Silica xerogel carrier material for controlled release of toremifene citrate

International Journal of Pharmaceutics

Volumn 195, Issue 1-2, 2000, Pages 219-227

  Ahola, Manja ^a   Kortesuo, Pirjo ^b   Kangasniemi, Ilkka ^a   Kiesvaara, Juha ^b   Yli Urpo, Antti ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b ORION CORPORATION   (Finland)

Author keywords

Controlled release; Polyethylene glycol; Silica xerogel; Sol gel; Toremifene citrate

Indexed keywords

DRUG ADDITIVE; DRUG CARRIER; MACROGOL; SILICON DIOXIDE; TOREMIFENE;

ARTICLE; CONTROLLED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG IMPLANT; DRUG TARGETING; PRIORITY JOURNAL; SURFACE PROPERTY;

DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG IMPLANTS; GELS; POLYETHYLENE GLYCOLS; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SILICON DIOXIDE; TECHNOLOGY, PHARMACEUTICAL; TOREMIFENE;

EID: 0033954591     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00403-2     Document Type: Article

References (22)

1. Ahola M., Kortesuo P., Kangasniemi I., Kiesvaara J., Yli-Urpo A. Effect of processing parameters on the structure of silica xerogel matrix and on the release rate of toremifene citrate and silica. 24th Annual Meeting of the Society for Biomaterials, San Diego, USA. 1998;343.
2. Böttcher H., Kallies K.-H., Haufe H. Model investigation of controlled release of bioactive compounds from thin metal oxide layers. J. Sol-Gel Sci. 8:1997;651-654.
3. Chen K.C., Tsuchiya T., Mackenzie J.D. Sol-gel processing of silica. I. The role of the starting compounds. J. Non-Cryst. Solids. 81:1986;227-237.
4. Heigal-Segal O., Rappoport S., Braun S. Immobilization in alginate silicate sol-gel matrix protects beta-glucosidase against chemical denaturation. Biotechnology. 13:1995;798-800.
5. Iler R.K. The Chemistry of Silica. 1979;Wiley, New York. pp. 639.
6. Jokinen M., Györvary E., Rosenholm J.B. Viscoelastic characterisation of three different sol-gel derived silica gels. Coll. Surf. A Physicochem. Eng. Asp. 141:1998;205-216.
7. Kallio S., Kangas L., Blanco G., Johansson R., Karjalainen A., Perilä M., Piippo I., Sundqvist H., Södervall M., Toivola R. A new triphenylethylene compound, Fc-1157a. I. Hormonal effects. Cancer Chemother. Pharmacol. 17:1986;103-108.
8. Koch O.G., Koch-Dedic G.A. Siliconmolybdänblau-Verfahren. Handbuch der Spurenanalyse. 1974;1105 Springer, Berlin.
9. Kortesuo, P., Ahola, M., Karlsson, S., Kangasniemi, I., Kiesvaara, J., Yli-Urpo, A., 1999a. Silica xerogels as implantable controlled release carrier system: evaluation of the tissue effects after implantation. Biomaterials (in press).
10. Kortesuo P., Ahola M., Karlsson S., Kangasniemi I., Kiesvaara J., Yli-Urpo A. Sol-gel processed sintered silica xerogel as a carrier in controlled drug delivery. J. Biomed. Mater. Res. 44(2):1999b;162-167.
11. Nicoll S.B., Radin S., Santos E.M., Tuan R.S., Ducheyne P. In vitro release kinetics of biologically active transforming growth factor-β1 from a novel porous glass carrier. Biomaterials. 18:1997;853-859.
12. Radin S., El-Bassyouni G., Vresilovic E.J., Schepers E., Ducheyne P. Tissue reactions to controlled release silica xerogel carriers. LeGeros R.Z., Geros J.P.L. Bioceramics 11. 11:1998;529-532 World Scientific, New York.
13. Ro J.C., Chung I.J. Structures and properties of silica gels prepared by the sol-gel method. J. Non-Cryst. Solids. 130:1991;8-17.
14. Sakka S., Kamiya K. The sol-gel transition in the hydrolysis of metal alkoxides in relation to the forming of glass fibers and films. J. Non-Cryst. Solids. 48:1982;31-46.
15. Sato S., Murakata T., Suzuki T., Ohgawara T. Control of pore size distribution of silica gel through sol-gel process using water soluble polymers as additives. J. Mater. Sci. 254:1990;4880-4885.
16. Scherer G.W. Effect of shrinkage on the modulus of silica gel. J. Non-Cryst. Solids. 109:1989;183-190.
17. Tan B.H., Santos E.M., Ducheyne P. Ultramicroscopic pore size and porosity of xerogels for controlled release of biological molecules. Fifth World Biomaterials Congress, Toronto, Canada. 2:1996;191.
18. Unger K., Rupprecht H., Valentin B., Kircher W. The use of porous and surface modified silicas as drug delivery and stabilizing agent. Drug Dev. Ind. Pharm. 9:1983;69-91.
19. Valavaara, R. 1990. Toremifene, a triphenyl antiestrogen, in the treatment of breast cancer. Ph.D. Thesis, University of Turku, Finland.
20. Vong M.S.W., Bazin N., Sermon P.A. Chemical modification of silica gels. J. Sol-Gel Sci. 8:1997;499-505.
21. Weetal H.H., Robertson B., Cullin D., Brown J., Walch M. Bacteriorhodopsin immobilized in sol-gel glass. Biochem. Biophys. Acta. 1142:1993;211-213.
22. Yamanaka S.A., Nishida F., Ellerby L.M., Nishida C.L., Dunn B., Valentine J.S., Zink J.I. Enzymatic activity of glucose oxidase encapsulated in transparent glass by the sol-gel method. Chem. Mater. 4:1992;495-497.