F.4
Leung, S.W.5
Koos, R.D.6
Semenza, G.L.7
-
5
-
-
0037064010
-
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
-
Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, Semenza GL. 2002. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 277:38205-38211.
-
(2002)
J Biol Chem
, vol.277
, pp. 38205-38211
-
-
Fukuda, R.1
Hirota, K.2
Fan, F.3
Jung, Y.D.4
Ellis, L.M.5
Semenza, G.L.6
-
6
-
-
0033584927
-
Protein synthesis inhibition by flavonoids: Roles of eukaryotic initiation factor 2α kinases
-
Ito T, Warnken SP, May WS. 1999. Protein synthesis inhibition by flavonoids: Roles of eukaryotic initiation factor 2α kinases. Biochem Biophys Res Commun 265:589-594.
-
(1999)
Biochem Biophys Res Commun
, vol.265
, pp. 589-594
-
-
Ito, T.1
Warnken, S.P.2
May, W.S.3
-
7
-
-
0035917313
-
2 sensing
-
2 sensing. Science 292:464-468.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
8
-
-
33749817738
-
Hypoxia-inducible factor-1alpha expression requires PI 3-kinase activity and correlates with Akt1 phosphorylation in invasive breast carcinomas
-
Gort EH, Groot AJ, Derks van de Ven TL, van der Groep P, Verlaan I, van Laar T, van Diest PJ, van der Wall E, Shvarts A. 2006. Hypoxia-inducible factor-1alpha expression requires PI 3-kinase activity and correlates with Akt1 phosphorylation in invasive breast carcinomas. Oncogene 25:6123-6127.
-
(2006)
Oncogene
, vol.25
, pp. 6123-6127
-
-
Gort, E.H.1
Groot, A.J.2
Derks van de Ven, T.L.3
van der Groep, P.4
Verlaan, I.5
van Laar, T.6
van Diest, P.J.7
van der Wall, E.8
Shvarts, A.9
-
9
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation. Science 292:468-472.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratcliffe, P.J.13
-
10
-
-
0033525830
-
Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway
-
Kallio PJ, Wilson WJ, O'Brien S, Makino Y, Poellinger L. 1999. Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway. J Biol Chem 274:6519-6525.
-
(1999)
J Biol Chem
, vol.274
, pp. 6519-6525
-
-
Kallio, P.J.1
Wilson, W.J.2
O'Brien, S.3
Makino, Y.4
Poellinger, L.5
-
11
-
-
0028644238
-
Free radical scavenging and antioxidant activity of plant flavonoids
-
Kandaswami C, Middleton E, Jr. 1994. Free radical scavenging and antioxidant activity of plant flavonoids. Adv Exp Med Biol 366:351-376.
-
(1994)
Adv Exp Med Biol
, vol.366
, pp. 351-376
-
-
Kandaswami, C.1
Middleton Jr., E.2
-
12
-
-
27744605175
-
Signal pathway of hypoxia-inducible factor-1alpha phosphorylation and its interaction with von Hippel-Lindau tumor suppressor protein during ischemia in MiaPaCa-2 pancreatic cancer cells
-
Kwon SJ, Song JJ, Lee YJ. 2005. Signal pathway of hypoxia-inducible factor-1alpha phosphorylation and its interaction with von Hippel-Lindau tumor suppressor protein during ischemia in MiaPaCa-2 pancreatic cancer cells. Clin Cancer Res 11:7607-7613.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 7607-7613
-
-
Kwon, S.J.1
Song, J.J.2
Lee, Y.J.3
-
13
-
-
0014949207
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
-
Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
-
(1970)
Nature
, vol.227
, pp. 680-685
-
-
Laemmli, U.K.1
-
14
-
-
0022455341
-
Protection of Chinese hamster ovary cells from hyperthermic killing by cycloheximide or puromycin
-
Lee YJ, Dewey WC. 1986. Protection of Chinese hamster ovary cells from hyperthermic killing by cycloheximide or puromycin. Radiat Res 106:98-110.
-
(1986)
Radiat Res
, vol.106
, pp. 98-110
-
-
Lee, Y.J.1
Dewey, W.C.2
-
16
-
-
41849148137
-
The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity
-
Lisztwan J, Imbert G, Wirbelauer C, Gstaiger M, Krek W. 1999. The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity. Genes Dev 12:3872-3881.
-
(1999)
Genes Dev
, vol.12
, pp. 3872-3881
-
-
Lisztwan, J.1
Imbert, G.2
Wirbelauer, C.3
Gstaiger, M.4
Krek, W.5
-
17
-
-
33749537296
-
Reactive oxygen species regulate epidermal growth factor-induced vascular endothelial growth factor and hypoxia-inducible factor-1alpha expression through activation of AKT and P70S6K1 in human ovarian cancer cells
-
Liu LZ, Hu XW, Xia C, He J, Zhou Q, Shi X, Fang J, Jiang BH. 2006. Reactive oxygen species regulate epidermal growth factor-induced vascular endothelial growth factor and hypoxia-inducible factor-1alpha expression through activation of AKT and P70S6K1 in human ovarian cancer cells. Free Radic Biol Med 41:1521-1533.
-
(2006)
Free Radic Biol Med
, vol.41
, pp. 1521-1533
-
-
Liu, L.Z.1
Hu, X.W.2
Xia, C.3
He, J.4
Zhou, Q.5
Shi, X.6
Fang, J.7
Jiang, B.H.8
-
19
-
-
0036569704
-
Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells
-
Mabjeesh NJ, Post DE, Willard MT, Kaur B, Van Meir EG, Simons JW, Zhong H. 2002. Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells. Cancer Res 62:2478-2482.
-
(2002)
Cancer Res
, vol.62
, pp. 2478-2482
-
-
Mabjeesh, N.J.1
Post, D.E.2
Willard, M.T.3
Kaur, B.4
Van Meir, E.G.5
Simons, J.W.6
Zhong, H.7
-
20
-
-
0030816109
-
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
-
Maxwell PH, Dachs GU, Gleadle JM, Nicholls LG, Harris AL, Stratford IJ, Hankinson O, Pugh CW, Ratcliffe PJ. 1997. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA 94:8104-8109.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 8104-8109
-
-
Maxwell, P.H.1
Dachs, G.U.2
Gleadle, J.M.3
Nicholls, L.G.4
Harris, A.L.5
Stratford, I.J.6
Hankinson, O.7
Pugh, C.W.8
Ratcliffe, P.J.9
-
21
-
-
34247640293
-
ARC-111 inhibits hypoxia-mediated hypoxia-inducible factor-1alpha accumulation
-
Meng F, Nguyen XT, Cai X, Duan J, Matteucci M, Hart CP. 2007. ARC-111 inhibits hypoxia-mediated hypoxia-inducible factor-1alpha accumulation. Anticancer Drugs 18:435-445.
-
(2007)
Anticancer Drugs
, vol.18
, pp. 435-445
-
-
Meng, F.1
Nguyen, X.T.2
Cai, X.3
Duan, J.4
Matteucci, M.5
Hart, C.P.6
-
22
-
-
84892138934
-
The impact of plant flavonoids on mammalian biology: Implication for immunity, inflammation and cancer
-
Harborne JB, editor, London, United Kingdom: Chapman & Hall. pp
-
Middleton E, Jr., Kandaswami C. 1993. The impact of plant flavonoids on mammalian biology: Implication for immunity, inflammation and cancer. In: Harborne JB, editor. The flavonoids: Advances in research since 1986. London, United Kingdom: Chapman & Hall. pp 619-645.
-
(1993)
The flavonoids: Advances in research since 1986
, pp. 619-645
-
-
Middleton Jr., E.1
Kandaswami, C.2
-
23
-
-
30644456411
-
Dietary flavonoids: Effects on xenobiotic and carcinogen metabolism
-
Moon YJ, Wang X, Morris ME. 2006. Dietary flavonoids: Effects on xenobiotic and carcinogen metabolism. Toxicol In Vitro 20:187-210.
-
(2006)
Toxicol In Vitro
, vol.20
, pp. 187-210
-
-
Moon, Y.J.1
Wang, X.2
Morris, M.E.3
-
24
-
-
0033776536
-
Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel-Lindau protein
-
Ohh M, Park CW, Ivan M, Hoffman MA, Kim TY, Huang LE, Pavletich N, Chau V, Kaelin WG. 2000. Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel-Lindau protein. Nat Cell Biol 2:423-427.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 423-427
-
-
Ohh, M.1
Park, C.W.2
Ivan, M.3
Hoffman, M.A.4
Kim, T.Y.5
Huang, L.E.6
Pavletich, N.7
Chau, V.8
Kaelin, W.G.9
-
25
-
-
41849117298
-
Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron
-
Park SS, Bae I, Lee YJ. 2008. Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron. J Cell Biochem 103:1989-1998.
-
(2008)
J Cell Biochem
, vol.103
, pp. 1989-1998
-
-
Park, S.S.1
Bae, I.2
Lee, Y.J.3
-
26
-
-
33748742635
-
Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression
-
Peng XH, Karna P, Cao Z, Jiang BH, Zhou M, Yang L. 2006. Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression. J Biol Chem 281:25903-25914.
-
(2006)
J Biol Chem
, vol.281
, pp. 25903-25914
-
-
Peng, X.H.1
Karna, P.2
Cao, Z.3
Jiang, B.H.4
Zhou, M.5
Yang, L.6
-
27
-
-
20444445920
-
Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha
-
Phillips RJ, Mestas J, Gharaee-Kermani M, Burdick MD, Sica A, Belperio JA, Keane MP, Strieter RM. 2005. Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha. J Biol Chem 280:22473-22481.
-
(2005)
J Biol Chem
, vol.280
, pp. 22473-22481
-
-
Phillips, R.J.1
Mestas, J.2
Gharaee-Kermani, M.3
Burdick, M.D.4
Sica, A.5
Belperio, J.A.6
Keane, M.P.7
Strieter, R.M.8
-
28
-
-
1242271198
-
Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: Mechanism and therapeutic implications
-
Rapisarda A, Uranchimeg B, Sordet O, Pommier Y, Shoemaker RH, Melillo G. 2004. Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: Mechanism and therapeutic implications. Cancer Res 64:1475-1482.
-
(2004)
Cancer Res
, vol.64
, pp. 1475-1482
-
-
Rapisarda, A.1
Uranchimeg, B.2
Sordet, O.3
Pommier, Y.4
Shoemaker, R.H.5
Melillo, G.6
-
29
-
-
0030961006
-
Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
-
Salceda S, Caro J. 1997. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272:22642-22647.
-
(1997)
J Biol Chem
, vol.272
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
30
-
-
35148828429
-
Hypoxia-inducible factor 1 (HIF-1) pathway
-
Semenza GL. 2007. Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE 407:cm8.
-
(2007)
Sci STKE
, vol.407
-
-
Semenza, G.L.1
-
31
-
-
33845803145
-
Hypoxia-independent overexpression of hypoxia-inducible factor 1alpha as an early change in mouse hepatocarcinogenesis
-
Tanaka H, Yamamoto M, Hashimoto N, Miyakoshi M, Tamakawa S, Yoshie M, Tokusashi Y, Yokoyama K, Yaginuma Y, Ogawa K. 2006. Hypoxia-independent overexpression of hypoxia-inducible factor 1alpha as an early change in mouse hepatocarcinogenesis. Cancer Res 66:11263-11270.
-
(2006)
Cancer Res
, vol.66
, pp. 11263-11270
-
-
Tanaka, H.1
Yamamoto, M.2
Hashimoto, N.3
Miyakoshi, M.4
Tamakawa, S.5
Yoshie, M.6
Tokusashi, Y.7
Yokoyama, K.8
Yaginuma, Y.9
Ogawa, K.10
-
32
-
-
0034663894
-
Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein
-
Tanimoto K, Makino Y, Pereira T, Poellinger L. 2000. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. EMBO J 19:4298-4309.
-
(2000)
EMBO J
, vol.19
, pp. 4298-4309
-
-
Tanimoto, K.1
Makino, Y.2
Pereira, T.3
Poellinger, L.4
-
33
-
-
34249877724
-
Vascular biology and bone formation: Hints from HIF
-
Towler DA. 2007. Vascular biology and bone formation: Hints from HIF. J Clin Invest 117:1477-1480.
-
(2007)
J Clin Invest
, vol.117
, pp. 1477-1480
-
-
Towler, D.A.1
-
34
-
-
3142774878
-
AE E788: A dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity
-
Traxler P, Allegrini PR, Brandt R, Brueggen J, Cozens R, Fabbro D, Grosios K, Lane HA, McSheehy P, Mestan J, Meyer T, Tang C, Wartmann M, Wood J, Caravatti G. 2004. AE E788: A dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res 64:4931-4941.
-
(2004)
Cancer Res
, vol.64
, pp. 4931-4941
-
-
Traxler, P.1
Allegrini, P.R.2
Brandt, R.3
Brueggen, J.4
Cozens, R.5
Fabbro, D.6
Grosios, K.7
Lane, H.A.8
McSheehy, P.9
Mestan, J.10
Meyer, T.11
Tang, C.12
Wartmann, M.13
Wood, J.14
Caravatti, G.15
-
35
-
-
19044379578
-
Inhibition of the metmyoglobin-induced peroxidation of linoleic acid by dietary antioxidants: Action in the aqueous vs. lipid phase
-
Vulcain E, Goupy P, Caris-Veyrat C, Dangles O. 2005. Inhibition of the metmyoglobin-induced peroxidation of linoleic acid by dietary antioxidants: Action in the aqueous vs. lipid phase. Free Radic Res 39:547-563.
-
(2005)
Free Radic Res
, vol.39
, pp. 547-563
-
-
Vulcain, E.1
Goupy, P.2
Caris-Veyrat, C.3
Dangles, O.4
-
36
-
-
0033855919
-
The therapeutic potential of flavonoids
-
Wang HK. 2000. The therapeutic potential of flavonoids. Expert Opin Investig Drugs 9:2103-2119.
-
(2000)
Expert Opin Investig Drugs
, vol.9
, pp. 2103-2119
-
-
Wang, H.K.1
-
37
-
-
0036299051
-
The dietary flavonoid quercetin modulates HIF-1 alpha activity in endothelial cells
-
Wilson WJ, Poellinger L. 2002. The dietary flavonoid quercetin modulates HIF-1 alpha activity in endothelial cells. Biochem Biophys Res Commun 293:446-450.
-
(2002)
Biochem Biophys Res Commun
, vol.293
, pp. 446-450
-
-
Wilson, W.J.1
Poellinger, L.2
-
38
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, Simons JW. 1999. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59:5830-5835.
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
Zagzag, D.6
Buechler, P.7
Isaacs, W.B.8
Semenza, G.L.9
Simons, J.W.10
|