Characterization of the interaction of 2-hydroxypropyl-β-cyclodextrin With itraconazole at pH 2, 4, and 7

Journal of Pharmaceutical Sciences

Volumn 91, Issue 6, 2002, Pages 1414-1422

  Peeters, Jef ^a   Neeskens, Peter ^a   Tollenaere, Jan P ^a   Van Remoortere, Pieter ^a   Brewster, Marcus E ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Calculation or stability constants; Complexation; Cyclodextrin; Itraconazole; Solubility

Indexed keywords

1,4 DIAMINOPHENYL DERIVATIVE; 2 BUTYLPIPERAZINE; 2 HYDROXYPROPYL BETA CYCLODEXTRIN; BETA CYCLODEXTRIN; ITRACONAZOLE; PHENYL GROUP; PIPERAZINE DERIVATIVE; TRIAZOLE; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; DRUG SOLUBILITY; MOLECULAR INTERACTION; MOLECULAR MECHANICS; MOLECULAR MODEL; MOLECULAR STABILITY; PH; PKA; PROTON TRANSPORT;

EID: 0036278959     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10126     Document Type: Article

References (35)

1. Pharmacology of itraconazole
2. Itraconazole: An effective oral antifungal for onychomychosis
3. Dissolution testing as a prognostic tool for oral drug absorption: Immediate release dosage forms
4. Theoretical basis for a biopharmaceutical drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability
5. Modern bioavailability, bioequivalence and biopharmaceutics classification systems. New scientific approaches to international regulatory standards
6. Improving drug solubility for oral delivery using solid dispersions
7. Intravenous itraconazole
8. Itraconazole oral solution and intravenous formulations: A review of pharmacokinetics and pharmacodynamics
9. The effect of food and dose on the oral systemic availability of itraconazole in healthy subjects
10. Influence of an acidic beverage (Coca-Cola) on the absorption of itraconazole
11. Optimizing the bioavailability of itraconazole
12. Alterations in gastric acidity in patients infected with human immunodeficiency
13. Itraconazole solution: Higher serum drug concentrations and better clinical response rates than the capsule formulation in acquired immunodeficiency syndrome patients with candidosis
14. Pharmacokinetics of itraconazole following oral administration to normal volunteers
15. Itraconazole in cyclodextrin solution
16. Food intercation and steady-state pharmacokinetics of itraconazole oral solution in healthy volunteers
17. Pharmaceutical applications fo cyclodextrins. 1. Drug solubilization and stabilization
18. Pharmacuetical applications of cyclodextrins. III. Toxicologixal issues and safety evaluation
19. An intravenous toxicity study of 2-hydroxypropyl-β-cyclodextrin, a useful drug solubilizer, in rats and monkeys
20. Pharmaceutical applications of 2-hydroxypropyl-β-cyclodextrin
21. Binding specificity between small organic solutes in aqueous solution: Classification of some solutes into two groups according to binding tendencies
22. Simplex techniques for nonlinear optimization
23. Molecular encapsulation of flurbiprophen and/or ibuprophen by hydroxypropyl-β-cyclodextrin in aqueous solution. Potentiometric and molecular modeling studies
24. Thermodynamic analysis of the binding of a hepatoprotectant drug, thioctic acid, by β-cyclodextrin
25. Inclusion complexation of ziprasidone mesylate with β-cyclodextrin sulfobutyl ether
26. Combined effect of complexation and pH on solubilization
27. Solubilization of thiazolobenzimidazole using a combination of pH adjustment and complexation with 2-hydroxypropyl-β-cyclodextrin
28. Formulation development for a zidovudine chemical delivery systems. 1. Parenteral dosage forms
29. Solubility and mass and nuclear magnetic resonance spectroscopic studies on interaction of cyclosporin a with dimethyl-α- and β-cyclodextrin in aqueous solution
30. Characterization of itraconazole/2-hydroxypropyl-β-cyclodextrin inclusion complex in aqueous propylene glycol solution
31. Solubilization of a tripeptide HIV protease inhibitor using a combination of ionization and complexation with chemically modified cyclodextrins