In vitro evaluation of sol-gel processed spray dried silica gel microspheres as carrier in controlled drug delivery

International Journal of Pharmaceutics

Volumn 200, Issue 2, 2000, Pages 223-229

  Kortesuo, Pirjo ^a   Ahola, Manja ^b   Kangas, Minna ^b   Kangasniemi, Ilkka ^b   Yli Urpo, Antti ^b   Kiesvaara, Juha ^a  

^a ORION CORPORATION   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

Dexmedetomidine HCl; Drug release; Silica gel microspheres; Spray drying; Toremifene citrate

Indexed keywords

DEXMEDETOMIDINE; DRUG CARRIER; MICROSPHERE; SILICA GEL; TOREMIFENE;

ARTICLE; CONTROLLED DRUG RELEASE; DISSOLUTION; DRUG RELEASE; DRUG SOLUBILITY; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

DELAYED-ACTION PREPARATIONS; DEXMEDETOMIDINE; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GELS; MICROSPHERES; SILICON DIOXIDE; TOREMIFENE;

EID: 0034630866     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00393-8     Document Type: Article

References (14)

1. Ahola M., Kortesuo P., Kangasniemi I., Kiesvaara J., Yli-Urpo A. Silica xerogel carrier material for controlled release of toremifene citrate. Int. J. Pharm. 195:2000;219-227.
2. Broadhead J., Rouan S.K.E., Rhodes C.T. The spray drying of pharmaceuticals. Drug Dev. Ind. Pharm. 18:1992;1169-1206.
3. Böttcher H., Slowik P., Suss W. Sol-gel carrier systems for controlled drug delivery. J. Sol-Gel Sci. Tech. 13:1998;277-281.
4. Clarke N., Connor K., Ramtoola Z. Influence of formulation variables on the morphology of biodegradable microparticles prepared by spray drying. Drug Dev. Ind. Pharm. 24:1998;169-174.
5. Jain R., Shah N.V., Malick A.W., Rhodes C.T. Controlled drug delivery by biodegradable polyester devices: different preparative approaches. Drug Dev. Ind. Pharm. 24:1998;703-727.
6. Koch O.G., Koch-Dedic G.A. Handbuch Der Spurenanalyse. 1974;1105 Springer-Verlag, Berlin.
7. Kortesuo P., Ahola M., Karlsson S. et al. Sol-gel-processed sintered silica xerogel as a carrier in controlled drug delivery. J. Biomed. Mater. Res. 44:1999;162-167.
8. Nicoll S.B., Radin S., Santos E.M., Tuan R.S., Ducheyne P. In vitro release kinetics of biologically active transforming growth factor-1 from a novel porous glass carrier. Biomaterials. 18:1997;853-859.
9. Okada H., Doken Y., Ogawa Y., Toguchi H. Preparation of three-month depot injectable microspheres of leuprorelin acetate using biodegradable polymers. Pharm. Res. 11:1994;1143-1147.
10. Radin S., El-Bassyouni G., Vresilovic E.J., Schepers E., Ducheyne P. Tissue reactions to controlled release silica xerogel carriers, Bioceramics 11, World Scientific Publishing, New York. 1998;529-532.
11. Takada S., Uda Y., Toguchi H., Ogawa Y. Application of a spray drying technique in the production of TRH-containing injectable sustained-release microparticles of biodegradable polymers. PDA J. Pharm. Sci. Technol. 49:1995;180-184.
12. Tan B.H., Santos E.M., Ducheyne P. Ultramicroscopic pore size and porosity of xerogels for controlled release of biological molecules. Fifth World Biomaterials Congress. 2:1996;191 Toronto, Canada.
13. Unger K., Rupprecht H., Valentin B., Kircher W. The use of porous and surface modified silicas as drug delivery and stabilizing agent. Drug Dev. Ind. Pharm. 9:1983;69-91.
14. Wagenaar B.W., Muller B.W. Piroxicam release from spray-dried biodegradable microspheres. Biomaterials. 15:1994;49-54.