Activation of Paired-homeobox gene PITX1 by del(5)(q31) in T-cell acute lymphoblastic leukemia

Leukemia and Lymphoma

Volumn 52, Issue 7, 2011, Pages 1348-1359

  Nagel, Stefan ^a   Venturini, Letizia ^b   Przybylski, Grzegorz K ^c   Grabarczyk, Piotr ^d   Schneider, Björn ^a   Meyer, Corinna ^a   Kaufmann, Maren ^a   Schmidt, Christian A ^c   Scherr, Michaela ^b   Drexler, Hans G ^a   MacLeod, Roderick A F ^a  

^a LEIBNIZ INSTITUTE DSMZ GERMAN COLLECTION OF MICROORGANISMS AND CELL CULTURES   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c INSTITUTE OF HUMAN GENETICS   (Poland)

^d UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Aberration; del(5q); homeobox; oncogen; PITX1; RUNX; STAT1

Indexed keywords

HOMEODOMAIN PROTEIN; INTERLEUKIN 2; INTERLEUKIN 7; PROTEIN NKX3 1; PROTEIN TRIB2; STAT1 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR JUNB; TRANSCRIPTION FACTOR PITX1; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BINDING SITE; CHROMOSOME 5Q; CHROMOSOME DELETION 5; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LEUKEMOGENESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ADOLESCENT; ADULT; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; CHILD; CHILD, PRESCHOOL; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 5; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; IMMUNOLOGIC FACTORS; INTERLEUKIN-2; JURKAT CELLS; MADS DOMAIN PROTEINS; MYOGENIC REGULATORY FACTORS; PAIRED BOX TRANSCRIPTION FACTORS; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; STAT1 TRANSCRIPTION FACTOR; YOUNG ADULT;

EID: 79959583210     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2011.566391     Document Type: Article

References (47)

1. Duboule D. Guidebook to the homeobox genes. Oxford: Oxford University Press; 1994.
2. Bondos SE, Tan XX. Combinatorial transcriptional regulation: the interaction of transcription factors and cell signaling molecules with homeodomain proteins in Drosophila development. Crit Rev Eukaryot Gene Expr 2001;11:145-171. (Pubitemid 32994864)
3. Holland PW, Booth HA, Bruford EA. Classification and nomenclature of all human homeobox genes. BMC Biol 2007;5:47.
4. Hatano M, Roberts CW, Minden M, Crist WM, Korsmeyer SJ. Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia. Science 1991;253:79-82. (Pubitemid 21917124)
5. Bernard OA, Busson-LeConiat M, Ballerini P, et al. A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia. Leukemia 2001;15:1495-1504. (Pubitemid 32994666)
6. Nagel S, Kaufmann M, Drexler HG, MacLeod RA. The cardiac homeobox gene NKX2-5 is deregulated by juxtaposition with BCL11B in pediatric T-ALL cell lines via a novel t(5;14)(q35.1;q32.2). Cancer Res 2003;63:5329-5334. (Pubitemid 37139847)
7. Przybylski GK, Dik WA, Grabarczyk P, et al. The effect of a novel recombination between the homeobox gene NKX2-5 and the TRD locus in T-cell acute lymphoblastic leukemia on activation of the NKX2-5 gene. Haematologica 2006;91:317-321.
8. Soulier J, Clappier E, Cayuela JM, et al. HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL). Blood 2005;106:274-286. (Pubitemid 40967203)
9. Nagel S, Venturini L, Przybylski GK, et al. NK-like homeodomain proteins activate NOTCH3-signaling in leukemic Tcells. BMC Cancer 2009;9:371.
10. Radtke F, Wilson A, Mancini SJ, MacDonald HR. Notch regulation of lymphocyte development and function. Nat Immunol 2004;5:247-253. (Pubitemid 38332121)
11. Bain G, Engel I, Robanus Maandag EC, et al. E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas. Mol Cell Biol 1997;17:4782-4791. (Pubitemid 27318153)
12. Yarilin AA, Belyakov IM. Cytokines in the thymus: production and biological effects. Curr Med Chem 2004;11:447-464. (Pubitemid 38292379)
13. Delespine-Carmagnat M, Bouvier G, Bertoglio J. Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain. Eur J Immunol 2000;30:59-68. (Pubitemid 30011766)
14. Kang J, DiBenedetto B, Narayan K, Zhao H, Der SD, Chambers CA. STAT5 is required for thymopoiesis in a development stage-specific manner. J Immunol 2004;173: 2307-2314. (Pubitemid 39063086)
15. Ferrando AA, Neuberg DS, Staunton J, et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 2002;1:75-87. (Pubitemid 41039178)
16. Nagel S, Meyer C, Quentmeier H, Kaufmann M, Drexler HG, MacLeod RA. MEF2C is activated by multiple mechanisms in a subset of T-acute lymphoblastic leukemia cell lines. Leukemia 2008;22:600-607. (Pubitemid 351386731)
17. Drexler HG. Leukemia-lymphoma cell lines. 2nd ed. Braunschweig, Germany: DMSZ; 2010. [eBook on CD].
18. MacLeod RA, Kaufmann M, Drexler HG. Cytogenetic harvesting of commonly used tumor cell lines. Nat Protoc 2007;2:372-382. (Pubitemid 47040052)
19. Nagel S, Burek C, Venturini L, et al. Comprehensive analysis of homeobox genes in Hodgkin lymphoma cell lines identifies dysregulated expression of HOXB9 mediated via ERK5 signaling and BMI1. Blood 2007;109:3015-3023. (Pubitemid 46482102)
20. Nagel S, Venturini L, Meyer C, et al. Multiple mechanisms induce ectopic expression of LYL1 in subsets of T-ALL cell lines. Leuk Res 2010;34:521-528.
21. Scherr M, Battmer K, Blömer U, et al. Lentiviral gene transfer into peripheral blood-derived CD34+ NOD/SCID-repopulating cells. Blood 2002;99:709-712. (Pubitemid 34533114)
22. Strizzi L, Hardy KM, Seftor EA, et al. Development and cancer: at the crossroads of nodal and Notch signaling. Cancer Res 2009;69:7131-7134.
23. Shiratori H, Sakuma R, Watanabe M, et al. Two-step regulation of left-right asymmetric expression of Pitx2: initiation by nodal signaling and maintenance by Nkx2. Mol Cell 2001;7:137-149. (Pubitemid 32162907)
24. Chan YF, Marks ME, Jones FC, et al. Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer. Science 2010;327:302-305.
25. Jothi R, Cuddapah S, Barski A, Cui K, Zhao K. Genome-wide identification of in vivo protein-DNA binding sites from ChIP-Seq data. Nucleic Acids Res 2008;36:5221-5231.
26. Swanson BJ, Jäck HM, Lyons GE. Characterization of myocyte enhancer factor 2 (MEF2) expression in B and T cells: MEF2C is a B cell-restricted transcription factor in lymphocytes. Mol Immunol 1998;35:445-458. (Pubitemid 28474039)
27. Wilker PR, Kohyama M, Sandau MM, et al. Transcription factor Mef2c is required forBcell proliferation and survival after antigen receptor stimulation. Nat Immunol 2008;9:603-612. (Pubitemid 351712631)
28. Egawa T, Tillman RE, Naoe Y, Taniuchi I, Littman DR. The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J Exp Med 2007;204:1945-1957. (Pubitemid 47236329)
29. Vaillant F, Blyth K, Andrew L, Neil JC, Cameron ER. Enforced expression of Runx2 perturbs T cell development at a stage coincident with beta-selection. J Immunol 2002;169: 2866-2874. (Pubitemid 35013127)
30. Bee T, Liddiard K, Swiers G, et al. Alternative Runx1 promoter usage in mouse developmental hematopoiesis. Blood Cells Mol Dis 2009;43:35-42.
31. Sroczynska P, Lancrin C, Kouskoff V, Lacaud G. The differential activities of Runx1 promoters define milestones during embryonic hematopoiesis. Blood 2009;114:5279-5289.
32. Lamonerie T, Tremblay JJ, Lanctôt C, Therrien M, Gauthier Y, Drouin J. Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene. Genes Dev 1996;10:1284-1295. (Pubitemid 26171108)
33. Taniuchi I, Osato M, Egawa T, et al. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 2002;111: 621-633. (Pubitemid 35441245)
34. Green PD, Hjalt TA, Kirk DE, et al. Antagonistic regulation of Dlx2 expression by PITX2 and Msx2: implications for tooth development. Gene Expr 2001;9:265-281. (Pubitemid 33096398)
35. Gage PJ, Suh H, Camper SA. The bicoid-related Pitx gene family in development. Mamm Genome 1999;10:197-200. (Pubitemid 29390548)
36. Shapiro MD, Marks ME, Peichel CL, et al. Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. Nature 2004;428:717-723. (Pubitemid 38508276)
37. Cobaleda C, Schebesta A, Delogu A, Busslinger M. Pax5: the guardian of B cell identity and function. Nat Immunol 2007;8:463-470. (Pubitemid 46605911)
38. Nagel S, Venturini L, Meyer C, et al. Transcriptional deregulation of oncogenic MEF2C in T-cell acute lymphoblastic leukemia. Leuk Lymphoma 2011;52:290-297.
39. Shaulian E. AP-1-The Jun proteins: oncogenes or tumor suppressors in disguise? Cell Signal 2010;22:894-899.
40. Cui J, Wang Q, Wang J, et al. Basal c-Jun NH2-terminal protein kinase activity is essential for survival and proliferation of T-cell acute lymphoblastic leukemia cells.Mol Cancer Ther 2009;8:3214-3222.
41. Welcker M, Clurman BE. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer 2008;8:83-93. (Pubitemid 351161321)
42. Jeong KH, Chin WW, Kaiser UB. Essential role of the homeodomain for pituitary homeobox 1 activation of mouse gonadotropin-releasing hormone receptor gene expression through interactions with c-Jun and DNA. Mol Cell Biol 2004;24:6127-6139. (Pubitemid 38891116)
43. Kusy S, Gerby B, Goardon N, et al. NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. J Exp Med 2010;207:2141-2156.
44. Shen MM, Abate-Shen C. Roles of the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis. Dev Dyn 2003;228:767-778. (Pubitemid 37493996)
45. Wong WF, Nakazato M, Watanabe T, et al. Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double-negative to double-positive stages. Immunology 2010;130:243-253.
46. Poulin G, Lebel M, Chamberland M, Paradis FW, Drouin J. Specific protein-protein interaction between basic helix-loophelix transcription factors and homeoproteins of the Pitx family. Mol Cell Biol 2000;20:4826-4837. (Pubitemid 30396129)
47. Wouters BJ, Jordà MA, Keeshan K, et al. Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. Blood 2007;110:3706-3714. (Pubitemid 350159640)