Comparison of mesoporous silicon and non-ordered mesoporous silica materials as drug carriers for itraconazole

International Journal of Pharmaceutics

Volumn 414, Issue 1-2, 2011, Pages 148-156

  Kinnari, Päivi ^a   Mäkilä, Ermei ^b   Heikkilä, Teemu ^b   Salonen, Jarno ^b   Hirvonen, Jouni ^a   Santos, Hélder A ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

Dissolution; Drug loading; Drug release; Itraconazole; Mesoporous silicon; Silica gel

Indexed keywords

DRUG CARRIER; ITRACONAZOLE; SILICON; SILICON DIOXIDE;

ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DEGRADATION; DRUG SOLUBILITY; HUMIDITY; HYDROPHOBICITY; KINETICS; MORPHOLOGY; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY; POROSITY; PRIORITY JOURNAL; STORAGE TEMPERATURE; SURFACE PROPERTY;

ANTIFUNGAL AGENTS; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; ITRACONAZOLE; MODELS, THEORETICAL; PARTICLE SIZE; POROSITY; SILICON; SILICON DIOXIDE; SOLUBILITY;

EID: 79959689369     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.05.021     Document Type: Article

References (67)

1. C.A. Aerts, E. Verraedt, R. Mellaerts, A. Depla, P. Augustijns, J. Van Humbeeck, G. Van den Mooter, and J.A. Martens Tunability of pore diameter and particle size of amorphous microporous silica for diffusive controlled release of drug compounds J. Phys. Chem. C 111 2007 13404 13409 (Pubitemid 47481931)
2. M. Ahola, P. Kortesuo, I. Kangasniemi, J. Kiesvaara, and A. Yli-Urpo Silica xerogel carrier material for controlled release of toremifene citrate Int. J. Pharm. 195 2000 219 227 (Pubitemid 30089506)
3. V. Ambrogi, L. Perioli, F. Marmottini, S. Giovagnoli, M. Esposito, and C. Rossi Improvement of dissolution rate of piroxicam by inclusion into MCM-41 mesoporous silicate Eur. J. Pharm. Sci. 32 2007 216 222 (Pubitemid 47532714)
4. V. Ambrogi, L. Perioli, F. Marmottini, O. Accorsi, C. Pagano, M. Ricci, and C. Rossi Role of mesoporous silicates on carbamazepine dissolution rate enhancement Micropor. Mesopor. Mater. 113 2008 445 452
5. J. Andersson, J. Rosenholm, S. Areva, and M. Linden Influences of material characteristics on ibuprofen drug loading and release profiles from ordered micro-and mesoporous silica matrices Chem. Mater. 16 2004 4160 4167
6. J. Beck, J. Vartuli, W. Roth, M. Leonowicz, C. Kresge, K. Schmitt, C. Chu, D. Olson, and E. Sheppard A new family of mesoporous molecular sieves prepared with liquid crystal templates J. Am. Chem. Soc. 114 1992 10834 10843
7. K.D. Beule Itraconazole: pharmacology, clinical experience and future development Int. J. Antimicrob. Agents 6 1996 175 181
8. L.M. Bimbo, E. Mäkilä, T. Laaksonen, V.P. Lehto, J. Salonen, J. Hirvonen, and H.A. Santos Drug permeation across intestinal epithelial cells using porous silicon nanoparticles Biomaterials 32 2011 2625 2633
9. L.M. Bimbo, M. Sarparanta, H.A. Santos, A.J. Airaksinen, E. Mäkilä, T. Laaksonen, L. Peltonen, V.P. Lehto, J. Hirvonen, and J. Salonen Biocompatibility of thermally hydrocarbonized porous silicon nanoparticles and their biodistribution in rats ACS Nano 4 2010 3023 3032
10. H. Böttcher, P. Slowik, and W. Süß Sol-gel carrier systems for controlled drug delivery J. Sol-Gel Sci. Technol. 13 1998 277 281
11. C. Charnay, S. Begu, C. Tourne-Peteilh, L. Nicole, D. Lerner, and J. Devoisselle Inclusion of ibuprofen in mesoporous templated silica: drug loading and release property Eur. J. Pharm. Biopharm. 57 2004 533 540 (Pubitemid 38490572)
12. J.F. Chen, H.M. Ding, J.X. Wang, and L. Shao Preparation and characterization of porous hollow silica nanoparticles for drug delivery application Biomaterials 25 2004 723 727 (Pubitemid 37357286)
13. A. Doadrio, E. Sousa, J. Doadrio, J. Pérez Pariente, and I. Izquierdo-Barba Mesoporous SBA-15 HPLC evaluation for controlled gentamicin drug delivery J. Control. Release 97 2004 125 132 (Pubitemid 38624515)
14. W. Feng, H. Liu, G. Chen, R. Malchow, F. Bennett, E. Lin, B. Pramanik, and T.M. Chan Structural characterization of the oxidative degradation products of an antifungal agent SCH 56592 by LC-NMR and LC-MS J. Pharm. Biomed. Anal. 25 2001 545 557 (Pubitemid 32496272)
15. K.A. Fisher, K.D. Huddersman, and M.J. Taylor Comparison of micro- and mesoporous inorganic materials in the uptake and release of the drug model fluorescein and its analogues Chemistry 9 2003 5873 5878
16. A.B. Foraker, R.J. Walczak, M.H. Cohen, T.A. Boiarski, C.F. Grove, and P.W. Swaan Microfabricated porous silicon particles enhance paracellular delivery of insulin across intestinal Caco-2 cell monolayers Pharm. Res. 20 2003 110 116 (Pubitemid 36152925)
17. B.C. Hancock, G.T. Carlson, D.D. Ladipo, B.A. Langdon, and M.P. Mullarney Comparison of the mechanical properties of the crystalline and amorphous forms of a drug substance Int. J. Pharm. 241 2002 73 85 (Pubitemid 34667068)
18. T. Heikkilä, J. Salonen, J. Tuura, M. Hamdy, G. Mul, N. Kumar, T. Salmi, D.Y. Murzin, L. Laitinen, and A. Kaukonen Mesoporous silica material TUD-1 as a drug delivery system Int. J. Pharm. 331 2007 133 138 (Pubitemid 46176505)
19. T. Heikkilä, J. Salonen, J. Tuura, N. Kumar, T. Salmi, D.Y. Murzin, M.S. Hamdy, G. Mul, L. Laitinen, A.M. Kaukonen, J. Hirvonen, and V.P. Lehto Evaluation of mesoporous TCPSi, MCM-41, SBA-15, and TUD-1 materials as API carriers for oral drug delivery Drug Deliv. 14 2007 337 347 (Pubitemid 47265819)
20. T. Higuchi Mechanism of sustained-action medication: Theoretical analysis of rate of release of solid drugs dispersed in solid matrices J. Pharm. Sci. 52 1963 1145 1149
21. P. Horcajada, A. Rámila, J. Pérez-Pariente, and M. Vallet-Regí Influence of pore size of MCM-41 matrices on drug delivery rate Micropor. Mesopor. Mater. 68 2004 105 109 (Pubitemid 38265756)
22. P. Horcajada, A. Rámila, G. Férey, and M. Vallet-Regí Influence of superficial organic modification of MCM-41 matrices on drug delivery rate Solid State Sci. 8 2006 1243 1249 (Pubitemid 44548423)
23. T. Jesionowski, M. Pokora, K. Sobaszkiewicz, and J. Pernak Preparation and characterization of functionalized precipitated silica SYLOID® 244 using ionic liquids as modifiers Surf. Interface Anal. 36 2004 1491 1496
24. A.M. Kaukonen, L. Laitinen, J. Salonen, J. Tuura, T. Heikkila, T. Limnell, J. Hirvonen, and V.P. Lehto Enhanced in vitro permeation of furosemide loaded into thermally carbonized mesoporous silicon (TCPSi) microparticles Eur. J. Pharm. Biopharm. 66 2007 348 356 (Pubitemid 46756223)
25. M. Kilpeläinen, J. Riikonen, M.A. Vlasova, A. Huotari, V.P. Lehto, J. Salonen, K.H. Herzig, and K. Järvinen In vivo delivery of a peptide, ghrelin antagonist, with mesoporous silicon microparticles J. Control. Release 137 2009 166 170
26. 2 for magnetic drug targeting J. Mater. Chem. 16 2006 1617 1621 (Pubitemid 43797571)
27. P. Kortesuo, M. Ahola, M. Kangas, I. Kangasniemi, A. Yli-Urpo, and J. Kiesvaara In vitro evaluation of sol-gel processed spray dried silica gel microspheres as carrier in controlled drug delivery Int. J. Pharm. 200 2000 223 229 (Pubitemid 30364909)
28. P. Kortesuo, M. Ahola, M. Kangas, T. Leino, S. Laakso, L. Vuorilehto, A. Yli-Urpo, J. Kiesvaara, and M. Marvola Alkyl-substituted silica gel as a carrier in the controlled release of dexmedetomidine J. Control. Release 76 2001 227 238 (Pubitemid 32913432)
29. T. Laaksonen, H. Santos, H. Vihola, J. Salonen, J. Riikonen, T. Heikkilä, L. Peltonen, N. Kumar, D.Y. Murzin, V.-P. Lehto, and J. Hirvonen Failure of MTT as a toxicity testing agent for mesoporous silicon microparticles Chem. Res. Toxicol. 20 2007 1913 1918
30. T. Limnell, H. Santos, E. Mäkilä, T. Heikkilä, J. Salonen, D.Y. Murzin, N. Kumar, T. Laaksonen, L. Peltonen, and J. Hirvonen Drug delivery formulations of ordered and non-ordered mesoporous silica: comparison of three drug loading methods J. Pharm. Sci. 2011 10.1002/jps.22577
31. T. Limnell, J. Riikonen, J. Salonen, A.M. Kaukonen, L. Laitinen, J. Hirvonen, and V.P. Lehto Surface chemistry and pore size affect carrier properties of mesoporous silicon microparticles Int. J. Pharm. 343 2007 141 147 (Pubitemid 47321019)
32. L. Lhomme, S. Brosillon, and D. Wolbert Photocatalytic degradation of triazole pesticide, cyproconazole, in water J. Photochem. Photobiol. A 188 2007 34 42
33. R. Mellaerts, R. Mols, J.A.G. Jammaer, C.A. Aerts, P. Annaert, J. Van Humbeeck, G. Van den Mooter, P. Augustijns, and J.A. Martens Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica Eur. J. Pharm. Biopharm. 69 2008 223 230
34. R. Mellaerts, C.A. Aerts, J. Van Humbeeck, P. Augustijns, G. Van den Mooter, and J.A. Martens Enhanced release of itraconazole from ordered mesoporous SBA-15 silica materials Chem. Commun. (Cambridge, U.K.) 2007 1375 1377 (Pubitemid 46465984)
35. R. Mellaerts, J.A. Jammaer, M. Van Speybroeck, H. Chen, J. Van Humbeeck, P. Augustijns, G. Van den Mooter, and J.A. Martens Physical state of poorly water soluble therapeutic molecules loaded into SBA-15 ordered mesoporous silica carriers: a case study with itraconazole and ibuprofen Langmuir 24 2008 8651 8659
36. D.C. Monkhouse, and J.L. Lach Use of adsorbents in enhancement of drug dissolution, I and II J. Pharm. Sci. 61 1972 1430 1441
37. B. Muñoz, A. Rámila, J. Pérez-Pariente, I. Díaz, and M. Vallet-Regí MCM-41 organic modification as drug delivery rate regulator Chem. Mater. 15 2003 500 503
38. K. Nakanishi, R. Takahashi, T. Nagakane, K. Kitayama, N. Koheiya, H. Shikata, and N. Soga Formation of hierarchical pore structure in silica gel J. Sol-Gel Sci. Technol. 17 2000 191 210 (Pubitemid 30572347)
39. A.N. Narurkar, and C.I. Jarowski Dissolution rates of prednisolone triturations using porous and non-porous silicas. I. Pilot oral absorption study in dogs Drug Dev. Ind. Pharm. 9 1983 999 1010 (Pubitemid 13076451)
40. J. Peeters, P. Neeskens, J.P. Tollenaere, P. Van Remoortere, and M.E. Brewster Characterization of the interaction of 2-hydroxypropyl-beta- cyclodextrin with itraconazole at pH 2, 4, and 7 J. Pharm. Sci. 91 2002 1414 1422
41. F. Qu, G. Zhu, H. Lin, W. Zhang, J. Sun, S. Li, and S. Qiu A controlled release of ibuprofen by systematically tailoring the morphology of mesoporous silica materials J. Solid State Chem. 179 2006 2027 2035 (Pubitemid 43867553)
42. F. Qu, G. Zhu, S. Huang, S. Li, and S. Qiu Effective controlled release of captopril by silylation of mesoporous MCM-41 ChemPhysChem 7 2006 400 406
43. S. Radin, P. Ducheyne, T. Kamplain, and B.H. Tan Silica sol-gel for the controlled release of antibiotics. I. Synthesis, characterization, and in vitro release J. Biomed. Mater. Res. A 57 2001 313 320 (Pubitemid 32988512)
44. S. Rigby, M. Fairhead, and C. Van Der Walle Engineering silica particles as oral drug delivery vehicles Curr. Pharm. Des. 14 2008 1821 1831 (Pubitemid 351998586)
45. J. Riikonen, E. Mäkilä, J. Salonen, and V.P. Lehto Determination of the physical state of drug molecules in mesoporous silicon with different surface chemistries Langmuir 25 2009 6137 6142
46. J.M. Rosenholm, and M. Lindén Towards establishing structure-activity relationships for mesoporous silica in drug delivery applications J. Control. Release 128 2008 157 164
47. R.C. Rowe, P.J. Sheskey, and P.J. Weller Handbook of pharmaceutical excipients 2003 Pharmaceutical Press London
48. J. Salonen, E. Laine, and L. Niinistö Thermal carbonization of porous silicon surface by acetylene J. Appl. Phys. 91 2002 456 (Pubitemid 34047297)
49. J. Salonen, V.P. Lehto, and E. Laine Thermal oxidation of free-standing porous silicon films Appl. Phys. Lett. 70 1997 637
50. J. Salonen, V.P. Lehto, and E. Laine The room temperature oxidation of porous silicon Appl. Surf. Sci. 120 1997 191 198 (Pubitemid 127380735)
51. J. Salonen, A.M. Kaukonen, J. Hirvonen, and V.P. Lehto Mesoporous silicon in drug delivery applications J. Pharm. Sci. 97 2008 632 653 (Pubitemid 351293873)
52. J. Salonen, L. Laitinen, A.M. Kaukonen, J. Tuura, M. Bjorkqvist, T. Heikkila, K. Vaha-Heikkila, J. Hirvonen, and V.P. Lehto Mesoporous silicon microparticles for oral drug delivery: loading and release of five model drugs J. Control. Release 108 2005 362 374 (Pubitemid 41608668)
53. J. Salonen, and V. Lehto Fabrication and chemical surface modification of mesoporous silicon for biomedical applications Chem. Eng. J. 137 2008 162 172 (Pubitemid 351226634)
54. E.M. Santos, S. Radin, and P. Ducheyne Sol-gel derived carrier for the controlled release of proteins Biomaterials 20 1999 1695 1700 (Pubitemid 29393124)
55. H.A. Santos, J. Riikonen, J. Salonen, E. Mäkilä, T. Heikkilä, T. Laaksonen, L. Peltonen, V. Lehto, and J. Hirvonen In vitro cytotoxicity of porous silicon microparticles: Effect of the particle concentration, surface chemistry and size Acta Biomater. 6 2010 2721 2731
56. S.W. Song, K. Hidajat, and S. Kawi Functionalized SBA-15 materials as carriers for controlled drug delivery: influence of surface properties on matrix-drug interactions Langmuir 21 2005 9568 9575 (Pubitemid 41507008)
57. M. Van Speybroeck, V. Barillaro, T.D. Thi, R. Mellaerts, J. Martens, J. Van Humbeeck, J. Vermant, P. Annaert, G. Van den Mooter, and P. Augustijns Ordered mesoporous silica material SBA-15: a broad-spectrum formulation platform for poorly soluble drugs J. Pharm. Sci. 98 2009 2648 2658
58. M. Van Speybroeck, R. Mols, R. Mellaerts, T.D. Thi, J.A. Martens, J.V. Humbeeck, P. Annaert, G.V. Mooter, and d.P. Augustijns Combined use of ordered mesoporous silica and precipitation inhibitors for improved oral absorption of the poorly soluble weak base itraconazole Eur. J. Pharm. Biopharm. 75 2010 354 365
59. S. Wang Ordered mesoporous materials for drug delivery Micropor. Mesopor. Mater. 117 2009 1 9
60. F. Wang, H. Hui, T.J. Barnes, C. Barnett, and C.A. Prestidge Oxidized mesoporous silicon microparticles for improved oral delivery of poorly soluble drugs Mol. Pharm. 7 2010 227 236
61. S. Wang, and H.T. Li Structure directed reversible adsorption of organic dye on mesoporous silica in aqueous solution Micropor. Mesopor. Mater. 97 2006 21 26 (Pubitemid 44810137)
62. W.R.; Grace, Co.-Conn.; 2006. Products and Applications. http://www.grace.com/EngineeredMaterials/ProductsAndApplications/Default.aspx (accessed 14.03.2011).
63. K.Y. Yang, R. Glemza, and C.I. Jarowski Effects of amorphous silicon dioxides on drug dissolution J. Pharm. Sci. 68 1979 560 565 (Pubitemid 9186374)
64. D. Zhao, J. Feng, Q. Huo, N. Melosh, G.H. Fredrickson, B.F. Chmelka, and G.D. Stucky Triblock copolymer syntheses of mesoporous silica with periodic 50-300 pores Science 279 1998 548
65. X. Zhao, G. Lu, A. Whittaker, G. Millar, and H. Zhu Comprehensive study of surface chemistry of MCM-41 using 29Si CP/MAS NMR, FTIR, pyridine-TPD, and TGA J. Phys. Chem. B 101 1997 6525 6531 (Pubitemid 127591311)
66. L. Zhuravlev Concentration of hydroxyl groups on the surface of amorphous silicas Langmuir 3 1987 316 318
67. L.T. Zhuravlev The surface chemistry of amorphous silica. Zhuravlev model Colloids Surf. A: Physicochem. Eng. Aspects 173 2000 1 38